SU946550A1 - Method of treating ischemic injuries of brain - Google Patents
Method of treating ischemic injuries of brain Download PDFInfo
- Publication number
- SU946550A1 SU946550A1 SU772492677A SU2492677A SU946550A1 SU 946550 A1 SU946550 A1 SU 946550A1 SU 772492677 A SU772492677 A SU 772492677A SU 2492677 A SU2492677 A SU 2492677A SU 946550 A1 SU946550 A1 SU 946550A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- brain
- treating ischemic
- ischemic injuries
- hours
- blood flow
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 9
- 210000004556 brain Anatomy 0.000 title description 4
- 208000037906 ischaemic injury Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 230000007171 neuropathology Effects 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 description 5
- 230000010412 perfusion Effects 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 206010051290 Central nervous system lesion Diseases 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical group OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 230000002262 irrigation Effects 0.000 description 2
- 238000003973 irrigation Methods 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- -1 6 ml Chemical compound 0.000 description 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108010088842 Fibrinolysin Proteins 0.000 description 1
- 208000032382 Ischaemic stroke Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 108010054327 angiotrofin Proteins 0.000 description 1
- 239000002473 artificial blood Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001168 carotid artery common Anatomy 0.000 description 1
- 230000003727 cerebral blood flow Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229950001485 cocarboxylase Drugs 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229940001501 fibrinolysin Drugs 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229960001789 papaverine Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- YXVCLPJQTZXJLH-UHFFFAOYSA-N thiamine(1+) diphosphate chloride Chemical compound [Cl-].CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N YXVCLPJQTZXJLH-UHFFFAOYSA-N 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Description
Изобретение относитс к медицине, а именно к способам нейрохирургии при ликвидации последствий ишемических инсультов в сосудах головноп. мозга.The invention relates to medicine, in particular to methods of neurosurgery in the elimination of the consequences of ischemic strokes in the blood vessels of the brain. the brain.
Известен способ лечени ишемических поражений головного мозга путем внутривенного сосудистого введени растворов лекарственных препаратов 1.There is a method of treating ischemic brain lesions by intravenous vascular administration of drug solutions 1.
Однако эффективность известного способа недостаточна, так как концентраци достигающих очага поражени активных веществ незначительна, а их многократное введение в больших дозах вызывает разнообразные отрицательные реакции организма ( локальное мозговое обкрадывание, влени интоксикации и другие). Реставрацию кровотока удаетс осугцествить только частично и не во всех случа х.However, the effectiveness of this method is not sufficient, since the concentration of active substances reaching the focus of damage of the substance is insignificant, and their repeated administration in large doses causes various negative reactions of the body (local brain robbery, intoxication and others). The restoration of blood flow can only be partially compromised and not in all cases.
Цель изобретени - улучшение реставрации кровотока и уменьшение общей реакции организма.The purpose of the invention is to improve the restoration of blood flow and reduce the overall reaction of the body.
Поставленна цель достигаетс тем, что при осуществлении способа лечени ишемических поражений головного мозга путем внутрисосудистого введени -растворов лекарственных препаратов лекарственные вещества ввод тThe goal is achieved by the fact that in the implementation of the method of treatment of ischemic brain lesions by intravascular administration of solutions of drugs, medicinal substances are administered
непрерывно в течение 5-80 ч через баллон-катетер, фиксируемый вблизи очага поражени .continuously for 5-80 hours through a balloon catheter fixed near the lesion.
Способ осуществл ют следующим образом.The method is carried out as follows.
Производ т пункцию общей сонной артерии под контролем электроннолучевого преобразовател . К очагу поражени подвод т баллон-катетер. Введением контрастного вещества убеждаютс в правильности катетеризации , провод т укрепление катетера путем его раздувани . К баллонкатетеру подключают систему Дл посто нного орошени сосудистого ложа, после чего осуществл ют перфузию . На начальном этапе орошени в течение 1,5 ч ввод т 10000 единиц гепарина, растворенного в 200 мл геМодеза, далее последовательно . в течение 1 ч ввод т 100 мг фибринолизина в физиологическом растворе, в течение ч смесь из ферментов, витаминов (4 мл витамина С, по 2 мл 25 витаминов В, В, 100 мг кокарбоксилaзы ,6 мл, папаверина, 4 ип ангиотрофина , причем общее количество физиологического раствора, в котором ввод т вышеупом нутые препараты,до 1000 мл. Затем в течение 1 чA puncture of the common carotid artery is performed under the control of an electron beam transducer. A catheter balloon is attached to the lesion. By introducing a contrast agent, one is convinced of the correctness of the catheterization and the strengthening of the catheter is carried out by inflating it. A vascular bed irrigation system is connected to the balloon catheter, and perfusion is then performed. At the initial stage of irrigation, 10,000 units of heparin dissolved in 200 ml of heModez were introduced for 1.5 hours, then sequentially. During 1 hour, 100 mg of fibrinolysin in physiological solution was administered; for h, a mixture of enzymes and vitamins (4 ml of vitamin C, 2 ml of 25 vitamins B, B, 100 mg of cocarboxylase, 6 ml, papaverine, 4 sp of angiotrophin, and the total amount of saline in which the above preparations are administered is up to 1000 ml. Then within 1 hour
нагнетают цитратную кровь (150 мл), после чего в течение 1,5ч повтор ю введение того же количества гепарина в растворе гемодеза. Общее врем перфузии 7 ч, после чего производ т рентгеноконтроЛь функционировани восстанавливаемого участка ( ре дуцированного кровотока;. В случае свежих тромбов достаточно однократной перфузии, более организованные tзастарелые) процессы требуют многократной перфузии. Дл предотвращени возникновени возможных искусственных тромбов, св занных с длительной фиксацией баллона-катетера, требуетс обеспечение не только пр мого ,, но и ретроградного кровотока в проксимальных отделах сосуда,, что может быть достигнуто перфорацией проксимального участка катетера.citrate blood is injected (150 ml), after which the same amount of heparin in the hemodetic solution is repeated for 1.5 hours. The total perfusion time is 7 hours, after which the reconstructed area (reduced blood flow;; in the case of fresh blood clots, a single perfusion is sufficient; more organized t-old) processes require repeated perfusion. To prevent the occurrence of possible artificial blood clots associated with prolonged fixation of the balloon catheter, it is necessary to ensure not only direct, but also retrograde blood flow in the proximal parts of the vessel, which can be achieved by perforating the proximal section of the catheter.
Предлагаемый способ применен при лечении больных как со свежими, так и застарелыми нарушени ми мозгового кровотока, при этом реставраци кровотока наступает через 5-7 чThe proposed method is applied in the treatment of patients with both fresh and old disorders of cerebral blood flow, with the restoration of blood flow occurs in 5-7 hours
при свежих тромбах и через 15-80 ч при застарелых при уменьшенной общеЛ реакции организма. Предлагаемый способ эффективен и прост в исполнении .with fresh blood clots and after 15-80 hours with chronic ones with a reduced total reaction of the body. The proposed method is effective and easy to implement.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU772492677A SU946550A1 (en) | 1977-06-06 | 1977-06-06 | Method of treating ischemic injuries of brain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU772492677A SU946550A1 (en) | 1977-06-06 | 1977-06-06 | Method of treating ischemic injuries of brain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU946550A1 true SU946550A1 (en) | 1982-07-30 |
Family
ID=20711788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772492677A SU946550A1 (en) | 1977-06-06 | 1977-06-06 | Method of treating ischemic injuries of brain |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU946550A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2201261C2 (en) * | 2000-12-13 | 2003-03-27 | ГУ Научный центр реконструктивной и восстановительной хирургии ВСНЦ СО РАМН | Method for treating craniocerebral trauma |
-
1977
- 1977-06-06 SU SU772492677A patent/SU946550A1/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2201261C2 (en) * | 2000-12-13 | 2003-03-27 | ГУ Научный центр реконструктивной и восстановительной хирургии ВСНЦ СО РАМН | Method for treating craniocerebral trauma |
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