SU1710057A1 - Method for treatment of sheep with entering nematodosis - Google Patents

Description

The invention relates to the field of veterinary medicine, in particular to methods for treating sheep nematodoses.

The aim of the invention is to increase the efficiency of the method. ;

Example 1, Preparation of N- (3,4-. Dichloropheyl) -2- (benzo-2,1,3-thiadiazole-4-sulphonyl) amino | -5-chlorobenzamide (preparation G-1501).

Stage I, Preparation of 2- (benzo-2,1,3-thiadiazole-4-sulfonesh 1) aminoZ-5-chlorobenzoic acid chloride,

A mixture of 62.3 g (0.168 mol) of 2- (benzo-2, 1, 3 thiadiazole-4-sulfonyl) aninZ5 of chlorobenvoic acid and 122 ml (1.68 mol) of thionyl chloride kip-g

t for 2 h. The excess thionyl chloride is distilled off to dryness, the solid residue (acid chloride) is used in the next step without further purification.

Stage II. Receiving - preparation G-1501,

The acid chloride from the previous step is dissolved in 500 ml of dry dichloroethane and at room temperature 30.0 g (0.185 mol) of 3,4-dichloroaniline and 29 ml of triethylamine are added to the resulting solution. The reaction mass is stirred at room temperature for 12 hours. The volatile products are distilled off in vacuo to dryness. Remainder

treat with acetic acid and 6 tflItro, are dissolved in 150 ml of dimethylAormamide, clarified with activated charcoal and poured into aqueous isopropanol (300 ml of isopropanol and 600 ml of water).

The filter cake is washed with water and alcohol.

Yield 59.0 g (68.4%), m.p. „205207 ° С.

Found,%: C 44.51; H 2.30 | N 11.21; S 12.74.

Ciqlli.

Calculated,%: C, 44.40; H 2.15; . N 10.90; S 12.48.

Example 2, 21 sheep of 10-12 months old, spontaneously infected with intestinal nematodes, are used. In 5 g of feces they are found on average 57 copies. (10-157 copies.) Of intestinal strongyl t, 13.8 copies. (1030 copies). Its trichotheilus. Sheep are divided into 7 groups, 3 heads each.

Sheep of the first anthelmintic group do not receive, they serve as invasive control. Sheep of the second group are given phenothiazine at 0.5 g / kg, the third group - naphthamone at 0.5, g / kg, the fourth group - the drug at 30 mg / kg, in the same group - drug G-1501 at 60 mg / kg, the sixth group, the G-1501 preparation, 100 mg / kg; the seventh group, f.ikur 5 mg / kg. All preparations to sheep are given individually, by mouth, a 15-day cut of all sheep is killed and subjected to a helminthological dissection.

From the data it follows that the drug G-1501 has a high activity against all intestinal sheep nematodes. Thus, the dose of the drug at 3060 mg / kg was extremely effective (33 66.6 - 100%, with IE 54.310052) with hemonosis, habertiosis, bunostomiasis, nematodirosis and trichocephalosis, and the dose of 100 mg / kg shows 100% effectiveness for all the listed nematodoses, Example 3, In the experience I use

25 one-year-old sheep spontaneously infested by nematodes, In 5 g sheep feces, an average of 3,758 specimens were found, eggs of intestinal strongil (53-250 copies), 28.6 copies each. Her trichocephalus (18-89 copies,). The experimental sheep were divided into 5 groups, 5 animals each.

Anthelmintic sheep are not received in the first group, they serve as an invasive control. Sheep of the second group receive phenothiazine at 0.5 g / kg, the third — naphthamone at 0.5 g / kg, the fourth — fepcourt at 10 mg / kg, and the fifth drug G-1501 at 100 mg / kg. All drugs are given with food, group method. After 15 days of all, the sheep are killed and subjected to helminthological dissection.

From the experience it follows that in the control group all the sheep were invaded by the hemonchuses, nematodira, bunnotomas, habertias and trichocephaluses. In the second group, the eczema varied between 0–40%, the ne 30.6–77.4% % with IE, 3-99.3%. In the fourth group EE; ranges from 80-100% with IE 98.8-99.8%. In the fifth group (G-1501 preparation in a dose of 100 mg / kg by the group method with feed), all the sheep were freed from hemonhus, namatodir, bunost, haberti and trichocephalus, EE is 100%,

New preparation G-1501 is highly effective in nematodes of the gastrointestinal tract of sheep,

The test data for spontaneous hemonosis, nematodirosis and sheep bunostomiasis are given in Table.

The results of testing drugs for spontaneous habertiosis and trichocephalosis of sheep are given in Table 2,

Claims (1)

Invention Formula The method of treatment of intestinal nematodes of sheep, including oral administration of anthelmintic, characterized in that, in order to improve the effectiveness of the method, ve antgelmintika using N- (3,4 dichlorophenyl) -2- (benzo-2,1,3-thiadiazole-4-sulfonyl) aminoZ-5-chlorobenzamide CONH KOTOpbtfi is given to animals once individually at a dose of 60 mg / kg or as a group method with feed at a dose of 100 mg / kg of animal weight. T a b L n C B Oopotpvey 0.5 g / kg Naftamo 0.5 g / kg Fencourt 10 mg / kg The drug G-1501 100 ng / hg