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SV2009003258A - Nuevos derivados aminopirimidina como inhibidores de plk1 - Google Patents

Nuevos derivados aminopirimidina como inhibidores de plk1

Info

Publication number
SV2009003258A
SV2009003258A SV2009003258A SV2009003258A SV2009003258A SV 2009003258 A SV2009003258 A SV 2009003258A SV 2009003258 A SV2009003258 A SV 2009003258A SV 2009003258 A SV2009003258 A SV 2009003258A SV 2009003258 A SV2009003258 A SV 2009003258A
Authority
SV
El Salvador
Prior art keywords
group
members
aminopirimidine
derivatives
new
Prior art date
Application number
SV2009003258A
Other languages
English (en)
Inventor
Hashihayata Takashi
Kaeamura Mikako
Mitsuya Morihiro
Satoh Yoshiyuki
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of SV2009003258A publication Critical patent/SV2009003258A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN COMPUESTO REPRESENTADO POR LA FORMULA [I]: (VER FORMULA); O UNA SAL FARMACÉUTICAMENTE ACEPTABLE O ESTER DEL MISMO, DONDE CADA UNO DE R1 Y R2, QUE PUEDEN SER IGUALES O DIFERENTES, ES UN ÁTOMO DE HIDROGENO, UN ÁTOMO DE HALÓGENO, UN GRUPO ALQUILO INFERIOR QUE PUEDE ESTAR SUSTITUIDO, O UN GRUPO CICLOPROPILO; CADA UNO DE R3 Y R4, QUE PUEDEN SER IGUALES O DIFERENTES, ES UN ÁTOMO DE HIDROGENO, UN GRUPO ALQUILO INFERIOR SUSTITUIDO CON NRARB, UN GRUPO HETEROCÍCLICO ALIFÁTICO DE 4 A 6 MIEMBROS, UN GRUPO ALQUILO INFERIOR SUSTITUIDO CON UN GRUPO HETEROCÍCLICO ALIFÁTICO DE 4 A 6 MIEMBROS, UN GRUPO HETEROCÍCLICO AROMÁTICO DE 5 Ó 6 MIEMBROS, O UN GRUPO ALQUILO INFERIOR SUSTITUIDO CON UN GRUPO HETEROCÍCLICO AROMÁTICO DE 5 Ó 6 MIEMBROS; Y R5 ES UN ÁTOMO DE HIDROGENO, UN GRUPO CIANO, UN ÁTOMO DE HALÓGENO, 0 UN GRUPO ALQUILO INFERIOR
SV2009003258A 2006-12-28 2009-05-12 Nuevos derivados aminopirimidina como inhibidores de plk1 SV2009003258A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006356575 2006-12-28
JP2007265783 2007-10-11

Publications (1)

Publication Number Publication Date
SV2009003258A true SV2009003258A (es) 2010-08-23

Family

ID=39588592

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2009003258A SV2009003258A (es) 2006-12-28 2009-05-12 Nuevos derivados aminopirimidina como inhibidores de plk1

Country Status (24)

Country Link
US (1) US7977336B2 (es)
EP (2) EP2114942B1 (es)
JP (1) JPWO2008081914A1 (es)
KR (1) KR101481388B1 (es)
CN (1) CN101573361B (es)
AR (1) AR064619A1 (es)
AU (1) AU2007340530B2 (es)
BR (1) BRPI0718966B8 (es)
CA (1) CA2668738A1 (es)
CL (1) CL2007003758A1 (es)
CO (1) CO6190523A2 (es)
CR (1) CR10784A (es)
EC (1) ECSP099324A (es)
GT (1) GT200900124A (es)
IL (1) IL198675A0 (es)
MA (1) MA31109B1 (es)
MX (1) MX2009004920A (es)
NO (1) NO20092770L (es)
NZ (1) NZ577273A (es)
PE (1) PE20081845A1 (es)
RU (1) RU2458062C2 (es)
SV (1) SV2009003258A (es)
TW (1) TW200835485A (es)
WO (2) WO2008081910A1 (es)

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ES2607184T3 (es) 2012-07-09 2017-03-29 Janssen Pharmaceutica, N.V. Inhibidores de la enzima fosfodiesterasa 10
ES2668861T3 (es) 2012-07-31 2018-05-22 Crown Bioscience, Inc. (Taicang) Marcadores histológicos para identificar pacientes con carcinoma de pulmón de células no pequeñas para el tratamiento con un fármaco anti EGFR
WO2014046617A1 (en) * 2012-09-19 2014-03-27 Agency For Science, Technology And Research Compositions and methods for treating cancer
WO2016041845A1 (en) 2014-09-17 2016-03-24 Boehringer Ingelheim International Gmbh Tetrahydroisoquinoline derivatives and pharmaceutical compositions useful for the treatment of obesity and diabetes
US20230190717A1 (en) * 2017-04-10 2023-06-22 City Of Hope P38 gamma inhibitors and method of use thereof
CA3146375A1 (en) * 2019-07-10 2021-01-14 Aucentra Therapeutics Pty Ltd Derivatives of 4-(imidazo[l,2-a]pyridin-3-yl)-n-(pyridinyl)pyrimidin-2-amine as therapeutic agents
CN118955500A (zh) * 2019-07-24 2024-11-15 默克专利股份公司 4-(咪唑并[1,2-a]吡啶-3-基)-嘧啶衍生物
CN112592318B (zh) * 2020-12-12 2022-05-03 贵州医科大学 2-(4-甲氨酰基)苯胺基-4-氨基嘧啶衍生物及应用
WO2024071401A1 (ja) 2022-09-29 2024-04-04 公益財団法人がん研究会 Ｐｌｋ１キナーゼ活性化による染色体制御破綻が誘導するがん細胞増殖抑制を創薬概念とする医薬のスクリーニング方法
CN119318874B (zh) * 2024-12-18 2025-04-15 淄博凯美可工贸有限公司 一种节能型复合脱硫剂的制备方法

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Also Published As

Publication number Publication date
KR101481388B1 (ko) 2015-01-12
PE20081845A1 (es) 2008-12-27
JPWO2008081914A1 (ja) 2010-04-30
RU2009128966A (ru) 2011-02-10
TW200835485A (en) 2008-09-01
RU2458062C2 (ru) 2012-08-10
KR20090092822A (ko) 2009-09-01
BRPI0718966A2 (pt) 2014-01-07
EP2114942B1 (en) 2012-10-31
AU2007340530B2 (en) 2012-09-13
EP2114942A1 (en) 2009-11-11
WO2008081914A1 (ja) 2008-07-10
EP2116543A1 (en) 2009-11-11
AU2007340530A1 (en) 2008-07-10
US7977336B2 (en) 2011-07-12
BRPI0718966B1 (pt) 2020-11-17
CN101573361B (zh) 2012-05-30
CN101573361A (zh) 2009-11-04
IL198675A0 (en) 2010-02-17
EP2114942A4 (en) 2010-09-08
BRPI0718966B8 (pt) 2021-05-25
ECSP099324A (es) 2009-06-30
AR064619A1 (es) 2009-04-15
GT200900124A (es) 2010-11-03
EP2116543A4 (en) 2010-09-08
MX2009004920A (es) 2009-05-21
US20080305081A1 (en) 2008-12-11
CO6190523A2 (es) 2010-08-19
CA2668738A1 (en) 2008-07-10
WO2008081910A1 (en) 2008-07-10
MA31109B1 (fr) 2010-01-04
NZ577273A (en) 2011-03-31
CL2007003758A1 (es) 2008-07-04
CR10784A (es) 2009-09-16
NO20092770L (no) 2009-09-25

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