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PE20160899A1 - Derivados de acido heteroaril butanoico como inhibidores de lta4h - Google Patents

Derivados de acido heteroaril butanoico como inhibidores de lta4h

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Publication number
PE20160899A1
PE20160899A1 PE2016000846A PE2016000846A PE20160899A1 PE 20160899 A1 PE20160899 A1 PE 20160899A1 PE 2016000846 A PE2016000846 A PE 2016000846A PE 2016000846 A PE2016000846 A PE 2016000846A PE 20160899 A1 PE20160899 A1 PE 20160899A1
Authority
PE
Peru
Prior art keywords
butanoic acid
derivatives
heteroaryl
lta4h
inhibitors
Prior art date
Application number
PE2016000846A
Other languages
English (en)
Inventor
Birgit Bollbuck
Till Roehn
Wofgang Miltz
Christian Markert
Original Assignee
Novartis Ag
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Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20160899A1 publication Critical patent/PE20160899A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

La presente invencion se refiere a derivados de acido heteroaril butanoico de formula (I), en donde R1 es OH o NH2; Y es O, S o CH2; X1, X2, X3 y X4 son N; o X1, X2, X3 y X4 se seleccionan de N, NH, entre otros, siempre que al menos dos de X1, X2, X3 o X4 sean N o NH; R2 es alquilo C1-C6, entre otros. Son compuestos preferidos: acido (R)-3-amino-4-(5-(4-(benzo[d|tiazol-2-iloxi)fenil)-2H-tetrazol-2-il)butanoico; acido (R)-3-amino-4-(5-(4-((5-cloropiridin-2-il)oxi)fenil)-2H-tetrazol-2-il)butanoico; entre otros. Tambien se refiere a una composicion farmaceutica que lo comprende. Dichos compuestos son inhibidores de leucotrieno A4 hidrolasa (LTA4H), siendo utiles en el tratamiento de trastornos de la inflamacion como artritis, alergias, entre otros
PE2016000846A 2013-12-20 2014-12-18 Derivados de acido heteroaril butanoico como inhibidores de lta4h PE20160899A1 (es)

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EP13199138 2013-12-20
EP14181155 2014-08-15

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EP (1) EP3083564B1 (es)
JP (1) JP6500024B2 (es)
KR (2) KR102368958B1 (es)
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AP (1) AP2016009301A0 (es)
AU (1) AU2014369180B2 (es)
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MY (1) MY180165A (es)
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PE (1) PE20160899A1 (es)
PH (1) PH12016500814B1 (es)
PL (1) PL3083564T3 (es)
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MX2016008247A (es) 2013-12-20 2016-10-21 Novartis Ag Derivados de acido heteroaril butanoico como inhibidores de lta4h.
WO2017175185A1 (en) 2016-04-08 2017-10-12 Novartis Ag Heteroaryl butanoic acid derivatives as lta4h inhibitors
CN112469439A (zh) 2018-05-15 2021-03-09 万能溶剂有限公司 用白三烯a4水解酶调节剂治疗衰老相关性疾病
CN112424207B (zh) 2018-07-25 2024-03-19 诺华股份有限公司 Nlrp3炎性小体抑制剂
KR102858471B1 (ko) * 2018-07-31 2025-09-12 노파르티스 아게 Lta4h 저해제의 결정질 형태
WO2020095983A1 (ja) * 2018-11-07 2020-05-14 中外製薬株式会社 Ｏ－置換セリン誘導体の製造方法
EP3908279B1 (en) * 2019-01-11 2024-08-28 Novartis AG Lta4h inhibitor for the treatment or prevention of hidradenitis suppurativa
US10610280B1 (en) 2019-02-02 2020-04-07 Ayad K. M. Agha Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat
UY38687A (es) 2019-05-17 2023-05-15 Novartis Ag Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso
WO2021044351A1 (en) 2019-09-06 2021-03-11 Novartis Ag Methods of treating liver disease using lta4h inhibitors
KR20230051227A (ko) 2020-08-14 2023-04-17 노파르티스 아게 헤테로아릴 치환된 스피로피페리디닐 유도체 및 이의 제약 용도
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