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SV2016005230A - Derivados de acido heteroaril butanoico como inhibidores de lta4h - Google Patents

Derivados de acido heteroaril butanoico como inhibidores de lta4h

Info

Publication number
SV2016005230A
SV2016005230A SV2016005230A SV2016005230A SV2016005230A SV 2016005230 A SV2016005230 A SV 2016005230A SV 2016005230 A SV2016005230 A SV 2016005230A SV 2016005230 A SV2016005230 A SV 2016005230A SV 2016005230 A SV2016005230 A SV 2016005230A
Authority
SV
El Salvador
Prior art keywords
heteroaril
butanoic
derivatives
acid
lta4h
Prior art date
Application number
SV2016005230A
Other languages
English (en)
Inventor
Birgit Bollbuck
Cristian Markert
Wofgang Miltz
Till Roehn
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SV2016005230A publication Critical patent/SV2016005230A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCIÓN DESCRIBE DERIVADOS NOVEDOSOS DE ÁCIDO HETEROARIL BUTANOICO QUE SON BUENOS CANDIDATOS A FÁRMACOS ESPECIALMENTE, EN RELACIÓN CON LA LEUCOTRIENO A4 HIDRO LASA (LTA4H). LA PRESENTE INVENCIÓN TAMBIÉN SE RELACIONA CON COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHOS DERIVADOS NOVEDOSOS DE ÁCIDO HETEROARIL BUTANOICO, MÉTODOS DE USO DE DICHOS COMPUESTOS EN EL TRATAMIENTO DE VARIAS ENFERMEDADES Y TRASTORNOS Y PROCESOS PARA LA PREPARACIÓN DE TALES COMPUESTOS NOVEDOSOS
SV2016005230A 2013-12-20 2016-06-20 Derivados de acido heteroaril butanoico como inhibidores de lta4h SV2016005230A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13199138 2013-12-20
EP14181155 2014-08-15

Publications (1)

Publication Number Publication Date
SV2016005230A true SV2016005230A (es) 2016-11-21

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US (4) US9981926B2 (es)
EP (1) EP3083564B1 (es)
JP (1) JP6500024B2 (es)
KR (2) KR102368958B1 (es)
CN (1) CN105829286B (es)
AP (1) AP2016009301A0 (es)
AU (1) AU2014369180B2 (es)
BR (1) BR112016011170B1 (es)
CA (1) CA2927564C (es)
CL (1) CL2016001255A1 (es)
CR (1) CR20160279A (es)
CU (1) CU24360B1 (es)
CY (1) CY1120715T1 (es)
DK (1) DK3083564T3 (es)
EA (1) EA034436B1 (es)
EC (1) ECSP16062173A (es)
ES (1) ES2690790T3 (es)
GT (1) GT201600132A (es)
HR (1) HRP20181506T1 (es)
HU (1) HUE039615T2 (es)
IL (1) IL245011B (es)
LT (1) LT3083564T (es)
MX (1) MX2016008247A (es)
MY (1) MY180165A (es)
NZ (1) NZ719169A (es)
PE (1) PE20160899A1 (es)
PH (1) PH12016500814B1 (es)
PL (1) PL3083564T3 (es)
PT (1) PT3083564T (es)
RS (1) RS57642B1 (es)
SG (1) SG11201602787YA (es)
SI (1) SI3083564T1 (es)
SV (1) SV2016005230A (es)
TN (1) TN2016000127A1 (es)
UA (1) UA117498C2 (es)
UY (1) UY36178A (es)
WO (1) WO2015092740A1 (es)
ZA (1) ZA201602445B (es)

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WO2017175185A1 (en) 2016-04-08 2017-10-12 Novartis Ag Heteroaryl butanoic acid derivatives as lta4h inhibitors
EP3793602A4 (en) 2018-05-15 2022-04-20 Alkahest, Inc. Treatment of aging-associated disease with modulators of leukotriene a4 hydrolase
CR20210045A (es) 2018-07-25 2021-06-18 Novartis Ag Inhibidores de inflamasoma nlrp3
ES2984584T3 (es) 2018-07-31 2024-10-30 Novartis Ag Formas cristalinas de un inhibidor de LTA4H
KR102841441B1 (ko) * 2018-11-07 2025-07-31 추가이 세이야쿠 가부시키가이샤 O-치환 세린 유도체의 제조 방법
MX2021008303A (es) 2019-01-11 2021-10-13 Novartis Ag Inhibidores de lta4h para el tratamiento de la hidradenitis supurativa.
US10610280B1 (en) 2019-02-02 2020-04-07 Ayad K. M. Agha Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat
UY38687A (es) 2019-05-17 2023-05-15 Novartis Ag Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso
WO2021044351A1 (en) 2019-09-06 2021-03-11 Novartis Ag Methods of treating liver disease using lta4h inhibitors
AR123241A1 (es) 2020-08-14 2022-11-09 Novartis Ag Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismos
US11932630B2 (en) * 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
AU2022376563A1 (en) 2021-11-01 2023-12-07 Alkahest, Inc. Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases
UY40374A (es) 2022-08-03 2024-02-15 Novartis Ag Inhibidores de inflamasoma nlrp3

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