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SG165387A1 - 5-lipoxygenase-activating protein (flap) inhibitors - Google Patents

5-lipoxygenase-activating protein (flap) inhibitors

Info

Publication number
SG165387A1
SG165387A1 SG201006712-2A SG2010067122A SG165387A1 SG 165387 A1 SG165387 A1 SG 165387A1 SG 2010067122 A SG2010067122 A SG 2010067122A SG 165387 A1 SG165387 A1 SG 165387A1
Authority
SG
Singapore
Prior art keywords
flap
lipoxygenase
activating protein
inhibitors
compounds
Prior art date
Application number
SG201006712-2A
Other languages
English (en)
Inventor
John H Hutchinson
Petpiboon Peppi Prasit
Mark Moran
Jillian F Evans
Yiwei Li
Jasmine Eleanor Zunic
Mustapha Haddach
Nicholas Simon Stock
Original Assignee
Amira Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37546284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG165387(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amira Pharmaceuticals Inc filed Critical Amira Pharmaceuticals Inc
Publication of SG165387A1 publication Critical patent/SG165387A1/en

Links

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0775490B2 (ja) 1994-01-07 1995-08-16 彦重 藤井 菌糸体の培養方法
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US20070244128A1 (en) * 2005-11-04 2007-10-18 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
US20070219206A1 (en) * 2005-11-04 2007-09-20 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US20070225285A1 (en) * 2005-11-04 2007-09-27 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
WO2008067566A1 (fr) 2006-11-30 2008-06-05 Amira Pharmaceuticals, Inc. Compositions et traitements comprenant des inhibiteurs de la protéine activant la 5-lipoxygénase et des modulateurs de l'oxyde nitrique
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
US20110160249A1 (en) 2008-05-23 2011-06-30 Schaab Kevin Murray 5-lipoxygenase-activating protein inhibitor
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
CA2744898A1 (fr) * 2008-12-23 2010-07-01 Amira Pharmaceuticals, Inc. Formules topiques d'inhibiteurs de flap pouvant etre appliquees sur un ƒil
EP2381945A4 (fr) * 2008-12-23 2012-06-13 Panmira Pharmaceuticals Llc Formules topiques d'inhibiteurs de flap pour le traitement des maladies dermatologiques
MX2011011517A (es) 2009-04-29 2012-06-19 Amarin Corp Plc Composiciones farmaceuticas que comprenden epa y un agente cardiovascular y metodos para utilizar el mismo.
KR20120046762A (ko) * 2009-07-31 2012-05-10 판미라 파마슈티칼스, 엘엘씨 Ｄｐ2 수용체 길항제의 피부 제형
EA201290262A1 (ru) * 2009-11-03 2013-01-30 Глэксо Груп Лимитед Способы получения ингибиторов активирующего 5-липоксигеназу белка и их промежуточных продуктов
JP5690839B2 (ja) 2009-12-04 2015-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のベンゾイミダゾール阻害薬
WO2011153433A1 (fr) * 2010-06-04 2011-12-08 Colin Hislop Composés conjugués inhibiteurs de spla2 et leurs méthodes d'utilisation
AU2011292285A1 (en) 2010-08-16 2013-01-31 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
EP2609092B1 (fr) 2010-08-26 2015-04-01 Boehringer Ingelheim International GmbH Composés oxadiazole, inhibiteurs de la production de leucotriènes
PH12013500545A1 (en) 2010-09-23 2013-05-06 Boehringer Ingelheim Int Oxadiazole inhibitors of leukotriene production
WO2012040137A1 (fr) * 2010-09-23 2012-03-29 Boehringer Ingelheim International Gmbh Inhibiteurs oxadiazole de production de leucotriènes
JP5928958B2 (ja) * 2010-10-29 2016-06-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のベンゾイミダゾールインヒビター
JP5789888B2 (ja) * 2010-11-01 2015-10-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のベンゾイミダゾールインヒビター
AR089853A1 (es) 2012-02-01 2014-09-24 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso
EP2865756A1 (fr) 2013-10-22 2015-04-29 Sylentis, S.A.U. ARNsi et leur utilisation dans des procédés et des compositions pour inhiber l'expression du gène FLAP
CA2938879C (fr) 2014-02-04 2023-05-09 Bioscience Pharma Partners, Llc Utilisation d'inhibiteurs de flap pour reduire une lesion mediee par une neuro-inflammation dans le systeme nerveux central
CN104277042A (zh) * 2014-10-15 2015-01-14 湖南华腾制药有限公司 一种咪唑并吡啶衍生物的制备方法
TWI718146B (zh) * 2015-05-04 2021-02-11 瑞典商阿斯特捷利康公司 新穎的5-脂氧合酶啟動蛋白（ｆｌａｐ）抑制劑
US10689387B2 (en) * 2016-10-28 2020-06-23 Astrazeneca Ab Crystalline form of (1R,2R)-2-[4-(3-methyl-1H-pyrazol-5-yl)benzoyl]-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazin-3-yl)cyclohexanecarboxamide
HRP20230069T1 (hr) * 2017-01-17 2023-03-17 Astrazeneca Ab Selektivni inhibitori jak1

Family Cites Families (208)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2431491A1 (fr) 1978-07-18 1980-02-15 Delalande Sa Nouveaux derives aminoalkoxy-5 benzofurannes et indoles, leur procede de preparation et leur application en therapeutique
DK151884C (da) * 1979-03-07 1988-06-13 Pfizer Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf
JPS60123485A (ja) * 1983-12-08 1985-07-02 Yoshitomi Pharmaceut Ind Ltd インド−ル−３−カルボキサミド誘導体
IE58870B1 (en) * 1985-03-08 1993-11-17 Leo Pharm Prod Ltd Pyridine derivatives
US5109009A (en) * 1985-03-08 1992-04-28 Leo Pharmaceutical Products Ltd. Quinoline and pyridine compounds and inhibition of 5-lipoxygenases therewith
DE3632411A1 (de) 1986-09-24 1988-04-07 Merck Patent Gmbh Verfahren zur herstellung von ethanderivaten
US5225421A (en) * 1986-12-17 1993-07-06 Merck Frosst Canada, Inc. 3-hetero-substituted-N-benzyl-indoles and medical methods of use therefor
NZ222878A (en) * 1986-12-17 1991-02-26 Merck Frosst Canada Inc 3-hetero-substituted-n-benzyl-indole derivatives, and pharmaceutical compositions
US5081138A (en) * 1986-12-17 1992-01-14 Merck Frosst Canada, Inc. 3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith
MY103259A (en) * 1987-04-15 1993-05-29 Ici America Inc Aliphatic carboxamides
CA1337202C (fr) * 1988-04-13 1995-10-03 Victor Giulio Matassa Amides cycliques qui sont des antagonistes des leucotrienes
US5232916A (en) * 1988-06-27 1993-08-03 Merck Frosst Canada, Inc. Quinoline ether alkanoic acids
NZ234883A (en) 1989-08-22 1995-01-27 Merck Frosst Canada Inc Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof
CA1337427C (fr) 1989-08-22 1995-10-24 Merck Frosst Canada Incorporated (quinoleine-2-ylmethoxy)indoles utilises en tant qu'inhibiteurs de la biosynthese des leucotrienes
US5204344A (en) * 1989-08-22 1993-04-20 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
US5272145A (en) 1989-08-22 1993-12-21 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
US5252585A (en) * 1992-02-03 1993-10-12 Merck Frosst Canada, Inc. Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
US5229516A (en) * 1989-10-27 1993-07-20 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
CA2032253C (fr) 1989-12-15 2000-11-28 John W. Gillard Proteine activant la 5-lipoxygenase
US5093356A (en) * 1990-01-16 1992-03-03 Merck Frosst Canada, Inc. Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
US5081145A (en) * 1990-02-01 1992-01-14 Merck Frosst Canada, Inc. Indole-2-alkanoic acids compositions of and anti allergic use thereof
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
JPH0764841B2 (ja) * 1990-10-03 1995-07-12 ファイザー製薬株式会社 インドール誘導体およびその用途
US5182367A (en) * 1990-11-30 1993-01-26 Merck & Co., Inc. 5-lipoxygenase activating protein
CA2060557C (fr) * 1991-02-05 2002-06-04 Merck Frosst Canada Incorporated (quinolein-2-ylmethoxy)indoles, inhibiteurs de la biosynthese de leucotrienes
GB9108811D0 (en) 1991-04-24 1991-06-12 Erba Carlo Spa N-imidazolyl derivatives of substituted indole
US5202321A (en) * 1991-06-13 1993-04-13 Merck Frosst Canada, Inc. Thiopyrano[2,3,4-c,d]indoles as inhibitors of leukotriene biosynthesis
JPH06100551A (ja) 1991-09-06 1994-04-12 Dainippon Ink & Chem Inc 光学活性な２，５置換テトラヒドロフラン誘導体、その製造方法、その誘導体を含む液晶組成物及び液晶表示素子
CA2079374C (fr) * 1991-09-30 2003-08-05 Merck Frosst Canada Incorporated Indol (azaarylmethoxy bicyclique) comme inhibiteur de leucotriene biosynthetique
US5190968A (en) * 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5290798A (en) * 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) * 1991-09-30 1995-02-14 Merck Frosst Canada, Inc. (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5273980A (en) * 1991-09-30 1993-12-28 Merck Frosst Canada Inc. Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5308850A (en) * 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
ZA928276B (en) 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
US5254567A (en) * 1991-11-15 1993-10-19 Merck Frosst Canada, Inc. Amorphous (quinolin-2-ylmethoxy)indole compounds which have useful pharmaceutical utility
AU3488693A (en) * 1992-02-13 1993-09-03 Merck Frosst Canada Inc. (Azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis
CH683522A5 (de) 1992-03-13 1994-03-31 Hoffmann La Roche Verfahren zur Herstellung von Diarylen.
WO1993020065A1 (fr) * 1992-03-27 1993-10-14 Kyoto Pharmaceutical Industries, Ltd. Nouveau derive d'imidazole, son utilisation pharmaceutique, et intermediaire associe
NZ249729A (en) 1992-05-13 1996-12-20 Syntex Inc Substituted indoles and azaindoles, preparation and pharmaceutical compositions thereof
JPH0658881A (ja) 1992-06-12 1994-03-04 Mitsubishi Rayon Co Ltd 光学活性化合物の絶対配置判定法、絶対配置判定用試薬及び絶対配置判定装置
US5334719A (en) * 1992-06-17 1994-08-02 Merck Frosst Canada, Inc. Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis
WO1994000446A1 (fr) 1992-06-22 1994-01-06 Merck Frosst Canada Inc. Quinoleine indoles fluores utilises comme inhibiteurs de la biosynthese de leucotrienes
US5314898A (en) * 1992-06-29 1994-05-24 Merck & Co., Inc. Aryl thiopyrano[4,3,2-cd]indoles as inhibitors of leukotriene biosynthesis
US5314900A (en) 1992-11-19 1994-05-24 Merck Frosst Canada, Inc. Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene biosynthesis
US5288743A (en) * 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
ZA939516B (en) 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
JP3457694B2 (ja) 1993-02-04 2003-10-20 第一製薬株式会社 インフルエンザ感染予防・治療薬
US5374635A (en) * 1993-03-29 1994-12-20 Merck Frosst Canada, Inc. Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
ATE154935T1 (de) 1993-06-14 1997-07-15 Pfizer Zweite amine als antidiabetische mittel und für die behandlung von fettleibigkeit
JPH075651A (ja) 1993-06-14 1995-01-10 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料の処理方法
JP3328936B2 (ja) 1993-09-03 2002-09-30 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ｈｔ１ｄレセプター拮抗薬用インドールおよびインドリン誘導体
DE4338770A1 (de) * 1993-11-12 1995-05-18 Matthias Dr Lehr Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶
US5399699A (en) * 1994-01-24 1995-03-21 Abbott Laboratories Indole iminooxy derivatives which inhibit leukotriene biosynthesis
US5420282A (en) * 1994-02-15 1995-05-30 Abbott Laboratories Thiopyrano(2,3,4-c,d) indolyloxime ether alkylcarboxylates
US5696076A (en) 1994-06-22 1997-12-09 Human Genome Sciences, Inc. 5-lipoxygenase-activating protein II
FR2721610B1 (fr) * 1994-06-28 1996-08-23 Adir Nouveaux dérivés (thia)cycloalkyl [b] indoles, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
JPH0820532A (ja) 1994-07-05 1996-01-23 Dai Ichi Seiyaku Co Ltd 抗膵炎剤
HUT76923A (hu) 1994-07-27 1998-01-28 Sankyo Company Limited Muszkarinreceptorokra alloszterikus hatást kifejtő heterociklusos vegyületek
TW396200B (en) * 1994-10-19 2000-07-01 Sumitomo Chemical Co Liquid crystal composition and liquid crystal element containing such composition
TW321649B (fr) 1994-11-12 1997-12-01 Zeneca Ltd
AU4514496A (en) * 1994-12-13 1996-07-03 Smithkline Beecham Corporation Novel compounds
WO1996032379A1 (fr) * 1995-04-10 1996-10-17 Fujisawa Pharmaceutical Co., Ltd. Derives d'indole utilises en tant qu'inhibiteurs de cgmp-pde
US5702637A (en) * 1995-04-19 1997-12-30 Minnesota Mining And Manufacturing Company Liquid crystal compounds having a chiral fluorinated terminal portion
JPH11504648A (ja) 1995-05-10 1999-04-27 ファイザー・インコーポレーテッド β−アドレナリン作動性アゴニスト
JPH092977A (ja) 1995-06-21 1997-01-07 Dai Ichi Seiyaku Co Ltd 経口投与用医薬組成物
WO1997027190A1 (fr) * 1996-01-22 1997-07-31 Fujisawa Pharmaceutical Co., Ltd. Derives du thiazolylbenzofuranne et compositions pharmaceutiques les contenant
ATE240918T1 (de) 1996-01-29 2003-06-15 Kaneka Corp Verfahren zur reduktion von carbonylverbindungen
US5756531A (en) * 1996-04-30 1998-05-26 Abbott Laboratories Iminoxy derivatives of indole and indene compounds as inhibitors of prostaglandin biosynthesis
US5750558A (en) * 1996-06-06 1998-05-12 Abbott Laboratories Oxime derivatives of indole and indene compounds as inhibitors of prostaglandin biosynthesis
BR9710383A (pt) 1996-07-23 1999-08-17 Daiichi Seiyaku Co Intensificador de absor-Æo
US5877329A (en) * 1996-08-13 1999-03-02 Merck & Co., Inc. Palladium catalyzed indolization
WO1998021184A1 (fr) 1996-11-14 1998-05-22 Pfizer Inc. Procede de preparation de pyridines substituees
GB9710523D0 (en) 1997-05-23 1997-07-16 Smithkline Beecham Plc Novel compounds
WO1998056757A1 (fr) 1997-06-11 1998-12-17 Sankyo Company, Limited Derives de benzylamine
GB9716657D0 (en) * 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
JPH1180032A (ja) 1997-09-12 1999-03-23 Dai Ichi Seiyaku Co Ltd 複合体
US6548490B1 (en) 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
ES2241194T3 (es) * 1997-12-24 2005-10-16 Aventis Pharma Deutschland Gmbh Derivados de indol en calidad de inhibidores de factor xa.
AU1689999A (en) 1997-12-25 1999-07-19 Daiichi Pharmaceutical Co., Ltd. Medicinal composition for percutaneous administration
JPH11189531A (ja) 1997-12-26 1999-07-13 Dai Ichi Seiyaku Co Ltd 経粘膜投与用医薬組成物
JPH11193265A (ja) 1997-12-26 1999-07-21 Dai Ichi Seiyaku Co Ltd ３−（７−アミジノ−２−ナフチル）−２−フェニルプロピオン酸誘導体の塩
CA2260499A1 (fr) 1998-01-29 1999-07-29 Sumitomo Pharmaceuticals Company Limited Compositions pharmaceutiques pour le traitement de dommages ischemiques au cerveau
EP1062216A1 (fr) 1998-02-25 2000-12-27 Genetics Institute, Inc. Inhibiteurs de la phospholipase a2
US6500853B1 (en) * 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
JP4472173B2 (ja) 1998-04-15 2010-06-02 セローノ ジェネティクス インスティテュート ソシエテ アノニム ５−リポキシゲナーゼ活性化タンパク（ｆｌａｐ）のゲノム配列、その多型マーカーおよび喘息の検出方法
ES2258331T3 (es) * 1998-05-22 2006-08-16 Scios Inc. Compuestos heterociclicos y procedimientos de tratamiento de insuficiencia cardiaca y otros trastornos.
US6867209B1 (en) * 1998-05-22 2005-03-15 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase
JP2000007590A (ja) 1998-06-23 2000-01-11 Daicel Chem Ind Ltd 置換芳香族化合物の製造方法
EP1131425A2 (fr) 1998-11-18 2001-09-12 Incyte Pharmaceuticals, Inc. Genes associes a des inflammations
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
JP2000302671A (ja) 1999-04-27 2000-10-31 Hitoshi Sezaki 経口投与用医薬組成物
AU772295B2 (en) * 1999-05-21 2004-04-22 Scios Inc. Indole-type derivatives as inhibitors of p38 kinase
HK1046688A1 (zh) 1999-09-21 2003-01-24 Astrazeneca Ab 喹唑啉化合物和含有喹唑啉化合物的藥物組合物
DE19948417A1 (de) * 1999-10-07 2001-04-19 Morphochem Ag Imidazol-Derivate und ihre Verwendung als Arzneimittel
WO2001032621A1 (fr) 1999-10-29 2001-05-10 Wakunaga Pharmaceutical Co., Ltd. Nouveaux derives d'indole, et medicaments contenant lesdits derives comme principe actif
JP2001139462A (ja) 1999-11-10 2001-05-22 Dai Ichi Seiyaku Co Ltd 新規製剤
WO2001036403A1 (fr) 1999-11-16 2001-05-25 Boehringer Ingelheim Pharmaceuticals, Inc. Derives d'uree utilises comme agents anti-inflammatoires
AU2050001A (en) 1999-12-16 2001-06-25 Eli Lilly And Company Synthesis of indole-containing spla2 inhibitors
US7345051B2 (en) 2000-01-31 2008-03-18 Genaera Corporation Mucin synthesis inhibitors
GB0003079D0 (en) 2000-02-10 2000-03-29 Glaxo Group Ltd Novel protein
US6653304B2 (en) * 2000-02-11 2003-11-25 Bristol-Myers Squibb Co. Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases
US6436965B1 (en) 2000-03-02 2002-08-20 Merck Frosst Canada & Co. PDE IV inhibiting amides, compositions and methods of treatment
WO2003022814A1 (fr) 2001-09-07 2003-03-20 Ono Pharmaceutical Co., Ltd. Derives d'indole
NZ521192A (en) 2000-03-09 2005-01-28 Ono Pharmaceutical Co Indole derivatives, process for preparation of the same and use thereof
US6476037B1 (en) 2000-03-23 2002-11-05 The Regents Of The University Of California L-arginine and phosphodiesterase (PDE) inhibitor synergism
US20010039037A1 (en) * 2000-04-05 2001-11-08 Lee Harland Novel polypeptide
WO2001077149A2 (fr) 2000-04-07 2001-10-18 Bayer Aktiengesellschaft Regulation d'une proteine gpcr type cyslt2 humaine
MXPA02010763A (es) * 2000-06-14 2003-03-10 Warner Lambert Co Heterociclicos biciclos-6,5 fusionados.
WO2002000621A1 (fr) 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Composes inhibiteurs de la spla2 de type x
DE10037310A1 (de) 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
MXPA03003002A (es) 2000-10-05 2004-12-06 Fujisawa Pharmaceutical Co Compuestos de benzamina como inhibidores de la secrecion de la apo b.
AU2002211901A1 (en) * 2000-10-10 2002-04-22 Smithkline Beecham Corporation Substituted indoles, pharmaceutical compositions containing such indoles and their use as PPAR-gamma binding agents
WO2002051397A1 (fr) 2000-12-22 2002-07-04 Ishihara Sangyo Kaisha, Ltd. Derives d'aniline ou sels de ceux-ci, ainsi qu'inhibiteurs de production de cytokine contenant ces derives
WO2002051837A2 (fr) 2000-12-22 2002-07-04 Wyeth Composes heterocyclylindazole et azaindazole utilises en tant que ligands 5-hydroxytryptamine-6
US6855722B2 (en) * 2001-01-29 2005-02-15 Dimensional Pharmaceuticals, Inc. Substituted indoles and their use as integrin antagonists
JP2002226429A (ja) 2001-02-06 2002-08-14 Fuji Photo Film Co Ltd アクリル酸エステル化合物の製造方法
US7153852B2 (en) 2001-09-07 2006-12-26 Ono Pharmaceutical Co., Ltd. Indole compounds, process for producing the same and drugs containing the same as the active ingredient
CA2460680A1 (fr) 2001-09-19 2003-05-01 Pharmacia Corporation Composes d'indazole substitues destines au traitement de l'inflammation
DE10147672A1 (de) 2001-09-27 2003-04-10 Bayer Ag Substituierte 2,5-Diamidoindole und ihre Verwendung
EP1314733A1 (fr) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides comme inhibiteurs du facteur Xa
WO2003050174A1 (fr) 2001-12-11 2003-06-19 Rhodia Chimie Melange de metaux du groupe platine catalytiques destine a l'hydrosilylation
USH2153H1 (en) * 2002-04-24 2006-04-04 Smithkline Beecham Corp. Association of asthma with polymorphisms in the cysteinyl leukotriene 2 receptor
JPWO2003094889A1 (ja) 2002-05-13 2005-10-13 第一製薬株式会社 凍結乾燥物
PE20040522A1 (es) 2002-05-29 2004-09-28 Novartis Ag Derivados de diarilurea dependientes de la cinasa de proteina
DE10224888A1 (de) * 2002-06-05 2003-12-24 Merck Patent Gmbh Pyridazinderivate
US20050209477A1 (en) 2002-06-20 2005-09-22 Sachiko Kato Process for producing vinyl perfluoroalkanesulfonate derivative
MXPA05000193A (es) * 2002-06-24 2005-04-08 Schering Corp Derivados de indol utiles como antagonistas de la histamina h2.
CN1671639A (zh) 2002-08-23 2005-09-21 康涅狄格大学 新型联苯大麻素和类似联苯的大麻素
EP1536684A2 (fr) * 2002-08-26 2005-06-08 Merck & Co., Inc. Procede pour la prevention et/ou le traitement de l'atherosclerose
DK1537078T3 (da) 2002-08-29 2010-08-02 Merck Sharp & Dohme Indoler med anti-diabetisk aktivitet
WO2004048331A1 (fr) 2002-11-28 2004-06-10 Suven Life Sciences Limited N-arylalkyl-3-aminoalcoxyindoles et leur utilisation en tant que ligands des recepteurs 5-ht
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
US20040198800A1 (en) * 2002-12-19 2004-10-07 Geoffrey Allan Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents
GB0301350D0 (en) 2003-01-21 2003-02-19 Merck Sharp & Dohme Therapeutic agents
JP4513351B2 (ja) 2003-02-12 2010-07-28 チッソ株式会社 結合基にフッ素化されたアルキル基を有する液晶性化合物、液晶組成物および液晶表示素子
JPWO2004078719A1 (ja) 2003-03-06 2006-06-08 小野薬品工業株式会社 インドール誘導体化合物およびその化合物を有効成分とする薬剤
EP1479677A1 (fr) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Nouveaux derivés d'indole en tant qu'inhibiteurs du facteur xa
WO2004108671A1 (fr) 2003-06-06 2004-12-16 Suven Life Sciences Limited Indoles substitues dotes d'une affinite pour le recepteur de la serotonine, leur procede de fabrication et compositions pharmaceutiques les contenant
JP2006528630A (ja) * 2003-07-24 2006-12-21 メルク　エンド　カムパニー　インコーポレーテッド ジフェニル置換シクロアルカン類、そのような化合物を含む組成物、ならびに使用方法
EP1658352B1 (fr) 2003-08-25 2008-04-02 MERCK PATENT GmbH Milieu cristallin liquide
AU2004270187A1 (en) 2003-09-04 2005-03-17 Aventis Pharmaceuticals Inc. Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP)
CN1878773A (zh) 2003-09-05 2006-12-13 神经能质公司 作为crf1受体配位体的杂芳基稠合的吡啶,吡嗪及嘧啶
JP4363133B2 (ja) 2003-09-09 2009-11-11 東洋インキ製造株式会社 有機エレクトロルミネッセンス用素子材料およびそれを用いた有機エレクトロルミネッセンス素子
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
AU2004285811B2 (en) * 2003-10-31 2008-06-12 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-6-nitroimidazo (2,1-B) oxazole compounds for the treatment of tuberculosis
JP2005170939A (ja) 2003-11-20 2005-06-30 Takeda Chem Ind Ltd 糖尿病の予防・治療剤
DE602004011985T2 (de) 2003-11-25 2009-03-05 Eli Lilly And Co., Indianapolis Modulatoren des peroxisomproliferatoraktivierten rezeptors
EP1690538A4 (fr) 2003-12-02 2009-02-25 Shionogi & Co Derive d'isoxazole presentant un effet agoniste sur le recepteur active par les proliferateurs des peroxysomes
JP2007513128A (ja) 2003-12-03 2007-05-24 メルク　エンド　カムパニー　インコーポレーテッド アルツハイマー病および関連状態の治療に有用な１−アルキル−３−チオ置換インドール−２−アルキン酸
WO2005066151A2 (fr) 2003-12-19 2005-07-21 Takeda San Diego, Inc. Inhibiteurs d'histone desacetylase
JP5142450B2 (ja) 2003-12-25 2013-02-13 徹也 西尾 ジアミノ化合物、ビニル化合物、高分子化合物、配向膜、該配向膜を用いた有機半導体装置、導電性高分子、該導電性高分子を使用したエレクトロルミネッセンス素子、液晶配向膜、及び該液晶配向膜を用いた光学素子
US7064203B2 (en) 2003-12-29 2006-06-20 Bristol Myers Squibb Company Di-substituted pyrrolotriazine compounds
WO2005066157A1 (fr) 2004-01-02 2005-07-21 Suven Life Sciences 3-(pyrrolidine-3-l)indoles en tant que modulateurs du recepteur 5-ht6
JP2005194250A (ja) 2004-01-09 2005-07-21 Sumitomo Chemical Takeda Agro Co Ltd トリアゾール化合物、その製造法および用途
US8158362B2 (en) 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
US20070197585A1 (en) 2004-02-26 2007-08-23 Jilly Evans Use of cysteinyl leukotriene 2 receptor antagonists
WO2005097203A2 (fr) 2004-04-01 2005-10-20 Cardiome Pharma Corp. Conjugues de proteine serique de composes de modulation du canal ionique, utilisations de ces derniers
WO2005112921A2 (fr) 2004-04-26 2005-12-01 Vanderbilt University Derives d'acides indoleacetique et indenacetique comme agents therapeutiques a toxicite gastrointestinale reduite
ES2329489T3 (es) * 2004-05-03 2009-11-26 F. Hoffmann-La Roche Ag Derivados de indolilo como moduladores del receptor x del higado.
WO2005123674A1 (fr) 2004-06-18 2005-12-29 Biolipox Ab Indoles utilisables pour le traitement d'inflammations
JP2008505091A (ja) * 2004-07-02 2008-02-21 メルク　エンド　カムパニー　インコーポレーテッド 抗糖尿病活性を有するインドール
CA2577664A1 (fr) 2004-08-20 2006-03-02 Bayer Pharmaceuticals Corporation Nouveaux heterocycles
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
WO2006041961A1 (fr) 2004-10-05 2006-04-20 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES Inhibiteurs de la polymerisation de la tubuline de type arylthioindole, et procedes pour traiter ou prevenir un cancer au moyen de ces inhibiteurs
AU2005295646B2 (en) 2004-10-18 2008-11-20 Merck Sharp & Dohme Corp. Diphenyl substituted alkanes as flap inhibitors
ES2345997T3 (es) 2005-01-14 2010-10-07 Janssen Pharmaceutica Nv Pirazolopiramidinas como inhibidores de las quinasas del ciclo celular.
AU2005325497A1 (en) 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
WO2006077364A1 (fr) 2005-01-19 2006-07-27 Biolipox Ab Indoles utiles dans le traitement de l'inflammation
EP1841736A1 (fr) 2005-01-19 2007-10-10 Biolipox AB Indoles utiles dans le traitement de l'inflammation
CA2594773A1 (fr) 2005-01-19 2006-07-27 Biolipox Ab Indoles utiles dans le traitement de l'inflammation
WO2006098912A1 (fr) 2005-03-09 2006-09-21 Merck & Co., Inc. Cycloalcanes substitues par un diphenyle, compositions contenant de tels composes et methodes d’utilisation
ATE524182T1 (de) * 2005-04-21 2011-09-15 Merck Serono Sa 2,3-substituierte pyrazinsulfonamide als crth2- hemmer
US20090220583A1 (en) 2005-06-09 2009-09-03 Lena Pereswetoff-Morath Method and composition for treating inflammatory disorders
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
EP1947942B1 (fr) 2005-08-18 2015-07-29 Accelalox, Inc. Methodes de traitement osseux par modulation d'une voie metabolique ou de signalisation de l'acide arachidonique
US7405302B2 (en) 2005-10-11 2008-07-29 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (FLAP) inhibitors
WO2007047204A1 (fr) 2005-10-11 2007-04-26 University Of Pittsburgh Composes de benzofuranne marques par des isotopes en tant qu'agents d'imagerie pour des proteines amyloidogenes
US20090176776A1 (en) 2005-10-21 2009-07-09 University Of Alabama At Birmingham Small molecule inhibitors of hiv-1 capsid assembly
US20070219206A1 (en) * 2005-11-04 2007-09-20 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
NL2000284C2 (nl) 2005-11-04 2007-09-28 Pfizer Ltd Pyrazine-derivaten.
UY29896A1 (es) 2005-11-04 2007-06-29 Astrazeneca Ab Nuevos derivados de cromano, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones
US20070244128A1 (en) * 2005-11-04 2007-10-18 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
UY29892A1 (es) 2005-11-04 2007-06-29 Astrazeneca Ab Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US20070225285A1 (en) * 2005-11-04 2007-09-27 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
AR059901A1 (es) 2006-03-20 2008-05-07 Bayer Pharmaceuticals Corp Compuestos de tetrahidropiridotienopirimidina utiles para tratar o prevenir trastornos proliferativos celulares.
TW200815377A (en) 2006-04-24 2008-04-01 Astellas Pharma Inc Oxadiazolidinedione compound
JP5564251B2 (ja) 2006-06-29 2014-07-30 キネックス ファーマシューティカルズ， エルエルシー キナーゼカスケードを調節するためのビアリール組成物および方法
JP2009023986A (ja) 2006-11-08 2009-02-05 Pharma Ip 抗癌剤としてのビアリール誘導体
EP3048099A3 (fr) 2006-11-15 2016-09-21 YM BioSciences Australia Pty Ltd Inhibiteurs de l'activite de kinase
WO2008067566A1 (fr) 2006-11-30 2008-06-05 Amira Pharmaceuticals, Inc. Compositions et traitements comprenant des inhibiteurs de la protéine activant la 5-lipoxygénase et des modulateurs de l'oxyde nitrique
JP2010518025A (ja) 2007-02-05 2010-05-27 アミラ ファーマシューティカルス，インコーポレーテッド ５−リポキシゲナーゼ活性化タンパク質（ｆｌａｐ）インヒビターとしての逆インドール
US8039505B2 (en) * 2007-04-11 2011-10-18 University Of Utah Research Foundation Compounds for modulating T-cells
WO2009002746A1 (fr) 2007-06-22 2008-12-31 Decode Genetics Ehf. Programmes de dosage d'inhibiteurs de synthèse de leucotriène pour thérapie humaine
WO2009009041A2 (fr) 2007-07-06 2009-01-15 Kinex Pharmaceuticals, Llc Compositions et procédés permettant de moduler une cascade de kinases
WO2009045700A2 (fr) 2007-10-05 2009-04-09 Amira Pharmaceuticals, Inc. Inhibiteurs de protéine activant la 5-lipoxygénase
TW200920369A (en) 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
US8685740B2 (en) 2008-03-14 2014-04-01 National Jewish Health Methods to determine susceptibility to treatment with leukotriene modifiers
US20110160249A1 (en) * 2008-05-23 2011-06-30 Schaab Kevin Murray 5-lipoxygenase-activating protein inhibitor
US8546431B2 (en) * 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
CA2744898A1 (fr) * 2008-12-23 2010-07-01 Amira Pharmaceuticals, Inc. Formules topiques d'inhibiteurs de flap pouvant etre appliquees sur un ƒil

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TW200804277A (en) 2008-01-16
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