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SI2819663T1 - Novi terapevtski pristopi za preprečevanje parkinsonove bolezni - Google Patents

Novi terapevtski pristopi za preprečevanje parkinsonove bolezni Download PDF

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Publication number
SI2819663T1
SI2819663T1 SI201330796T SI201330796T SI2819663T1 SI 2819663 T1 SI2819663 T1 SI 2819663T1 SI 201330796 T SI201330796 T SI 201330796T SI 201330796 T SI201330796 T SI 201330796T SI 2819663 T1 SI2819663 T1 SI 2819663T1
Authority
SI
Slovenia
Prior art keywords
composition
use according
baclofen
sustained
levodopa
Prior art date
Application number
SI201330796T
Other languages
English (en)
Inventor
Daniel Cohen
Serguei Nabirochkin
Ilya Chumakov
Rodolphe Hajj
Original Assignee
Pharnext
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/053565 external-priority patent/WO2012117073A2/en
Priority claimed from PCT/EP2012/053568 external-priority patent/WO2012117075A2/en
Application filed by Pharnext filed Critical Pharnext
Publication of SI2819663T1 publication Critical patent/SI2819663T1/sl

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
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    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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Claims (19)

  1. -- - · ··· · NOVI TERAPEVTSKI PRISTOPI ZA PREPREČEVANJE PARKINSONOVE BOLEZNI PATENTNI ZAHTEVKI
    1. Sestavek za uporabo pri zdravljenju parkinsonizma, omenjeni sestavek obsega akamprozat in baklofen, ali soli le-teh ali formulacije z zadržanim sproščanjem le-teh.
  2. 2. Sestavek za uporabo po zahtevku 1, kjer je parkinsonizem stanje, izbrano izmed Parkinsonove bolezni, progresivno supranuklearne paralize, večkratne sistemske atrofije, kortikalno-bazalne ganglionske degeneracije, razpršene Lewyove bolezni telesa, Parkinsonove demence, X-povezane distonija-parkinsonizma in sekundarnega parkinsonizma.
  3. 3. Sestavek za uporabo po zahtevku 1, kjer je parkinsonizem Parkinsonova bolezen.
  4. 4. Sestavek za uporabo po zahtevku 1 ali 3, ki obsega vsaj eno izmed naslednjih kombinacij zdravil: - baklofen in akamprozat ter cinakalcet, - baklofen in akamprozat ter torasemid, ali - baklofen in akamprozat ter meksiletin, ali njihove soli ali njihove formulacije z zadržanim sproščanjem. ** ** w w w m
  5. 5. Sestavek za uporabo po katerem koli od zahtevkov 1-4, ki nadalje obsega vsaj en dopaminski prekurzor, vsaj en agonist dopaminskega receptorja in/ali vsaj en inhibitor encimov, ki presnavljajo dopamin.
  6. 6. Sestavek za uporabo po zahtevku 5, kjer je vsaj en dopaminski prekurzor izbran iz skupine, ki jo sestavljajo levodopa in melevodopa, ali njihove soli ali njihove formulacije z zadržanim sproščanjem, vsaj en agonist dopaminskega receptorja izbran iz skupine, ki jo sestavljajo talipeksol, piribedil, rotigotin, bromokriptin, pergolid, kabergolin, lizurid, pramipeksol, ropinirol ali apomorfin ali soli ali formulacije z zadržanim sproščanjem le-teh in vsaj en inhibitor encimov, ki presnavljajo dopamin je izbran iz skupine, ki jo sestavljajo selegilin in razagilin, ali soli ali formulacije z zadržanim sproščanjem le-teh.
  7. 7. Sestavek za uporabo po zahtevku 5 ali 6, ki obsega vsaj eno od naslednjih zdravilnih kombinacij ali soli ati formulacije z zadržanim sproščanjem le-teh: - baklofen in akamprozat ter levodopa, - baklofen in akamprozat ter cinakalcet in levodopa, - baklofen in akamprozat ter torasemid in levodopa, ali - baklofen in akamprozat ter meksiletin in levodopa.
  8. 8. Sestavek za uporabo po zahtevku 7, ki nadalje obsega karbidopo ali njeno sol ali njeno formulacijo z zadržanim sproščanjem. » * · » · « ·
  9. 9. Sestavek za uporabo po katerem koli od prejšnjih zahtevkov, ki nadalje obsega farmacevtsko sprejemljiv nosilec ali ekscipient.
  10. 10. Sestavek za uporabo po katerem koli od prejšnjih zahtevkov, kjer so spojine formulirane ali aplicirane skupaj, ločeno ali zaporedno.
  11. 11. Sestavek za uporabo po katerem koli od prejšnjih zahtevkov, kjer se omenjeni sestavek večkrat daje subjektu.
  12. 12. Sestavek za uporabo po katerem koli izmed predhodnih zahtevkov, kjer se navedeni sestavek daje oralno.
  13. 13. Sestavek za uporabo po katerem koli od zahtevkov 1 do 12, kjer je acamprozat apliciran v odmerku manj več kot 50 mg na dan, bolj prednostno manj kot 10 mg na dan.
  14. 14. Sestavek za uporabo po katerem koli izmed zahtevkov 1 do 13, kjer se baklofen daje v odmerku, manjšem od 30 mg na dan.
  15. 15. Sestavek za uporabo po katerem koli od zahtevkov 1 do 14, za uporabo pri zaščiti dopaminergičnih nevronov nigrostriatalnega sistema pred degeneracijo.
  16. 16. Sestavek za uporabo po katerem koli izmed zahtevkov od 1 do 14 za uporabo pri zdravljenju bradikinezije ali akinezije.
  17. 17. Sestavek za uporabo po katerem koli od predhodnih zahtevkov, za uporabo pri preventivnem zdravljenju pri subjektu, ki to potrebuje in tveganju za parkinsonizem.
  18. 18. Sestavek, ki obsega baklofen, akamprozat in levodopo ali farmacevtsko sprejemljive soli le-teh.
  19. 19.Sestavek po zahtevku 18, ki nadalje obsega karbidopo ali farmacevtsko sprejemljivo sol ali formulacijo z zadržanim sproščanjem le-teh.
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PCT/EP2012/053570 WO2012117076A2 (en) 2011-03-01 2012-03-01 Baclofen and acamprosate based therapy of neurogical disorders
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EP2819663A1 (en) 2015-01-07
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WO2014037416A2 (en) 2014-03-13
IL234101A0 (en) 2014-09-30
CN104487062B (zh) 2017-08-04
RS56405B1 (sr) 2018-01-31
MX2014010214A (es) 2014-11-26
MX356865B (es) 2018-06-18
AU2013224960A1 (en) 2014-10-16
US20180263989A1 (en) 2018-09-20
PT2819663T (pt) 2017-10-16
EP3254682A1 (en) 2017-12-13
HUE034615T2 (en) 2018-02-28
ES2690061T3 (es) 2018-11-19
AU2013224960A2 (en) 2014-10-23
KR20150002640A (ko) 2015-01-07

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