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SG11201910100PA - Treatment of hepatocellular carcinoma - Google Patents

Treatment of hepatocellular carcinoma

Info

Publication number
SG11201910100PA
SG11201910100PA SG11201910100PA SG11201910100PA SG 11201910100P A SG11201910100P A SG 11201910100PA SG 11201910100P A SG11201910100P A SG 11201910100PA SG 11201910100P A SG11201910100P A SG 11201910100PA
Authority
SG
Singapore
Prior art keywords
international
hepatocellular carcinoma
tokyo
pct
koishikawa
Prior art date
Application number
Inventor
Toshiyuki Tamai
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of SG11201910100PA publication Critical patent/SG11201910100PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

WO 18/ 21220 2 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 November 2018 (22.11.2018) WIPO I PCT olimion ono o Holum oloiloinio oimIE (10) International Publication Number WO 2018/212202 Al (51) International Patent Classification: A61K 31/47 (2006.01) A61P 35/00 (2006.01) A61P 1/16 (2006.01) (21) International Application Number: PCT/JP2018/018810 (22) International Filing Date: 15 May 2018 (15.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/506,900 16 May 2017 (16.05.2017) US (71) Applicant: EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 4-6-10 Koishikawa, Bunkyo-ku, Tokyo, 1128088 (JP). (72) Inventor: TAMAI Toshiyuki; C/O Eisai Co., Ltd., 4-6-10 Koishikawa, Bunkyo-ku, Tokyo, 1128088 (JP). (74) Agent: HASEGAWA Yoshiki et al.; SOEI PATENT AND LAW FIRM, Marunouchi MY PLAZA (Meiji Yasuda Life Bldg.) 9th fl., 1-1, Marunouchi 2-chome, Chiyoda-ku, Tokyo, 1000005 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) (54) Title: TREATMENT OF HEPATOCELLULAR CARCINOMA (57) : This disclosure provides methods for treating a hepatocellular carcinoma (e.g., unresectable HCC) with lenvatinib or a pharmaceutically acceptable salt thereof. Also encompassed by the disclosure are dosage regimens described herein of lenvatinib or a pharmaceutically acceptable salt thereof for use in treating hepatocellular carcinoma (e.g., unresectable hepatocellular carcinoma) according to any of the methods described herein. Particularly useful dosages and dose modifications upon the occurrence of an adverse event or events are also disclosed.
SG11201910100P 2017-05-16 2018-05-15 Treatment of hepatocellular carcinoma SG11201910100PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762506900P 2017-05-16 2017-05-16
PCT/JP2018/018810 WO2018212202A1 (en) 2017-05-16 2018-05-15 Treatment of hepatocellular carcinoma

Publications (1)

Publication Number Publication Date
SG11201910100PA true SG11201910100PA (en) 2019-11-28

Family

ID=64273837

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201910100P SG11201910100PA (en) 2017-05-16 2018-05-15 Treatment of hepatocellular carcinoma

Country Status (12)

Country Link
US (2) US20200197384A1 (en)
EP (1) EP3624800A4 (en)
JP (1) JP2020519576A (en)
KR (1) KR20200013644A (en)
CN (1) CN110831597A (en)
AU (1) AU2018269996A1 (en)
BR (1) BR112019023064A2 (en)
CA (1) CA3061888A1 (en)
MX (1) MX2019013014A (en)
RU (1) RU2019134940A (en)
SG (1) SG11201910100PA (en)
WO (1) WO2018212202A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7564097B2 (en) 2018-10-05 2024-10-08 エーザイ・アール・アンド・ディー・マネジメント株式会社 Biomarkers for Therapies Containing Sorafenib Compounds
US20220280499A1 (en) * 2019-10-21 2022-09-08 Stichting Het Nederlands Kanker Instituue-Antoni van Leeuwenhoek Ziekenhuis Novel drug combinations for treatment of a carcinoma
CN115485029A (en) * 2020-04-15 2022-12-16 美迪维尔公司 MIV-818/lenvatinib combination therapy for liver cancer
US20220034871A1 (en) * 2020-07-31 2022-02-03 Daiichi Sankyo Company, Limited Methods for administering pexidartinib

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