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SI1237878T1 - 4-pirimidinil-n-acil-l-fenilanin - Google Patents

4-pirimidinil-n-acil-l-fenilanin

Info

Publication number
SI1237878T1
SI1237878T1 SI200030948T SI200030948T SI1237878T1 SI 1237878 T1 SI1237878 T1 SI 1237878T1 SI 200030948 T SI200030948 T SI 200030948T SI 200030948 T SI200030948 T SI 200030948T SI 1237878 T1 SI1237878 T1 SI 1237878T1
Authority
SI
Slovenia
Prior art keywords
phenylalanines
pyrimidinyl
acyl
Prior art date
Application number
SI200030948T
Other languages
English (en)
Inventor
Achyutharao Sidduri
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SI1237878T1 publication Critical patent/SI1237878T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI200030948T 1999-12-06 2000-11-28 4-pirimidinil-n-acil-l-fenilanin SI1237878T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16908999P 1999-12-06 1999-12-06
EP00989906A EP1237878B1 (en) 1999-12-06 2000-11-28 4-pyrimidinyl-n-acyl-l-phenylalanines
PCT/EP2000/011884 WO2001042225A2 (en) 1999-12-06 2000-11-28 4-pyrimidinyl-n-acyl-l-phenylalanines

Publications (1)

Publication Number Publication Date
SI1237878T1 true SI1237878T1 (sl) 2007-08-31

Family

ID=22614222

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030948T SI1237878T1 (sl) 1999-12-06 2000-11-28 4-pirimidinil-n-acil-l-fenilanin

Country Status (35)

Country Link
EP (1) EP1237878B1 (sl)
JP (1) JP3824935B2 (sl)
KR (1) KR100522344B1 (sl)
CN (1) CN1218943C (sl)
AR (1) AR034401A1 (sl)
AT (1) ATE357433T1 (sl)
AU (1) AU783348B2 (sl)
BR (1) BR0016195A (sl)
CA (1) CA2392570C (sl)
CO (1) CO5080772A1 (sl)
CY (1) CY1106626T1 (sl)
CZ (1) CZ303435B6 (sl)
DE (1) DE60034061T2 (sl)
DK (1) DK1237878T3 (sl)
EG (1) EG24361A (sl)
ES (1) ES2282162T3 (sl)
HK (1) HK1054384B (sl)
HR (1) HRP20020468B1 (sl)
HU (1) HU229105B1 (sl)
IL (2) IL149617A0 (sl)
JO (1) JO2283B1 (sl)
MA (1) MA26850A1 (sl)
MX (1) MXPA02005564A (sl)
MY (1) MY126972A (sl)
NO (1) NO322866B1 (sl)
NZ (1) NZ518828A (sl)
PE (1) PE20010961A1 (sl)
PL (1) PL207160B1 (sl)
PT (1) PT1237878E (sl)
RS (1) RS50371B (sl)
RU (1) RU2266901C2 (sl)
SI (1) SI1237878T1 (sl)
TW (1) TWI256387B (sl)
WO (1) WO2001042225A2 (sl)
ZA (1) ZA200203533B (sl)

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US6960597B2 (en) 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
NZ524122A (en) * 2000-08-18 2005-02-25 Ajinomoto Kk Phenylalanine derivatives useful as pharmaceutical agents
AR033765A1 (es) * 2001-05-22 2004-01-07 Syngenta Participations Ag Procedimiento para la preparacion de derivados 3-alquil-3h-isobenzofuran-1-ona 7-sustituidos.
JP4452899B2 (ja) 2001-12-13 2010-04-21 味の素株式会社 新規フェニルアラニン誘導体
WO2005061466A1 (ja) 2003-12-22 2005-07-07 Ajinomoto Co., Inc. 新規フェニルアラニン誘導体
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
CN101006097B (zh) * 2004-08-16 2012-07-11 默沙东公司 Vla-4拮抗剂
JP4784224B2 (ja) 2004-09-24 2011-10-05 味の素株式会社 糖鎖転移方法および糖鎖転移酵素
WO2007060408A2 (en) * 2005-11-23 2007-05-31 Astrazeneca Ab L-phenylalanine derivatives and their use as integrin antagonists
AR059224A1 (es) * 2006-01-31 2008-03-19 Jerini Ag Compuestos para la inhibicion de integrinas y uso de estas
WO2007091046A1 (en) * 2006-02-09 2007-08-16 Astrazeneca Ab Chemical compounds
US7879837B2 (en) 2006-06-19 2011-02-01 Toray Industries, Inc. Therapeutic or prophylactic agent for multiple sclerosis
PL2203431T3 (pl) 2007-09-17 2012-01-31 Abbvie Bahamas Ltd Pirymidyny o działaniu przeciw zakaźnym oraz ich zastosowania
RU2543620C2 (ru) 2007-09-17 2015-03-10 Эббви Бахамаз Лтд. Производные урацила или тимина для лечения гепатита с
MX2010002904A (es) 2007-09-17 2010-06-02 Abbott Lab N-fenil-dioxo-hidropirimidinas utiles como inhibidores de virus de hepatitis c (hcv).
KR101701395B1 (ko) * 2008-12-22 2017-02-01 아이씨엘-아이피 아메리카 아이엔씨. 비스포스페이트를 정제하기 위한 수용성 용매 기반 정제 방법
US9216952B2 (en) 2010-03-23 2015-12-22 Abbvie Inc. Process for preparing antiviral compound
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
AU2011278927B2 (en) 2010-07-16 2015-05-21 Abbvie Ireland Unlimited Company Process for preparing antiviral compounds
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
BR112013001138A2 (pt) 2010-07-16 2016-07-05 Abbvie Inc ligantes de fosfina para reações catalíticas
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
KR20140127234A (ko) * 2012-01-27 2014-11-03 에프. 호프만-라 로슈 아게 Ｖｌａ-4 발현 세포로의 표적화된 전달을 위한 인테그린 안타고니스트 접합체
US9447035B2 (en) * 2012-01-27 2016-09-20 Hoffmann-La Roche Inc. Integrin antagonist conjugates for targeted delivery to cells expressing VLA-4
AU2014324426A1 (en) 2013-09-30 2016-04-21 The Regents Of The University Of California Anti-alphavbeta1 integrin compounds and methods
BR112016009515B1 (pt) * 2013-10-29 2022-05-03 EA Pharma Co., Ltd Derivado de sulfonamida, composição farmacêutica, agente terapêutico ou um agente preventivo para doença inflamatória, e, inibidor de integrina a4ß7
WO2016145258A1 (en) 2015-03-10 2016-09-15 The Regents Of The University Of California Anti-alphavbeta1 integrin inhibitors and methods of use
DK3873884T3 (da) 2018-10-30 2025-02-17 Gilead Sciences Inc 3-(quinolin-8-yl)-1,4-dihydropyrido[3,4-d]pyrimidin-2,4-dion-derivater som alpha4beta7-integrinhæmmere til behandling af inflammatoriske sygdomme
PL3873605T3 (pl) 2018-10-30 2025-03-03 Gilead Sciences, Inc. Związki hamujące integrynę alfa4beta7
WO2020092394A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
EP3873897B1 (en) 2018-10-30 2024-08-14 Gilead Sciences, Inc. N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases
US11578069B2 (en) 2019-08-14 2023-02-14 Gilead Sciences, Inc. Compounds for inhibition of α4 β7 integrin

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CH516578A (de) * 1967-11-02 1971-12-15 Bayer Ag Verfahren zur Herstellung von heterocyclische Acylaminogruppen enthaltenden Arylsulfonylharnstoffen mit blutdrucksenkender Wirkung
JP2001517245A (ja) * 1997-05-29 2001-10-02 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としてのビアリールアルカン酸類
CA2291778A1 (en) * 1997-05-29 1998-12-03 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
RU2220950C2 (ru) * 1997-08-22 2004-01-10 Ф.Хоффманн-Ля Рош Аг N-алканоилфенилаланиновые производные
JP3727536B2 (ja) * 1997-08-22 2005-12-14 エフ．ホフマン−ラ ロシュ アーゲー Ｎ−アルカノイルフェニルアラニン誘導体
DE60021251D1 (de) * 1999-01-22 2005-08-18 Elan Pharm Inc Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion

Also Published As

Publication number Publication date
DK1237878T3 (da) 2007-07-30
AU2669601A (en) 2001-06-18
JP2003516396A (ja) 2003-05-13
CN1218943C (zh) 2005-09-14
NO20022633D0 (no) 2002-06-04
KR100522344B1 (ko) 2005-10-20
HRP20020468A2 (en) 2004-04-30
EP1237878A2 (en) 2002-09-11
CA2392570A1 (en) 2001-06-14
ES2282162T3 (es) 2007-10-16
IL149617A0 (en) 2002-11-10
CA2392570C (en) 2010-05-11
HUP0204081A2 (en) 2003-05-28
YU40402A (sh) 2005-03-15
AU783348B2 (en) 2005-10-20
ATE357433T1 (de) 2007-04-15
HK1054384B (zh) 2005-12-09
WO2001042225A8 (en) 2002-06-06
JO2283B1 (en) 2005-09-12
PE20010961A1 (es) 2001-09-26
DE60034061T2 (de) 2007-12-13
CZ303435B6 (cs) 2012-09-12
TWI256387B (en) 2006-06-11
CN1407972A (zh) 2003-04-02
IL149617A (en) 2007-10-31
CO5080772A1 (es) 2001-09-25
PL357601A1 (en) 2004-07-26
WO2001042225A3 (en) 2002-02-21
HU229105B1 (en) 2013-07-29
KR20020063906A (ko) 2002-08-05
HRP20020468B1 (en) 2009-02-28
ZA200203533B (en) 2003-08-04
BR0016195A (pt) 2002-08-13
RU2266901C2 (ru) 2005-12-27
NO322866B1 (no) 2006-12-18
RU2002117422A (ru) 2004-03-10
CY1106626T1 (el) 2012-01-25
DE60034061D1 (de) 2007-05-03
NO20022633L (no) 2002-06-04
CZ20022351A3 (cs) 2003-04-16
MA26850A1 (fr) 2004-12-20
EP1237878B1 (en) 2007-03-21
PL207160B1 (pl) 2010-11-30
AR034401A1 (es) 2004-02-25
HK1054384A1 (en) 2003-11-28
EG24361A (en) 2009-03-04
NZ518828A (en) 2004-03-26
HUP0204081A3 (en) 2003-07-28
JP3824935B2 (ja) 2006-09-20
PT1237878E (pt) 2007-06-18
RS50371B (sr) 2009-11-10
MY126972A (en) 2006-11-30
MXPA02005564A (es) 2002-09-02
WO2001042225A2 (en) 2001-06-14

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