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CL2007003758A1 - Compuestos derivados de aminopirimidina, inhibidores de plk1; composicion farmaceutica, util para el tratamiento de cancer. - Google Patents

Compuestos derivados de aminopirimidina, inhibidores de plk1; composicion farmaceutica, util para el tratamiento de cancer.

Info

Publication number
CL2007003758A1
CL2007003758A1 CL200703758A CL2007003758A CL2007003758A1 CL 2007003758 A1 CL2007003758 A1 CL 2007003758A1 CL 200703758 A CL200703758 A CL 200703758A CL 2007003758 A CL2007003758 A CL 2007003758A CL 2007003758 A1 CL2007003758 A1 CL 2007003758A1
Authority
CL
Chile
Prior art keywords
aminopirimidine
plk1
inhibitors
useful
pharmaceutical composition
Prior art date
Application number
CL200703758A
Other languages
English (en)
Inventor
Takashi Mitsuya Mo Hashihayata
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of CL2007003758A1 publication Critical patent/CL2007003758A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CL200703758A 2006-12-28 2007-12-20 Compuestos derivados de aminopirimidina, inhibidores de plk1; composicion farmaceutica, util para el tratamiento de cancer. CL2007003758A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006356575 2006-12-28
JP2007265783 2007-10-11

Publications (1)

Publication Number Publication Date
CL2007003758A1 true CL2007003758A1 (es) 2008-07-04

Family

ID=39588592

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200703758A CL2007003758A1 (es) 2006-12-28 2007-12-20 Compuestos derivados de aminopirimidina, inhibidores de plk1; composicion farmaceutica, util para el tratamiento de cancer.

Country Status (24)

Country Link
US (1) US7977336B2 (es)
EP (2) EP2114942B1 (es)
JP (1) JPWO2008081914A1 (es)
KR (1) KR101481388B1 (es)
CN (1) CN101573361B (es)
AR (1) AR064619A1 (es)
AU (1) AU2007340530B2 (es)
BR (1) BRPI0718966B8 (es)
CA (1) CA2668738A1 (es)
CL (1) CL2007003758A1 (es)
CO (1) CO6190523A2 (es)
CR (1) CR10784A (es)
EC (1) ECSP099324A (es)
GT (1) GT200900124A (es)
IL (1) IL198675A0 (es)
MA (1) MA31109B1 (es)
MX (1) MX2009004920A (es)
NO (1) NO20092770L (es)
NZ (1) NZ577273A (es)
PE (1) PE20081845A1 (es)
RU (1) RU2458062C2 (es)
SV (1) SV2009003258A (es)
TW (1) TW200835485A (es)
WO (2) WO2008081914A1 (es)

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GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
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EP2493889B1 (en) 2009-10-30 2017-09-06 Janssen Pharmaceutica, N.V. IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
UY33213A (es) 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
EP2463289A1 (en) 2010-11-26 2012-06-13 Almirall, S.A. Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
MX344600B (es) 2011-06-27 2016-12-20 Janssen Pharmaceutica Nv Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxalina.
EP2554544A1 (en) 2011-08-01 2013-02-06 Almirall, S.A. Pyridin-2(1h)-one derivatives as jak inhibitors
JP6026544B2 (ja) 2011-09-27 2016-11-16 ノバルティス アーゲー 変異体ｉｄｈの阻害剤としての３−ピリミジン−４−イル−オキサゾリジン−２−オン類
HK1206250A1 (en) 2012-06-26 2016-01-08 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl-[1,2,4] triazolo [4,3-a] quinoxaline compounds and ped 10 inhibitors for use in the treatment of neurological or metabolic disorders
CN104411314B (zh) 2012-07-09 2017-10-20 詹森药业有限公司 磷酸二酯酶10的抑制剂
ES2668861T3 (es) 2012-07-31 2018-05-22 Crown Bioscience, Inc. (Taicang) Marcadores histológicos para identificar pacientes con carcinoma de pulmón de células no pequeñas para el tratamiento con un fármaco anti EGFR
WO2014046617A1 (en) * 2012-09-19 2014-03-27 Agency For Science, Technology And Research Compositions and methods for treating cancer
WO2016041845A1 (en) 2014-09-17 2016-03-24 Boehringer Ingelheim International Gmbh Tetrahydroisoquinoline derivatives and pharmaceutical compositions useful for the treatment of obesity and diabetes
WO2018191171A1 (en) * 2017-04-10 2018-10-18 City Of Hope P38 gamma inhibitors and method of use thereof
WO2021003517A1 (en) * 2019-07-10 2021-01-14 Aucentra Therapeutics Pty Ltd Derivatives of 4-(imidazo[l,2-a]pyridin-3-yl)-n-(pyridinyl)pyrimidin- 2-amine as therapeutic agents
EP4003992A1 (en) * 2019-07-24 2022-06-01 Merck Patent GmbH 4-(imidazo[1,2-a]pyridin-3-yl) -pyrimidine derivatives
CN112592318B (zh) * 2020-12-12 2022-05-03 贵州医科大学 2-(4-甲氨酰基)苯胺基-4-氨基嘧啶衍生物及应用
WO2024071401A1 (ja) 2022-09-29 2024-04-04 公益財団法人がん研究会 Ｐｌｋ１キナーゼ活性化による染色体制御破綻が誘導するがん細胞増殖抑制を創薬概念とする医薬のスクリーニング方法
CN119318874B (zh) * 2024-12-18 2025-04-15 淄博凯美可工贸有限公司 一种节能型复合脱硫剂的制备方法

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Also Published As

Publication number Publication date
AU2007340530A1 (en) 2008-07-10
MX2009004920A (es) 2009-05-21
US20080305081A1 (en) 2008-12-11
US7977336B2 (en) 2011-07-12
CN101573361A (zh) 2009-11-04
ECSP099324A (es) 2009-06-30
EP2114942A1 (en) 2009-11-11
JPWO2008081914A1 (ja) 2010-04-30
SV2009003258A (es) 2010-08-23
BRPI0718966B8 (pt) 2021-05-25
EP2116543A1 (en) 2009-11-11
RU2009128966A (ru) 2011-02-10
PE20081845A1 (es) 2008-12-27
NZ577273A (en) 2011-03-31
IL198675A0 (en) 2010-02-17
AU2007340530B2 (en) 2012-09-13
EP2114942B1 (en) 2012-10-31
TW200835485A (en) 2008-09-01
WO2008081910A1 (en) 2008-07-10
RU2458062C2 (ru) 2012-08-10
MA31109B1 (fr) 2010-01-04
NO20092770L (no) 2009-09-25
KR20090092822A (ko) 2009-09-01
GT200900124A (es) 2010-11-03
WO2008081914A1 (ja) 2008-07-10
BRPI0718966A2 (pt) 2014-01-07
CO6190523A2 (es) 2010-08-19
EP2116543A4 (en) 2010-09-08
CA2668738A1 (en) 2008-07-10
EP2114942A4 (en) 2010-09-08
BRPI0718966B1 (pt) 2020-11-17
CN101573361B (zh) 2012-05-30
CR10784A (es) 2009-09-16
KR101481388B1 (ko) 2015-01-12
AR064619A1 (es) 2009-04-15

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