RU2268731C1 - Method for treating conjunctivo-keratitis in cattle - Google Patents

Abstract

FIELD: veterinary ophthalmology.

SUBSTANCE: the present innovation deals with treating infectious-inflammatory ocular diseases in cattle due to complex treatment with applying antibiotic preparation and biolan, moreover, antibiotic should be introduced into parotid lymphatic center through catheter once or twice daily at the quantity of about 8-10 ml, and biolan - at the dosage of 3-10 mg into the lower conjunctival arch of an eyeball. Such a technique due to taking into account optimal conditions of intraocular liquid circulation provides synergistic effect of the preparations introduced.

EFFECT: higher efficiency of therapy.

1 cl, 1 ex

Description

The invention relates to the field of veterinary medicine, namely to veterinary ophthalmology.

Known methods of treating conjunctivitis and keratitis in animals by retrobulbar novocaine blockade with a 0.5% solution of novocaine. In the treatment of phlegmonous conjunctivitis, novocaine with antibiotics is administered (intravenously, intraarterially, retrobulbarly). The conjunctival sac is moistened with warm disinfectant solutions (furatsillin, ethacridine lactate, potassium permanganate), antibiotics. Apply liniment and ointment with antibiotics and sulfonamides. For various types of keratitis, persistent and prolonged use of antibiotics and sulfa drugs is carried out, as well as retrobulbar novocaine blockade (Avrorov V.N., Lebedev A.V. "Veterinary Ophthalmology", M., Agropromizdat, 1985, pp. 95-160) - prototype.

However, such treatment does not always give a quick recovery. Treatment can last from 1.5 to 3-4 weeks.

The introduction of drugs directly into the lymphatic system increases the effectiveness of therapy. There is a method of treating complicated cholecystitis in humans by introducing an antibiotic solution into the pericholedochal lymph node (2).

The amino-peptide complex Biolan is known, which is a set of peptides and amino acids with anti-radical and membrane-stabilizing action stabilizing cell homeostasis (3). The adhesion of leukocytes, their migration and subsequent activation are the processes that result in the release of free radicals, proteolytic enzymes and other toxic components that cause serious disturbances in capillary blood flow. Biolan prevents the formation of oxygen free radicals and protects the microcirculation system at the stage of intravascular dehydration (4), and promotes the activation of the lymphatic system.

The prior art does not know a method for treating conjunctival keratitis in cattle by catheterizing lymph vessels entering the regional lymph node and injecting antibiotic solutions through them, while injecting a biolan solution into the lower conjunctival arch.

The purpose of the invention is improving the effectiveness of treatment and expanding the arsenal of means of treating conjunctivokeratitis of various etiologies.

In this regard, the task was to develop a method for the treatment of conjunctivitis, keratitis and conjunctivokeratitis of various etiologies (bacterial, traumatic, ulcerative, etc.) in cattle by endolymphatic administration of antibiotics, which accelerates the regeneration of the cornea and surrounding tissues and restores the function of the sick eye.

In pathology of the lymphatic system in cattle, the lymphatic capillaries and blood vessels increase by 20 times, and the lymph nodes - by 3-4 times, which makes it possible to detect and administer drugs to the lymphatic channel without any difficulties. Therefore, their detection and catheterization are not difficult for a veterinarian of ordinary skill.

Conducting endolymphatic antibiotic therapy for conjunctivokeratitis should be local, enhanced by the use of biologically active substances. Injections of the lymphotropic drug biolan during endolymphatic infusions can prevent complications in the form of lymphorrhea and lymphostasis. The recommended injection site for the biolan preparation is the lower arch of the conjunctiva of the eyeball, where the accumulations of lymphatic follicles are concentrated.

The invention consists in carrying out endolymphatic antibiotic therapy for bacterial, traumatic, ulcerative keratitis and injections of the lymphotropic drug Biolan.

A method for the treatment of conjunctiokeratitis in cattle is as follows. Previously, under local anesthesia of a 2% solution of novocaine in the parotid salivary gland in its cranial part, a skin incision is performed from 2 to 4 cm, subcutaneous tissue, superficial two-leaf fascia and deep fascia, the parotid lymph center (node) is isolated and 1-2 are most large lymphatic vessels. The purse-string sutures are applied to the isolated lymphatic vessels, these vessels are catheterized, and an antibiotic solution of 1-3% concentration with a total amount of 8-10 ml per injection is administered 1-2 times a day through catheters. At the same time, after local anesthesia with a solution of dicaine of 0.5% concentration, a biolan solution is injected into the lower conjunctival arch of the eyeball once at a dose of 3-10 mg per day, which is dissolved in 2-5 ml of water for injection before administration. In the method of treatment, chloramphenicol, ampicillin, gentamicin and other antibiotics can be used.

The proposed method treated 48 sick animals (48 eyes) with traumatic, ulcerative, bacterial conjunctivokeratitis. Compared with the control group, the course of the inflammatory process was less pronounced, epithelialization occurred on the 1st day, transparency, sphericity, and sensitivity of the cornea were restored, pain syndrome was significantly reduced, treatment terms averaged 3-4 days, in the control group 14-15 days .

Example 1. Cow No. 3951. Superficial purulent conjunctivokeratitis of the right eye was detected. Clinical signs are vascular hyperemia, corneal vascularization, photophobia, mucopurulent outflow from the conjunctival sac. The cornea is clouded, opaque, local temperature is increased, pain in the eye area.

The animal was treated (antibiotics, sulfa drugs, corticosteroid therapy). The condition did not improve on the 3rd day of treatment. There was a threat of the transition of the pathological process to a healthy eye. The animal is highly milky, valuable, so it was necessary to conduct a more effective treatment.

In this regard, the treatment was carried out by the proposed method of endolymphatic administration of antibiotics. Previously, under local anesthesia of a 2% solution of novocaine in the parotid salivary gland in its cranial part, a 3 cm skin incision, subcutaneous tissue, superficial two-leaf fascia and deep fascia were performed, the parotid lymph center (node) and 1 largest lymphatic vessel were isolated. A purse string suture was placed on this lymphatic vessel and the vessel was catheterized. Ampicillin solution was administered through the catheter 2 times a day with a total amount of 9 ml per administration. At the same time, after local anesthesia with 0.5% concentration of dicaine solution, a solution of 5 mg of biolan dissolved in 3 ml of water for injection was injected once into the lower conjunctival arch of the eyeball.

The antibiotic infusion was carried out for two days. On the 3rd day, the catheter was removed, the condition of the diseased animal quickly improved and returned to normal on the 4th day. The cornea is shiny, spherical, transparent, there is no growth of newly formed vessels.

The method of endolymphatic administration of an antibiotic and injection of the aminopeptide complex biolan can reduce the treatment time to 3-4 days, while the treatment time in a known manner is 14-21 days.

The manifestation of the therapeutic effect and the restoration of the basic properties of the cornea occurs much faster, on average in the first day. With significant effectiveness, the treatment method is quite simple.

Information sources

1. Avrorov V.N., Lebedev A.V. Veterinary Ophthalmology, M., Agropromizdat, 1985, pp. 95-160 - prototype.

2. SU 1832012 A1, 01/16/1991.

3. V.A. Dotsenko, A.S. Buldakov, V.I. Loyko. Kpiniko-hygienic assessment of the Biolan polypeptide amino acid complex. - Report on the research work of St. Petersburg. gos. Academy named after I.I. Mechnikova. 1995.

4. N.N. Silmonovich, A.V. Banny, D.I. Zubovsky. Clinical and morphological parallels in the study of lymphatic circulation. - M., 1986.

Claims (2)

1. A method for the treatment of conjunctiokeratitis in cattle, comprising administering an antibiotic solution, characterized in that previously, under local anesthesia of a 2% solution of novocaine in the cranial part of the parotid salivary gland, a skin incision is performed from 2 to 4 cm, subcutaneous tissue, superficial two-leaf fascia and deep fascia, secrete a parotid lymph center and 1-2 of the largest lymphatic vessels, purse string sutures are applied to them, catheterization of these vessels is carried out and 1-2 are introduced through catheters once a day, an antibiotic solution with a total amount of 8-10 ml per administration, simultaneously after local anesthesia with a solution of dicaine of 0.5% concentration in the lower conjunctival arch of the eyeball, a single injection of biolan in a dose of 3-10 mg dissolved in 2- 5 ml of water for injection. 2. The method according to claim 1, characterized in that ampicillin or chloramphenicol or gentamicin are used as antibiotics.