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CY1123137T1 - Ιμιδαζο[1.2α]πυριδινες για αντιμετωπιση ή προληψη υπερουριχαιμιας ή ουρικης αρθριτιδας - Google Patents

Ιμιδαζο[1.2α]πυριδινες για αντιμετωπιση ή προληψη υπερουριχαιμιας ή ουρικης αρθριτιδας

Info

Publication number
CY1123137T1
CY1123137T1 CY20201100660T CY201100660T CY1123137T1 CY 1123137 T1 CY1123137 T1 CY 1123137T1 CY 20201100660 T CY20201100660 T CY 20201100660T CY 201100660 T CY201100660 T CY 201100660T CY 1123137 T1 CY1123137 T1 CY 1123137T1
Authority
CY
Cyprus
Prior art keywords
prevention
treatment
hyperurachemia
pyridines
imidazo
Prior art date
Application number
CY20201100660T
Other languages
English (en)
Inventor
Dongfang Shi
Changjin FU
Xi CHENG
Jianghua Zhu
Jie Wen
Jie Gu
Original Assignee
Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd filed Critical Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd
Publication of CY1123137T1 publication Critical patent/CY1123137T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Παρέχονται μία ένωση όπως παριστάνεται στον Τύπο (Ι), φαρμακευτικώς αποδεκτά άλατα αυτής,φαρμακευτικές συνθέσεις αυτής, και χρήσεις αυτής. Η ένωση όπως παριστάνεται στον Τύπο (Ι) και τα φαρμακευτικώς αποδεκτά άλατα αυτής χρησιμοποιούνται στην παρασκευή φαρμάκων για τηναντιμετώπιση ή πρόληψη υπέρουριχαιμίας ή ουρικής αρθρίτιδας μέσω της απέκκρισης ουρικού οξέος.
CY20201100660T 2015-09-10 2020-07-17 Ιμιδαζο[1.2α]πυριδινες για αντιμετωπιση ή προληψη υπερουριχαιμιας ή ουρικης αρθριτιδας CY1123137T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510576110 2015-09-10
PCT/CN2016/098468 WO2017041732A1 (zh) 2015-09-10 2016-09-08 一类用于治疗或预防高尿酸血症或痛风的化合物

Publications (1)

Publication Number Publication Date
CY1123137T1 true CY1123137T1 (el) 2021-10-29

Family

ID=58164535

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100660T CY1123137T1 (el) 2015-09-10 2020-07-17 Ιμιδαζο[1.2α]πυριδινες για αντιμετωπιση ή προληψη υπερουριχαιμιας ή ουρικης αρθριτιδας

Country Status (27)

Country Link
US (1) US10399971B2 (el)
EP (1) EP3348557B1 (el)
JP (1) JP6635527B2 (el)
KR (1) KR102109061B1 (el)
CN (1) CN106432229B (el)
AU (1) AU2016320073B2 (el)
BR (1) BR112018004863B1 (el)
CA (1) CA2998034C (el)
CY (1) CY1123137T1 (el)
DK (1) DK3348557T3 (el)
EA (1) EA037280B1 (el)
ES (1) ES2803223T3 (el)
HR (1) HRP20201094T1 (el)
HU (1) HUE051448T2 (el)
IL (1) IL257960A (el)
LT (1) LT3348557T (el)
MX (1) MX375068B (el)
MY (1) MY195675A (el)
NZ (1) NZ741318A (el)
PL (1) PL3348557T3 (el)
PT (1) PT3348557T (el)
RS (1) RS60697B1 (el)
SG (1) SG11201802010QA (el)
SI (1) SI3348557T1 (el)
TW (1) TWI681772B (el)
WO (1) WO2017041732A1 (el)
ZA (1) ZA201802312B (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018090921A1 (zh) * 2016-11-16 2018-05-24 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
CN108084186B (zh) * 2016-11-16 2021-06-25 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
US11597725B2 (en) * 2017-05-26 2023-03-07 Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd. URAT1 inhibitor for promoting uric acid excretion
CN108727267B (zh) * 2017-05-26 2022-05-13 江苏新元素医药科技有限公司 一类urat1抑制剂及其应用
CN111615515B (zh) * 2018-01-19 2023-11-24 苏州信诺维医药科技股份有限公司 杂环化合物、制备方法及其在医药上的应用
CN111410654B (zh) * 2019-01-19 2022-05-17 江苏新元素医药科技有限公司 3-溴-5-(2-乙基咪唑并[1,2-a]吡啶-3-羰基)-2-羟基苯甲腈的合成
CN111943957B (zh) * 2019-05-17 2023-01-06 中国医学科学院药物研究所 喹啉甲酰胺类化合物及其制备方法和用途
WO2022169974A1 (en) * 2021-02-05 2022-08-11 Nexys Therapeutics, Inc. Inhibitors of urat1 and pharmaceutical uses thereof
CN116715633B (zh) * 2022-04-27 2025-08-12 杭州新元素药业股份有限公司 可用于降尿酸的化合物
WO2023221078A1 (en) * 2022-05-20 2023-11-23 Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd. Solid forms of a compound for treating or preventing hyperuricemia or gout
TWI898321B (zh) * 2023-11-17 2025-09-21 大陸商杭州新元素藥業有限公司 用於治療或預防高尿酸血症或痛風的化合物的固體晶型
WO2025237171A1 (zh) * 2024-05-11 2025-11-20 广州市联瑞制药有限公司 嘧啶并五元氮杂环酚类化合物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ193926A (en) * 1979-07-06 1984-05-31 Labaz Sanofi Nv 2-(alkyl or phenyl)-3(4-hydroxybenzoyl)indolizines
FR2647451B1 (fr) * 1989-05-26 1994-08-05 Sanofi Sa Derives d'imidazo(1,2-a)pyridine, procede de preparation, compositions pharmaceutiques les contenant
JP5325065B2 (ja) * 2009-09-30 2013-10-23 株式会社富士薬品 新規フェノール誘導体
WO2012048058A2 (en) * 2010-10-06 2012-04-12 J-Pharma Co., Ltd. Developing potent urate transporter inhibitors: compounds designed for their uricosuric action
US9512119B2 (en) * 2012-07-27 2016-12-06 Sato Pharmaceutical Co., Ltd. Difluoromethylene compound

Also Published As

Publication number Publication date
CA2998034A1 (en) 2017-03-16
NZ741318A (en) 2019-03-29
ZA201802312B (en) 2024-11-27
BR112018004863B1 (pt) 2023-04-18
BR112018004863A2 (el) 2018-10-02
EP3348557A1 (en) 2018-07-18
EA037280B1 (ru) 2021-03-03
ES2803223T3 (es) 2021-01-25
LT3348557T (lt) 2020-08-10
PT3348557T (pt) 2020-08-03
TW201808284A (zh) 2018-03-16
HUE051448T2 (hu) 2021-03-01
SI3348557T1 (sl) 2020-09-30
IL257960A (en) 2018-05-31
WO2017041732A1 (zh) 2017-03-16
US10399971B2 (en) 2019-09-03
US20180282321A1 (en) 2018-10-04
EA201890694A1 (ru) 2018-10-31
CN106432229B (zh) 2018-01-12
HRP20201094T1 (hr) 2020-10-30
AU2016320073A1 (en) 2018-04-26
MY195675A (en) 2023-02-03
MX375068B (es) 2025-03-06
PL3348557T3 (pl) 2020-11-16
MX2018003006A (es) 2018-08-09
JP6635527B2 (ja) 2020-01-29
SG11201802010QA (en) 2018-04-27
CA2998034C (en) 2021-05-04
KR102109061B1 (ko) 2020-05-11
DK3348557T3 (da) 2020-07-20
JP2018526417A (ja) 2018-09-13
AU2016320073B2 (en) 2019-05-09
CN106432229A (zh) 2017-02-22
EP3348557B1 (en) 2020-04-29
KR20180044426A (ko) 2018-05-02
RS60697B1 (sr) 2020-09-30
EP3348557A4 (en) 2019-03-06
TWI681772B (zh) 2020-01-11

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