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SE8306298L - 7beta-ISOTIAZOLYLTIOACETAMIDO-7alpha-METOXICEFALOSPORANSYRADERIVAT - Google Patents

7beta-ISOTIAZOLYLTIOACETAMIDO-7alpha-METOXICEFALOSPORANSYRADERIVAT

Info

Publication number
SE8306298L
SE8306298L SE8306298A SE8306298A SE8306298L SE 8306298 L SE8306298 L SE 8306298L SE 8306298 A SE8306298 A SE 8306298A SE 8306298 A SE8306298 A SE 8306298A SE 8306298 L SE8306298 L SE 8306298L
Authority
SE
Sweden
Prior art keywords
group
lower alkyl
optionally substituted
substituted
carboxy
Prior art date
Application number
SE8306298A
Other languages
Swedish (sv)
Other versions
SE454512B (en
SE8306298D0 (en
Inventor
M Iwanami
T Maeda
Y Nagano
M Fujimoto
N Nagano
A Yamazaki
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of SE8306298L publication Critical patent/SE8306298L/en
Publication of SE8306298D0 publication Critical patent/SE8306298D0/en
Publication of SE454512B publication Critical patent/SE454512B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE:Cephalosporin derivative I (A is (substituted) isothiazolyl; B is H, methoxy; R is H, lower alkyl).

Claims (2)

PATENTKRAVPATENT REQUIREMENTS 1. 7A-isotiazo1y1tioacetamido-7a-metoxicefa1osporansyraderivat representerade med den allmanna formeln van i R betecknar en lagre alkylsubstituerad tetrazolylgrupp eller en lagre alkylsubstituerad tiadiazolylgrupp och Y betecknar HORiR2 ",../-\/_ R2 II" 1 I (a) eller (b) Neller (c) .van i R1 representerarydroxigrupp,minogrupp eller en lagre alkoxigrupp; R2 representerar en aminogrupp, en cyanogrupp, en karboxigrupp, en karbamoylgrupp eventuellt substituerad med en eller tvA lagre alkylgrupper, en karbezoylgrupp, en fenylgrupp, en lagre alkylgrupp eventuellt substituerad med en hydroxigrupp eller en lagze alkoxikarbonylaminogrupp; och R3 representerar en lagre alkylgrupp eventuellt substituerad med en hydroxigrupp; eller ett farmaceutiskt acceptabelt salt darav. 2. 73-(4-karboxi-3-hydroxiisotiazol-5-yl)tioacetamido-7a-metoxi-3-(1-metyltetrazol-5-yl)tiometyl-A3- -cefem-4-karboxylsyra enligt krav7A-Isothiazolylthioacetamido-7α-methoxycephalosporanic acid derivatives represented by the general formula van in R represent a lower alkyl-substituted tetrazolyl group or a lower alkyl-substituted thiadiazolyl group and Y represents HOR 1 R 2 ",. b) N or (c) .van of R 1 represents arydoxy group, minogroup or a lower alkoxy group; R 2 represents an amino group, a cyano group, a carboxy group, a carbamoyl group optionally substituted by one or two lower alkyl groups, a carbezoyl group, a phenyl group, a lower alkyl group optionally substituted by a hydroxy group or a lower alkoxycarbonylamino group; and R 3 represents a lower alkyl group optionally substituted with a hydroxy group; or a pharmaceutically acceptable salt thereof. 73- (4-Carboxy-3-hydroxyisothiazol-5-yl) thioacetamido-7α-methoxy-3- (1-methyltetrazol-5-yl) thiomethyl-33-cephem-4-carboxylic acid according to claim 2. OCH 1 3 , Y-SCH2CONH 61"2. AND 1 3, Y-SCH2CONH 61 "
SE8306298A 1977-06-10 1983-11-16 7beta-ISOTIAZOLYLTIOACETAMIDO-7alpha-METOXICEFALOSPORANSYRADERIVAT SE454512B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52068699A JPS5854157B2 (en) 1977-06-10 1977-06-10 New derivatives of cephalosporin compounds and their production method

Publications (3)

Publication Number Publication Date
SE8306298L true SE8306298L (en) 1983-11-16
SE8306298D0 SE8306298D0 (en) 1983-11-16
SE454512B SE454512B (en) 1988-05-09

Family

ID=13381266

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8306298A SE454512B (en) 1977-06-10 1983-11-16 7beta-ISOTIAZOLYLTIOACETAMIDO-7alpha-METOXICEFALOSPORANSYRADERIVAT

Country Status (10)

Country Link
JP (1) JPS5854157B2 (en)
AU (1) AU518620B2 (en)
BE (1) BE867994A (en)
DE (1) DE2857816C2 (en)
FR (1) FR2405953A1 (en)
GB (1) GB1604740A (en)
HU (1) HU184788B (en)
SE (1) SE454512B (en)
SU (2) SU843752A3 (en)
UA (2) UA5924A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187355A1 (en) 1981-09-23 1986-07-16 E.R. Squibb & Sons, Inc. Process for preparing beta-lactam antibiotics
ZA874696B (en) 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives
PT620225E (en) 1993-04-16 2003-03-31 Basilea Pharmaceutica Ag DERIVATIVES OF CEFALOSPORINA
US5811419A (en) * 1996-01-16 1998-09-22 Hoffmann-La Roche Inc. Isooxacephem-derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL29235A (en) * 1967-01-05 1971-10-20 Bristol Myers Co 7-(pyridylthioacetamido)cephalosporanic acid derivatives and their preparation
JPS5165789A (en) * 1974-11-30 1976-06-07 Sankyo Co 77 metokishisefuarosuhorinkagobutsuno seiho
CA1088049A (en) * 1975-06-03 1980-10-21 Takashi Masugi 3-substituted-7-substituted alkanamido-3-cephem-4- carboxylic acid compounds and processes for preparation thereof
DE2539214C2 (en) * 1975-09-03 1984-03-29 E.R. Squibb & Sons, Inc., 08540 Princeton, N.J. 7-methoxythienyl-ureido-cephalosporin and medicinal product containing it

Also Published As

Publication number Publication date
AU3698878A (en) 1979-12-13
UA5922A1 (en) 1994-12-29
BE867994A (en) 1978-12-11
DE2857816C2 (en) 1985-05-09
SU904525A3 (en) 1982-02-07
AU518620B2 (en) 1981-10-08
SE454512B (en) 1988-05-09
FR2405953B1 (en) 1983-07-18
GB1604740A (en) 1981-12-16
JPS543090A (en) 1979-01-11
UA5924A1 (en) 1994-12-29
FR2405953A1 (en) 1979-05-11
JPS5854157B2 (en) 1983-12-02
HU184788B (en) 1984-10-29
SU843752A3 (en) 1981-06-30
SE8306298D0 (en) 1983-11-16

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