SK11612003A3 - Izoxazolínové deriváty ako antidepresívne činidlá - Google Patents

Izoxazolínové deriváty ako antidepresívne činidlá Download PDF

Info

Publication number: SK11612003A3
Authority: SK; Slovakia
Prior art keywords: compound; formula; mol; group; alkyl
Prior art date: 2001-02-21

Application number

SK1161-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Jos� Ignacio Andr�S-Gil

Francisco Javier Fern�Ndez-Gadea

Manuel Jes�S Alc�Zar-Vaca

Jos Maria Cid-Nunez

Joaquin Pastor-Fernandez

Antonius Adrianus Hendrikus Petrus Megens

Godelieve Irma Christine Maria Heylen

Xavier Jean Michel Langlois

Margaretha Henrica Maria Bakker

Thomas Horst Wolfgang Steckler

Original Assignee

Janssen Pharmaceutica N. V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-21

Filing date

2002-02-13

Publication date

2004-04-06

2002-02-13 Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.

2004-04-06 Publication of SK11612003A3 publication Critical patent/SK11612003A3/sk

Links

239000000935 antidepressant agent Substances 0.000 title claims abstract description 20
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150000001875 compounds Chemical class 0.000 claims abstract description 139
238000002360 preparation method Methods 0.000 claims abstract description 74
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125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
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AXDBMNUQOVZXJM-UHFFFAOYSA-N methyl 4-bromobut-3-enoate Chemical compound COC(=O)CC=CBr AXDBMNUQOVZXJM-UHFFFAOYSA-N 0.000 description 1
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SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
238000010534 nucleophilic substitution reaction Methods 0.000 description 1
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239000001301 oxygen Substances 0.000 description 1
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208000027753 pain disease Diseases 0.000 description 1
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FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
WWPITPSIWMXDPE-UHFFFAOYSA-N para-chloroamphetamine Chemical compound CC(N)CC1=CC=C(Cl)C=C1 WWPITPSIWMXDPE-UHFFFAOYSA-N 0.000 description 1
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230000037361 pathway Effects 0.000 description 1
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229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
229910000105 potassium hydride Inorganic materials 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000004237 preparative chromatography Methods 0.000 description 1
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230000000391 smoking effect Effects 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
229910000033 sodium borohydride Inorganic materials 0.000 description 1
MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 1
238000003746 solid phase reaction Methods 0.000 description 1
239000006104 solid solution Substances 0.000 description 1
239000008137 solubility enhancer Substances 0.000 description 1
201000001716 specific phobia Diseases 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
230000000707 stereoselective effect Effects 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
QTENRWWVYAAPBI-YCRXJPFRSA-N streptomycin sulfate Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O QTENRWWVYAAPBI-YCRXJPFRSA-N 0.000 description 1
201000009032 substance abuse Diseases 0.000 description 1
231100000736 substance abuse Toxicity 0.000 description 1
208000011117 substance-related disease Diseases 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
210000003478 temporal lobe Anatomy 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
235000019157 thiamine Nutrition 0.000 description 1
239000011721 thiamine Substances 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
229960001479 tosylchloramide sodium Drugs 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000009466 transformation Effects 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
238000003569 transporter assay Methods 0.000 description 1
230000008733 trauma Effects 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
HDWHGDDNMJOCCU-UHFFFAOYSA-N trimethyl(pyridin-2-yl)stannane Chemical compound C[Sn](C)(C)C1=CC=CC=N1 HDWHGDDNMJOCCU-UHFFFAOYSA-N 0.000 description 1
210000001364 upper extremity Anatomy 0.000 description 1
208000030401 vitamin deficiency disease Diseases 0.000 description 1
230000008673 vomiting Effects 0.000 description 1
235000012431 wafers Nutrition 0.000 description 1
239000011534 wash buffer Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

SK1161-2003A 2001-02-21 2002-02-13 Izoxazolínové deriváty ako antidepresívne činidlá SK11612003A3 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP01200611		2001-02-21
EP01201264		2001-04-05
PCT/EP2002/001567 WO2002066484A1 (en)	2001-02-21	2002-02-13	Isoxazoline derivatives as anti-depressants

Publications (1)

Publication Number	Publication Date
SK11612003A3 true SK11612003A3 (sk)	2004-04-06

Family

ID=26076836

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1161-2003A SK11612003A3 (sk)	2001-02-21	2002-02-13	Izoxazolínové deriváty ako antidepresívne činidlá

Country Status (32)

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US (1)	US7169786B2 (da)
EP (1)	EP1368358B1 (da)
JP (1)	JP3953424B2 (da)
KR (1)	KR100848898B1 (da)
CN (1)	CN100400540C (da)
AR (1)	AR035685A1 (da)
AT (1)	ATE337322T1 (da)
AU (1)	AU2002244717B2 (da)
BG (1)	BG107984A (da)
BR (1)	BR0207433A (da)
CA (1)	CA2437505C (da)
CY (1)	CY1106448T1 (da)
CZ (1)	CZ20032515A3 (da)
DE (1)	DE60214138T2 (da)
DK (1)	DK1368358T3 (da)
EA (1)	EA006747B1 (da)
EE (1)	EE200300398A (da)
EG (1)	EG23929A (da)
ES (1)	ES2271230T3 (da)
HR (1)	HRP20030647A2 (da)
HU (1)	HUP0303270A3 (da)
IL (2)	IL157470A0 (da)
MX (1)	MXPA03007432A (da)
MY (1)	MY137836A (da)
NO (1)	NO20033700L (da)
NZ (1)	NZ526741A (da)
PL (1)	PL208593B1 (da)
PT (1)	PT1368358E (da)
SI (1)	SI1368358T1 (da)
SK (1)	SK11612003A3 (da)
TW (1)	TWI257392B (da)
WO (1)	WO2002066484A1 (da)

Families Citing this family (13)

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Publication number	Priority date	Publication date	Assignee	Title
GB0203299D0 (en) *	2002-02-12	2002-03-27	Glaxo Group Ltd	Novel compounds
IL164341A0 (en) *	2002-04-02	2005-12-18	Janssen Pharmaceutica Nv	Substituted amino isoxazoline derivatives and their use as anti-depressants
AR040967A1 (es) *	2002-08-12	2005-04-27	Janssen Pharmaceutica Nv	Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
JP4478571B2 (ja) *	2002-08-15	2010-06-09	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	縮合複素環式イソオキサゾリン誘導体及び抗うつ薬としてのそれらの使用
MY134287A (en)	2002-08-21	2007-11-30	Janssen Pharmaceutica Nv	C6- and c9-substituted isoxazoline derivatives and their use as anti-depressants
KR20050114641A (ko) *	2003-03-07	2005-12-06	아스텔라스세이야쿠 가부시키가이샤	2,6-이치환된 스티릴을 갖는 질소 함유 헤테로환 유도체
EP1944306A1 (en) *	2003-09-17	2008-07-16	Janssen Pharmaceutica, N.V.	Fused heterocyclic compounds as serotonin receptor modulators
AU2004283196B2 (en)	2003-09-17	2011-08-25	Janssen Pharmaceutica, N.V.	Fused heterocyclic compounds
DE602005016836D1 (de)	2004-11-26	2009-11-05	Janssen Pharmaceutica Nv	Chotischer und anxiolytischer aktivität
MY147757A (en)	2007-03-09	2013-01-15	Sanofi Aventis	Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof
US7863266B2 (en) *	2007-06-08	2011-01-04	Helicon Therapeutics, Inc.	Therapeutic pyrazoloquinoline urea derivatives
WO2009082268A2 (ru)	2007-12-21	2009-07-02	Alla Chem, Llc	ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
AR078171A1 (es)	2009-09-15	2011-10-19	Sanofi Aventis	Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparacion y uso de las mismas

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ES2055011T3 (es) *	1988-09-19	1994-08-16	Akzo Nv	Un procedimiento para la preparacion de derivados de tetrahidronaftaleno e indano.
US5880121A (en) *	1996-01-05	1999-03-09	Hoechst Marion Roussel Inc.	4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
ES2182064T3 (es) *	1996-04-12	2003-03-01	Janssen Pharmaceutica Nv	Derivados de isoxazolidina.
HUP9602763A3 (en) *	1996-10-09	1999-05-28	Egyt Gyogyszervegyeszeti Gyar	3-phenyl isoxazole derivatives, process for producing them and pharmaceutical compositions containing the same
DE69914931T2 (de) *	1998-10-09	2004-12-16	Janssen Pharmaceutica N.V.	4,5-dehydroisoxazole derivate und ihre pharmazeutische verwendung

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- 2002-02-13 AU AU2002244717A patent/AU2002244717B2/en not_active Expired
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- 2002-02-13 WO PCT/EP2002/001567 patent/WO2002066484A1/en not_active Ceased
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2003
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Also Published As

Publication number	Publication date
CN1492871A (zh)	2004-04-28
EG23929A (en)	2008-01-14
EP1368358A1 (en)	2003-12-10
KR20030076590A (ko)	2003-09-26
US20040122037A1 (en)	2004-06-24
DK1368358T3 (da)	2007-01-02
EP1368358B1 (en)	2006-08-23
JP3953424B2 (ja)	2007-08-08
EA200300915A1 (ru)	2004-06-24
HUP0303270A2 (hu)	2004-01-28
EA006747B1 (ru)	2006-04-28
MY137836A (en)	2009-03-31
CY1106448T1 (el)	2011-10-12
PT1368358E (pt)	2007-01-31
KR100848898B1 (ko)	2008-07-29
CN100400540C (zh)	2008-07-09
SI1368358T1 (sl)	2007-02-28
JP2004518748A (ja)	2004-06-24
IL157470A (en)	2008-07-08
PL208593B1 (pl)	2011-05-31
ES2271230T3 (es)	2007-04-16
EE200300398A (et)	2003-12-15
HUP0303270A3 (en)	2007-03-28
DE60214138T2 (de)	2007-03-29
CZ20032515A3 (cs)	2003-12-17
DE60214138D1 (de)	2006-10-05
BG107984A (bg)	2004-09-30
NO20033700D0 (no)	2003-08-20
TWI257392B (en)	2006-07-01
MXPA03007432A (es)	2003-11-18
WO2002066484A1 (en)	2002-08-29
IL157470A0 (en)	2004-03-28
NZ526741A (en)	2004-04-30
HK1065537A1 (zh)	2005-02-25
PL363264A1 (en)	2004-11-15
ATE337322T1 (de)	2006-09-15
CA2437505C (en)	2010-02-09
BR0207433A (pt)	2004-06-01
AU2002244717B2 (en)	2007-07-19
AR035685A1 (es)	2004-06-23
CA2437505A1 (en)	2002-08-29
US7169786B2 (en)	2007-01-30
NO20033700L (no)	2003-10-21
HRP20030647A2 (en)	2005-06-30

Publication	Publication Date	Title
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