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SE7807810L - 3-METHYLENIC LAMIC ACID DERIVATIVE - Google Patents

3-METHYLENIC LAMIC ACID DERIVATIVE

Info

Publication number
SE7807810L
SE7807810L SE7807810A SE7807810A SE7807810L SE 7807810 L SE7807810 L SE 7807810L SE 7807810 A SE7807810 A SE 7807810A SE 7807810 A SE7807810 A SE 7807810A SE 7807810 L SE7807810 L SE 7807810L
Authority
SE
Sweden
Prior art keywords
methylenic
acid derivative
protecting group
group
ceph
Prior art date
Application number
SE7807810A
Other languages
Swedish (sv)
Other versions
SE438854B (en
Inventor
R B Woodward
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH269374A external-priority patent/CH601310A5/en
Priority claimed from CH776674A external-priority patent/CH610584A5/en
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of SE7807810L publication Critical patent/SE7807810L/en
Publication of SE438854B publication Critical patent/SE438854B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1503581 Preparation of ceph-2- or -3-em derivatives CIBA-GEIGY AG 24 Feb 1975 [26 Feb 1974 5 June 1974 12 Aug 1974] 7625/75 Heading C2C Compounds IA and IB (R 1 <SP>a</SP> is H or a protecting group; R 1 b is H or acyl; or R 1 <SP>a</SP> and R 1 <SP>b</SP> together form a divalent protecting group; R 2 is OH or a group which with the adjacent -CO- group forms protected carboxyl; and R 3 is H, 1-7C alkyl or a protecting group) and the 1-oxides of the ceph- 3-em compounds are prepared by cyclization of a compound II followed, where necessary, by deprotection and/or other conventional modifications.
SE7807810A 1974-02-26 1978-07-13 3-METHYLENOIC ACID DERIVATIVES FOR USE AS INTERMEDIATE IN THE SYNTHESIS OF 3-CEFEM SUBSTANCES SE438854B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH269374A CH601310A5 (en) 1974-02-26 1974-02-26 7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn
CH776674A CH610584A5 (en) 1974-02-26 1974-06-05 Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives
CH1100074 1974-08-12

Publications (2)

Publication Number Publication Date
SE7807810L true SE7807810L (en) 1978-07-13
SE438854B SE438854B (en) 1985-05-13

Family

ID=27173851

Family Applications (3)

Application Number Title Priority Date Filing Date
SE7501317A SE431652B (en) 1974-02-26 1975-02-06 PROCEDURE FOR PREPARING 7BETA-AMINO-3CEFEM-3OL-4-CARBOXYLIC ACID DERIVATIVES
SE7807811A SE438855B (en) 1974-02-26 1978-07-13 3-HYDROXICROTONIC ACID DERIVATIVES FOR USE AS INTERMEDIATE IN THE SYNTHESIS OF 3-CEFEM SUBSTANCES
SE7807810A SE438854B (en) 1974-02-26 1978-07-13 3-METHYLENOIC ACID DERIVATIVES FOR USE AS INTERMEDIATE IN THE SYNTHESIS OF 3-CEFEM SUBSTANCES

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SE7501317A SE431652B (en) 1974-02-26 1975-02-06 PROCEDURE FOR PREPARING 7BETA-AMINO-3CEFEM-3OL-4-CARBOXYLIC ACID DERIVATIVES
SE7807811A SE438855B (en) 1974-02-26 1978-07-13 3-HYDROXICROTONIC ACID DERIVATIVES FOR USE AS INTERMEDIATE IN THE SYNTHESIS OF 3-CEFEM SUBSTANCES

Country Status (21)

Country Link
JP (1) JPS625919B2 (en)
AR (1) AR208538A1 (en)
AT (2) AT337362B (en)
AU (1) AU498131B2 (en)
BE (1) BE825919A (en)
BG (1) BG26201A3 (en)
CA (2) CA1059988A (en)
DD (1) DD117074A5 (en)
DE (1) DE2506330A1 (en)
DK (2) DK73475A (en)
ES (2) ES435110A1 (en)
FI (1) FI66389C (en)
FR (1) FR2261761B1 (en)
GB (1) GB1503581A (en)
HU (1) HU175212B (en)
IE (1) IE40695B1 (en)
IL (1) IL46699A (en)
NL (1) NL7502292A (en)
NO (1) NO750625L (en)
NZ (1) NZ176623A (en)
SE (3) SE431652B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044247B (en) * 1974-08-02 1980-03-20 Farmaceutici Italia INTERMEDIATES FOR THE SYNTHESIS OF LACTAMIC DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
JPS5198265A (en) * 1975-02-17 1976-08-30
AT342197B (en) * 1975-02-20 1978-03-28 Ciba Geigy Ag NEW PROCESS FOR PRODUCING 3-CEPHEM CONNECTIONS
US4029645A (en) * 1975-11-17 1977-06-14 E. R. Squibb & Sons, Inc. Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins
US4301279A (en) 1979-02-23 1981-11-17 Ciba-Geigy Corporation Process for the production of 3-hydroxy compounds
JPH0639474B2 (en) * 1983-03-04 1994-05-25 大塚化学株式会社 Method for producing cephalosporin compound
JPS59228854A (en) * 1983-06-08 1984-12-22 真井　康博 Chemical liquid injection by compressed gas and chemical liquid storing syringe
JPS60115562A (en) * 1983-11-28 1985-06-22 Otsuka Chem Co Ltd Production of azetidinone derivative
GB2152497B (en) * 1983-11-28 1987-08-05 Otsuka Kagaku Kk Process for the preparation of azetidinone derivatives
JPS60126263A (en) * 1983-12-12 1985-07-05 Otsuka Chem Co Ltd Production of azetidinone derivative
JPS60237061A (en) * 1984-05-08 1985-11-25 Otsuka Chem Co Ltd Preparation of azetidinone derivative
JPS61178961A (en) * 1985-02-01 1986-08-11 Otsuka Chem Co Ltd Production of azetidinone derivative
DE3725375A1 (en) * 1987-07-31 1989-02-09 Bayer Ag STABLE OXAPENEM-3-CARBONSAEURES
JP3195959B2 (en) * 1991-03-13 2001-08-06 大塚化学株式会社 Method for producing 3-hydroxycephem derivative
AU2003269416A1 (en) * 2002-11-01 2004-05-25 Orchid Chemicals And Pharmaceuticals Ltd An improved process for the preparation of chloro methyl cephem derivatives
WO2013092481A1 (en) 2011-12-20 2013-06-27 F. Hoffmann-La Roche Ag 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
HK1200835A1 (en) 2011-12-20 2015-08-14 Riboscience Llc 4'-azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication
UA123533C2 (en) 2013-05-16 2021-04-21 Рібосаєнс Ллс 4'-fluor0-2'-methyl substituted nucleoside derivatives
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
EP2996696A4 (en) 2013-05-16 2016-12-21 Riboscience Llc NUCLEOSIDE DERIVATIVES SUBSTITUTED 4'-AZIDO, 3'-DEOXY-3'-FLUORO
AU2018335411B2 (en) 2017-09-21 2024-06-27 Riboscience Llc 4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230372A1 (en) * 1972-06-21 1973-01-11 Fujisawa Pharmaceutical Co Cepham and cephem derivs - useful as antibiotics
SE428022B (en) * 1972-06-29 1983-05-30 Ciba Geigy Ag 7BETA-AMINO-CEFAM-3-ON-4-CARBOXYLIC ACID COMPOUNDS FOR USE FOR THE PRODUCTION OF CEPHALOSPORINE DERIVATIVES
AR206201A1 (en) * 1972-06-29 1976-07-07 Ciba Geigy Ag PROCEDURE FOR OBTAINING ACID COMPOUNDS 7BETA-AMINO-3-CEFEM-3-01-4-CARBOXILICO0-SUBSTITUIDOS

Also Published As

Publication number Publication date
BG26201A3 (en) 1979-02-15
FI750503A7 (en) 1975-08-27
FI66389B (en) 1984-06-29
AU498131B2 (en) 1979-02-15
FR2261761B1 (en) 1978-08-18
HU175212B (en) 1980-06-28
BE825919A (en) 1975-08-25
SE438855B (en) 1985-05-13
DE2506330A1 (en) 1975-09-04
SE438854B (en) 1985-05-13
FR2261761A1 (en) 1975-09-19
DK348678A (en) 1978-08-07
CA1059988A (en) 1979-08-07
CA1080713A (en) 1980-07-01
GB1503581A (en) 1978-03-15
ATA28178A (en) 1978-10-15
AT337362B (en) 1977-06-27
SE7501317L (en) 1975-08-27
ES435110A1 (en) 1977-03-16
NL7502292A (en) 1975-08-28
DK73475A (en) 1975-10-20
IL46699A0 (en) 1975-04-25
NO750625L (en) 1975-08-27
IE40695B1 (en) 1979-08-01
JPS50129590A (en) 1975-10-13
AR208538A1 (en) 1977-02-15
DD117074A5 (en) 1975-12-20
SE431652B (en) 1984-02-20
AU7849875A (en) 1976-08-26
ATA108275A (en) 1976-10-15
SE7807811L (en) 1978-07-13
ES452915A1 (en) 1977-11-01
IL46699A (en) 1977-11-30
IE40695L (en) 1975-08-26
JPS625919B2 (en) 1987-02-07
NZ176623A (en) 1978-04-03
AT350068B (en) 1979-05-10
FI66389C (en) 1984-10-10

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