[go: up one dir, main page]

SI3166925T1 - Izoindolinski derivati za uporabo pri zdravljenju virusne infekcije - Google Patents

Izoindolinski derivati za uporabo pri zdravljenju virusne infekcije Download PDF

Info

Publication number
SI3166925T1
SI3166925T1 SI201530238T SI201530238T SI3166925T1 SI 3166925 T1 SI3166925 T1 SI 3166925T1 SI 201530238 T SI201530238 T SI 201530238T SI 201530238 T SI201530238 T SI 201530238T SI 3166925 T1 SI3166925 T1 SI 3166925T1
Authority
SI
Slovenia
Prior art keywords
compound
alkyl
viral infection
phenyl
attached
Prior art date
Application number
SI201530238T
Other languages
English (en)
Inventor
Brian Alvin Johns
Emile Johann Velthuisen
Jason Gordon Weatherhead
Lita Suwandi
David Temelkoff
Original Assignee
Viiv Healthcare Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viiv Healthcare Uk Limited filed Critical Viiv Healthcare Uk Limited
Publication of SI3166925T1 publication Critical patent/SI3166925T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (16)

  1. ·· * - Izoindolinski derivati za uporabo pri zdravljenju virusne infekcije Patentni zahtevki L Spojina s formulo I: kjer:
    R1 je Ci_6alkil; R2 je C5_i4aril, C3_7cikloalkil, C3.7cikloalkenil, C2-9heterocikel ali C2-9heteroaril, kjer je vsaka skupina R2 po izbiri substituirana z 1-4 substituenti, izbranimi izmed halo, Ci^alkila, Ci^hetereoalkila ali C^alkilena ali Ci.6heteroalkilena, kjer sta Ci^alkilen ali Ci.6heteroalkilen vezana na sosednje atome ogljika na C5_i4arilu, C3_7cikloalkilu, C3.7cikloalkemlu, C3.9heterociklu ali C5.9heteroarilu, da se tvori kondenziran obroč; L je vez, -CH2(CO)-, -C^alkilen-, -S02-, -C(0>, -C(S>, -C(NH)-, -C(0)NH-, -C(0)NHCH2-, -C(0)N-, -C(0)0CH2-, -C(0)0-, -C(0)C(0)-, -S02-NH- ali -CH2C(0)-; R3 je H, CN, C|_6alkil, C5.i4aril, CH2C5.i4aril, CH2C3.7cikloalkil, C3.7cikloalkil, C3.7spirocikloalkil, C3.7cikloalkenil, C2.9heterocikel ali C2_9heteroaril, kjer je vsaka skupina R3 po izbiri substituirana z 1-4 substituenti, izbranimi izmed halo, Ci^alkila, premoščenega C2.8heterocikla, C3.7cikloalkila, Ci.3fluoroalkila, -OCj.6alkila, -C(0)R4, -C(0)NR4, -C(0)NHR4, C5.i4arila, C^hetereoalkila, -Β(ΟΗ)2, C2_9heterocikla, Ci^heteroarila, -C(0)OCi_6alkila, ali sta dva substituenta, ki sta vezana na sosednje atome, lahko vezana skupaj, da se tvori kondenziran obroč in je ta kondenziran obroč po izbiri lahko substituiran z R4; R4 je CN, halo, -OCi.6alkil, Cj^alkil, C3.7cikloalkil, C2-9heterocikel ali C5_i4aril; in kjer vsak heterocikel, heteroaril, heteroalkil in heteroalkilen obsega 1-3 heteroatome, izbrane izmed S, N, B ali O.
  2. 2. Spojina po zahtevku 1, kjer je R1 t-butil.
  3. 3. Spojina po katerem koli od zahtevkov 1-2, kjer je R2 po izbiri substituiran fenil.
  4. 4. Spojina po zahtevku 3, kjer je R2 fenil, substituiran z 1-4 substituenti, izbranimi izmed fluora, metila, -CH2CH2CH2O-, kjer je -CH2CH2CH2O- vezan na sosednje atome ogljika na fenilu, da se tvori bicikličen obroč, ali -NHCH2CH2O-, kjer je NHCH2CH2O- vezan na sosednje atome ogljika na fenilu, da se tvori bicikličen obroč.
  5. 5. Spojina po katerem koli od zahtevkov 1-4, kjer je R3 C^aUdl, fenil, naftil, ciklopentil, cikloheksil, piridil ali tetrahidropiranil, od katerih je vsak po izbiri substituiran z 1-3 substituenti, izbranimi izmed halogena, Ci^alkila, -OC^alkila, Ci_3fluoroalkila ali fenila.
  6. 6. Spojina po katerem koli od zahtevkov 1-5, kjer je stereokemija na ogljiku, na katerega je vezan OR1, prikazana spodaj :
  7. 7. Spojina po zahtevku 1, kjer je spojina:
  8. 8. Spojina po zahtevku 1, kjer je spojina:
  9. 9. Spojina po zahtevku 1, kjer je spojina:
  10. 10. Farmacevtsko sprejemljiva sol spojine po katerem koli od zahtevkov 1-9.
  11. 11. Farmacevtski sestavek, ki obsega spojino ali sol po katerem koli od zahtevkov Ι-ΙΟ.
  12. 12. Farmacevtski sestavek po zahtevku 11 za uporabo pri zdravljenju virusne infekcije pri pacientu, posredovane vsaj delno z virusom retrovirusne družine virusov.
  13. 13. Farmacevtski sestavek za uporabo po zahtevku 12, kjer je virusna infekcija posredovana z virusom HIV.
  14. 14. Spojina ali sol, kot je definirana v katerem koli od zahtevkov 1-10, za uporabo v medicinski terapiji.
  15. 15. Spojina ali sol, kot je definirana v katerem koli od zahtevkov 1-10, za uporabo pri zdravljenju virusne infekcije pri človeku.
  16. 16. Uporaba spojine ali soli, kot je definirana v katerem koli od zahtevkov 1-10, pri izdelavi zdravila za uporabo pri zdravljenju virusne infekcije pri človeku.
SI201530238T 2014-07-08 2015-07-06 Izoindolinski derivati za uporabo pri zdravljenju virusne infekcije SI3166925T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462021844P 2014-07-08 2014-07-08
US201462064615P 2014-10-16 2014-10-16
US201562134616P 2015-03-18 2015-03-18
EP15742106.6A EP3166925B1 (en) 2014-07-08 2015-07-06 Isoindoline derivatives for use in the treatment of a viral infection
PCT/IB2015/055095 WO2016005878A1 (en) 2014-07-08 2015-07-06 Isoindoline derivatives for use in the treatment of a viral infection

Publications (1)

Publication Number Publication Date
SI3166925T1 true SI3166925T1 (sl) 2018-06-29

Family

ID=53724405

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201530238T SI3166925T1 (sl) 2014-07-08 2015-07-06 Izoindolinski derivati za uporabo pri zdravljenju virusne infekcije

Country Status (37)

Country Link
US (1) US10112899B2 (sl)
EP (1) EP3166925B1 (sl)
JP (1) JP2017521428A (sl)
KR (1) KR20170024115A (sl)
CN (1) CN106795141A (sl)
AU (1) AU2015287334B2 (sl)
BR (1) BR112017000246A2 (sl)
CA (1) CA2954603A1 (sl)
CL (1) CL2017000014A1 (sl)
CR (1) CR20170005A (sl)
CY (1) CY1120607T1 (sl)
DK (1) DK3166925T3 (sl)
DO (1) DOP2016000336A (sl)
EA (1) EA030204B8 (sl)
ES (1) ES2667793T3 (sl)
HK (1) HK1231466A1 (sl)
HR (1) HRP20180639T1 (sl)
HU (1) HUE037884T2 (sl)
IL (1) IL249520A0 (sl)
LT (1) LT3166925T (sl)
MA (1) MA40221A (sl)
ME (1) ME03066B (sl)
MX (1) MX2017000312A (sl)
PE (1) PE20170440A1 (sl)
PH (1) PH12016502559A1 (sl)
PL (1) PL3166925T3 (sl)
PT (1) PT3166925T (sl)
RS (1) RS57108B1 (sl)
RU (1) RU2016150326A (sl)
SG (1) SG11201610746SA (sl)
SI (1) SI3166925T1 (sl)
SM (1) SMT201800276T1 (sl)
TR (1) TR201807217T4 (sl)
TW (1) TW201617331A (sl)
UY (1) UY36204A (sl)
WO (1) WO2016005878A1 (sl)
ZA (1) ZA201608554B (sl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6579549B2 (ja) 2014-05-16 2019-09-25 塩野義製薬株式会社 Ｈｉｖ複製阻害作用を有する３環性複素環誘導体
CA2987384A1 (en) 2015-05-29 2016-12-08 Shionogi & Co., Ltd. Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity
TW201720798A (zh) * 2015-09-17 2017-06-16 Ｖｉｉｖ醫療保健英國有限公司 苯并氮呯衍生物
WO2017093937A1 (en) * 2015-12-04 2017-06-08 Viiv Healthcare Uk Limited Isoindoline derivatives
WO2017093930A1 (en) * 2015-12-04 2017-06-08 Viiv Healthcare Uk Limited Isoindoline derivatives
JP2018536000A (ja) * 2015-12-04 2018-12-06 ヴィーブ ヘルスケア ユーケー リミテッド イソインドリン誘導体
GB201604647D0 (en) 2016-03-18 2016-05-04 Mission Therapeutics Ltd Novel compounds
JP6936820B2 (ja) * 2016-06-30 2021-09-22 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド ヒト免疫不全ウイルス複製の阻害剤としてのアザデカリン誘導体
WO2018020357A1 (en) 2016-07-25 2018-02-01 Viiv Healthcare Uk Limited Indoline derivatives
WO2018051250A1 (en) 2016-09-14 2018-03-22 Viiv Healthcare Company Combination comprising tenofovir alafenamide, bictegravir and 3tc
US20230382831A1 (en) * 2020-10-12 2023-11-30 Basf Se Process for the preparation of alpha-alkyl-2-(trifluoromethyl)-benzyl alcohols
TW202432557A (zh) * 2022-10-28 2024-08-16 大陸商紐歐申醫藥（上海）有限公司 一種含氮雜環化合物、其藥學上可接受的鹽及其製備方法與應用
WO2025089372A1 (ja) * 2023-10-26 2025-05-01 国立研究開発法人理化学研究所 イソインドリン誘導体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405237B2 (en) * 2004-07-28 2008-07-29 Celgene Corporation Isoindoline compounds and methods of their use
DE102007028521A1 (de) 2007-06-21 2008-12-24 Merck Patent Gmbh Indazolamidderivate
DE102007041116A1 (de) 2007-08-30 2009-03-05 Merck Patent Gmbh 1,3-Dihydro-isoindolderivate
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US8609653B2 (en) * 2011-07-15 2013-12-17 Glaxosmithkline Llc Azaindole compounds and methods for treating HIV
CN102491932A (zh) * 2011-12-26 2012-06-13 天津科技大学 一种3-吲哚啉酮类衍生物及其制备方法及其应用
WO2013103738A1 (en) * 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
US9006235B2 (en) 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
EP3070081B1 (en) * 2012-04-20 2018-02-28 Gilead Sciences, Inc. Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection
AU2013288369B2 (en) * 2012-07-12 2018-03-29 Viiv Healthcare Uk Limited Compounds and methods for treating HIV

Also Published As

Publication number Publication date
RS57108B1 (sr) 2018-06-29
ES2667793T3 (es) 2018-05-14
EA201692358A1 (ru) 2017-06-30
PT3166925T (pt) 2018-05-24
RU2016150326A (ru) 2018-08-08
PH12016502559A1 (en) 2017-04-17
HUE037884T2 (hu) 2018-09-28
WO2016005878A1 (en) 2016-01-14
US20180244617A1 (en) 2018-08-30
ZA201608554B (en) 2018-11-28
US10112899B2 (en) 2018-10-30
AU2015287334A1 (en) 2017-01-12
HRP20180639T1 (hr) 2018-06-29
MA40221A (fr) 2018-03-14
TW201617331A (zh) 2016-05-16
ME03066B (me) 2019-01-20
PL3166925T3 (pl) 2018-08-31
KR20170024115A (ko) 2017-03-06
BR112017000246A2 (pt) 2018-03-27
UY36204A (es) 2016-01-29
EP3166925A1 (en) 2017-05-17
DOP2016000336A (es) 2017-02-28
SG11201610746SA (en) 2017-01-27
TR201807217T4 (tr) 2018-06-21
LT3166925T (lt) 2018-06-11
IL249520A0 (en) 2017-02-28
PE20170440A1 (es) 2017-05-09
EA030204B8 (ru) 2018-08-31
CN106795141A (zh) 2017-05-31
CR20170005A (es) 2017-05-08
CY1120607T1 (el) 2019-12-11
HK1231466A1 (zh) 2017-12-22
EA030204B1 (ru) 2018-07-31
SMT201800276T1 (it) 2018-07-17
AU2015287334B2 (en) 2017-08-31
MX2017000312A (es) 2017-04-27
CA2954603A1 (en) 2016-01-14
CL2017000014A1 (es) 2017-06-23
EP3166925B1 (en) 2018-03-14
JP2017521428A (ja) 2017-08-03
DK3166925T3 (en) 2018-06-18

Similar Documents

Publication Publication Date Title
SI3166925T1 (sl) Izoindolinski derivati za uporabo pri zdravljenju virusne infekcije
BR112015021027A8 (pt) compostos terapêuticos, seus usos, e composições farmacêuticas
PH12018550201A1 (en) Hepatitis b antiviral agents
CY1123627T1 (el) Παραγωγα διυδροϊμιδαζοπυραζινονης χρησιμα στη θεραπευτικη αντιμετωπιση του καρκινου
EA201791515A1 (ru) Соединения пиразина для лечения инфекционных заболеваний
EA201490647A1 (ru) Производные бензотиазол-6-илуксусной кислоты и их применение для лечения вич-инфекции
WO2019143902A3 (en) Substituted heterocycles as antiviral agents
JP2016506962A5 (sl)
JP2016530259A5 (sl)
JP2016506960A5 (sl)
JP2014518882A5 (sl)
NZ631738A (en) (hetero) arylacetamide derivatives as antiretroviral agents
MA42232B1 (fr) Nouveaux dérivés d'acide aminé, leur procédé de préparation et compositions pharmaceutiques les contenant
RU2017103656A (ru) Производные изоиндолинона, полезные в качестве противовирусных средств
EA201791872A1 (ru) Полициклические карбамоилпиридоновые соединения и их фармацевтическое применение
CY1123137T1 (el) Ιμιδαζο[1.2α]πυριδινες για αντιμετωπιση ή προληψη υπερουριχαιμιας ή ουρικης αρθριτιδας
HK1211290A1 (en) Heterocycle-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases
JOP20210249A1 (ar) مشتقات البيرميدون الحلقية المدمجة للاستخدام في علاج عدوىhbv أو الأمراض التي يسببها فيروس hbv
JP2020500182A5 (sl)
JP2016531126A5 (sl)
MX2021003253A (es) Heterociclos funcionalizados como agentes antivirales.
TN2019000117A1 (en) Liposomal formulation for use in the treatment of cancer
EA201490213A1 (ru) Бензофурановые соединения для лечения инфекций вирусом гепатита с
EA201992771A1 (ru) Ингибитор поверхностного антигена вируса гепатита b
MX379015B (es) Inhibidores de la polimerasa del virus de la hepatitis c.