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SI3433238T1 - Za prostato specifična, na membranski antigen usmerjena visoko afinitetna sredstva za endoradioterapijo raka prostate - Google Patents

Za prostato specifična, na membranski antigen usmerjena visoko afinitetna sredstva za endoradioterapijo raka prostate

Info

Publication number
SI3433238T1
SI3433238T1 SI201730908T SI201730908T SI3433238T1 SI 3433238 T1 SI3433238 T1 SI 3433238T1 SI 201730908 T SI201730908 T SI 201730908T SI 201730908 T SI201730908 T SI 201730908T SI 3433238 T1 SI3433238 T1 SI 3433238T1
Authority
SI
Slovenia
Prior art keywords
prostate
endoradiotherapy
antigen
affinity
targeted
Prior art date
Application number
SI201730908T
Other languages
English (en)
Inventor
Sangeeta Ray
Martin G. Pomper
Original Assignee
The Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Johns Hopkins University filed Critical The Johns Hopkins University
Publication of SI3433238T1 publication Critical patent/SI3433238T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0402Organic compounds carboxylic acid carriers, fatty acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
SI201730908T 2016-03-22 2017-03-22 Za prostato specifična, na membranski antigen usmerjena visoko afinitetna sredstva za endoradioterapijo raka prostate SI3433238T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662311697P 2016-03-22 2016-03-22
PCT/US2017/023508 WO2017165473A1 (en) 2016-03-22 2017-03-22 Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
EP17771028.2A EP3433238B1 (en) 2016-03-22 2017-03-22 Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer

Publications (1)

Publication Number Publication Date
SI3433238T1 true SI3433238T1 (sl) 2021-11-30

Family

ID=59899817

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201730908T SI3433238T1 (sl) 2016-03-22 2017-03-22 Za prostato specifična, na membranski antigen usmerjena visoko afinitetna sredstva za endoradioterapijo raka prostate
SI201731477T SI3925952T1 (sl) 2016-03-22 2017-03-22 Za prostato specifična, na membranski antigen usmerjena visoko afinitetna sredstva za endoradioterapijo raka prostate

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201731477T SI3925952T1 (sl) 2016-03-22 2017-03-22 Za prostato specifična, na membranski antigen usmerjena visoko afinitetna sredstva za endoradioterapijo raka prostate

Country Status (27)

Country Link
US (3) US11458213B2 (sl)
EP (3) EP3433238B1 (sl)
JP (3) JP7073270B2 (sl)
KR (4) KR20230147751A (sl)
CN (3) CN120172884A (sl)
AU (1) AU2017238181B2 (sl)
BR (1) BR112018069507A2 (sl)
CA (1) CA3018709A1 (sl)
CL (1) CL2018002683A1 (sl)
CY (1) CY1124487T1 (sl)
DK (2) DK3925952T3 (sl)
ES (2) ES2877572T3 (sl)
FI (1) FI3925952T3 (sl)
HR (2) HRP20240215T1 (sl)
HU (2) HUE055607T2 (sl)
LT (2) LT3433238T (sl)
MX (1) MX384823B (sl)
PH (1) PH12018502048A1 (sl)
PL (2) PL3925952T3 (sl)
PT (2) PT3925952T (sl)
RS (2) RS65188B1 (sl)
RU (2) RU2021115958A (sl)
SA (1) SA518400103B1 (sl)
SI (2) SI3433238T1 (sl)
TR (1) TR201813644T1 (sl)
WO (1) WO2017165473A1 (sl)
ZA (1) ZA201806389B (sl)

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JP7162592B2 (ja) 2016-12-14 2022-10-28 パーデュー・リサーチ・ファウンデイション 線維芽細胞活性化タンパク質(fap)標的イメージングおよび治療
EP3618867A4 (en) 2017-05-02 2021-01-20 Cornell University METHODS AND REAGENTS FOR TUMOR TARGETING WITH IMPROVED EFFICIENCY AND REDUCED TOXICITY
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EP3494999A1 (en) * 2017-12-11 2019-06-12 Technische Universität München Psma ligands for imaging and endoradiotherapy
EP3494998A1 (en) * 2017-12-11 2019-06-12 Technische Universität München Glycosylated psma inhibitors for imaging and endoradiotherapy
CN116617421A (zh) * 2017-12-11 2023-08-22 慕尼黑工业大学 用于诊断和/或治疗的药物组合物
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AU2019287595B2 (en) 2018-04-27 2024-10-31 University Of Iowa Research Foundation Compositions for chelating metals at low temperatures
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WO2020139012A1 (ko) * 2018-12-27 2020-07-02 (주)퓨쳐켐 카르복시산이 도입된 psma-표적 화합물 및 그의 용도
WO2021001362A1 (en) 2019-07-02 2021-01-07 Advanced Accelerator Applications (Italy) Srl Prostate specific membrane antigen (psma) ligands and uses thereof
RU2713151C1 (ru) * 2019-07-02 2020-02-04 Общество с ограниченной ответственностью "Изварино Фарма" Конъюгат флуоресцентного красителя с веществом пептидной природы, включающим псма-связывающий лиганд на основе производного мочевины для визуализации клеток, экспрессирующих псма, способ его получения и применения
CN114341118A (zh) * 2019-07-02 2022-04-12 先进加速器应用意大利公司 前列腺特异性膜抗原(psma)配体及其用途
RU2730507C1 (ru) * 2019-08-27 2020-08-24 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Соединение для диагностики опухолей, экспрессирующих псма, и композиция на его основе
JP2023523235A (ja) * 2020-04-29 2023-06-02 ノバルティス アーゲー Psma結合リガンドを放射標識するための方法及びそれらのキット
WO2022043556A1 (en) 2020-08-31 2022-03-03 Novartis Ag Stable radiopharmaceutical composition
EP4204020A1 (en) 2020-08-31 2023-07-05 Advanced Accelerator Applications International S.A. Method of treating psma-expressing cancers
WO2022043557A1 (en) 2020-08-31 2022-03-03 Advanced Accelerator Applications International Sa Method of treating psma-expressing cancers
US20230406847A1 (en) 2020-11-12 2023-12-21 Abx Advanced Biochemical Compounds Gmbh Ligands of prostate specific membrane antigen (psma) containing heteroaromatic linker building blocks
US20240010623A1 (en) 2020-11-19 2024-01-11 Novartis Ag Synthesis of prostate specific membrane antigen (psma) ligands
MX2021005089A (es) * 2021-04-30 2022-11-01 Instituto Nac De Investigaciones Nucleares Radiofarmacos basados en el acido ((r)-1-((6-hidrazinilnicotinoil) d-alanil)pirrolidin-2-il)boronico (hynic-ifap) para la deteccion de la sobreexpresion de la proteina de activacion de fibrolastos.
WO2022266499A1 (en) * 2021-06-17 2022-12-22 Mayo Foundation For Medical Education And Research Methods and materials for combining biologics with multiple chelators
KR20230050552A (ko) * 2021-10-07 2023-04-17 (주)퓨쳐켐 가돌리늄 화합물 및 이를 포함하는 전립선암의 진단 및 치료용 약학적 조성물
JP2025506001A (ja) 2022-02-09 2025-03-05 ノバルティス アーゲー 225-アクチニウム標識錯体及びビスマス封鎖剤を含む医薬組成物
KR20250127126A (ko) * 2022-12-21 2025-08-26 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 복수의 킬레이트제와 생물학적 제제를 조합하기 위한 방법 및 재료
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Also Published As

Publication number Publication date
EP3433238A4 (en) 2019-09-11
NZ746701A (en) 2024-12-20
TR201813644T1 (tr) 2018-11-21
HRP20211386T1 (hr) 2021-12-10
LT3925952T (lt) 2024-01-25
RU2021115958A (ru) 2021-07-12
SI3925952T1 (sl) 2024-03-29
RS62274B1 (sr) 2021-09-30
US20200155713A1 (en) 2020-05-21
RU2749399C2 (ru) 2021-06-09
WO2017165473A1 (en) 2017-09-28
EP3433238A1 (en) 2019-01-30
KR20180134918A (ko) 2018-12-19
ES2877572T3 (es) 2021-11-17
EP3925952A1 (en) 2021-12-22
ES2972148T3 (es) 2024-06-11
FI3925952T3 (fi) 2024-02-13
CN114716387B (zh) 2025-04-01
DK3925952T3 (da) 2024-02-05
AU2017238181A1 (en) 2018-10-18
SA518400103B1 (ar) 2022-03-20
ZA201806389B (en) 2024-01-31
CN109311827A (zh) 2019-02-05
PL3433238T3 (pl) 2021-12-13
EP3433238B1 (en) 2021-06-16
MX384823B (es) 2025-03-14
NZ786380A (en) 2025-05-02
MX2018011519A (es) 2019-01-28
BR112018069507A2 (pt) 2019-01-29
KR20250057132A (ko) 2025-04-28
CL2018002683A1 (es) 2019-04-22
US11458213B2 (en) 2022-10-04
EP4385981A1 (en) 2024-06-19
PL3925952T3 (pl) 2024-04-22
US20230015736A1 (en) 2023-01-19
CN120172884A (zh) 2025-06-20
PH12018502048A1 (en) 2019-07-01
JP2019519467A (ja) 2019-07-11
DK3433238T3 (da) 2021-09-06
CY1124487T1 (el) 2022-07-22
RU2018133693A (ru) 2020-04-22
HUE055607T2 (hu) 2021-12-28
JP2022116028A (ja) 2022-08-09
CN114716387A (zh) 2022-07-08
JP2024050608A (ja) 2024-04-10
CA3018709A1 (en) 2017-09-28
LT3433238T (lt) 2021-09-27
HRP20240215T1 (hr) 2024-04-26
US20250195700A1 (en) 2025-06-19
PT3925952T (pt) 2023-12-13
HUE065327T2 (hu) 2024-05-28
KR20230147751A (ko) 2023-10-23
EP3925952B1 (en) 2023-11-29
PT3433238T (pt) 2021-07-28
RU2018133693A3 (sl) 2020-04-22
JP7073270B2 (ja) 2022-05-23
KR102396307B1 (ko) 2022-05-09
CN109311827B (zh) 2022-04-12
AU2017238181B2 (en) 2021-05-27
RS65188B1 (sr) 2024-03-29
KR20220063298A (ko) 2022-05-17

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