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RU94042465A - Энантиомерный 1-фенил-2-(2-пиридинил) этиламин для лечения нейродегенеративных расстройств - Google Patents

Энантиомерный 1-фенил-2-(2-пиридинил) этиламин для лечения нейродегенеративных расстройств

Info

Publication number
RU94042465A
RU94042465A RU94042465/04A RU94042465A RU94042465A RU 94042465 A RU94042465 A RU 94042465A RU 94042465/04 A RU94042465/04 A RU 94042465/04A RU 94042465 A RU94042465 A RU 94042465A RU 94042465 A RU94042465 A RU 94042465A
Authority
RU
Russia
Prior art keywords
phenyl
enantiomeric
ethylamine
pyridinyl
neurodegenerative disorder
Prior art date
Application number
RU94042465/04A
Other languages
English (en)
Other versions
RU2128650C1 (ru
Inventor
Конрад Гриффит Рональд
Us]
Джон Мюррэй Роберт
Бэйлстра Майкл
Original Assignee
Физонз Корпорейшн (US)
Физонз Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929207339A external-priority patent/GB9207339D0/en
Priority claimed from GB929208290A external-priority patent/GB9208290D0/en
Application filed by Физонз Корпорейшн (US), Физонз Корпорейшн filed Critical Физонз Корпорейшн (US)
Publication of RU94042465A publication Critical patent/RU94042465A/ru
Application granted granted Critical
Publication of RU2128650C1 publication Critical patent/RU2128650C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

(S)-альфа-фенил-2-пиридинэтанамин и его фармацевтически приемлемые производные, полезные при лечении нейродегенеративных расстройств и проявляющие линейные фармакокинетические свойства.

Claims (1)

  1. (S)-альфа-фенил-2-пиридинэтанамин и его фармацевтически приемлемые производные, полезные при лечении нейродегенеративных расстройств и проявляющие линейные фармакокинетические свойства.
RU94042465A 1992-04-03 1993-04-01 (S)-α-ФЕНИЛ-2-ПИРИДИНЭТАНАМИН И ЕГО СОЛЬ С НЕОРГАНИЧЕСКИМИ КИСЛОТАМИ, СПОСОБ ИХ ПОЛУЧЕНИЯ, ЛЕКАРСТВЕННЫЙ ПРЕПАРАТ НА ИХ ОСНОВЕ И СПОСОБ ЛЕЧЕНИЯ СУДОРОГ RU2128650C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB929207339A GB9207339D0 (en) 1992-04-03 1992-04-03 Pharmaceutical compound
GB9207339.4 1992-04-03
GB9208290.8 1992-04-15
GB929208290A GB9208290D0 (en) 1992-04-15 1992-04-15 Pharmaceutical compound having neuroprotective properties
PCT/GB1993/000689 WO1993020052A1 (en) 1992-04-03 1993-04-01 Enantiomeric 1-phenyl-2-(2-pyridinyl)ethylamine for the treatment of neurodegenerative disorders

Publications (2)

Publication Number Publication Date
RU94042465A true RU94042465A (ru) 1996-07-20
RU2128650C1 RU2128650C1 (ru) 1999-04-10

Family

ID=26300643

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94042465A RU2128650C1 (ru) 1992-04-03 1993-04-01 (S)-α-ФЕНИЛ-2-ПИРИДИНЭТАНАМИН И ЕГО СОЛЬ С НЕОРГАНИЧЕСКИМИ КИСЛОТАМИ, СПОСОБ ИХ ПОЛУЧЕНИЯ, ЛЕКАРСТВЕННЫЙ ПРЕПАРАТ НА ИХ ОСНОВЕ И СПОСОБ ЛЕЧЕНИЯ СУДОРОГ

Country Status (28)

Country Link
EP (1) EP0633879B1 (ru)
JP (2) JP3120810B2 (ru)
KR (1) KR100259567B1 (ru)
CN (1) CN1044367C (ru)
AT (1) ATE163925T1 (ru)
AU (2) AU3897693A (ru)
CA (1) CA2133427C (ru)
CZ (1) CZ288519B6 (ru)
DE (1) DE69317411T2 (ru)
DK (1) DK0633879T3 (ru)
DZ (1) DZ1677A1 (ru)
ES (1) ES2115055T3 (ru)
FI (1) FI105025B (ru)
HU (1) HU211529A9 (ru)
IL (1) IL105276A (ru)
MA (1) MA22866A1 (ru)
MX (1) MX9301935A (ru)
MY (1) MY110149A (ru)
NO (1) NO302170B1 (ru)
NZ (1) NZ251384A (ru)
PL (1) PL180014B1 (ru)
RU (1) RU2128650C1 (ru)
SG (1) SG47948A1 (ru)
SK (1) SK281258B6 (ru)
TW (1) TW282455B (ru)
UA (1) UA29437C2 (ru)
WO (1) WO1993020052A1 (ru)
ZA (1) ZA932415B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320273D0 (en) * 1993-04-01 1993-11-17 Fisons Corp Compound useful in therapy
EP0356035B1 (en) * 1988-08-12 1996-03-13 Astra Aktiebolag Arylkalkyl-amines and -amides having anticonvulsant and neuroprotective properties
ZA942140B (en) * 1993-04-01 1994-10-03 Fisons Corp Salt of (S)-alpha-phenyl-2-pyridineethanamine useful in therapy
SE9901077D0 (sv) * 1999-03-23 1999-03-23 Astra Ab Novel use
SE9901237D0 (sv) * 1999-04-06 1999-04-06 Astra Ab Novel use
SE9901340D0 (sv) 1999-04-15 1999-04-15 Astra Pharma Prod Novel process
DK1202986T3 (da) * 1999-07-28 2006-02-20 Ortho Mcneil Pharm Inc Amin- og amidderivater som ligander for neuropeptid Y-Y5-receptoren, der er nyttige ved behandlingen af obesitet og andre lidelser
WO2007017652A2 (en) * 2005-08-10 2007-02-15 Astrazeneca Ab Arylakylamines for the treatment of cancer
US8013165B2 (en) * 2008-12-24 2011-09-06 Astrazeneca Ab Ethanamine compounds and methods of using the same 545
JP2015501652A (ja) 2011-12-14 2015-01-19 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ Ｇａｂｒ−ａ２診断
ES2894903T3 (es) 2013-11-05 2022-02-16 Astrazeneca Ab Profármacos antagonistas de NMDA
KR20230026449A (ko) * 2020-06-23 2023-02-24 바이오하벤 테라퓨틱스 리미티드 (1s)-1-페닐-2-피리딘-2-일레탄아민의 국소 제형

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2673588A (en) * 1987-12-11 1989-06-15 Laboratoires Syntex 1,4-dihydropyridine derivatives as neuroprotective compounds
EP0356035B1 (en) * 1988-08-12 1996-03-13 Astra Aktiebolag Arylkalkyl-amines and -amides having anticonvulsant and neuroprotective properties

Also Published As

Publication number Publication date
AU3897693A (en) 1993-11-08
CA2133427A1 (en) 1993-10-14
KR100259567B1 (ko) 2000-07-01
SK281258B6 (sk) 2001-01-18
DE69317411D1 (de) 1998-04-16
CZ240994A3 (en) 1995-12-13
DE69317411T2 (de) 1998-07-30
RU2128650C1 (ru) 1999-04-10
TW282455B (ru) 1996-08-01
AU705419B2 (en) 1999-05-20
MY110149A (en) 1998-02-28
AU7545696A (en) 1997-02-13
DZ1677A1 (fr) 2002-02-17
EP0633879A1 (en) 1995-01-18
UA29437C2 (ru) 2000-11-15
NO943645D0 (no) 1994-09-30
ES2115055T3 (es) 1998-06-16
CZ288519B6 (cs) 2001-07-11
SG47948A1 (en) 1998-04-17
ZA932415B (en) 1993-10-22
CN1044367C (zh) 1999-07-28
ATE163925T1 (de) 1998-03-15
NZ251384A (en) 1996-10-28
FI105025B (fi) 2000-05-31
NO302170B1 (no) 1998-02-02
HU211529A9 (en) 1995-11-28
MA22866A1 (fr) 1993-12-31
IL105276A0 (en) 1993-08-18
WO1993020052A1 (en) 1993-10-14
NO943645L (no) 1994-11-16
CN1081669A (zh) 1994-02-09
JP2000319259A (ja) 2000-11-21
PL180014B1 (pl) 2000-11-30
EP0633879B1 (en) 1998-03-11
MX9301935A (es) 1994-08-31
SK117794A3 (en) 1995-05-10
CA2133427C (en) 2003-06-10
FI944546A0 (fi) 1994-09-30
HK1009331A1 (en) 1999-05-28
DK0633879T3 (da) 1998-09-28
JP3120810B2 (ja) 2000-12-25
FI944546L (fi) 1994-09-30
JPH07505385A (ja) 1995-06-15
IL105276A (en) 1997-06-10

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