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FR2405953A1 - DERIVATIVES OF METHOXY-7A-THIOMETHYLHETEROCYCLIQUE-3-CEPHALOSPORIN REPRESENTING ANTI-BACTERIAL ACTIVITY - Google Patents

DERIVATIVES OF METHOXY-7A-THIOMETHYLHETEROCYCLIQUE-3-CEPHALOSPORIN REPRESENTING ANTI-BACTERIAL ACTIVITY

Info

Publication number
FR2405953A1
FR2405953A1 FR7834349A FR7834349A FR2405953A1 FR 2405953 A1 FR2405953 A1 FR 2405953A1 FR 7834349 A FR7834349 A FR 7834349A FR 7834349 A FR7834349 A FR 7834349A FR 2405953 A1 FR2405953 A1 FR 2405953A1
Authority
FR
France
Prior art keywords
methoxy
cephalosporin
derivatives
thiomethylheterocyclique
bacterial activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7834349A
Other languages
French (fr)
Other versions
FR2405953B1 (en
Inventor
Masaru Iwanami
Tetsuya Maeda
Yoshinoby Nagano
Masaharu Fujimoto
Noriaki Nagano
Atsuki Yamazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of FR2405953A1 publication Critical patent/FR2405953A1/en
Application granted granted Critical
Publication of FR2405953B1 publication Critical patent/FR2405953B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des dérivés de la méthoxy-7 alpha -thiométhylhétérocyclique-3-céphalosporine présentant une activité anti-bactérienne. L'acide (hydroxy-3-isothiazole substitué-4-yl-5) thioacétamido-7 beta -méthoxy-7 alpha -thiométhyle hétérocyclique-3- DELTA ** 3-céphem-carboxylique-4 est représenté par la formule générale :The present invention relates to derivatives of methoxy-7 alpha -thiomethylheterocyclic-3-cephalosporin exhibiting anti-bacterial activity. (Hydroxy-3-isothiazole-4-yl-5) thioacetamido-7 beta -methoxy-7 alpha -thiomethyl heterocyclic-3- DELTA ** 3-cephem-carboxylic acid-4 is represented by the general formula:

FR7834349A 1977-06-10 1978-12-06 DERIVATIVES OF METHOXY-7A-THIOMETHYLHETEROCYCLIQUE-3-CEPHALOSPORIN REPRESENTING ANTI-BACTERIAL ACTIVITY Granted FR2405953A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52068699A JPS5854157B2 (en) 1977-06-10 1977-06-10 New derivatives of cephalosporin compounds and their production method

Publications (2)

Publication Number Publication Date
FR2405953A1 true FR2405953A1 (en) 1979-05-11
FR2405953B1 FR2405953B1 (en) 1983-07-18

Family

ID=13381266

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7834349A Granted FR2405953A1 (en) 1977-06-10 1978-12-06 DERIVATIVES OF METHOXY-7A-THIOMETHYLHETEROCYCLIQUE-3-CEPHALOSPORIN REPRESENTING ANTI-BACTERIAL ACTIVITY

Country Status (10)

Country Link
JP (1) JPS5854157B2 (en)
AU (1) AU518620B2 (en)
BE (1) BE867994A (en)
DE (1) DE2857816C2 (en)
FR (1) FR2405953A1 (en)
GB (1) GB1604740A (en)
HU (1) HU184788B (en)
SE (1) SE454512B (en)
SU (2) SU843752A3 (en)
UA (2) UA5924A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187355A1 (en) 1981-09-23 1986-07-16 E.R. Squibb & Sons, Inc. Process for preparing beta-lactam antibiotics
ZA874696B (en) 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives
PT620225E (en) 1993-04-16 2003-03-31 Basilea Pharmaceutica Ag DERIVATIVES OF CEFALOSPORINA
US5811419A (en) * 1996-01-16 1998-09-22 Hoffmann-La Roche Inc. Isooxacephem-derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL29235A (en) * 1967-01-05 1971-10-20 Bristol Myers Co 7-(pyridylthioacetamido)cephalosporanic acid derivatives and their preparation
JPS5165789A (en) * 1974-11-30 1976-06-07 Sankyo Co 77 metokishisefuarosuhorinkagobutsuno seiho
CA1088049A (en) * 1975-06-03 1980-10-21 Takashi Masugi 3-substituted-7-substituted alkanamido-3-cephem-4- carboxylic acid compounds and processes for preparation thereof
DE2539214C2 (en) * 1975-09-03 1984-03-29 E.R. Squibb & Sons, Inc., 08540 Princeton, N.J. 7-methoxythienyl-ureido-cephalosporin and medicinal product containing it

Also Published As

Publication number Publication date
AU3698878A (en) 1979-12-13
UA5922A1 (en) 1994-12-29
BE867994A (en) 1978-12-11
DE2857816C2 (en) 1985-05-09
SU904525A3 (en) 1982-02-07
AU518620B2 (en) 1981-10-08
SE454512B (en) 1988-05-09
FR2405953B1 (en) 1983-07-18
SE8306298L (en) 1983-11-16
GB1604740A (en) 1981-12-16
JPS543090A (en) 1979-01-11
UA5924A1 (en) 1994-12-29
JPS5854157B2 (en) 1983-12-02
HU184788B (en) 1984-10-29
SU843752A3 (en) 1981-06-30
SE8306298D0 (en) 1983-11-16

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