SK4032001A3 - Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes - Google Patents
Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes Download PDFInfo
- Publication number
- SK4032001A3 SK4032001A3 SK403-2001A SK4032001A SK4032001A3 SK 4032001 A3 SK4032001 A3 SK 4032001A3 SK 4032001 A SK4032001 A SK 4032001A SK 4032001 A3 SK4032001 A3 SK 4032001A3
- Authority
- SK
- Slovakia
- Prior art keywords
- alkyl
- substituted
- amino
- group
- alkylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19844003A DE19844003A1 (de) | 1998-09-25 | 1998-09-25 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19937496A DE19937496A1 (de) | 1999-08-07 | 1999-08-07 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP1999/007040 WO2000018734A1 (fr) | 1998-09-25 | 1999-09-22 | Nouvelles indolinones substituees a effet inhibiteur sur differentes kinases et differents complexes cycline/cdk |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK4032001A3 true SK4032001A3 (en) | 2001-11-06 |
Family
ID=26049076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK403-2001A SK4032001A3 (en) | 1998-09-25 | 1999-09-22 | Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6855710B2 (fr) |
| EP (1) | EP1115704B1 (fr) |
| JP (1) | JP2002525356A (fr) |
| KR (1) | KR20010085841A (fr) |
| CN (1) | CN1319090A (fr) |
| AT (1) | ATE243195T1 (fr) |
| AU (1) | AU763361B2 (fr) |
| BG (1) | BG105327A (fr) |
| BR (1) | BR9914065A (fr) |
| CA (1) | CA2342622A1 (fr) |
| DE (1) | DE59906030D1 (fr) |
| DK (1) | DK1115704T3 (fr) |
| EA (1) | EA200100320A1 (fr) |
| EE (1) | EE200100184A (fr) |
| ES (1) | ES2196860T3 (fr) |
| HR (1) | HRP20010216A2 (fr) |
| HU (1) | HUP0104973A3 (fr) |
| ID (1) | ID27757A (fr) |
| IL (1) | IL141622A0 (fr) |
| NO (1) | NO20011477D0 (fr) |
| NZ (1) | NZ510845A (fr) |
| PL (1) | PL346898A1 (fr) |
| PT (1) | PT1115704E (fr) |
| SI (1) | SI1115704T1 (fr) |
| SK (1) | SK4032001A3 (fr) |
| TR (1) | TR200100854T2 (fr) |
| WO (1) | WO2000018734A1 (fr) |
| YU (1) | YU21301A (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| EP1430048A1 (fr) * | 2001-09-27 | 2004-06-23 | Allergan, Inc. | L'utilisation de 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones en tant qu'inhibiteurs de kinases |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
| HRP20040887A2 (en) | 2002-03-26 | 2005-04-30 | Boehringer Ingelheim Pharmaceuticals Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US7514468B2 (en) | 2002-07-23 | 2009-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions |
| PE20040701A1 (es) * | 2002-07-23 | 2004-11-30 | Boehringer Ingelheim Pharma | Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos |
| US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
| DE10233366A1 (de) * | 2002-07-23 | 2004-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
| DE10237423A1 (de) | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| HRP20050185A2 (en) * | 2002-08-29 | 2006-05-31 | Boehringer Ingelheim Pharmaceuticals Inc. | -3 (sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases |
| US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
| JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| WO2005033330A2 (fr) * | 2003-10-03 | 2005-04-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Sondes fluorescentes pour test de liaison d'inhibiteur de proteine kinase |
| CN1929834B (zh) | 2004-03-11 | 2010-12-08 | 埃科特莱茵药品有限公司 | 吲哚-1-基乙酸衍生物 |
| US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
| DE602005015027D1 (de) | 2004-12-27 | 2009-07-30 | Boehringer Ingelheim Pharma | Glucocorticoid-mimetika, verfahren zu deren herstellung, pharmazeutische zusammensetzungen und deren verwendung |
| MX2007012907A (es) | 2005-04-28 | 2008-03-14 | Boehringer Ingelheim Int | Nuevos compuestos para el tratamiento de enfermedades inflamatorias. |
| KR20090097908A (ko) | 2006-12-06 | 2009-09-16 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루코코르티코이드 모사물, 이의 제조 방법, 이의 약제학적 조성물 및 용도 |
| JP2010512407A (ja) * | 2006-12-11 | 2010-04-22 | ジェネンテック インコーポレイテッド | 新生物を処置するための組成物および方法 |
| CN101273991B (zh) * | 2007-03-28 | 2010-05-26 | 广东同德药业有限公司 | 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用 |
| KR20100094497A (ko) * | 2007-12-03 | 2010-08-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 인돌리논 유도체의 제조 방법 |
| PE20091445A1 (es) * | 2007-12-03 | 2009-10-19 | Boehringer Ingelheim Int | Derivados de indolinona y procedimiento para su fabricacion |
| MX2010007950A (es) * | 2008-01-25 | 2010-08-04 | Boehringer Ingelheim Int | Formas salinas de un derivado de 6-fluoro-1,2-dihidro-2-oxo-3h-ind ol-3-ilideno, procedimiento para su preparacion y composiciones farmaceuticas que las contienen. |
| KR20110020902A (ko) | 2008-06-06 | 2011-03-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루코코르티코이드 유사체, 이의 제조방법, 약제학적 조성물 및 이의 용도 |
| JP5651110B2 (ja) | 2008-07-29 | 2015-01-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物 |
| WO2013137371A1 (fr) * | 2012-03-15 | 2013-09-19 | 興和株式会社 | Nouveau composé pyrimidine et médicament comprenant celui-ci |
| CN103664737A (zh) * | 2012-09-25 | 2014-03-26 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
| CN111683976B (zh) | 2018-02-05 | 2022-11-18 | 生物辐射实验室股份有限公司 | 具有阴离子交换-疏水混合模式配体的色谱树脂 |
| CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
| WO2025155711A1 (fr) * | 2024-01-17 | 2025-07-24 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibiteurs de lrrk2 et compositions et utilisations associées |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
-
1999
- 1999-09-22 JP JP2000572194A patent/JP2002525356A/ja active Pending
- 1999-09-22 EA EA200100320A patent/EA200100320A1/ru unknown
- 1999-09-22 SI SI9930391T patent/SI1115704T1/xx unknown
- 1999-09-22 SK SK403-2001A patent/SK4032001A3/sk unknown
- 1999-09-22 NZ NZ510845A patent/NZ510845A/en unknown
- 1999-09-22 IL IL14162299A patent/IL141622A0/xx unknown
- 1999-09-22 HU HU0104973A patent/HUP0104973A3/hu unknown
- 1999-09-22 DE DE59906030T patent/DE59906030D1/de not_active Expired - Fee Related
- 1999-09-22 AT AT99947404T patent/ATE243195T1/de not_active IP Right Cessation
- 1999-09-22 DK DK99947404T patent/DK1115704T3/da active
- 1999-09-22 ID IDW20010688A patent/ID27757A/id unknown
- 1999-09-22 YU YU21301A patent/YU21301A/sh unknown
- 1999-09-22 HR HR20010216A patent/HRP20010216A2/hr not_active Application Discontinuation
- 1999-09-22 EE EEP200100184A patent/EE200100184A/xx unknown
- 1999-09-22 PT PT99947404T patent/PT1115704E/pt unknown
- 1999-09-22 EP EP99947404A patent/EP1115704B1/fr not_active Expired - Lifetime
- 1999-09-22 BR BR9914065-9A patent/BR9914065A/pt unknown
- 1999-09-22 KR KR1020017003773A patent/KR20010085841A/ko not_active Withdrawn
- 1999-09-22 WO PCT/EP1999/007040 patent/WO2000018734A1/fr not_active Ceased
- 1999-09-22 ES ES99947404T patent/ES2196860T3/es not_active Expired - Lifetime
- 1999-09-22 CN CN99811297A patent/CN1319090A/zh active Pending
- 1999-09-22 AU AU60863/99A patent/AU763361B2/en not_active Ceased
- 1999-09-22 TR TR2001/00854T patent/TR200100854T2/xx unknown
- 1999-09-22 PL PL99346898A patent/PL346898A1/xx not_active Application Discontinuation
- 1999-09-22 CA CA002342622A patent/CA2342622A1/fr not_active Abandoned
-
2001
- 2001-03-09 BG BG105327A patent/BG105327A/xx unknown
- 2001-03-22 NO NO20011477A patent/NO20011477D0/no not_active Application Discontinuation
-
2003
- 2003-09-19 US US10/666,643 patent/US6855710B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE243195T1 (de) | 2003-07-15 |
| AU763361B2 (en) | 2003-07-17 |
| YU21301A (sh) | 2003-04-30 |
| NZ510845A (en) | 2003-10-31 |
| CA2342622A1 (fr) | 2000-04-06 |
| EE200100184A (et) | 2002-08-15 |
| ID27757A (id) | 2001-04-26 |
| JP2002525356A (ja) | 2002-08-13 |
| EA200100320A1 (ru) | 2001-10-22 |
| DK1115704T3 (da) | 2003-09-29 |
| BG105327A (bg) | 2001-12-29 |
| US20040058978A1 (en) | 2004-03-25 |
| US6855710B2 (en) | 2005-02-15 |
| AU6086399A (en) | 2000-04-17 |
| NO20011477L (no) | 2001-03-22 |
| HUP0104973A2 (hu) | 2002-04-29 |
| NO20011477D0 (no) | 2001-03-22 |
| BR9914065A (pt) | 2001-06-19 |
| HRP20010216A2 (en) | 2002-04-30 |
| WO2000018734A1 (fr) | 2000-04-06 |
| ES2196860T3 (es) | 2003-12-16 |
| PL346898A1 (en) | 2002-03-11 |
| SI1115704T1 (sl) | 2003-12-31 |
| EP1115704A1 (fr) | 2001-07-18 |
| PT1115704E (pt) | 2003-11-28 |
| EP1115704B1 (fr) | 2003-06-18 |
| KR20010085841A (ko) | 2001-09-07 |
| HUP0104973A3 (en) | 2002-06-28 |
| TR200100854T2 (tr) | 2001-12-21 |
| DE59906030D1 (de) | 2003-07-24 |
| CN1319090A (zh) | 2001-10-24 |
| IL141622A0 (en) | 2002-03-10 |
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