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RU95110762A - Производные 5-гидразинохинолона, композиция для лечения или профилактики инфекционного заболевания, способ лечения или профилактики - Google Patents

Производные 5-гидразинохинолона, композиция для лечения или профилактики инфекционного заболевания, способ лечения или профилактики

Info

Publication number
RU95110762A
RU95110762A RU95110762/04A RU95110762A RU95110762A RU 95110762 A RU95110762 A RU 95110762A RU 95110762/04 A RU95110762/04 A RU 95110762/04A RU 95110762 A RU95110762 A RU 95110762A RU 95110762 A RU95110762 A RU 95110762A
Authority
RU
Russia
Prior art keywords
prophylaxis
treatment
lower alkyl
quinolone
heterocyclic ring
Prior art date
Application number
RU95110762/04A
Other languages
English (en)
Other versions
RU2126000C1 (ru
Inventor
Проссер Демут Томас (младший)
Us]
Юджин Уайт Рональд
Original Assignee
Дзе Проктер Энд Гэмбл Компани (US)
Дзе Проктер Энд Гэмбл Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Проктер Энд Гэмбл Компани (US), Дзе Проктер Энд Гэмбл Компани filed Critical Дзе Проктер Энд Гэмбл Компани (US)
Publication of RU95110762A publication Critical patent/RU95110762A/ru
Application granted granted Critical
Publication of RU2126000C1 publication Critical patent/RU2126000C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Противомикробные 5- (N - гетерозамещенные амино) хинолоновые соединения общей формулы I, где (1) R, Rи Rобразуют любой из множества хинолонов и близких гетероциклических структур подобных тем, которые известны специалистам как обладающие противомикробной активностью, и (2) (а) Rи Rявляются, независимо, водородом, низшим алкилом, циклоалкилом, гетероалкилом или - С (= О)-Х-, R, где Х является ковалентной связью, N, O или S и Rявляется низшим алкилом, низшим алкенилом, арилалкилом, карбоциклическим кольцом, гетероциклическим кольцом, или (в) Rи Rвместе образуют гетероциклическое кольцо, которое включает азот, к которому они присоединены, и их фармацевтически приемлемые соли и биогидролизуемые эфиры и сольваты.

Claims (1)

  1. Противомикробные 5- (N - гетерозамещенные амино) хинолоновые соединения общей формулы I, где (1) R1, R2 и R3 образуют любой из множества хинолонов и близких гетероциклических структур подобных тем, которые известны специалистам как обладающие противомикробной активностью, и (2) (а) R4 и R5 являются, независимо, водородом, низшим алкилом, циклоалкилом, гетероалкилом или - С (= О)-Х-, R8, где Х является ковалентной связью, N, O или S и R8 является низшим алкилом, низшим алкенилом, арилалкилом, карбоциклическим кольцом, гетероциклическим кольцом, или (в) R4 и R5 вместе образуют гетероциклическое кольцо, которое включает азот, к которому они присоединены, и их фармацевтически приемлемые соли и биогидролизуемые эфиры и сольваты.
RU95110762A 1992-10-30 1993-10-22 Производные 5-гидразинохинолона, композиция для лечения или профилактики инфекционного заболевания, способ лечения или профилактики RU2126000C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US96896092A 1992-10-30 1992-10-30
US07/968.960 1992-10-30
US07/968,960 1992-10-30
PCT/US1993/010091 WO1994010163A1 (en) 1992-10-30 1993-10-22 Antimicrobial 5-hydrazino-quinolone derivatives

Publications (2)

Publication Number Publication Date
RU95110762A true RU95110762A (ru) 1997-01-10
RU2126000C1 RU2126000C1 (ru) 1999-02-10

Family

ID=25514997

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95110762A RU2126000C1 (ru) 1992-10-30 1993-10-22 Производные 5-гидразинохинолона, композиция для лечения или профилактики инфекционного заболевания, способ лечения или профилактики

Country Status (21)

Country Link
EP (1) EP0666853A1 (ru)
JP (1) JPH08502750A (ru)
KR (1) KR950704301A (ru)
CN (1) CN1064357C (ru)
AU (1) AU687018B2 (ru)
BR (1) BR9307347A (ru)
CA (1) CA2148003A1 (ru)
CZ (1) CZ282581B6 (ru)
EG (1) EG20543A (ru)
FI (1) FI952049L (ru)
HU (1) HUT72072A (ru)
IL (1) IL107323A (ru)
MX (1) MX9306814A (ru)
NO (1) NO951640L (ru)
NZ (1) NZ257470A (ru)
PL (1) PL178094B1 (ru)
RU (1) RU2126000C1 (ru)
SG (1) SG59979A1 (ru)
SK (1) SK54795A3 (ru)
WO (1) WO1994010163A1 (ru)
ZA (1) ZA938089B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
EP0775114B1 (en) * 1994-08-02 2000-03-22 The Procter & Gamble Company Process for making antimicrobial compounds
NZ290722A (en) * 1994-08-02 1999-03-29 Procter & Gamble A process for making derivatives of quinolonyl lactam (qla's); intermediates
ES2188890T3 (es) * 1996-02-09 2003-07-01 Toyama Chemical Co Ltd Derivados del acido quinoleincarboxilico y sus sales.
RU2248199C1 (ru) * 2003-06-02 2005-03-20 Открытое Акционерное Общество "Акционерное Курганское общество медицинских препаратов и изделий "Синтез" (ОАО "Синтез") Глазные капли и способ их получения
RU2265437C2 (ru) * 2003-07-02 2005-12-10 Суханов Александр Владимирович Способ лечения заболеваний желудка и двенадцатиперстной кишки, вызванных helicobacter pylori
RU2245134C1 (ru) * 2003-09-02 2005-01-27 Открытое акционерное общество "Красфарма" Состав офлоксацина для инъекций
WO2005026147A1 (ja) 2003-09-10 2005-03-24 Kyorin Pharmaceutical Co., Ltd. ７−（４−置換−３−シクロプロピルアミノメチル−１−ピロリジニル）キノロンカルボン酸誘導体
RS55114B1 (sr) * 2005-05-18 2016-12-30 Raptor Pharmaceuticals Inc Aerosolizovani fluorohinoloni i njihove upotrebe
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
CA2528849C (en) 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
EA010601B1 (ru) * 2005-06-09 2008-10-30 Янссен Фармацевтика Н.В. Производные хинолина в качестве антибактериальных агентов
CN101020647B (zh) * 2007-02-14 2011-03-30 杭州师范学院 一种β-环丙胺基丙烯酸(酯)的合成方法
WO2008115890A2 (en) * 2007-03-19 2008-09-25 Takeda Pharmaceutical Company Limited Mapk/erk kinase inhibitors
CA2701630C (en) * 2007-10-05 2016-10-25 Cylene Pharmaceuticals, Inc. Quinolone analogs and methods related thereto
CN102046603B (zh) * 2008-06-03 2014-08-13 埃科特莱茵药品有限公司 作为抗细菌剂的[4-(1-氨基-乙基)-环己基]-甲基-胺及[6-(1-氨基-乙基)-四氢-吡喃-3-基]-甲基-胺衍生物
PT2346509T (pt) 2008-10-07 2020-08-05 Horizon Orphan Llc Inalação de levofloxacina para redução da inflamação pulmonar
NO2344129T3 (ru) 2008-10-07 2018-07-21
AR076222A1 (es) * 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
BR112012004692B8 (pt) 2009-09-04 2021-05-25 Mpex Pharmaceuticals Inc solução que compreende levofloxacina para uso em um método para tratar a fibrose cística em um ser humano

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
JPH0228178A (ja) * 1988-04-23 1990-01-30 Toyama Chem Co Ltd 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
HU219403B (hu) * 1989-08-16 2001-04-28 Pfizer Inc. Azabiciklo-csoporttal helyettesített kinolon- és naftiridon-karbonsavak és eljárás ezek előállítására
EP0525057B1 (en) * 1990-04-18 2000-06-14 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolonyl lactams
AU658384B2 (en) * 1990-11-30 1995-04-13 Warner-Lambert Company Individual stereoisomers of 7-{3-(1-aminoalkyl)-1-pyrrolidinyl}-quinolones and naphthyridones as antibacterial agents

Also Published As

Publication number Publication date
ZA938089B (en) 1994-06-07
SG59979A1 (en) 1999-02-22
CZ282581B6 (cs) 1997-08-13
BR9307347A (pt) 1999-05-25
FI952049A7 (fi) 1995-04-28
NZ257470A (en) 1997-08-22
KR950704301A (ko) 1995-11-17
AU5409794A (en) 1994-05-24
NO951640L (no) 1995-06-30
CN1064357C (zh) 2001-04-11
MX9306814A (es) 1994-07-29
HUT72072A (en) 1996-03-28
HU9501237D0 (en) 1995-06-28
FI952049A0 (fi) 1995-04-28
EG20543A (en) 1999-07-31
NO951640D0 (no) 1995-04-28
IL107323A (en) 2000-06-01
RU2126000C1 (ru) 1999-02-10
PL178094B1 (pl) 2000-02-29
AU687018B2 (en) 1998-02-19
IL107323A0 (en) 1994-01-25
FI952049L (fi) 1995-04-28
CA2148003A1 (en) 1994-05-11
PL308671A1 (en) 1995-08-21
CN1092773A (zh) 1994-09-28
CZ109795A3 (en) 1995-12-13
WO1994010163A1 (en) 1994-05-11
SK54795A3 (en) 1995-12-06
EP0666853A1 (en) 1995-08-16
JPH08502750A (ja) 1996-03-26

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