[go: up one dir, main page]

SI1225875T1 - Apparatus and process for preparing crystalline particles - Google Patents

Apparatus and process for preparing crystalline particles

Info

Publication number
SI1225875T1
SI1225875T1 SI200030500T SI200030500T SI1225875T1 SI 1225875 T1 SI1225875 T1 SI 1225875T1 SI 200030500 T SI200030500 T SI 200030500T SI 200030500 T SI200030500 T SI 200030500T SI 1225875 T1 SI1225875 T1 SI 1225875T1
Authority
SI
Slovenia
Prior art keywords
mixing chamber
crystalline particles
substance
liquid
reservoir
Prior art date
Application number
SI200030500T
Other languages
English (en)
Slovenian (sl)
Inventor
Alan Ronald Ferrie
Andrew Patrick Savage
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of SI1225875T1 publication Critical patent/SI1225875T1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Steroid Compounds (AREA)
SI200030500T 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles SI1225875T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9925934.3A GB9925934D0 (en) 1999-11-03 1999-11-03 Novel apparatus and process
GBGB0024511.8A GB0024511D0 (en) 1999-11-03 2000-10-06 Novel apparatus and process
PCT/GB2000/004237 WO2001032125A2 (fr) 1999-11-03 2000-11-03 Dispositif et procede nouveaux de preparation de particules cristallines
EP00973049A EP1225875B1 (fr) 1999-11-03 2000-11-03 Dispositif et procede nouveaux de preparation de particules cristallines

Publications (1)

Publication Number Publication Date
SI1225875T1 true SI1225875T1 (en) 2004-12-31

Family

ID=10863815

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030500T SI1225875T1 (en) 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles

Country Status (25)

Country Link
EP (2) EP1466595A1 (fr)
JP (1) JP4700247B2 (fr)
KR (1) KR20020047322A (fr)
CN (1) CN1409627A (fr)
AT (1) ATE271853T1 (fr)
AU (1) AU768915B2 (fr)
BR (1) BR0015271A (fr)
CA (1) CA2389908A1 (fr)
CZ (1) CZ20021555A3 (fr)
DE (1) DE60012558T2 (fr)
DK (1) DK1225875T3 (fr)
ES (1) ES2225247T3 (fr)
GB (2) GB9925934D0 (fr)
HK (1) HK1045268B (fr)
HU (1) HUP0203278A3 (fr)
IL (1) IL149366A0 (fr)
MX (1) MXPA02004394A (fr)
NO (1) NO20022059L (fr)
NZ (1) NZ518565A (fr)
PL (1) PL356746A1 (fr)
PT (1) PT1225875E (fr)
SI (1) SI1225875T1 (fr)
TR (1) TR200402709T4 (fr)
WO (1) WO2001032125A2 (fr)
ZA (1) ZA200203434B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1412078E (pt) 2001-08-02 2009-01-08 Lg Life Sciences Ltd Processos para a produção de derivados amino-protegidos da 4- aminometileno-pirrolidin-3-ona, gemifloxacina ou um seu sal
US20030049323A1 (en) * 2001-08-29 2003-03-13 Hitt James E. Process to precipitate drug particles
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
GB0202564D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process
JP3691459B2 (ja) * 2002-06-14 2005-09-07 久光メディカル株式会社 粉末状吸入剤組成物
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0300427D0 (en) * 2003-01-09 2003-02-05 Univ Strathclyde Pharmaceutical composition
CA2516733C (fr) * 2003-02-21 2011-09-27 The University Of Bath Procede de production de particules
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
MXPA05009413A (es) * 2003-03-04 2005-11-04 Five Star Technologies Inc Dispositivo y procedimiento para cristalizacion por cavitacion hidrodinamica.
MXPA05010379A (es) 2003-03-27 2006-05-31 Bioactis Ltd Aparato para administrar una medicina en polvo en la cavidad intranasal.
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US7811606B2 (en) 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
WO2005009375A2 (fr) * 2003-07-22 2005-02-03 Baxter International Inc. Petites particules spheriques de molecules organiques de faible poids moleculaire et procedes de preparation et d'utilisation correspondants
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
JO3102B1 (ar) * 2004-03-17 2017-09-20 Chiesi Framaceutici S P A صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة
US8673360B2 (en) 2004-08-10 2014-03-18 Shin Nippon Biomedical Laboratories, Ltd. Compositions that enable rapid-acting and highly absorptive intranasal administration
WO2006045795A2 (fr) * 2004-10-29 2006-05-04 Akzo Nobel N.V. Procedes consistant a utiliser la cristallisation par effet antisolvant
JPWO2006062129A1 (ja) * 2004-12-08 2008-06-12 株式会社クラレ （５α，７α）−３−スピロ−２’−（１’，３’−ジオキソラン）−２４−オキソコレスト−２２−エン−７−イルベンゾアートの製造方法
NZ556709A (en) 2005-02-10 2009-09-25 Glaxo Group Ltd Process for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
JP5415769B2 (ja) 2006-12-26 2014-02-12 株式会社新日本科学 経鼻投与用製剤
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
GB0724498D0 (en) 2007-12-15 2008-01-30 Univ Strathclyde Slow release compositions
MX2011000410A (es) * 2008-07-18 2011-03-24 Prosonix Ltd Proceso para mejorar la cristalinidad de particulas de fluticasona.
US9101539B2 (en) 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
GB2472327B (en) 2009-07-31 2013-03-13 Shin Nippon Biomedical Lab Ltd Intranasal granisetron and nasal applicator
PT105058B (pt) * 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos
WO2013009591A1 (fr) * 2011-07-08 2013-01-17 Pfizer Limited Procédé de préparation du propionate de fluticasone, forme 1
CN102366405A (zh) * 2011-10-21 2012-03-07 江阴长风医药科技有限公司 以氢氟烷烃为抛射剂的氟替卡松丙酸酯气雾剂制剂
ES2946549T3 (es) * 2012-01-13 2023-07-20 Xspray Pharma Ab Publ Composición farmacéutica de nilotinib
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
PL3517541T3 (pl) 2012-05-08 2020-12-28 Nicox Ophthalmics, Inc. Postać polimorficzna propionianu flutykazonu
EP2705838A1 (fr) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Préparations de tiotropium
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
AU2014261539A1 (en) * 2013-04-29 2015-12-10 Sanofi Sa Inhalable pharmaceutical compositions and the inhaler devices containing them
PT108368B (pt) * 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas
PT108885B (pt) * 2015-10-12 2019-02-13 Hovione Farm S A Método de produção de partículas compósitas inaláveis mediante a utilização de um atomizador de três fluidos
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
EP3860580A4 (fr) * 2018-10-01 2022-07-20 Kindeva Drug Delivery L.P. Formulation et cartouches d'aérosol, inhalateurs et analogues contenant la formulation
CN110960504A (zh) * 2019-10-31 2020-04-07 上海新黄河制药有限公司 中空颗粒制备方法及干粉吸入制剂
JP2023540134A (ja) * 2020-09-08 2023-09-21 ジェネンテック， インコーポレイテッド 蠕動式ポンプおよび減衰装置を使用して薬学的組成物を生産するためのシステムおよび方法
CN112755301B (zh) * 2021-01-20 2022-03-29 孙洪坤 一种血液病造血干细胞移植用皮肤清洁器

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8404749D0 (en) 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
CA1282405C (fr) * 1984-05-21 1991-04-02 Michael R. Violante Methode pour produire des particules dimensionnellement uniformes a partir des composes organiques insolubles dans l'eau
US4826589A (en) * 1988-06-30 1989-05-02 Gene Hirs Bar screen filter
GB8911259D0 (en) * 1989-05-17 1989-07-05 Fisons Plc Inhalation medicament
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
GB9007027D0 (en) 1990-03-29 1990-05-30 Atomic Energy Authority Uk Precipitation apparatus and method
GB9101967D0 (en) 1991-01-30 1991-03-13 Atomic Energy Authority Uk Reagent mixing
GB9320455D0 (en) 1993-10-05 1993-11-24 Atomic Energy Authority Uk Vortex mixer
GB9620187D0 (en) * 1996-09-27 1996-11-13 Minnesota Mining & Mfg Medicinal aerosol formulations

Also Published As

Publication number Publication date
WO2001032125A2 (fr) 2001-05-10
DE60012558T2 (de) 2005-07-28
CZ20021555A3 (cs) 2002-11-13
HUP0203278A2 (hu) 2003-01-28
DK1225875T3 (da) 2004-11-22
TR200402709T4 (tr) 2004-11-22
NZ518565A (en) 2004-04-30
ZA200203434B (en) 2003-02-25
DE60012558D1 (de) 2004-09-02
ATE271853T1 (de) 2004-08-15
CN1409627A (zh) 2003-04-09
PT1225875E (pt) 2004-12-31
BR0015271A (pt) 2002-12-31
GB9925934D0 (en) 1999-12-29
AU768915B2 (en) 2004-01-08
IL149366A0 (en) 2002-11-10
JP2003512892A (ja) 2003-04-08
EP1225875A2 (fr) 2002-07-31
WO2001032125A3 (fr) 2002-05-16
CA2389908A1 (fr) 2001-05-10
PL356746A1 (en) 2004-06-28
AU1160401A (en) 2001-05-14
ES2225247T3 (es) 2005-03-16
MXPA02004394A (es) 2002-09-02
NO20022059L (no) 2002-06-14
HK1045268B (en) 2005-02-18
EP1466595A1 (fr) 2004-10-13
EP1225875B1 (fr) 2004-07-28
JP4700247B2 (ja) 2011-06-15
HUP0203278A3 (en) 2004-06-28
HK1045268A1 (en) 2002-11-22
NO20022059D0 (no) 2002-04-30
KR20020047322A (ko) 2002-06-21
GB0024511D0 (en) 2000-11-22

Similar Documents

Publication Publication Date Title
SI1225875T1 (en) Apparatus and process for preparing crystalline particles
US5536479A (en) Solubilizing apparatus
CA2256387C (fr) Appareil melangeur ou dissolveur
KR100251826B1 (ko) 하수 정화 장치 및 그 방법
US3782695A (en) Apparatus and method for dispersing solid particles in a liquid
US4838701A (en) Mixer
FI116368B (fi) Kaasunkäsittely-/vaahdotusreaktori, jossa on laitteet kiintoaineiden erottamiseksi nesteistä
JPH11514273A (ja) ポンプとプラテンとが組み合わされた容器
CA2553864A1 (fr) Amelioration de l'eau filtree
US4193950A (en) Apparatus for introducing gas into a liquid
RU2004120549A (ru) Способ и устройство для получения кристаллических частиц
JPH10503127A (ja) 流動性の媒体から液体を分離するための十字流−濾過方法およびこの方法を実施するためのプラント
EP0829305A3 (fr) Séparateur du type à flottation
JPH07509181A (ja) 一定量の流れる液体に一定量の気体を溶解させる方法および装置
US4516726A (en) Mixing and spraying apparatus for liquids, optionally for powder and liquid
US5505840A (en) Chlorinator-filter system for sewage treatment plants
US5489380A (en) Apparatus for the biological purification of sewage
FI95211C (fi) Menetelmä ja laitteisto flotaatiolaitokseen tai vastaavaan johdettavan puhdistettavan nestevirtauksen käsittelemiseksi
CS215043B2 (en) Facility for cleaning and/or aerating the water
JP3420140B2 (ja) 粉粒体移送装置及び該粉粒体移送装置を用いた水処理設備
JP2000024420A (ja) 水の浄化システム
DK169284B1 (da) Apparat til blanding af kloakslam og en polyelektrolyt
WO2023078874A1 (fr) Appareil pour éliminer des matières particulaires d'un flux de liquide
RU2077512C1 (ru) Реагентная станция
AU734918B2 (en) A mixing or dissolving apparatus