SU1018641A1 - Method of producing sum of polyphenol compounds having cholagogic activities - Google Patents

Abstract

METHOD FOR PRODUCING POLY 1 SUM№1 Enol COMPOUNDS OBLADAYUYIH choleretic activity by extraction of vegetable raw material aqueous alcohol solution, evaporation of the extract evaporation residue with alcohol treatment, filtering, evaporating the filtrate and cyibttt, of m and n ich th and u, and in that, In order to increase the yield of the target product, increase its activity and preserve the content of bile acids, Vicky sowing grass (CH1C1A sc (tW4 2)) is extracted as a plant raw material with a 30% hydrochloric alcohol at a ratio of raw extract nt equal 1,5g10, and evaporation of the extract is carried out to 1 / 7-1 / 8 parts of the original volume.

Description

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A: The invention relates to the pharmaceutical industry, namely the production of medicinal preparations from herbal raw materials. A method is known for producing polyphenolic compounds by extracting vegetable matter with water, evaporation of extracts, separating the precipitates of purifying the aqueous residue with an organic solvent, evaporating the filtrate, followed by drying. The disadvantage of this method is the low yield of the desired product. The closest to the proposed technical essence to the achieved effect is a method of obtaining the sum of polyphenolic compounds, possessing choleretic activity by extracting the plant raw material with an aqueous solution of alcohol, evaporation of the extract, treating the evaporated residue with alcohol, filtering, evaporation of the filtrate and drying However, the known method does not provide preparation of a preparation consisting of flavonoids and oxycoumarins, which increases the rate of bile of laziness and does not reduce the content of bile acids, as well as It does not provide a sufficiently high product yield. The aim of the invention is to increase the yield of the target product, increase its activity and preserve the content of bile acids. The goal is achieved by the fact that according to the method of obtaining the sum of polyphenolic compounds with choleretic activity by extracting plant raw material with an aqueous solution of alcohol, evaporation of the extract, processing the evaporated residue with alcohol, filtering, evaporation of filtrate and drying, use Vika grass as a plant raw material ( VlEfo soliiv extraction is carried out with 30% hydrolysis alcohol with a ratio of raw materials extractant equal to 1.5: 10, and the extract is evaporated to 1 / 7-1 / 8 parts of the original volume. Example: 3 kg of air - dry, collected during the period of bloom, Vika sowing grass (Vtcicx soitivc z) variety - Vinnytsa -30, extracted twice five times with a rolled process .30% hydrolysis alcohol (first time 6 l 15 h at 20 ° С then four times 3 hours with each time also 6). Aqueous-alcoholic extracts of C27 l) are evaporated to .4 l and left for 4 hours to settle. The insufficient liquid is decanted and treated with 5 liters of 96% ethanol. The brown precipitate is filtered off and the filtrate is evaporated in a vacuum at a temperature not exceeding 50 ° C and a residual pressure of 20 mm Hg. Art. until a dry residue is obtained. Yield - 0.494 kg. In terms of physico-chemical properties, the resulting preparation is a brown powder, well soluble in water and lower alcohols. The main components of the obtained product are biologically active polyphenols: flavones, flavonones and their glycosides, phenol carboxylic acids, oxycoumarins. Pharmacological studies have shown that the preparation of purified amounts of polyphenolic compounds from Vicky Sowing campaign has a pronounced choleretic activity, not yielding to the activity of flaming, which is used in medical practice, and, with a number of advantages, namely, it increases the rate of bile secretion without reducing the content of bile acids. Thus, the positive effect of the method lies in increasing the yield of the drug by 1.8% using available and cheap raw materials and solvents, as well as in the presence of a rather large specific activity and no side effect.

Claims (1)

METHOD FOR PRODUCING THE AMOUNT OF POLYPHENOLIC COMPOUNDS PREPARING BELLOPHONE ACTIVITY by extraction of plant materials with an aqueous solution! ” alcohol, evaporation of the extract, processing the evaporated residue with alcohol, filtration, evaporation of the filtrate and drying, distinguished by the fact that, in order to increase the yield of the target product, increase its activity and preserve the content of bile acids, plant materials are used Vicki sowing grass, ONs (a) () the extraction is carried out with 30% hydrolysis alcohol with a ratio of raw material extractant equal to 1.5: 10, and the evaporation of the extract is carried out to 1 / 7-1 / 8 of the original volume. § ω