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NO20022059L - Ny anordning og fremgangsmåte for fremstilling av krystallinske partikler - Google Patents

Ny anordning og fremgangsmåte for fremstilling av krystallinske partikler

Info

Publication number
NO20022059L
NO20022059L NO20022059A NO20022059A NO20022059L NO 20022059 L NO20022059 L NO 20022059L NO 20022059 A NO20022059 A NO 20022059A NO 20022059 A NO20022059 A NO 20022059A NO 20022059 L NO20022059 L NO 20022059L
Authority
NO
Norway
Prior art keywords
crystalline particles
mixing chamber
substance
liquid
reservoir
Prior art date
Application number
NO20022059A
Other languages
English (en)
Other versions
NO20022059D0 (no
Inventor
Alan Ronald Ferrie
Andrew Patrick Savage
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO20022059D0 publication Critical patent/NO20022059D0/no
Publication of NO20022059L publication Critical patent/NO20022059L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Steroid Compounds (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
NO20022059A 1999-11-03 2002-04-30 Ny anordning og fremgangsmåte for fremstilling av krystallinske partikler NO20022059L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9925934.3A GB9925934D0 (en) 1999-11-03 1999-11-03 Novel apparatus and process
GBGB0024511.8A GB0024511D0 (en) 1999-11-03 2000-10-06 Novel apparatus and process
PCT/GB2000/004237 WO2001032125A2 (en) 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles

Publications (2)

Publication Number Publication Date
NO20022059D0 NO20022059D0 (no) 2002-04-30
NO20022059L true NO20022059L (no) 2002-06-14

Family

ID=10863815

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20022059A NO20022059L (no) 1999-11-03 2002-04-30 Ny anordning og fremgangsmåte for fremstilling av krystallinske partikler

Country Status (25)

Country Link
EP (2) EP1466595A1 (no)
JP (1) JP4700247B2 (no)
KR (1) KR20020047322A (no)
CN (1) CN1409627A (no)
AT (1) ATE271853T1 (no)
AU (1) AU768915B2 (no)
BR (1) BR0015271A (no)
CA (1) CA2389908A1 (no)
CZ (1) CZ20021555A3 (no)
DE (1) DE60012558T2 (no)
DK (1) DK1225875T3 (no)
ES (1) ES2225247T3 (no)
GB (2) GB9925934D0 (no)
HK (1) HK1045268B (no)
HU (1) HUP0203278A3 (no)
IL (1) IL149366A0 (no)
MX (1) MXPA02004394A (no)
NO (1) NO20022059L (no)
NZ (1) NZ518565A (no)
PL (1) PL356746A1 (no)
PT (1) PT1225875E (no)
SI (1) SI1225875T1 (no)
TR (1) TR200402709T4 (no)
WO (1) WO2001032125A2 (no)
ZA (1) ZA200203434B (no)

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ATE410225T1 (de) 2001-08-02 2008-10-15 Lg Life Sciences Ltd Verfahren zur herstellung von amino-geschützten 4-aminomethylene-pyrrolidin-3-on-derivaten, gemifloxacin und deren salze
CA2458889C (en) * 2001-08-29 2011-06-21 Dow Global Technologies Inc. A process for preparing crystalline drug particles by means of precipitation
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
GB0202564D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process
JP3691459B2 (ja) * 2002-06-14 2005-09-07 久光メディカル株式会社 粉末状吸入剤組成物
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0300427D0 (en) * 2003-01-09 2003-02-05 Univ Strathclyde Pharmaceutical composition
JP5154078B2 (ja) * 2003-02-21 2013-02-27 ザ ユニヴァーシティ オブ バース 粒子の製造プロセス
WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
EP1603652B1 (en) * 2003-03-04 2009-07-01 Five Star Technologies, Inc. Hydrodynamic cavitation crystallization process
CN1758930B (zh) 2003-03-27 2010-06-09 株式会社新日本科学 鼻腔用粉末药剂喷药装置
US7811606B2 (en) * 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US9808471B2 (en) 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
EP1646354A4 (en) * 2003-07-22 2010-03-17 Baxter Int SMALL SPHERICAL PARTICLES OF LOW MOLECULAR WEIGHT MOLECULES AND PROCESSES FOR THEIR PREPARATION AND USE
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
JO3102B1 (ar) * 2004-03-17 2017-09-20 Chiesi Framaceutici S P A صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة
JP4922762B2 (ja) 2004-08-10 2012-04-25 株式会社新日本科学 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
WO2006045795A2 (en) * 2004-10-29 2006-05-04 Akzo Nobel N.V. Processes involving the use of antisolvent crystallization
EP1837343A4 (en) * 2004-12-08 2009-07-29 Kuraray Co METHOD OF PREPARING BENZOIC ACID (5 ', 7') - 3-SPIRO-2 '- (1', 3'-DIOXILANE) -24-OXOCHOLEST-22-EN-7-YLESTER
EP3199164B1 (en) 2005-02-10 2020-03-18 Glaxo Group Limited Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
ES2652415T3 (es) 2006-12-26 2018-02-02 Shin Nippon Biomedical Laboratories, Ltd. Preparación para aplicación transnasal
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
GB0724498D0 (en) 2007-12-15 2008-01-30 Univ Strathclyde Slow release compositions
AU2009272445B2 (en) 2008-07-18 2012-11-22 Circassia Limited Process for improving crystallinity
US9101539B2 (en) 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
GB2472327B (en) 2009-07-31 2013-03-13 Shin Nippon Biomedical Lab Ltd Intranasal granisetron and nasal applicator
PT105058B (pt) 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos
CN103649104A (zh) * 2011-07-08 2014-03-19 辉瑞股份有限公司 用于制备氟替卡松丙酸酯形式1的方法
CN102366405A (zh) * 2011-10-21 2012-03-07 江阴长风医药科技有限公司 以氢氟烷烃为抛射剂的氟替卡松丙酸酯气雾剂制剂
WO2013105895A1 (en) * 2012-01-13 2013-07-18 Xspray Microparticles Ab A pharmaceutical composition comprising stable, amorphous hybrid nanopraticles of at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix-forming component
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
ES2727474T3 (es) 2012-05-08 2019-10-16 Nicox Ophthalmics Inc Nanocristales de propionato de fluticasona
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
BR112015027247A2 (pt) * 2013-04-29 2017-07-25 Sanofi Sa composições farmacêuticas inaláveis e dispositivos inaladores contendo as mesmas
PT108368B (pt) * 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas
PT108885B (pt) * 2015-10-12 2019-02-13 Hovione Farm S A Método de produção de partículas compósitas inaláveis mediante a utilização de um atomizador de três fluidos
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
WO2020070620A2 (en) * 2018-10-01 2020-04-09 3M Innovative Properties Company Formulation and aerosol canisters, inhalers, and the like containing the formulation
CN110960504A (zh) * 2019-10-31 2020-04-07 上海新黄河制药有限公司 中空颗粒制备方法及干粉吸入制剂
EP4210864A2 (en) * 2020-09-08 2023-07-19 Genentech, Inc. Systems and methods for producing pharmaceutical compositions using peristaltic pumps and dampeners
CN112755301B (zh) * 2021-01-20 2022-03-29 孙洪坤 一种血液病造血干细胞移植用皮肤清洁器

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GB8404749D0 (en) 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor
CA1282405C (en) * 1984-05-21 1991-04-02 Michael R. Violante Method for making uniformly sized particles from water-insoluble organic compounds
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
US4826589A (en) * 1988-06-30 1989-05-02 Gene Hirs Bar screen filter
GB8911259D0 (en) * 1989-05-17 1989-07-05 Fisons Plc Inhalation medicament
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
GB9007027D0 (en) 1990-03-29 1990-05-30 Atomic Energy Authority Uk Precipitation apparatus and method
GB9101967D0 (en) 1991-01-30 1991-03-13 Atomic Energy Authority Uk Reagent mixing
GB9320455D0 (en) 1993-10-05 1993-11-24 Atomic Energy Authority Uk Vortex mixer
GB9620187D0 (en) * 1996-09-27 1996-11-13 Minnesota Mining & Mfg Medicinal aerosol formulations

Also Published As

Publication number Publication date
GB9925934D0 (en) 1999-12-29
CZ20021555A3 (cs) 2002-11-13
BR0015271A (pt) 2002-12-31
HUP0203278A2 (hu) 2003-01-28
CN1409627A (zh) 2003-04-09
IL149366A0 (en) 2002-11-10
DE60012558D1 (de) 2004-09-02
ZA200203434B (en) 2003-02-25
MXPA02004394A (es) 2002-09-02
SI1225875T1 (en) 2004-12-31
HUP0203278A3 (en) 2004-06-28
HK1045268B (en) 2005-02-18
NO20022059D0 (no) 2002-04-30
DK1225875T3 (da) 2004-11-22
PT1225875E (pt) 2004-12-31
GB0024511D0 (en) 2000-11-22
EP1225875B1 (en) 2004-07-28
PL356746A1 (en) 2004-06-28
KR20020047322A (ko) 2002-06-21
TR200402709T4 (tr) 2004-11-22
JP4700247B2 (ja) 2011-06-15
ES2225247T3 (es) 2005-03-16
JP2003512892A (ja) 2003-04-08
WO2001032125A2 (en) 2001-05-10
DE60012558T2 (de) 2005-07-28
WO2001032125A3 (en) 2002-05-16
AU768915B2 (en) 2004-01-08
CA2389908A1 (en) 2001-05-10
ATE271853T1 (de) 2004-08-15
HK1045268A1 (en) 2002-11-22
EP1225875A2 (en) 2002-07-31
NZ518565A (en) 2004-04-30
AU1160401A (en) 2001-05-14
EP1466595A1 (en) 2004-10-13

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