SI3201176T1 - Mono-ali di-substituirani derivati indola kot inhibitorji replikacije virusa denga - Google Patents

Mono-ali di-substituirani derivati indola kot inhibitorji replikacije virusa denga

Info

Publication number: SI3201176T1
Authority: SI; Slovenia
Prior art keywords: mono; viral replication; indole derivatives; substituted indole; replication inhibitors
Prior art date: 2014-10-01

Application number

SI201530603T

Other languages

English (en)

Inventor

Bart Rudolf Romanie Kesteleyn

Jean-Francois Bonfanti

Tim Hugo Maria Jonckers

Pierre Jean-Marie Bernard Raboisson

Dorothee Alice Marie-Eve Bardiot

Arnaud Didier M Marchand

Original Assignee

Janssen Pharmaceuticals, Inc.

Katholieke Universiteit Leuven

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-01

Filing date

2015-09-30

Publication date

2019-05-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54199687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3201176(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2015-09-30 Application filed by Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven filed Critical Janssen Pharmaceuticals, Inc.

2019-05-31 Publication of SI3201176T1 publication Critical patent/SI3201176T1/sl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

SI201530603T 2014-10-01 2015-09-30 Mono-ali di-substituirani derivati indola kot inhibitorji replikacije virusa denga SI3201176T1 (sl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP14187374		2014-10-01
EP15159164		2015-03-16
PCT/EP2015/072551 WO2016050841A1 (en)	2014-10-01	2015-09-30	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
EP15771136.7A EP3201176B1 (en)	2014-10-01	2015-09-30	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number	Publication Date
SI3201176T1 true SI3201176T1 (sl)	2019-05-31

Family

ID=54199687

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI201530603T SI3201176T1 (sl)	2014-10-01	2015-09-30	Mono-ali di-substituirani derivati indola kot inhibitorji replikacije virusa denga

Country Status (32)

Country	Link
US (1)	US9944598B2 (sl)
EP (1)	EP3201176B1 (sl)
JP (1)	JP6732736B2 (sl)
KR (1)	KR102478311B1 (sl)
CN (1)	CN107001264B (sl)
AU (1)	AU2015326930B2 (sl)
BR (1)	BR112017006299A2 (sl)
CA (1)	CA2959573A1 (sl)
CL (1)	CL2017000782A1 (sl)
CY (1)	CY1121874T1 (sl)
DK (1)	DK3201176T3 (sl)
EA (1)	EA032546B1 (sl)
ES (1)	ES2714074T3 (sl)
HR (1)	HRP20190199T1 (sl)
HU (1)	HUE041888T2 (sl)
IL (1)	IL251396A0 (sl)
LT (1)	LT3201176T (sl)
MA (1)	MA40768B1 (sl)
ME (1)	ME03360B (sl)
MX (1)	MX2017004299A (sl)
PH (1)	PH12017500571A1 (sl)
PL (1)	PL3201176T3 (sl)
PT (1)	PT3201176T (sl)
RS (1)	RS58461B1 (sl)
SG (1)	SG11201702463YA (sl)
SI (1)	SI3201176T1 (sl)
SM (1)	SMT201900162T1 (sl)
TW (1)	TWI681951B (sl)
UA (1)	UA121119C2 (sl)
UY (1)	UY36340A (sl)
WO (1)	WO2016050841A1 (sl)
ZA (1)	ZA201702301B (sl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201116559D0 (en)	2011-09-26	2011-11-09	Univ Leuven Kath	Novel viral replication inhibitors
GB201305376D0 (en)	2013-03-25	2013-05-08	Univ Leuven Kath	Novel viral replication inhibitors
DK3201206T3 (da)	2014-10-01	2019-12-16	Merck Patent Gmbh	Borsyrederivater
US9453018B2 (en)	2014-10-01	2016-09-27	Bristol-Myers Squibb Company	Pyrimidinones as factor XIa inhibitors
PL3201177T3 (pl) *	2014-10-01	2019-05-31	Janssen Pharmaceuticals Inc	Mono- lub di-podstawione indole jako inhibitory replikacji wirusa dengi
JOP20160086B1 (ar) *	2015-05-08	2021-08-17	2 Katholieke Univ Leuven Ku Leuven Research And Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) *	2015-09-16	2020-08-27	Katholieke Univ Leuven Ku Leuven Research & Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar)	2015-09-16	2022-03-14	Janssen Pharmaceuticals Inc	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
EA201892216A1 (ru) *	2016-03-31	2019-03-29	Янссен Фармасьютикалз, Инк.	Замещенные производные индолина в качестве ингибиторов репликации вирусов денге
US10646469B2 (en)	2016-03-31	2020-05-12	Janssen Pharmaceuticals, Inc.	Substituted indole derivatives as dengue viral replication inhibitors
JOP20170069B1 (ar) *	2016-04-01	2021-08-17	1 Janssen Pharmaceuticals Inc	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CN109069482B (zh) *	2016-04-01	2022-04-05	杨森制药公司	作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物
JOP20180025B1 (ar)	2017-03-31	2021-08-17	Janssen Pharmaceuticals Inc	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar)	2017-03-31	2019-01-30	Univ Leuven Kath	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
TWI771420B (zh) *	2017-05-22	2022-07-21	美商健生醫藥公司	作為登革熱病毒複製抑制劑之經取代之吲哚啉衍生物（一）
AU2018274100B2 (en)	2017-05-22	2022-06-23	Janssen Pharmaceuticals, Inc.	Substituted indoline derivatives as dengue viral replication inhibitors
WO2024252254A1 (en) *	2023-06-05	2024-12-12	Zydus Lifesciences Limited	Novel compounds to treat viral infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2012532102A (ja) *	2009-06-30	2012-12-13	シガ・テクノロジーズ・インコーポレーテッド	デングウイルス感染の治療法および予防法
GB201116559D0 (en) *	2011-09-26	2011-11-09	Univ Leuven Kath	Novel viral replication inhibitors
JOP20160086B1 (ar) *	2015-05-08	2021-08-17	2 Katholieke Univ Leuven Ku Leuven Research And Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) *	2015-09-16	2022-03-14	Janssen Pharmaceuticals Inc	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك

2015
- 2015-09-30 SI SI201530603T patent/SI3201176T1/sl unknown
- 2015-09-30 WO PCT/EP2015/072551 patent/WO2016050841A1/en not_active Ceased
- 2015-09-30 HU HUE15771136A patent/HUE041888T2/hu unknown
- 2015-09-30 CA CA2959573A patent/CA2959573A1/en not_active Abandoned
- 2015-09-30 EP EP15771136.7A patent/EP3201176B1/en active Active
- 2015-09-30 KR KR1020177011122A patent/KR102478311B1/ko active Active
- 2015-09-30 AU AU2015326930A patent/AU2015326930B2/en not_active Expired - Fee Related
- 2015-09-30 PT PT15771136T patent/PT3201176T/pt unknown
- 2015-09-30 ME MEP-2019-62A patent/ME03360B/me unknown
- 2015-09-30 SG SG11201702463YA patent/SG11201702463YA/en unknown
- 2015-09-30 PL PL15771136T patent/PL3201176T3/pl unknown
- 2015-09-30 BR BR112017006299-2A patent/BR112017006299A2/pt not_active Application Discontinuation
- 2015-09-30 EA EA201790758A patent/EA032546B1/ru not_active IP Right Cessation
- 2015-09-30 JP JP2017513061A patent/JP6732736B2/ja active Active
- 2015-09-30 CN CN201580053446.3A patent/CN107001264B/zh active Active
- 2015-09-30 ES ES15771136T patent/ES2714074T3/es active Active
- 2015-09-30 HR HRP20190199TT patent/HRP20190199T1/hr unknown
- 2015-09-30 MA MA40768A patent/MA40768B1/fr unknown
- 2015-09-30 TW TW104132008A patent/TWI681951B/zh not_active IP Right Cessation
- 2015-09-30 MX MX2017004299A patent/MX2017004299A/es unknown
- 2015-09-30 SM SM20190162T patent/SMT201900162T1/it unknown
- 2015-09-30 UA UAA201704215A patent/UA121119C2/uk unknown
- 2015-09-30 RS RS20190206A patent/RS58461B1/sr unknown
- 2015-09-30 LT LTEP15771136.7T patent/LT3201176T/lt unknown
- 2015-09-30 US US15/515,574 patent/US9944598B2/en active Active
- 2015-09-30 DK DK15771136.7T patent/DK3201176T3/en active
- 2015-10-01 UY UY0001036340A patent/UY36340A/es unknown
2017
- 2017-03-27 PH PH12017500571A patent/PH12017500571A1/en unknown
- 2017-03-27 IL IL251396A patent/IL251396A0/en unknown
- 2017-03-31 ZA ZA2017/02301A patent/ZA201702301B/en unknown
- 2017-03-31 CL CL2017000782A patent/CL2017000782A1/es unknown
2019
- 2019-03-01 CY CY20191100257T patent/CY1121874T1/el unknown

Also Published As

Publication number	Publication date
US20170298017A1 (en)	2017-10-19
ME03360B (me)	2019-10-20
HRP20190199T1 (hr)	2019-04-05
WO2016050841A9 (en)	2016-06-02
MA40768A (fr)	2017-09-08
RS58461B1 (sr)	2019-04-30
AU2015326930B2 (en)	2020-03-26
TWI681951B (zh)	2020-01-11
ZA201702301B (en)	2018-12-19
CY1121874T1 (el)	2020-10-14
KR102478311B1 (ko)	2022-12-15
MX2017004299A (es)	2017-07-19
TW201630879A (zh)	2016-09-01
EA201790758A1 (ru)	2017-07-31
EP3201176A1 (en)	2017-08-09
CN107001264A (zh)	2017-08-01
PH12017500571A1 (en)	2017-08-30
CA2959573A1 (en)	2016-04-07
DK3201176T3 (en)	2019-03-25
PL3201176T3 (pl)	2019-06-28
EA032546B1 (ru)	2019-06-28
CL2017000782A1 (es)	2017-11-03
AU2015326930A1 (en)	2017-03-16
ES2714074T3 (es)	2019-05-27
UY36340A (es)	2016-04-01
JP6732736B2 (ja)	2020-07-29
MA40768B1 (fr)	2019-03-29
SG11201702463YA (en)	2017-04-27
BR112017006299A2 (pt)	2018-01-16
IL251396A0 (en)	2017-05-29
JP2017531619A (ja)	2017-10-26
EP3201176B1 (en)	2018-12-12
PT3201176T (pt)	2019-03-04
WO2016050841A1 (en)	2016-04-07
US9944598B2 (en)	2018-04-17
CN107001264B (zh)	2021-06-15
LT3201176T (lt)	2019-03-25
HUE041888T2 (hu)	2019-06-28
SMT201900162T1 (it)	2019-05-10
UA121119C2 (uk)	2020-04-10
KR20170063802A (ko)	2017-06-08

Publication	Publication Date	Title
ZA202002435B (en)	2023-03-29	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
ZA201702301B (en)	2018-12-19	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
IL258043B (en)	2021-08-31	Mono- or di-converted indoles as inhibitors of dengue virus replication
ZA201801764B (en)	2021-04-28	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
ZA201702299B (en)	2018-12-19	Mono- or di-substituted indoles as dengue viral replication inhibitors
ZA201806473B (en)	2020-05-27	Substituted indole derivatives as dengue viral replication inhibitors
ZA201806482B (en)	2021-04-28	Substituted indoline derivatives as dengue viral replication inhibitors
IL261943A (en)	2018-10-31	Transformed indulin derivatives as inhibitors of dengue virus replication
ZA201704783B (en)	2019-01-30	Indole derivatives as dengue viral replication inhibitors
PT3294738T (pt)	2021-06-30	Derivados mono ou di-substituídos de indol como inibidores da replicação viral da dengue