SK132797A3 - Viral vectors and their use for treating hyperproliferative disorders, in particular restenosis - Google Patents
Viral vectors and their use for treating hyperproliferative disorders, in particular restenosis Download PDFInfo
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- SK132797A3 SK132797A3 SK1327-97A SK132797A SK132797A3 SK 132797 A3 SK132797 A3 SK 132797A3 SK 132797 A SK132797 A SK 132797A SK 132797 A3 SK132797 A3 SK 132797A3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9504234A FR2732357B1 (fr) | 1995-03-31 | 1995-03-31 | Vecteurs viraux et utilisation pour le traitement des desordres hyperproliferatifs, notamment de la restenose |
| PCT/US1996/004493 WO1996030385A1 (fr) | 1995-03-31 | 1996-03-28 | Vecteurs viraux et leur utilisation pour traiter des maladies hyperproliferatives, en particulier, la restenose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK132797A3 true SK132797A3 (en) | 1998-07-08 |
Family
ID=9477928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1327-97A SK132797A3 (en) | 1995-03-31 | 1996-03-28 | Viral vectors and their use for treating hyperproliferative disorders, in particular restenosis |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5851521A (fr) |
| EP (1) | EP0817791A4 (fr) |
| JP (1) | JPH11503314A (fr) |
| KR (1) | KR19980703454A (fr) |
| CN (1) | CN1190402A (fr) |
| AP (1) | AP1011A (fr) |
| AU (1) | AU701345B2 (fr) |
| BR (1) | BR9608449A (fr) |
| CA (1) | CA2216878A1 (fr) |
| CZ (1) | CZ308897A3 (fr) |
| FR (1) | FR2732357B1 (fr) |
| HU (1) | HUP9801767A3 (fr) |
| OA (1) | OA10516A (fr) |
| SI (1) | SI9620059A (fr) |
| SK (1) | SK132797A3 (fr) |
| WO (1) | WO1996030385A1 (fr) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5856121A (en) * | 1994-02-24 | 1999-01-05 | Case Western Reserve University | Growth arrest homebox gene |
| US7727761B2 (en) * | 1995-08-01 | 2010-06-01 | Vegenics Limited | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
| FR2740344B1 (fr) * | 1995-10-31 | 1997-11-21 | Rhone Poulenc Rorer Sa | Application de la proteine gax au traitement de cancers |
| FR2754822B1 (fr) * | 1996-10-18 | 1998-11-27 | Rhone Poulenc Rorer Sa | Polypeptides comprenant des domaines de la proteine gax, impliques dans la repression de transcription et/ou interagissant avec d'autres proteines, acides nucleiques correspondants et leurs utilisations |
| US6335010B1 (en) * | 1996-11-08 | 2002-01-01 | University Of California At San Diego | Gene therapy in coronary angioplasty and bypass |
| AU3347000A (en) | 1999-01-19 | 2000-08-01 | Children's Hospital Of Philadelphia, The | Hydrogel compositions for controlled delivery of virus vectors and methods of use thereof |
| DE60141567D1 (de) * | 2000-01-25 | 2010-04-29 | Edwards Lifesciences Corp | Freisetzungssysteme zur behandlung von restenose und anastomotischer intimaler hyperplasie |
| AU2001239884B2 (en) * | 2000-02-25 | 2006-08-10 | Vegenics Limited | Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins and screening methods for modulators |
| US20030100889A1 (en) * | 2001-07-05 | 2003-05-29 | Nicolas Duverger | Method of administration of a gene of interest to a vascular tissue |
| US20030180936A1 (en) * | 2002-03-15 | 2003-09-25 | Memarzadeh Bahram Eric | Method for the purification, production and formulation of oncolytic adenoviruses |
| US20040220656A1 (en) * | 2003-04-30 | 2004-11-04 | Epstein Samuel J. | Coated medical devices and methods of making the same |
| US20080215137A1 (en) * | 2003-04-30 | 2008-09-04 | Boston Scientific Scimed, Inc. | Therapeutic driving layer for a medical device |
| NZ545871A (en) * | 2003-09-12 | 2010-04-30 | Vertex Pharma | Animal model for protease activity and liver damage |
| WO2005087808A2 (fr) * | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Matieres et procedes de constructions de liaison de facteurs de croissance |
| US7582442B2 (en) * | 2004-03-16 | 2009-09-01 | The Regents Of The University Of Michigan | Methods and compositions for using aleveolar macrophage phospholipase A2 |
| US7319015B2 (en) * | 2004-03-16 | 2008-01-15 | The Regents Of The University Of Michigan | Methods and compositions for using alveolar macrophage phospholipase A2 |
| GB0416487D0 (en) | 2004-07-23 | 2004-08-25 | Isis Innovation | Modified virus |
| US20090233986A1 (en) * | 2004-07-27 | 2009-09-17 | Mount Sinai School Of Medicine | Methods and compositions for using sax2 |
| FI20050753A7 (fi) | 2004-09-03 | 2006-03-04 | Licentia Oy | Uudet peptidit |
| WO2006101629A2 (fr) * | 2005-02-17 | 2006-09-28 | Vertex Pharmaceuticals Incorporated | Variant d'epissage d'une sous-unite alpha de proteine type iii de canal sodique |
| KR100747646B1 (ko) | 2005-02-25 | 2007-08-08 | 연세대학교 산학협력단 | 데코린 유전자를 포함하는 유전자 전달 시스템 및 이를 포함하는 약제학적 항종양 조성물 |
| ES2363758T3 (es) | 2005-08-15 | 2011-08-16 | Vegenics Pty Ltd | Vegf y pdgf modificados con propiedades angiogénicas mejoradas. |
| US7972813B2 (en) * | 2005-09-30 | 2011-07-05 | Vertex Pharmaceuticals Incorporated | Tetrodotoxin-resistant sodium channel alpha subunit |
| US20080200408A1 (en) * | 2005-09-30 | 2008-08-21 | Mccormack Kenneth | Deletion mutants of tetrodotoxin-resistant sodium channel alpha subunit |
| DE602005023550D1 (de) | 2005-12-14 | 2010-10-21 | Licentia Ltd | Verwendungen eines neurotrophischen Faktors |
| WO2007089780A2 (fr) * | 2006-01-30 | 2007-08-09 | Licentia, Ltd. | Matériaux de thérapie gènique à tyrosine kinase bmx/etk et méthodes |
| US8114399B2 (en) | 2006-05-17 | 2012-02-14 | Ludwig Institute For Cancer Research | Targeting VEGF-B regulation of fatty acid transporters to modulate human diseases |
| FI20070808A0 (fi) | 2007-10-25 | 2007-10-25 | Mart Saarma | GDNF:n silmukointivariantit ja niiden käytöt |
| CN101952436B (zh) | 2008-01-09 | 2013-03-13 | 建国大学校产学协力团 | 基于杆状病毒的疫苗 |
| US20090196854A1 (en) * | 2008-02-04 | 2009-08-06 | Kytos Biosystems S.A. | Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery |
| FI20080326A0 (fi) | 2008-04-30 | 2008-04-30 | Licentia Oy | Neurotroofinen tekijä MANF ja sen käytöt |
| EP2318036B1 (fr) | 2008-06-30 | 2015-06-03 | The Regents of the University of Michigan | Activité phospholipase a2 lysosomale (lpla2) en tant que cible diagnostique et thérapeutique pour identifier et traiter le lupus érythémateux disséminé |
| EP2496268A4 (fr) | 2009-11-06 | 2013-06-19 | Univ Chung Ang Ind | Systèmes de délivrance de gènes à base de nanoparticules |
| KR101232123B1 (ko) | 2010-10-08 | 2013-02-12 | 연세대학교 산학협력단 | 재조합된 유전자발현 조절서열을 가지는 종양 특이적 발현이 개선된 유전자 전달체 |
| EP2710037B1 (fr) | 2011-05-19 | 2019-07-31 | The Regents of The University of Michigan | Agents se liant à l'intégrine alpha-2 et leur utilisation pour inhiber la prolifération des cellules cancéreuses |
| US9404090B2 (en) | 2011-11-24 | 2016-08-02 | Viromed Co., Ltd. | Adenovirus producing novel cell line and the use thereof |
| US9365496B2 (en) | 2011-11-30 | 2016-06-14 | Ludwig Institute For Cancer Research | iNKT cell modulators and methods of using the same |
| GB201120860D0 (en) | 2011-12-05 | 2012-01-18 | Cambridge Entpr Ltd | Cancer immunotherapy |
| WO2013184209A1 (fr) | 2012-06-04 | 2013-12-12 | Ludwig Institute For Cancer Research Ltd. | Mif destiné à être utilisé dans des méthodes de traitement de sujets atteints d'une maladie neurodégénérative |
| RS57789B1 (sr) | 2012-09-06 | 2018-12-31 | Univ Chicago | Antisens polinukleotidi za indukovanje preskakanja egzona i postupci lečenja distrofija |
| KR101429696B1 (ko) | 2012-11-21 | 2014-08-13 | 국립암센터 | 안전성 및 항암활성이 증가된 재조합 아데노바이러스 및 이의 용도 |
| MY170528A (en) | 2013-02-18 | 2019-08-09 | Vegenics Pty Ltd | Vegfr-3 ligand binding molecules and uses thereof |
| WO2014191630A2 (fr) | 2013-05-28 | 2014-12-04 | Helsingin Yliopisto | Modèle animal non humain codant pour un gène manf non fonctionnel |
| PT3283500T (pt) | 2015-04-08 | 2021-01-28 | Univ Chicago | Composições e métodos para corrigir distrofia muscular das cinturas tipo 2c com utilização de salto do exão |
| CN108289920A (zh) | 2015-10-12 | 2018-07-17 | 汉阳大学校产学协力团 | 用于基因转移和基因治疗的腺病毒复合物 |
| US10626414B2 (en) | 2016-09-20 | 2020-04-21 | Boehringer Ingelheim Vetmedica Gmbh | Swine influenza vaccine |
| UY37405A (es) | 2016-09-20 | 2018-03-23 | Boehringer Ingelheim Vetmedica Gmbh | Vectores de adenovirus canino |
| WO2018054840A1 (fr) | 2016-09-20 | 2018-03-29 | Boehringer Ingelheim Vetmedica Gmbh | Nouveaux promoteurs |
| AR109539A1 (es) | 2016-09-20 | 2018-12-19 | Boehringer Ingelheim Vetmedica Gmbh | Sitio de inserción orf70 de ehv |
| WO2019117632A1 (fr) | 2017-12-13 | 2019-06-20 | 한양대학교 산학협력단 | Adénovirus recombinants et cellules souches les comprenant |
| EP3802851A4 (fr) | 2018-06-11 | 2022-03-30 | University of Florida Research Foundation, Inc. | Matériaux et procédés de traitement de troubles et de cancer liés au stress |
| WO2024228167A1 (fr) | 2023-05-03 | 2024-11-07 | Iox Therapeutics Inc. | Compositions liposomales de modulateur de cellules inkt et procédés d'utilisation |
| WO2025113643A1 (fr) | 2023-12-01 | 2025-06-05 | Gilead Sciences Inc. | Protéine de fusion anti-fap-light et utilisation associée |
| WO2025259871A1 (fr) | 2024-06-14 | 2025-12-18 | Gilead Sciences, Inc. | Anticorps anti-ccr8 et leurs utilisations |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8424757D0 (en) * | 1984-10-01 | 1984-11-07 | Pasteur Institut | Retroviral vector |
| FR2573436B1 (fr) * | 1984-11-20 | 1989-02-17 | Pasteur Institut | Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins |
| US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US5139941A (en) * | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US4861719A (en) * | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| JP3082204B2 (ja) * | 1988-09-01 | 2000-08-28 | ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ | 両栄養性および環境栄養性宿主域を持つ組換え体レトロウイルス |
| US5585362A (en) * | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| CA2039921A1 (fr) * | 1990-04-16 | 1991-10-17 | Xandra O. Breakefield | Transfert et expression de la sequence d'adn dans les cellules du systeme nerveux central a l'aide de mutants du virus de l'herpes, avec deletions chez les genes en vue de repliquer le virus |
| WO1991018088A1 (fr) * | 1990-05-23 | 1991-11-28 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Vecteurs eucaryotiques a base de virus adeno-associes (aav) |
| US5173414A (en) * | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5252479A (en) * | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| EP1321526A3 (fr) * | 1992-11-18 | 2003-07-02 | Arch Development Corporation | Transfert de gènes au muscle lisse cardiaque et musculaire au moyen d'un Adenovirus |
| JPH08503855A (ja) * | 1992-12-03 | 1996-04-30 | ジェンザイム・コーポレイション | 嚢胞性線維症に対する遺伝子治療 |
| FR2705361B1 (fr) * | 1993-05-18 | 1995-08-04 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| DE69435108D1 (de) * | 1993-07-13 | 2008-08-14 | Centelion | Defekte adenovirus-vektoren und deren verwendung in der gentherapie |
| US5856121A (en) * | 1994-02-24 | 1999-01-05 | Case Western Reserve University | Growth arrest homebox gene |
-
1995
- 1995-03-31 FR FR9504234A patent/FR2732357B1/fr not_active Expired - Fee Related
-
1996
- 1996-03-28 BR BR9608449-9A patent/BR9608449A/pt not_active Application Discontinuation
- 1996-03-28 SK SK1327-97A patent/SK132797A3/sk unknown
- 1996-03-28 CN CN96193929A patent/CN1190402A/zh active Pending
- 1996-03-28 AU AU55315/96A patent/AU701345B2/en not_active Ceased
- 1996-03-28 WO PCT/US1996/004493 patent/WO1996030385A1/fr not_active Ceased
- 1996-03-28 CA CA002216878A patent/CA2216878A1/fr not_active Abandoned
- 1996-03-28 CZ CZ973088A patent/CZ308897A3/cs unknown
- 1996-03-28 SI SI9620059A patent/SI9620059A/sl not_active IP Right Cessation
- 1996-03-28 JP JP8529747A patent/JPH11503314A/ja not_active Ceased
- 1996-03-28 EP EP96912530A patent/EP0817791A4/fr not_active Withdrawn
- 1996-03-28 AP APAP/P/1997/001117A patent/AP1011A/en active
- 1996-03-28 HU HU9801767A patent/HUP9801767A3/hu unknown
- 1996-03-28 KR KR1019970706858A patent/KR19980703454A/ko not_active Ceased
- 1996-09-30 US US08/723,726 patent/US5851521A/en not_active Ceased
-
1997
- 1997-09-29 OA OA70089A patent/OA10516A/en unknown
-
2000
- 2000-12-21 US US09/740,876 patent/USRE37933E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| SI9620059A (sl) | 1998-06-30 |
| EP0817791A4 (fr) | 1998-07-15 |
| HUP9801767A2 (hu) | 1998-10-28 |
| CA2216878A1 (fr) | 1996-10-03 |
| WO1996030385A1 (fr) | 1996-10-03 |
| CN1190402A (zh) | 1998-08-12 |
| FR2732357B1 (fr) | 1997-04-30 |
| EP0817791A1 (fr) | 1998-01-14 |
| BR9608449A (pt) | 1999-11-30 |
| AP1011A (en) | 2001-09-22 |
| AU701345B2 (en) | 1999-01-28 |
| HUP9801767A3 (en) | 1999-04-28 |
| AU5531596A (en) | 1996-10-16 |
| MX9707549A (es) | 1998-07-31 |
| USRE37933E1 (en) | 2002-12-10 |
| CZ308897A3 (cs) | 1998-03-18 |
| AP9701117A0 (en) | 1996-03-28 |
| FR2732357A1 (fr) | 1996-10-04 |
| OA10516A (en) | 2002-04-22 |
| KR19980703454A (ko) | 1998-11-05 |
| US5851521A (en) | 1998-12-22 |
| JPH11503314A (ja) | 1999-03-26 |
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