SK284191B6 - Aktín-rezistentný variant humánnej DNázy I - Google Patents

Aktín-rezistentný variant humánnej DNázy I Download PDF

Info

Publication number: SK284191B6
Authority: SK; Slovakia
Prior art keywords: leu; wall; asp; ala; tyr
Prior art date: 1995-02-24

Application number

SK1148-97A

Other languages

English (en)

Slovak (sk)

Other versions

SK114897A3 (en

Inventor

Robert A. Lazarus

Steven Shak

Jana S. Ulmer

Original Assignee

Genentech, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-24

Filing date

1995-02-24

Publication date

2004-10-05

1995-02-24 Application filed by Genentech, Inc. filed Critical Genentech, Inc.

1995-02-24 Priority claimed from PCT/US1995/002366 external-priority patent/WO1996026278A1/fr

1998-03-04 Publication of SK114897A3 publication Critical patent/SK114897A3/sk

2004-10-05 Publication of SK284191B6 publication Critical patent/SK284191B6/sk

Links

101000863721 Homo sapiens Deoxyribonuclease-1 Proteins 0.000 title claims abstract description 138
108010085238 Actins Proteins 0.000 claims abstract description 109
102000007469 Actins Human genes 0.000 claims abstract description 109
150000007523 nucleic acids Chemical group 0.000 claims abstract description 6
150000001413 amino acids Chemical group 0.000 claims description 193
JDDYEZGPYBBPBN-JRQIVUDYSA-N Asp-Thr-Tyr Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O JDDYEZGPYBBPBN-JRQIVUDYSA-N 0.000 claims description 90
108010084758 arginyl-tyrosyl-aspartic acid Proteins 0.000 claims description 88
ZUKPVRWZDMRIEO-VKHMYHEASA-N L-cysteinylglycine Chemical compound SC[C@H]([NH3+])C(=O)NCC([O-])=O ZUKPVRWZDMRIEO-VKHMYHEASA-N 0.000 claims description 87
AOJYORNRFWWEIV-IHRRRGAJSA-N Arg-Tyr-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CC(O)=O)C(O)=O)CC1=CC=C(O)C=C1 AOJYORNRFWWEIV-IHRRRGAJSA-N 0.000 claims description 86
JLKVWTICWVWGSK-JYJNAYRXSA-N Tyr-Lys-Glu Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 JLKVWTICWVWGSK-JYJNAYRXSA-N 0.000 claims description 85
108010016616 cysteinylglycine Proteins 0.000 claims description 85
HKRXJBBCQBAGIM-FXQIFTODSA-N Arg-Asp-Ser Chemical compound C(C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O)N)CN=C(N)N HKRXJBBCQBAGIM-FXQIFTODSA-N 0.000 claims description 82
IOFVWPYSRSCWHI-JXUBOQSCSA-N Ala-Thr-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)N IOFVWPYSRSCWHI-JXUBOQSCSA-N 0.000 claims description 81
XYPJXLLXNSAWHZ-SRVKXCTJSA-N Asp-Ser-Tyr Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O XYPJXLLXNSAWHZ-SRVKXCTJSA-N 0.000 claims description 80
VPZKQTYZIVOJDV-LMVFSUKVSA-N Thr-Ala Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C)C(O)=O VPZKQTYZIVOJDV-LMVFSUKVSA-N 0.000 claims description 79
BIBYEFRASCNLAA-CDMKHQONSA-N Thr-Phe-Gly Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(=O)NCC(O)=O)CC1=CC=CC=C1 BIBYEFRASCNLAA-CDMKHQONSA-N 0.000 claims description 78
108010003137 tyrosyltyrosine Proteins 0.000 claims description 78
OJCISMMNNUNNJA-BZSNNMDCSA-N Tyr-Tyr-Asp Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(O)=O)C(O)=O)C1=CC=C(O)C=C1 OJCISMMNNUNNJA-BZSNNMDCSA-N 0.000 claims description 77
MHXKHKWHPNETGG-QWRGUYRKSA-N Gly-Lys-Leu Chemical compound [H]NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O MHXKHKWHPNETGG-QWRGUYRKSA-N 0.000 claims description 75
108010002311 N-glycylglutamic acid Proteins 0.000 claims description 74
CGWVCWFQGXOUSJ-ULQDDVLXSA-N Arg-Tyr-Leu Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(O)=O CGWVCWFQGXOUSJ-ULQDDVLXSA-N 0.000 claims description 73
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101100512078 Caenorhabditis elegans lys-1 gene Proteins 0.000 claims description 65
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102220502777 Putative C->U-editing enzyme APOBEC-4_G49K_mutation Human genes 0.000 claims description 2
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102220143882 rs886059694 Human genes 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK1148-97A 1995-02-24 1995-02-24 Aktín-rezistentný variant humánnej DNázy I SK284191B6 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PCT/US1995/002366 WO1996026278A1 (fr)	1995-02-24	1995-02-24	VARIANTES DE LA DNAse I HUMAINE
US54052795A	1995-10-10	1995-10-10
PCT/US1996/002421 WO1996026279A1 (fr)	1995-02-24	1996-02-21	Variantes de dnase i humaine

Publications (2)

Publication Number	Publication Date
SK114897A3 SK114897A3 (en)	1998-03-04
SK284191B6 true SK284191B6 (sk)	2004-10-05

Family

ID=26789529

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1148-97A SK284191B6 (sk)	1995-02-24	1995-02-24	Aktín-rezistentný variant humánnej DNázy I

Country Status (20)

Country	Link
EP (2)	EP1980618A2 (fr)
JP (1)	JP4549439B2 (fr)
AR (1)	AR003926A1 (fr)
AT (1)	ATE397073T1 (fr)
AU (1)	AU695863B2 (fr)
BR (1)	BR9607328A (fr)
CA (1)	CA2211413C (fr)
DE (1)	DE69637548D1 (fr)
DK (1)	DK0854927T3 (fr)
ES (1)	ES2308775T3 (fr)
HU (1)	HU222665B1 (fr)
IL (1)	IL117218A (fr)
NO (1)	NO326616B1 (fr)
NZ (1)	NZ334762A (fr)
PL (1)	PL184951B1 (fr)
RO (1)	RO118886B1 (fr)
SI (1)	SI9620043A (fr)
SK (1)	SK284191B6 (fr)
TR (1)	TR199700842T1 (fr)
WO (1)	WO1996026279A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6391607B1 (en)	1996-06-14	2002-05-21	Genentech, Inc.	Human DNase I hyperactive variants
WO2013114373A1 (fr) *	2012-02-01	2013-08-08	Protalix Ltd.	Formulations liquides inhalables d'adnase i
WO2015066550A1 (fr) *	2013-10-31	2015-05-07	Resolve Therapeutics, Llc	Fusions nucléase-albumine à visée thérapeutique et procédés associés
CN104131093B (zh) *	2014-07-23	2015-12-09	哈尔滨工程大学	DNA蛋白结合位点的DNase高通测序检测信号处理方法
HK1245822A1 (zh)	2015-01-04	2018-08-31	Protalix Ltd	一种经修饰的dnase及其应用
CA3194643A1 (fr)	2020-10-07	2022-04-14	Ilya Ruderfer	Dnase a action prolongee

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4511502A (en)	1982-12-22	1985-04-16	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
US4683195A (en)	1986-01-30	1987-07-28	Cetus Corporation	Process for amplifying, detecting, and/or-cloning nucleic acid sequences
WO1987005330A1 (fr)	1986-03-07	1987-09-11	Michel Louis Eugene Bergh	Procede pour ameliorer la stabilite des glycoproteines
EP0853121B1 (fr)	1988-12-23	2007-03-28	Genentech, Inc.	DNase humaine
US5464817A (en) *	1990-04-11	1995-11-07	Brigham And Women's Hospital	Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I
US5279823A (en)	1992-06-08	1994-01-18	Genentech, Inc.	Purified forms of DNASE
WO1994010567A1 (fr)	1992-11-02	1994-05-11	Genentech, Inc.	Titrage de compacite determinant l'efficacite de la therapie des maladies respiratoires
ATE230027T1 (de) *	1995-02-24	2003-01-15	Genentech Inc	Menschliche dnase i varianten

1995
- 1995-02-24 SK SK1148-97A patent/SK284191B6/sk not_active IP Right Cessation
1996
- 1996-02-21 AR ARP960101466A patent/AR003926A1/es active IP Right Grant
- 1996-02-21 HU HU9702147A patent/HU222665B1/hu not_active IP Right Cessation
- 1996-02-21 CA CA2211413A patent/CA2211413C/fr not_active Expired - Fee Related
- 1996-02-21 TR TR97/00842T patent/TR199700842T1/xx unknown
- 1996-02-21 JP JP52581996A patent/JP4549439B2/ja not_active Expired - Lifetime
- 1996-02-21 AT AT96907094T patent/ATE397073T1/de active
- 1996-02-21 PL PL96322002A patent/PL184951B1/pl not_active IP Right Cessation
- 1996-02-21 BR BR9607328A patent/BR9607328A/pt not_active Application Discontinuation
- 1996-02-21 RO RO97-01598A patent/RO118886B1/ro unknown
- 1996-02-21 DK DK96907094T patent/DK0854927T3/da active
- 1996-02-21 IL IL11721896A patent/IL117218A/en not_active IP Right Cessation
- 1996-02-21 DE DE69637548T patent/DE69637548D1/de not_active Expired - Lifetime
- 1996-02-21 EP EP08005896A patent/EP1980618A2/fr not_active Withdrawn
- 1996-02-21 AU AU50263/96A patent/AU695863B2/en not_active Ceased
- 1996-02-21 SI SI9620043A patent/SI9620043A/sl not_active IP Right Cessation
- 1996-02-21 WO PCT/US1996/002421 patent/WO1996026279A1/fr not_active Ceased
- 1996-02-21 ES ES96907094T patent/ES2308775T3/es not_active Expired - Lifetime
- 1996-02-21 EP EP96907094A patent/EP0854927B1/fr not_active Expired - Lifetime
1997
- 1997-08-22 NO NO19973877A patent/NO326616B1/no not_active IP Right Cessation
1999
- 1999-03-22 NZ NZ334762A patent/NZ334762A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUP9702147A3 (en)	1999-09-28
EP0854927A1 (fr)	1998-07-29
NO326616B1 (no)	2009-01-19
IL117218A (en)	2004-06-01
BR9607328A (pt)	1997-12-30
DK0854927T3 (da)	2008-09-08
JPH11503004A (ja)	1999-03-23
AU695863B2 (en)	1998-08-27
CA2211413A1 (fr)	1996-08-29
TR199700842T1 (xx)	1998-01-21
PL322002A1 (en)	1998-01-05
RO118886B1 (ro)	2003-12-30
EP1980618A2 (fr)	2008-10-15
HUP9702147A2 (hu)	1999-07-28
AU5026396A (en)	1996-09-11
WO1996026279A1 (fr)	1996-08-29
AR003926A1 (es)	1998-09-30
JP4549439B2 (ja)	2010-09-22
NZ334762A (en)	2000-10-27
DE69637548D1 (de)	2008-07-10
EP0854927B1 (fr)	2008-05-28
SI9620043A (sl)	1998-06-30
CA2211413C (fr)	2010-06-22
NO973877D0 (no)	1997-08-22
NO973877L (no)	1997-10-24
SK114897A3 (en)	1998-03-04
HU222665B1 (hu)	2003-09-29
ATE397073T1 (de)	2008-06-15
IL117218A0 (en)	1996-06-18
ES2308775T3 (es)	2008-12-01
PL184951B1 (pl)	2003-01-31

Publication	Publication Date	Title
US6348343B2 (en)	2002-02-19	Human DNase I variants
US7407785B2 (en)	2008-08-05	Human DNase I hyperactive variants
JP5185914B2 (ja)	2013-04-17	ヒトｄｎアーゼｉｉ
SK284191B6 (sk)	2004-10-05	Aktín-rezistentný variant humánnej DNázy I
EP0811068B1 (fr)	2002-12-18	VARIANTES DE LA DNAse I HUMAINE
JP4624380B2 (ja)	2011-02-02	ヒトｄｎアーゼ変異体
JP2009060900A (ja)	2009-03-26	ヒトｄｎアーゼｉ変異体
NZ505985A (en)	2002-02-01	Human DNase I variants with a lower binding affinity for actin that native human dnase

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2016-03-01	MK4A	Patent expired	Expiry date: 20160221