SV2018005750A - Derivados de compuestos de indol sustituidos como inhibidores de la replicacion virica del dengue - Google Patents
Derivados de compuestos de indol sustituidos como inhibidores de la replicacion virica del dengueInfo
- Publication number
- SV2018005750A SV2018005750A SV2018005750A SV2018005750A SV2018005750A SV 2018005750 A SV2018005750 A SV 2018005750A SV 2018005750 A SV2018005750 A SV 2018005750A SV 2018005750 A SV2018005750 A SV 2018005750A SV 2018005750 A SV2018005750 A SV 2018005750A
- Authority
- SV
- El Salvador
- Prior art keywords
- dengue
- compounds
- viric
- replication
- inhibitors
- Prior art date
Links
- 208000001490 Dengue Diseases 0.000 title abstract 3
- 206010012310 Dengue fever Diseases 0.000 title abstract 3
- 208000025729 dengue disease Diseases 0.000 title abstract 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 229940126601 medicinal product Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
LA PRESENTE INVENCIÓN TRATA SOBRE COMPUESTOS DE INDOL SUSTITUIDOS, MÉTODOS PARA PREVENIR O TRATAR INFECCIONES VÍRICAS POR DENGUE UTILIZANDO DICHOS COMPUESTOS Y TAMBIÉN SE REFIERE A DICHOS COMPUESTOS PARA SU USO COMO UN MEDICAMENTO, MÁS PREFERENTEMENTE, PARA SU USO COMO UN MEDICAMENTO PARA TRATAR O PREVENIR INFECCIONES VÍRICAS POR DENGUE. LA PRESENTE INVENCIÓN SE REFIERE ADEMÁS A COMPOSICIONES FARMACÉUTICAS O PREPARADOS COMBINADOS DE LOS COMPUESTOS, A LAS COMPOSICIONES O PREPARADOS PARA SU USO COMO UN MEDICAMENTO, MÁS PREFERENTEMENTE PARA LA PREVENCIÓN O EL TRATAMIENTO DE INFECCIONES VÍRICAS POR DENGUE. LA INVENCIÓN TAMBIÉN SE REFIERE A PROCESOS PARA LA PREPARACIÓN DE LOS COMPUESTOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163482 | 2016-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2018005750A true SV2018005750A (es) | 2018-11-15 |
Family
ID=55650310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2018005750A SV2018005750A (es) | 2016-04-01 | 2018-09-28 | Derivados de compuestos de indol sustituidos como inhibidores de la replicacion virica del dengue |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10730884B2 (es) |
| EP (1) | EP3436004B1 (es) |
| JP (2) | JP7007290B2 (es) |
| KR (1) | KR102359766B1 (es) |
| CN (1) | CN109069482B (es) |
| AU (1) | AU2017240076A1 (es) |
| BR (1) | BR112018068956A2 (es) |
| CA (1) | CA3013408A1 (es) |
| CL (1) | CL2018002784A1 (es) |
| CO (1) | CO2018009996A2 (es) |
| CR (1) | CR20180494A (es) |
| EA (1) | EA201892200A1 (es) |
| EC (1) | ECSP18073264A (es) |
| ES (1) | ES3010298T3 (es) |
| IL (1) | IL261947A (es) |
| MA (1) | MA44502A (es) |
| MX (1) | MX2018011786A (es) |
| PH (1) | PH12018502026A1 (es) |
| SG (1) | SG11201808237UA (es) |
| SV (1) | SV2018005750A (es) |
| WO (1) | WO2017167952A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| US10646469B2 (en) | 2016-03-31 | 2020-05-12 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| EA201892216A1 (ru) | 2016-03-31 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN109069482B (zh) | 2016-04-01 | 2022-04-05 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物 |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| TWI771420B (zh) | 2017-05-22 | 2022-07-21 | 美商健生醫藥公司 | 作為登革熱病毒複製抑制劑之經取代之吲哚啉衍生物（一） |
| AU2018274100B2 (en) | 2017-05-22 | 2022-06-23 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| CN108586404A (zh) * | 2018-06-12 | 2018-09-28 | 湖南大学 | 一种n-芳基萘并呋喃酮亚胺类化合物的合成方法 |
| CN108947948B (zh) * | 2018-06-12 | 2021-07-20 | 湖南大学 | 一种n-芳基萘并呋喃酮亚胺类化合物及其合成方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| WO2003050295A2 (en) | 2001-12-12 | 2003-06-19 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating hsp90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| BRPI0516751A (pt) * | 2004-09-30 | 2008-09-16 | Tibotec Pharm Ltd | pirimidinas bicìclicas que inibem hcv |
| EP1844042A1 (en) | 2005-01-14 | 2007-10-17 | Genelabs Technologies, Inc. | Indole derivatives for treating viral infections |
| EP1853317A2 (en) | 2005-02-09 | 2007-11-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| CN101903026B (zh) * | 2007-09-18 | 2013-05-08 | 斯坦福大学 | 抑制剂在制备用于治疗黄病毒家族病毒感染的药物中的用途 |
| AU2009256390A1 (en) | 2008-06-03 | 2009-12-10 | Siga Technologies, Inc. | Small molecule inhibitors for the treatment or prevention of dengue virus infection |
| US8143259B2 (en) | 2008-08-19 | 2012-03-27 | Janssen Pharmaceutica, Nv | Cold menthol receptor antagonists |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| US8524764B2 (en) | 2010-01-15 | 2013-09-03 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| AU2014338947B2 (en) | 2013-10-23 | 2018-02-22 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| PE20210470A1 (es) | 2014-01-31 | 2021-03-08 | Bristol Myers Squibb Co | Macrociclos con grupos p2' heterociclicos como inhibidores del factor xia |
| SI3201176T1 (sl) | 2014-10-01 | 2019-05-31 | Janssen Pharmaceuticals, Inc. | Mono-ali di-substituirani derivati indola kot inhibitorji replikacije virusa denga |
| PL3201177T3 (pl) | 2014-10-01 | 2019-05-31 | Janssen Pharmaceuticals Inc | Mono- lub di-podstawione indole jako inhibitory replikacji wirusa dengi |
| NO2721243T3 (es) | 2014-10-01 | 2018-10-20 | ||
| PH12017501272B1 (en) | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MX374683B (es) | 2015-11-03 | 2025-03-04 | Zoetis Services Llc | Compuestos polimericos sol-gel y sus usos. |
| AU2017245125B2 (en) | 2016-03-31 | 2020-10-22 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US10646469B2 (en) | 2016-03-31 | 2020-05-12 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| EA201892216A1 (ru) | 2016-03-31 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| PE20190173A1 (es) | 2016-04-01 | 2019-02-01 | Kite Pharma Inc | Receptores de antigenos quimericos y celulas t y metodos de uso |
| UA128326C2 (uk) | 2016-04-01 | 2024-06-12 | Амджен Інк. | Химерний рецептор до flt3 та спосіб його застосування |
| AU2017240788B2 (en) | 2016-04-01 | 2020-04-09 | Amgen Inc. | Chimeric receptors and methods of use thereof |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN109069482B (zh) | 2016-04-01 | 2022-04-05 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物 |
| CA3018986A1 (en) | 2016-04-01 | 2017-10-05 | Signal Pharmaceuticals, Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| JP7027329B2 (ja) | 2016-04-01 | 2022-03-01 | ビーエーエスエフ ソシエタス・ヨーロピア | 二環式化合物 |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| TWI771420B (zh) | 2017-05-22 | 2022-07-21 | 美商健生醫藥公司 | 作為登革熱病毒複製抑制劑之經取代之吲哚啉衍生物（一） |
| AU2018274100B2 (en) | 2017-05-22 | 2022-06-23 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
-
2017
- 2017-03-31 CN CN201780022068.1A patent/CN109069482B/zh active Active
- 2017-03-31 MX MX2018011786A patent/MX2018011786A/es unknown
- 2017-03-31 MA MA044502A patent/MA44502A/fr unknown
- 2017-03-31 BR BR112018068956A patent/BR112018068956A2/pt not_active Application Discontinuation
- 2017-03-31 US US16/088,198 patent/US10730884B2/en active Active
- 2017-03-31 JP JP2018549980A patent/JP7007290B2/ja active Active
- 2017-03-31 WO PCT/EP2017/057662 patent/WO2017167952A1/en not_active Ceased
- 2017-03-31 CR CR20180494A patent/CR20180494A/es unknown
- 2017-03-31 EA EA201892200A patent/EA201892200A1/ru unknown
- 2017-03-31 ES ES17714752T patent/ES3010298T3/es active Active
- 2017-03-31 EP EP17714752.7A patent/EP3436004B1/en active Active
- 2017-03-31 KR KR1020187027650A patent/KR102359766B1/ko active Active
- 2017-03-31 CA CA3013408A patent/CA3013408A1/en not_active Abandoned
- 2017-03-31 AU AU2017240076A patent/AU2017240076A1/en not_active Abandoned
- 2017-03-31 SG SG11201808237UA patent/SG11201808237UA/en unknown
-
2018
- 2018-09-21 CO CONC2018/0009996A patent/CO2018009996A2/es unknown
- 2018-09-21 PH PH12018502026A patent/PH12018502026A1/en unknown
- 2018-09-26 IL IL261947A patent/IL261947A/en unknown
- 2018-09-28 SV SV2018005750A patent/SV2018005750A/es unknown
- 2018-09-28 CL CL2018002784A patent/CL2018002784A1/es unknown
- 2018-09-28 EC ECSENADI201873264A patent/ECSP18073264A/es unknown
-
2021
- 2021-10-15 JP JP2021169228A patent/JP2022009166A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2018011786A (es) | 2019-05-20 |
| CR20180494A (es) | 2019-01-29 |
| JP2022009166A (ja) | 2022-01-14 |
| AU2017240076A1 (en) | 2018-08-09 |
| CA3013408A1 (en) | 2017-10-05 |
| EP3436004A1 (en) | 2019-02-06 |
| KR20180130502A (ko) | 2018-12-07 |
| MA44502A (fr) | 2019-02-06 |
| CN109069482A (zh) | 2018-12-21 |
| ES3010298T3 (en) | 2025-04-02 |
| BR112018068956A2 (pt) | 2019-01-22 |
| EA201892200A1 (ru) | 2019-03-29 |
| EP3436004B1 (en) | 2024-12-11 |
| JP2019511502A (ja) | 2019-04-25 |
| ECSP18073264A (es) | 2018-10-31 |
| EP3436004C0 (en) | 2024-12-11 |
| SG11201808237UA (en) | 2018-10-30 |
| CN109069482B (zh) | 2022-04-05 |
| US10730884B2 (en) | 2020-08-04 |
| PH12018502026A1 (en) | 2019-02-11 |
| CO2018009996A2 (es) | 2018-09-28 |
| US20190276467A1 (en) | 2019-09-12 |
| KR102359766B1 (ko) | 2022-02-07 |
| WO2017167952A1 (en) | 2017-10-05 |
| JP7007290B2 (ja) | 2022-01-24 |
| IL261947A (en) | 2018-10-31 |
| CL2018002784A1 (es) | 2018-12-14 |
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