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SG10201701634PA - Anti - sclerostin antibody crystals and formulations thereof - Google Patents

Anti - sclerostin antibody crystals and formulations thereof

Info

Publication number
SG10201701634PA
SG10201701634PA SG10201701634PA SG10201701634PA SG10201701634PA SG 10201701634P A SG10201701634P A SG 10201701634PA SG 10201701634P A SG10201701634P A SG 10201701634PA SG 10201701634P A SG10201701634P A SG 10201701634PA SG 10201701634P A SG10201701634P A SG 10201701634PA
Authority
SG
Singapore
Prior art keywords
formulations
sclerostin antibody
antibody crystals
crystals
sclerostin
Prior art date
Application number
SG10201701634PA
Other languages
English (en)
Inventor
Christi L Clogston
Twinkle R Christian
Timothy D Osslund
Elisabeth Freeman
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45922852&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201701634P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG10201701634PA publication Critical patent/SG10201701634PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG10201701634PA 2011-03-25 2012-03-23 Anti - sclerostin antibody crystals and formulations thereof SG10201701634PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161467868P 2011-03-25 2011-03-25

Publications (1)

Publication Number Publication Date
SG10201701634PA true SG10201701634PA (en) 2017-04-27

Family

ID=45922852

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201701634PA SG10201701634PA (en) 2011-03-25 2012-03-23 Anti - sclerostin antibody crystals and formulations thereof
SG2013071733A SG193610A1 (en) 2011-03-25 2012-03-23 Anti - sclerostin antibody crystals and formulations thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2013071733A SG193610A1 (en) 2011-03-25 2012-03-23 Anti - sclerostin antibody crystals and formulations thereof

Country Status (25)

Country Link
US (3) US9145457B2 (fr)
EP (1) EP2688910B1 (fr)
JP (2) JP2014511842A (fr)
KR (1) KR20140018315A (fr)
CN (1) CN103517920B (fr)
AP (1) AP3981A (fr)
AR (1) AR085575A1 (fr)
AU (1) AU2012236962B2 (fr)
BR (1) BR112013024493A2 (fr)
CA (1) CA2830538C (fr)
CL (1) CL2013002743A1 (fr)
CO (1) CO6801637A2 (fr)
CR (1) CR20160147A (fr)
EA (1) EA029956B1 (fr)
IL (1) IL228455A (fr)
MA (1) MA35009B1 (fr)
MX (1) MX338078B (fr)
MY (1) MY170720A (fr)
PE (1) PE20140437A1 (fr)
PH (1) PH12013501971B1 (fr)
SG (2) SG10201701634PA (fr)
TN (1) TN2013000378A1 (fr)
TW (1) TW201247703A (fr)
WO (1) WO2012135035A1 (fr)
ZA (2) ZA201307122B (fr)

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US7592429B2 (en) * 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
US10478498B2 (en) 2014-06-20 2019-11-19 Reform Biologics, Llc Excipient compounds for biopolymer formulations
CA2964470A1 (fr) * 2014-10-17 2016-04-21 Amgen Inc. Anticorps diriges contre l'angiopoietine 1 et l'angiopoietine 2 pour therapies oculaires
AR103726A1 (es) 2015-02-27 2017-05-31 Merck Sharp & Dohme Cristales de anticuerpos monoclonales anti-pd-1 humanos
CN107090443B (zh) * 2016-02-18 2020-12-08 中国农业大学 一种制备稻瘟病菌促分裂原活化蛋白激酶MoMps1晶体的方法
CN105777858B (zh) * 2016-03-22 2019-09-10 东软威特曼生物科技(南京)有限公司 多种抗体的复合稳定剂及其使用方法
US10279048B2 (en) * 2016-07-13 2019-05-07 Reform Biologics, Llc Stabilizing excipients for therapeutic protein formulations
JP2020502218A (ja) 2016-12-21 2020-01-23 メレオ バイオファーマ ３ リミテッド 骨形成不全症の処置における抗スクレロスチン抗体の使用
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JOP20190260A1 (ar) 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
UA127219C2 (uk) * 2017-07-27 2023-06-14 Джянгсу Хенгруй Медісін Ко., Лтд. Фармацевтична композиція, що містить анти-sost антитіло, та її застосування
CN109112153A (zh) * 2018-09-03 2019-01-01 浙江善测禾骑士生物科技有限公司 一种lpor-y193f突变体蛋白晶体的制备方法
BR112021008122A8 (pt) * 2018-10-31 2023-01-31 Merck Sharp & Dohme Cristais de anticorpo anti-pd-1 humano e métodos de uso dos mesmos
KR20210089215A (ko) 2018-11-07 2021-07-15 머크 샤프 앤드 돔 코포레이션 항-lag3 항체 및 항-pd-1 항체의 공동-제제
EP3653702A1 (fr) * 2018-11-15 2020-05-20 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Structure cristalline d'une protéine de réplication codée par un plasmide isolé d'un patient souffrant de sclérose en plaques
US20220275073A1 (en) * 2019-08-12 2022-09-01 Amgen Inc. Anti-Sclerostin Antibody Formulations
CN115361971A (zh) * 2020-04-06 2022-11-18 里兰斯坦福初级大学理事会 抗体制剂
CN113444800A (zh) * 2021-06-30 2021-09-28 北京泱深生物信息技术有限公司 基因群作为共预后因子在肾癌预后检测中的应用
CN115804338A (zh) * 2022-12-19 2023-03-17 新疆农业科学院经济作物研究所 一种海岛棉育种方法
CN118236484B (zh) * 2022-12-23 2025-11-04 信立泰(苏州)药业有限公司 一种Romosozumab抗体稳定制剂及其制备方法和用途
CN116375864B (zh) * 2023-05-16 2023-08-08 成都大熊猫繁育研究基地 一种抗大熊猫amh单克隆抗体、杂交瘤细胞株及其应用
WO2025030173A1 (fr) * 2023-08-03 2025-02-06 Next Science IP Holdings Pty Ltd Réduction de l'inflammation dans des tissus de site chirurgical

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CA2830538A1 (fr) 2012-10-04
EA029956B1 (ru) 2018-06-29
CN103517920B (zh) 2018-04-17
PE20140437A1 (es) 2014-04-17
KR20140018315A (ko) 2014-02-12
PH12013501971A1 (en) 2014-01-06
AU2012236962B2 (en) 2017-05-11
WO2012135035A1 (fr) 2012-10-04
CO6801637A2 (es) 2013-11-29
CA2830538C (fr) 2020-05-12
AR085575A1 (es) 2013-10-09
JP6412964B2 (ja) 2018-10-24
AP2013007135A0 (en) 2013-09-30
PH12013501971B1 (en) 2018-08-31
US9920114B2 (en) 2018-03-20
BR112013024493A2 (pt) 2018-06-26
US20160083460A1 (en) 2016-03-24
CN103517920A (zh) 2014-01-15
EP2688910B1 (fr) 2019-05-29
US20140105909A1 (en) 2014-04-17
MA35009B1 (fr) 2014-04-03
MY170720A (en) 2019-08-27
CR20160147A (es) 2016-08-03
MX338078B (es) 2016-04-01
AU2012236962A1 (en) 2013-10-10
US20170210792A1 (en) 2017-07-27
AP3981A (en) 2017-01-05
CL2013002743A1 (es) 2014-05-23
EP2688910A1 (fr) 2014-01-29
TN2013000378A1 (en) 2015-01-20
ZA201608660B (en) 2018-05-30
US9617333B2 (en) 2017-04-11
MX2013011012A (es) 2014-04-25
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US9145457B2 (en) 2015-09-29
IL228455A (en) 2017-05-29
EA201391389A1 (ru) 2014-03-31
JP2014511842A (ja) 2014-05-19
SG193610A1 (en) 2013-11-29
TW201247703A (en) 2012-12-01
ZA201307122B (en) 2017-08-30
IL228455A0 (en) 2013-12-31

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