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NO20053890L - Syntese av 4-amino-2-butenolklorider og anvendelse derav for fremstilling av 3-cyanokinoliner - Google Patents

Syntese av 4-amino-2-butenolklorider og anvendelse derav for fremstilling av 3-cyanokinoliner

Info

Publication number
NO20053890L
NO20053890L NO20053890A NO20053890A NO20053890L NO 20053890 L NO20053890 L NO 20053890L NO 20053890 A NO20053890 A NO 20053890A NO 20053890 A NO20053890 A NO 20053890A NO 20053890 L NO20053890 L NO 20053890L
Authority
NO
Norway
Prior art keywords
preparation
cyanoquinolines
butenol
chlorides
synthesis
Prior art date
Application number
NO20053890A
Other languages
English (en)
Norwegian (no)
Other versions
NO20053890D0 (no
Inventor
Jr John Leo Considine
Sylvain Daigneault
Warren Chew
Silvio Iera
Scott Mason Duncan
Jianxin Ren
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32825162&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20053890(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20053890D0 publication Critical patent/NO20053890D0/no
Publication of NO20053890L publication Critical patent/NO20053890L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
NO20053890A 2003-01-21 2005-08-19 Syntese av 4-amino-2-butenolklorider og anvendelse derav for fremstilling av 3-cyanokinoliner NO20053890L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44147003P 2003-01-21 2003-01-21
PCT/US2004/001133 WO2004066919A2 (fr) 2003-01-21 2004-01-16 Synthese de chlorures de 4amino-2-butenoyle et leur utilisation dans la preparation de 3-cyano quinoleines

Publications (2)

Publication Number Publication Date
NO20053890D0 NO20053890D0 (no) 2005-08-19
NO20053890L true NO20053890L (no) 2005-10-20

Family

ID=32825162

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053890A NO20053890L (no) 2003-01-21 2005-08-19 Syntese av 4-amino-2-butenolklorider og anvendelse derav for fremstilling av 3-cyanokinoliner

Country Status (15)

Country Link
US (1) US7126025B2 (fr)
EP (1) EP1585479A2 (fr)
CN (1) CN100537518C (fr)
AR (1) AR042877A1 (fr)
AU (1) AU2004207475A1 (fr)
CA (1) CA2514550A1 (fr)
CL (2) CL2004000016A1 (fr)
CR (1) CR7950A (fr)
EC (1) ECSP055974A (fr)
MX (1) MXPA05008876A (fr)
NO (1) NO20053890L (fr)
RU (1) RU2345984C2 (fr)
SG (1) SG166678A1 (fr)
TW (1) TW200418763A (fr)
WO (1) WO2004066919A2 (fr)

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* Cited by examiner, † Cited by third party
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UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
EP1694686A1 (fr) 2003-12-19 2006-08-30 Takeda San Diego, Inc. Inhibiteurs de kinase
CN1930128A (zh) * 2004-01-16 2007-03-14 惠氏公司 受体酪氨酸激酶抑制剂的喹啉中间体及其合成
JP2008510734A (ja) 2004-08-18 2008-04-10 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
EP1812439B2 (fr) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Inhibiteurs de kinase
RU2405566C9 (ru) 2005-02-03 2012-04-27 Дзе Дженерал Хоспитал Корпорейшн Способ лечения рака, устойчивого к гефитинибу
AU2006249596A1 (en) * 2005-05-25 2006-11-30 Wyeth Methods of synthesizing 6-alkylaminoquinoline derivatives
KR20080016671A (ko) * 2005-05-25 2008-02-21 와이어쓰 치환된 3-시아노퀴놀린 및 그것의 중간체를 합성하는 방법
WO2006127205A2 (fr) * 2005-05-25 2006-11-30 Wyeth Procedes de preparation de 3-cyano-quinoleines et intermediaires conçus au moyen de ceux-ci
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
PE20070763A1 (es) 2005-11-04 2007-08-08 Wyeth Corp COMBINACIONES ANTINEOPLASICAS DE UN INHIBIDOR DE mTOR, TRASTUZUMAB Y/O HKI-272
JP5688877B2 (ja) 2005-11-11 2015-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌疾患の治療用キナゾリン誘導体
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
DK2310011T3 (da) 2008-06-17 2013-10-14 Wyeth Llc Antineoplastiske kombinationer indeholdende hki-272 og vinorelbin
SG10202102855RA (en) 2008-08-04 2021-05-28 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
WO2010048477A2 (fr) * 2008-10-24 2010-04-29 Wyeth Llc Procede ameliore de preparation de produits couples a partir de 4-amino-3-cyanoquinoleines utilisant des intermediaires stabilises
JP2012508780A (ja) * 2008-11-17 2012-04-12 ノバルティス アーゲー γ−アミノ−α，β−不飽和カルボン酸誘導体のエナンチオ選択的合成
JP5992325B2 (ja) 2009-04-06 2016-09-14 ワイス・エルエルシー 乳癌のための、ネラチニブを活用する治療計画
WO2010131921A2 (fr) * 2009-05-14 2010-11-18 코오롱생명과학 주식회사 Procédé de production d'un dérivé d'alkylamine
JP5963672B2 (ja) 2009-07-06 2016-08-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｉｂｗ２９９２、その塩及びこの活性成分を含む固体医薬製剤の乾燥方法
CN102724962B (zh) 2009-11-09 2017-05-17 惠氏有限责任公司 包衣药物球状体及其用于消除或减少病症比如呕吐和腹泻的用途
CN102731395B (zh) * 2011-04-15 2015-02-04 中国科学院上海药物研究所 抗肿瘤药物来那替尼的中间体及其制备与应用
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN104926669A (zh) * 2014-03-18 2015-09-23 江苏豪森医药集团连云港宏创医药有限公司 反式-4-二甲基胺基巴豆酸盐酸盐的制备方法
US9758471B2 (en) 2014-06-02 2017-09-12 Sun Pharmaceutical Industries Limited Process for the preparation of 4-dimethylaminocrotonic acid
CN105439879B (zh) * 2014-08-07 2018-08-10 天津法莫西医药科技有限公司 一种反式-4-二甲胺基巴豆酸盐酸盐的制备方法
CN105669479B (zh) * 2015-12-31 2018-04-13 重庆威鹏药业有限公司 一锅法制备高纯度反式‑4‑二甲基胺基巴豆酸盐酸盐的方法
BR112018071617A2 (pt) 2016-04-28 2019-02-19 Jiangsu Hengrui Medicine Co., Ltd. método para preparar inibidor de tirosina quinase e derivado do mesmo
CA3079277A1 (fr) 2017-10-18 2019-04-25 Jiangsu Hengrui Medicine Co., Ltd. Procede de preparation d'inhibiteur de tyrosine kinase et d'intermediaire de celui-ci
CN111217850B (zh) * 2019-01-31 2023-05-26 微宏先进材料公司 硅基酯类化合物制备方法、硅基酯类化合物、包含其的电解液及二次电池
CN112679473B (zh) * 2019-10-18 2024-03-05 四川科伦药物研究院有限公司 来那替尼中间体晶体、制备方法及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194050A (en) 1976-04-30 1980-03-18 Sumitomo Chemical Company, Limited Process for producing an enamide
US4195021A (en) 1977-10-26 1980-03-25 Eli Lilly And Company 1,3-Disubstituted 2-azetidinone antibitotics
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
BE897134A (fr) 1983-06-24 1983-12-27 Solvay Dienes polysubstitues
US4478959A (en) 1983-09-29 1984-10-23 Air Products And Chemicals, Inc. Amino and amido divalent metal carboxylates useful as catalysts for polyurethane formulations
DE3347659A1 (de) 1983-12-31 1985-07-11 Bayer Ag, 5090 Leverkusen Neue lackloesungen auf der basis von hydantoingruppen enthaltenden polymeren
US4664825A (en) 1984-10-25 1987-05-12 The Lubrizol Corporation Sulfurized compositions and lubricants containing them
CA2038633A1 (fr) 1990-03-20 1991-09-21 Yoshimi Tsuchiya Derives d'amines a substitution qui ont une activite antihyperlipemique
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
UA77200C2 (en) * 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.

Also Published As

Publication number Publication date
CN1761644A (zh) 2006-04-19
CA2514550A1 (fr) 2004-08-12
CN100537518C (zh) 2009-09-09
CR7950A (es) 2006-05-30
MXPA05008876A (es) 2005-10-05
SG166678A1 (en) 2010-12-29
AR042877A1 (es) 2005-07-06
CL2007001286A1 (es) 2008-01-25
TW200418763A (en) 2004-10-01
AU2004207475A1 (en) 2004-08-12
RU2005126418A (ru) 2006-01-27
ECSP055974A (es) 2006-01-16
WO2004066919A2 (fr) 2004-08-12
US20040162442A1 (en) 2004-08-19
NO20053890D0 (no) 2005-08-19
US7126025B2 (en) 2006-10-24
CL2004000016A1 (es) 2005-04-15
EP1585479A2 (fr) 2005-10-19
RU2345984C2 (ru) 2009-02-10
WO2004066919A3 (fr) 2005-01-27

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