SG166678A1 - Synthesis of 4amino-2-butenoyl cholrides and their use in the preparation of 3-cyano quinolines - Google Patents

Synthesis of 4amino-2-butenoyl cholrides and their use in the preparation of 3-cyano quinolines

Info

Publication number: SG166678A1
Authority: SG; Singapore
Prior art keywords: preparation; cholrides; 4amino; butenoyl; synthesis
Prior art date: 2003-01-21

Application number

SG200704889-5A

Other languages

English (en)

Inventor

John Leo Considine

Sylvain Daigneault

Chew Warren

Silvio Iera

Scott Mason Duncan

Ren Jianxin

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-21

Filing date

2004-01-16

Publication date

2010-12-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32825162&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG166678(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-01-16 Application filed by Wyeth Corp filed Critical Wyeth Corp

2010-12-29 Publication of SG166678A1 publication Critical patent/SG166678A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)

SG200704889-5A 2003-01-21 2004-01-16 Synthesis of 4amino-2-butenoyl cholrides and their use in the preparation of 3-cyano quinolines SG166678A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US44147003P	2003-01-21	2003-01-21

Publications (1)

Publication Number	Publication Date
SG166678A1 true SG166678A1 (en)	2010-12-29

Family

ID=32825162

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200704889-5A SG166678A1 (en)	2003-01-21	2004-01-16	Synthesis of 4amino-2-butenoyl cholrides and their use in the preparation of 3-cyano quinolines

Country Status (15)

Country	Link
US (1)	US7126025B2 (fr)
EP (1)	EP1585479A2 (fr)
CN (1)	CN100537518C (fr)
AR (1)	AR042877A1 (fr)
AU (1)	AU2004207475A1 (fr)
CA (1)	CA2514550A1 (fr)
CL (2)	CL2004000016A1 (fr)
CR (1)	CR7950A (fr)
EC (1)	ECSP055974A (fr)
MX (1)	MXPA05008876A (fr)
NO (1)	NO20053890L (fr)
RU (1)	RU2345984C2 (fr)
SG (1)	SG166678A1 (fr)
TW (1)	TW200418763A (fr)
WO (1)	WO2004066919A2 (fr)

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CL2004000016A1 (es)	2003-01-21	2005-04-15	Wyeth Corp	Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
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WO2006127205A2 (fr) *	2005-05-25	2006-11-30	Wyeth	Procedes de preparation de 3-cyano-quinoleines et intermediaires conçus au moyen de ceux-ci
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PE20070763A1 (es)	2005-11-04	2007-08-08	Wyeth Corp	COMBINACIONES ANTINEOPLASICAS DE UN INHIBIDOR DE mTOR, TRASTUZUMAB Y/O HKI-272
JP5688877B2 (ja)	2005-11-11	2015-03-25	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	癌疾患の治療用キナゾリン誘導体
JP2010505962A (ja)	2006-10-09	2010-02-25	武田薬品工業株式会社	キナーゼ阻害剤
US8022216B2 (en)	2007-10-17	2011-09-20	Wyeth Llc	Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
DK2310011T3 (da)	2008-06-17	2013-10-14	Wyeth Llc	Antineoplastiske kombinationer indeholdende hki-272 og vinorelbin
SG10202102855RA (en)	2008-08-04	2021-05-28	Wyeth Llc	Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
WO2010048477A2 (fr) *	2008-10-24	2010-04-29	Wyeth Llc	Procede ameliore de preparation de produits couples a partir de 4-amino-3-cyanoquinoleines utilisant des intermediaires stabilises
JP2012508780A (ja) *	2008-11-17	2012-04-12	ノバルティスアーゲー	γ−アミノ−α，β−不飽和カルボン酸誘導体のエナンチオ選択的合成
JP5992325B2 (ja)	2009-04-06	2016-09-14	ワイス・エルエルシー	乳癌のための、ネラチニブを活用する治療計画
WO2010131921A2 (fr) *	2009-05-14	2010-11-18	코오롱생명과학 주식회사	Procédé de production d'un dérivé d'alkylamine
JP5963672B2 (ja)	2009-07-06	2016-08-03	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｂｉｂｗ２９９２、その塩及びこの活性成分を含む固体医薬製剤の乾燥方法
CN102724962B (zh)	2009-11-09	2017-05-17	惠氏有限责任公司	包衣药物球状体及其用于消除或减少病症比如呕吐和腹泻的用途
CN102731395B (zh) *	2011-04-15	2015-02-04	中国科学院上海药物研究所	抗肿瘤药物来那替尼的中间体及其制备与应用
US9242965B2 (en)	2013-12-31	2016-01-26	Boehringer Ingelheim International Gmbh	Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN104926669A (zh) *	2014-03-18	2015-09-23	江苏豪森医药集团连云港宏创医药有限公司	反式-4-二甲基胺基巴豆酸盐酸盐的制备方法
US9758471B2 (en)	2014-06-02	2017-09-12	Sun Pharmaceutical Industries Limited	Process for the preparation of 4-dimethylaminocrotonic acid
CN105439879B (zh) *	2014-08-07	2018-08-10	天津法莫西医药科技有限公司	一种反式-4-二甲胺基巴豆酸盐酸盐的制备方法
CN105669479B (zh) *	2015-12-31	2018-04-13	重庆威鹏药业有限公司	一锅法制备高纯度反式‑4‑二甲基胺基巴豆酸盐酸盐的方法
BR112018071617A2 (pt)	2016-04-28	2019-02-19	Jiangsu Hengrui Medicine Co., Ltd.	método para preparar inibidor de tirosina quinase e derivado do mesmo
CA3079277A1 (fr)	2017-10-18	2019-04-25	Jiangsu Hengrui Medicine Co., Ltd.	Procede de preparation d'inhibiteur de tyrosine kinase et d'intermediaire de celui-ci
CN111217850B (zh) *	2019-01-31	2023-05-26	微宏先进材料公司	硅基酯类化合物制备方法、硅基酯类化合物、包含其的电解液及二次电池
CN112679473B (zh) *	2019-10-18	2024-03-05	四川科伦药物研究院有限公司	来那替尼中间体晶体、制备方法及其用途

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2004
- 2004-01-05 CL CL200400016A patent/CL2004000016A1/es unknown
- 2004-01-12 TW TW093100676A patent/TW200418763A/zh unknown
- 2004-01-14 AR ARP040100092A patent/AR042877A1/es unknown
- 2004-01-15 US US10/758,187 patent/US7126025B2/en not_active Expired - Fee Related
- 2004-01-16 WO PCT/US2004/001133 patent/WO2004066919A2/fr not_active Ceased
- 2004-01-16 EP EP04702974A patent/EP1585479A2/fr not_active Withdrawn
- 2004-01-16 RU RU2005126418/04A patent/RU2345984C2/ru not_active IP Right Cessation
- 2004-01-16 CN CNB2004800077239A patent/CN100537518C/zh not_active Expired - Fee Related
- 2004-01-16 CA CA002514550A patent/CA2514550A1/fr not_active Abandoned
- 2004-01-16 AU AU2004207475A patent/AU2004207475A1/en not_active Abandoned
- 2004-01-16 MX MXPA05008876A patent/MXPA05008876A/es active IP Right Grant
- 2004-01-16 SG SG200704889-5A patent/SG166678A1/en unknown
2005
- 2005-08-19 CR CR7950A patent/CR7950A/es not_active Application Discontinuation
- 2005-08-19 NO NO20053890A patent/NO20053890L/no not_active Application Discontinuation
- 2005-08-22 EC EC2005005974A patent/ECSP055974A/es unknown
2007
- 2007-05-07 CL CL2007001286A patent/CL2007001286A1/es unknown

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 6,7-DISUBSTITUTED 4- ANILINOQUINOLINE-3-CARBONITRILES.. THE DESIGN OF AN ORALLY ACTIVE, IRREVERSIBLE *

Also Published As

Publication number	Publication date
CN1761644A (zh)	2006-04-19
CA2514550A1 (fr)	2004-08-12
CN100537518C (zh)	2009-09-09
CR7950A (es)	2006-05-30
MXPA05008876A (es)	2005-10-05
AR042877A1 (es)	2005-07-06
CL2007001286A1 (es)	2008-01-25
TW200418763A (en)	2004-10-01
AU2004207475A1 (en)	2004-08-12
RU2005126418A (ru)	2006-01-27
ECSP055974A (es)	2006-01-16
WO2004066919A2 (fr)	2004-08-12
NO20053890L (no)	2005-10-20
US20040162442A1 (en)	2004-08-19
NO20053890D0 (no)	2005-08-19
US7126025B2 (en)	2006-10-24
CL2004000016A1 (es)	2005-04-15
EP1585479A2 (fr)	2005-10-19
RU2345984C2 (ru)	2009-02-10
WO2004066919A3 (fr)	2005-01-27

Publication	Publication Date	Title
SG166678A1 (en)	2010-12-29	Synthesis of 4amino-2-butenoyl cholrides and their use in the preparation of 3-cyano quinolines
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PL1989174T3 (pl)	2011-11-30	Podstawione pochodne cykloheksylometylu
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