SG159390A1 - Use of n-desmethyclozapine to treat human neuropsychiatric disease - Google Patents
Use of n-desmethyclozapine to treat human neuropsychiatric diseaseInfo
- Publication number
- SG159390A1 SG159390A1 SG200705214-5A SG2007052145A SG159390A1 SG 159390 A1 SG159390 A1 SG 159390A1 SG 2007052145 A SG2007052145 A SG 2007052145A SG 159390 A1 SG159390 A1 SG 159390A1
- Authority
- SG
- Singapore
- Prior art keywords
- desmethyclozapine
- neuropsychiatric disease
- treat human
- human neuropsychiatric
- disease
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- JNNOSTQEZICQQP-UHFFFAOYSA-N N-desmethylclozapine Chemical compound N=1C2=CC(Cl)=CC=C2NC2=CC=CC=C2C=1N1CCNCC1 JNNOSTQEZICQQP-UHFFFAOYSA-N 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44269003P | 2003-01-23 | 2003-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG159390A1 true SG159390A1 (en) | 2010-03-30 |
Family
ID=32772052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200705214-5A SG159390A1 (en) | 2003-01-23 | 2004-01-21 | Use of n-desmethyclozapine to treat human neuropsychiatric disease |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20040224942A1 (fr) |
| EP (2) | EP1994932A1 (fr) |
| JP (1) | JP2006515628A (fr) |
| KR (1) | KR20050092123A (fr) |
| CN (1) | CN1741803A (fr) |
| AU (1) | AU2004206931A1 (fr) |
| BR (1) | BRPI0406592A (fr) |
| CA (1) | CA2512043A1 (fr) |
| MX (1) | MXPA05007784A (fr) |
| NZ (1) | NZ541014A (fr) |
| RU (2) | RU2336879C2 (fr) |
| SG (1) | SG159390A1 (fr) |
| WO (1) | WO2004064753A2 (fr) |
| ZA (1) | ZA200505878B (fr) |
Families Citing this family (51)
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| IL151164A0 (en) | 2000-03-06 | 2003-04-10 | Acadia Pharm Inc | Azacyclic compounds for use in the treatment of serotonin related diseases |
| DE60236206D1 (de) | 2001-12-28 | 2010-06-10 | Acadia Pharm Inc | Spiroazacyclische verbindungen als monoaminrezeptormodulatoren |
| US7253186B2 (en) | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
| MXPA04012893A (es) | 2002-06-24 | 2005-03-31 | Acadia Pharm Inc | Derivados de piperidina n-substituidos como agentes receptores de serotonina. |
| US7538222B2 (en) | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| ATE407117T1 (de) | 2003-01-16 | 2008-09-15 | Acadia Pharm Inc | Selektive serotonin 2a/2c inverse rezeptoragonisten als therapeutika für neurodegenerative erkrankungen |
| US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| NZ541014A (en) * | 2003-01-23 | 2008-05-30 | Acadia Pharm Inc | Use of N-desmethylclozapine to treat schizophrenia while increasing the level of activity of a muscarinic receptor |
| US20050085463A1 (en) * | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| WO2006017614A1 (fr) * | 2004-08-05 | 2006-02-16 | Acadia Pharmaceuticals Inc. | Utilisation de n-desmethylclozapine pour le traitement de maladie neuropsychiatrique humaine |
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| US20060217367A1 (en) * | 2004-07-01 | 2006-09-28 | Astrazeneca Ab | Method of treating anxiety disorders |
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| RS52703B (sr) * | 2008-06-20 | 2013-08-30 | Astrazeneca Ab | Derivat dibenzotiazepina i njegova upotreba |
| US9018202B2 (en) * | 2010-12-03 | 2015-04-28 | Allergan, Inc. | Methods for treating diseases of the retina |
| RU2506073C1 (ru) * | 2012-09-06 | 2014-02-10 | Алексей Николаевич Паршин | Способ лечения расстройства адаптации у пациентов с суицидальным риском |
| US20160184290A1 (en) * | 2014-12-31 | 2016-06-30 | Paul J. Markovitz | Method of treating schizophrenia |
| EP3325444B1 (fr) | 2015-07-20 | 2021-07-07 | Acadia Pharmaceuticals Inc. | Procédé de préparation de n-(4-fluorobenzyl)-n-(1-méthylpipéridin-4-yl)-n'-(4-(2-méthylpropyloxy) phénylméthyl)carbamide et son sel de tartrate et forme polymorphe c |
| WO2017117347A1 (fr) * | 2015-12-30 | 2017-07-06 | Markovitz M D Paul | Méthode de traitement de la schizophrénie |
| RU2667954C2 (ru) * | 2016-03-04 | 2018-09-25 | Общество С Ограниченной Ответственностью "Валентек" | Фармацевтическая композиция для лечения функциональных психических расстройств |
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| US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| US11464768B2 (en) | 2016-12-20 | 2022-10-11 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of Alzheimer's disease psychosis |
| US11135211B2 (en) | 2017-04-28 | 2021-10-05 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
| US20210077479A1 (en) | 2017-08-30 | 2021-03-18 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| CN107970243B (zh) * | 2017-10-30 | 2020-07-28 | 江苏理工学院 | 一种去甲氯氮平的新用途 |
| CN109761826B (zh) * | 2019-01-17 | 2022-02-25 | 烟台大学 | 一种o-去甲基文拉法辛苯醚化合物及其制备方法和用途 |
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| US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| US20050085463A1 (en) * | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| WO2004073639A2 (fr) * | 2003-02-19 | 2004-09-02 | Merck & Co. Inc. | Traitement de la psychose avec un activateur ectopique du recepteur m1 muscarinique |
| ATE426405T1 (de) * | 2003-12-22 | 2009-04-15 | Acadia Pharm Inc | Amino-substituierte diarylaa,ducyclohepten- analoga als muscarinische agonisten und verfahren zur behandlung von neuropsychiatrischen erkrankungen |
| CA2560671A1 (fr) * | 2004-04-01 | 2006-01-05 | Acadia Pharmaceuticals Inc. | Synthese et isolation de n-demethylclozapine et formes cristallines correspondantes |
| US20060063754A1 (en) * | 2004-09-21 | 2006-03-23 | Edgar Dale M | Methods of treating a sleep disorder |
| AU2005286713B2 (en) * | 2004-09-21 | 2010-10-28 | Hypnion, Inc. | Loxapine analogs and methods of use thereof |
| WO2006107948A2 (fr) * | 2005-04-04 | 2006-10-12 | Acadia Pharmaceuticals Inc. | Utilisation de n-desmethylclozapine et de composes associes comme agents stabilisateurs de dopamine |
| US20070105836A1 (en) * | 2005-10-31 | 2007-05-10 | Lars Pettersson | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
-
2004
- 2004-01-21 NZ NZ541014A patent/NZ541014A/en unknown
- 2004-01-21 SG SG200705214-5A patent/SG159390A1/en unknown
- 2004-01-21 MX MXPA05007784A patent/MXPA05007784A/es not_active Application Discontinuation
- 2004-01-21 WO PCT/US2004/001509 patent/WO2004064753A2/fr not_active Ceased
- 2004-01-21 CN CNA200480002642XA patent/CN1741803A/zh active Pending
- 2004-01-21 JP JP2006501063A patent/JP2006515628A/ja not_active Withdrawn
- 2004-01-21 CA CA002512043A patent/CA2512043A1/fr not_active Abandoned
- 2004-01-21 BR BR0406592-1A patent/BRPI0406592A/pt not_active IP Right Cessation
- 2004-01-21 RU RU2005126614/15A patent/RU2336879C2/ru not_active IP Right Cessation
- 2004-01-21 EP EP08016004A patent/EP1994932A1/fr not_active Withdrawn
- 2004-01-21 US US10/761,787 patent/US20040224942A1/en not_active Abandoned
- 2004-01-21 KR KR1020057013323A patent/KR20050092123A/ko not_active Withdrawn
- 2004-01-21 EP EP04704073A patent/EP1589974A2/fr not_active Ceased
- 2004-01-21 AU AU2004206931A patent/AU2004206931A1/en not_active Abandoned
-
2005
- 2005-07-21 ZA ZA200505878A patent/ZA200505878B/en unknown
-
2008
- 2008-04-28 RU RU2008116931/14A patent/RU2008116931A/ru not_active Application Discontinuation
- 2008-09-22 US US12/235,526 patent/US20090018119A1/en not_active Abandoned
Non-Patent Citations (2)
| Title |
|---|
| DOES THE PHARMACOLOGICALLY ACTIVE N- DEMETHYLATED METABOLITE OF CLOZAPINE PASS THE BLOOD-BRAIN BARRIER? * |
| EFFECTS OF DESMETHYLCLOZAPINE ON FOS PROTEIN EXPRESSION IN THE FOREBRIAN: IN VIVO BIOLOGICAL ACTIVITY OF THE clozapine metabolite * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2008116931A (ru) | 2009-11-10 |
| CN1741803A (zh) | 2006-03-01 |
| JP2006515628A (ja) | 2006-06-01 |
| WO2004064753A3 (fr) | 2004-11-25 |
| ZA200505878B (en) | 2006-04-26 |
| WO2004064753A2 (fr) | 2004-08-05 |
| MXPA05007784A (es) | 2005-09-30 |
| US20090018119A1 (en) | 2009-01-15 |
| RU2005126614A (ru) | 2006-01-27 |
| KR20050092123A (ko) | 2005-09-20 |
| BRPI0406592A (pt) | 2005-12-20 |
| EP1589974A2 (fr) | 2005-11-02 |
| RU2336879C2 (ru) | 2008-10-27 |
| AU2004206931A1 (en) | 2004-08-05 |
| CA2512043A1 (fr) | 2004-08-05 |
| EP1994932A1 (fr) | 2008-11-26 |
| US20040224942A1 (en) | 2004-11-11 |
| NZ541014A (en) | 2008-05-30 |
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