SI1115704T1 - Novi substituirani indolinoni z inhibitornim učinkom na različne kinaze in ciklin/CDK komplekse - Google Patents
Novi substituirani indolinoni z inhibitornim učinkom na različne kinaze in ciklin/CDK komplekseInfo
- Publication number
- SI1115704T1 SI1115704T1 SI9930391T SI9930391T SI1115704T1 SI 1115704 T1 SI1115704 T1 SI 1115704T1 SI 9930391 T SI9930391 T SI 9930391T SI 9930391 T SI9930391 T SI 9930391T SI 1115704 T1 SI1115704 T1 SI 1115704T1
- Authority
- SI
- Slovenia
- Prior art keywords
- cyclin
- inhibitory effect
- new substituted
- cdk complexes
- various kinases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19844003A DE19844003A1 (de) | 1998-09-25 | 1998-09-25 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19937496A DE19937496A1 (de) | 1999-08-07 | 1999-08-07 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| EP99947404A EP1115704B1 (de) | 1998-09-25 | 1999-09-22 | Neue substituierte indolinone mit einer inhibierenden wirkung auf verschiedene kinasen und cyclin/cdk-komplexe |
| PCT/EP1999/007040 WO2000018734A1 (de) | 1998-09-25 | 1999-09-22 | Neue substituierte indolinone mit inhibierender wirkung auf verschiedene kinasen und cyclin/cdk-komplexe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1115704T1 true SI1115704T1 (sl) | 2003-12-31 |
Family
ID=26049076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9930391T SI1115704T1 (sl) | 1998-09-25 | 1999-09-22 | Novi substituirani indolinoni z inhibitornim učinkom na različne kinaze in ciklin/CDK komplekse |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6855710B2 (xx) |
| EP (1) | EP1115704B1 (xx) |
| JP (1) | JP2002525356A (xx) |
| KR (1) | KR20010085841A (xx) |
| CN (1) | CN1319090A (xx) |
| AT (1) | ATE243195T1 (xx) |
| AU (1) | AU763361B2 (xx) |
| BG (1) | BG105327A (xx) |
| BR (1) | BR9914065A (xx) |
| CA (1) | CA2342622A1 (xx) |
| DE (1) | DE59906030D1 (xx) |
| DK (1) | DK1115704T3 (xx) |
| EA (1) | EA200100320A1 (xx) |
| EE (1) | EE200100184A (xx) |
| ES (1) | ES2196860T3 (xx) |
| HR (1) | HRP20010216A2 (xx) |
| HU (1) | HUP0104973A3 (xx) |
| ID (1) | ID27757A (xx) |
| IL (1) | IL141622A0 (xx) |
| NO (1) | NO20011477L (xx) |
| NZ (1) | NZ510845A (xx) |
| PL (1) | PL346898A1 (xx) |
| PT (1) | PT1115704E (xx) |
| SI (1) | SI1115704T1 (xx) |
| SK (1) | SK4032001A3 (xx) |
| TR (1) | TR200100854T2 (xx) |
| WO (1) | WO2000018734A1 (xx) |
| YU (1) | YU21301A (xx) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904933D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6765012B2 (en) * | 2001-09-27 | 2004-07-20 | Allergan, Inc. | 3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
| DE60318188T2 (de) | 2002-03-26 | 2008-12-11 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Glucocorticoid-mimetika, deren herstellung, pharmazeutische zusammensetzungen und verwendung |
| DE10233366A1 (de) * | 2002-07-23 | 2004-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US7514468B2 (en) | 2002-07-23 | 2009-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions |
| PE20040701A1 (es) * | 2002-07-23 | 2004-11-30 | Boehringer Ingelheim Pharma | Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos |
| US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
| US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
| DE10237423A1 (de) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| KR20050036982A (ko) * | 2002-08-29 | 2005-04-20 | 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 | 염증, 알러지 및 증식성 질환의 치료에 글루코코르티코이드모사체로 사용하기 위한 3-(설폰아미도에틸)-인돌 유도체 |
| US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
| JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| DE602004017884D1 (de) * | 2003-10-03 | 2009-01-02 | Boehringer Ingelheim Pharma | Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitoren |
| JP4861976B2 (ja) | 2004-03-11 | 2012-01-25 | アクテリオン ファーマシューティカルズ リミテッド | インドール−１−イル酢酸誘導体 |
| US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
| ES2326907T3 (es) | 2004-12-27 | 2009-10-21 | Boehringer Ingelheim Pharmaceuticals Inc. | Mimeticos de glucocorticoides, metodos para su preparacion, composiciones farmaceuticas y su uso. |
| JP5053997B2 (ja) * | 2005-04-28 | 2012-10-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 炎症性疾患の治療用の新規化合物 |
| BRPI0720131A2 (pt) | 2006-12-06 | 2014-02-04 | Boehringer Ingelheim Int | Glicocorticoides miméticos, métodos para fazê-los, composições farmacêuticas e usos dos mesmos. |
| WO2008073509A2 (en) * | 2006-12-11 | 2008-06-19 | Genentech, Inc. | Compositions and methods for treating a neoplasm |
| CN101273991B (zh) * | 2007-03-28 | 2010-05-26 | 广东同德药业有限公司 | 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用 |
| PE20091445A1 (es) | 2007-12-03 | 2009-10-19 | Boehringer Ingelheim Int | Derivados de indolinona y procedimiento para su fabricacion |
| RU2525114C2 (ru) | 2007-12-03 | 2014-08-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ получения производного индолинона |
| EP2238108B1 (en) * | 2008-01-25 | 2012-08-29 | Boehringer Ingelheim International GmbH | Salt forms of a 6-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene derivative, process for their manufacture and pharmaceutical compositions containing same |
| KR20110020902A (ko) | 2008-06-06 | 2011-03-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루코코르티코이드 유사체, 이의 제조방법, 약제학적 조성물 및 이의 용도 |
| UY32010A (es) | 2008-07-29 | 2010-02-26 | Boehringer Ingelheim Int | Nuevas indolinonas, composiciones conteniéndolas y aplicaciones |
| JPWO2013137371A1 (ja) * | 2012-03-15 | 2015-08-03 | 興和株式会社 | 新規ピリミジン化合物及びそれらを含有する医薬 |
| CN103664737A (zh) * | 2012-09-25 | 2014-03-26 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
| EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE |
| CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
| WO2025155711A1 (en) * | 2024-01-17 | 2025-07-24 | The Board Of Trustees Of The Leland Stanford Junior University | Lrrk2 inhibitors and compositions and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
-
1999
- 1999-09-22 DE DE59906030T patent/DE59906030D1/de not_active Expired - Fee Related
- 1999-09-22 AU AU60863/99A patent/AU763361B2/en not_active Ceased
- 1999-09-22 CA CA002342622A patent/CA2342622A1/en not_active Abandoned
- 1999-09-22 ID IDW20010688A patent/ID27757A/id unknown
- 1999-09-22 TR TR2001/00854T patent/TR200100854T2/xx unknown
- 1999-09-22 PL PL99346898A patent/PL346898A1/xx not_active Application Discontinuation
- 1999-09-22 KR KR1020017003773A patent/KR20010085841A/ko not_active Withdrawn
- 1999-09-22 SK SK403-2001A patent/SK4032001A3/sk unknown
- 1999-09-22 IL IL14162299A patent/IL141622A0/xx unknown
- 1999-09-22 SI SI9930391T patent/SI1115704T1/xx unknown
- 1999-09-22 WO PCT/EP1999/007040 patent/WO2000018734A1/de not_active Ceased
- 1999-09-22 BR BR9914065-9A patent/BR9914065A/pt unknown
- 1999-09-22 PT PT99947404T patent/PT1115704E/pt unknown
- 1999-09-22 NZ NZ510845A patent/NZ510845A/en unknown
- 1999-09-22 EA EA200100320A patent/EA200100320A1/ru unknown
- 1999-09-22 HR HR20010216A patent/HRP20010216A2/hr not_active Application Discontinuation
- 1999-09-22 YU YU21301A patent/YU21301A/sh unknown
- 1999-09-22 EE EEP200100184A patent/EE200100184A/xx unknown
- 1999-09-22 AT AT99947404T patent/ATE243195T1/de not_active IP Right Cessation
- 1999-09-22 JP JP2000572194A patent/JP2002525356A/ja active Pending
- 1999-09-22 ES ES99947404T patent/ES2196860T3/es not_active Expired - Lifetime
- 1999-09-22 DK DK99947404T patent/DK1115704T3/da active
- 1999-09-22 CN CN99811297A patent/CN1319090A/zh active Pending
- 1999-09-22 EP EP99947404A patent/EP1115704B1/de not_active Expired - Lifetime
- 1999-09-22 HU HU0104973A patent/HUP0104973A3/hu unknown
-
2001
- 2001-03-09 BG BG105327A patent/BG105327A/xx unknown
- 2001-03-22 NO NO20011477A patent/NO20011477L/no not_active Application Discontinuation
-
2003
- 2003-09-19 US US10/666,643 patent/US6855710B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20040058978A1 (en) | 2004-03-25 |
| TR200100854T2 (tr) | 2001-12-21 |
| NZ510845A (en) | 2003-10-31 |
| ID27757A (id) | 2001-04-26 |
| PL346898A1 (en) | 2002-03-11 |
| EA200100320A1 (ru) | 2001-10-22 |
| ATE243195T1 (de) | 2003-07-15 |
| KR20010085841A (ko) | 2001-09-07 |
| HRP20010216A2 (en) | 2002-04-30 |
| SK4032001A3 (en) | 2001-11-06 |
| YU21301A (sh) | 2003-04-30 |
| AU6086399A (en) | 2000-04-17 |
| PT1115704E (pt) | 2003-11-28 |
| IL141622A0 (en) | 2002-03-10 |
| DE59906030D1 (de) | 2003-07-24 |
| HUP0104973A2 (hu) | 2002-04-29 |
| NO20011477D0 (no) | 2001-03-22 |
| ES2196860T3 (es) | 2003-12-16 |
| CN1319090A (zh) | 2001-10-24 |
| EP1115704A1 (de) | 2001-07-18 |
| BR9914065A (pt) | 2001-06-19 |
| NO20011477L (no) | 2001-03-22 |
| HUP0104973A3 (en) | 2002-06-28 |
| JP2002525356A (ja) | 2002-08-13 |
| DK1115704T3 (da) | 2003-09-29 |
| AU763361B2 (en) | 2003-07-17 |
| EE200100184A (et) | 2002-08-15 |
| EP1115704B1 (de) | 2003-06-18 |
| CA2342622A1 (en) | 2000-04-06 |
| BG105327A (bg) | 2001-12-29 |
| US6855710B2 (en) | 2005-02-15 |
| WO2000018734A1 (de) | 2000-04-06 |
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