[go: up one dir, main page]

RU92009774A - METHOD FOR PRODUCING 2-P-4 (5 '') DERIVATIVES - NITROIMIDAZOLE - Google Patents

METHOD FOR PRODUCING 2-P-4 (5 '') DERIVATIVES - NITROIMIDAZOLE

Info

Publication number
RU92009774A
RU92009774A RU92009774/04A RU92009774A RU92009774A RU 92009774 A RU92009774 A RU 92009774A RU 92009774/04 A RU92009774/04 A RU 92009774/04A RU 92009774 A RU92009774 A RU 92009774A RU 92009774 A RU92009774 A RU 92009774A
Authority
RU
Russia
Prior art keywords
optimally
nitroimidazoles
nitroimidazole
derivatives
nitric acid
Prior art date
Application number
RU92009774/04A
Other languages
Russian (ru)
Other versions
RU2049780C1 (en
Inventor
А.С. Енин
Л.Н. Ушкова
В.Г. Додух
А.А. Семенова
В.Л. Егоренков
П.М. Кочергин
Original Assignee
Государственный научно-исследовательский институт "Кристалл"
Filing date
Publication date
Application filed by Государственный научно-исследовательский институт "Кристалл" filed Critical Государственный научно-исследовательский институт "Кристалл"
Priority to RU92009774A priority Critical patent/RU2049780C1/en
Priority claimed from RU92009774A external-priority patent/RU2049780C1/en
Application granted granted Critical
Publication of RU2049780C1 publication Critical patent/RU2049780C1/en
Publication of RU92009774A publication Critical patent/RU92009774A/en

Links

Claims (1)

Изобретение относится к производным нитроимидазолов, в частности к способу получения нитроимидазолов общей формулы 2-R-4(5)-нитроимидазол, где R - или H, или CH3, или C2H5, которые являются полупродуктами в синтезе важных фармацевтических препаратов. С целью улучшения экологической чистоты процесса нитрование исходного имидазола проводят в растворе нитрата аммония в азотной кислоте при температуре 65 - 97o в течение 1,5 - 6 ч при соотношении компонентов нитрующей смеси, мас.ч. на 1 мас.ч. исходного имидазола: азотная кислота 5,9 - 16 (оптимально 7 - 9), нитрат аммония 1,3 - 5,4 (оптимально 1,5 - 1,75), вода 0,10 - 0,35 (оптимально 0,10 - 0,22). После нейтрализации аммиаком или натриевой щелочью до рН 4 и отделения продукта образующийся маточник в зависимости от используемого нейтрализующего агента направляют либо на огневое обезвреживание, либо на изготовление бетонных смесей с пониженной температурой замерзания или для производства промышленных взрывчатых веществ.The invention relates to derivatives of nitroimidazoles, in particular to a method for producing nitroimidazoles of the general formula 2-R-4 (5) -nitroimidazole, where R is either H or CH 3 or C 2 H 5 , which are intermediates in the synthesis of important pharmaceutical preparations. In order to improve the ecological purity of the process, the nitration of the initial imidazole is carried out in a solution of ammonium nitrate in nitric acid at a temperature of 65 - 97 o for 1.5 - 6 hours at a ratio of the components of the nitrating mixture, wt.h. per 1 part by weight starting imidazole: nitric acid 5.9 - 16 (optimally 7 - 9), ammonium nitrate 1.3 - 5.4 (optimally 1.5 - 1.75), water 0.10 - 0.35 (optimally 0.10 - 0.22). After neutralization with ammonia or sodium alkali to pH 4 and separation of the product, the resulting mother liquor, depending on the neutralizing agent used, is sent either to fire neutralization, or to the manufacture of concrete mixtures with a low freezing temperature or for the production of industrial explosives.
RU92009774A 1992-12-04 1992-12-04 Method for production of derivatives of 2-r-4(5)-nitro imidazoles RU2049780C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU92009774A RU2049780C1 (en) 1992-12-04 1992-12-04 Method for production of derivatives of 2-r-4(5)-nitro imidazoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU92009774A RU2049780C1 (en) 1992-12-04 1992-12-04 Method for production of derivatives of 2-r-4(5)-nitro imidazoles

Publications (2)

Publication Number Publication Date
RU2049780C1 RU2049780C1 (en) 1995-12-10
RU92009774A true RU92009774A (en) 1996-12-20

Family

ID=20133079

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92009774A RU2049780C1 (en) 1992-12-04 1992-12-04 Method for production of derivatives of 2-r-4(5)-nitro imidazoles

Country Status (1)

Country Link
RU (1) RU2049780C1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2122542C1 (en) * 1997-01-23 1998-11-27 Акционерное общество открытого типа "Ника-ЛКС" Method of synthesis of 2-(r)-4(5)-nitroimidazoles
TWI300409B (en) * 2004-02-18 2008-09-01 Otsuka Pharma Co Ltd Method for producing 4-nitroimidazole compound
RU2486177C1 (en) * 2012-02-16 2013-06-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Национальный исследовательский Томский государственный университет" (ТГУ) Method for preparing 2-methyl-4(5)-nitroimidazole
RU2610267C1 (en) * 2016-02-16 2017-02-08 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский государственный университет" (ТГУ, НИ ТГУ) Method for producing 4(5)-nitroimidazole
CN113788794B (en) * 2021-10-20 2023-07-14 西安海泽微流工程技术有限公司 Continuous nitration process for 2-methyl-5 nitroimidazole

Similar Documents

Publication Publication Date Title
ES2159039T3 (en) METHOD OF PREPARATION OF DINITRAMIDIC ACID AND ITS SALTS.
KR100381133B1 (en) An energetic placitizer comprising a eutetic mixture of bis(2,2-dinitropropyl)formal, 2,2-dinitropropyl 2,2-dinitrobutyl formal and bis(2,2-dinitrobutyl)formal, and a preparation method thereof
RU92009774A (en) METHOD FOR PRODUCING 2-P-4 (5 '') DERIVATIVES - NITROIMIDAZOLE
US4136117A (en) Preparation of 2,6-dinitroanilines
KR920701119A (en) Process for preparing dinitrotoluene using inorganic salt as phase separator
HU228517B1 (en) Method for producing isoureas
US4028410A (en) Process of preparing 1,3-bis(2-chloroethyl)-1-nitrosourea
IL63464A0 (en) Novel process for the production of a nitrate of a carbohydrate derivative and pharmaceutical compositions containing the compound produced by said process
RU2049780C1 (en) Method for production of derivatives of 2-r-4(5)-nitro imidazoles
EP0057889B1 (en) Process for preparing 1-alkyl-2-chloro-5-nitro-benzene-4-sulphonic acids
RU2147577C1 (en) Method of preparing n-(2-nitroxyethyl)nicotineamide
Shozda et al. Derivatives of azidosulfonic acid. Halides, amides, and salts
US4271300A (en) Method for producing 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-piperazinyl] qu
LV12185A (en) The yield of 4-halogen-2'-nitro-butyrophenone
KR100365648B1 (en) An energetic plasticizer comprising bis(2,2-dinitropropyl)formal and bis(2,2-dinitropropyl)diformal, and a preparative method thereof
RU1779243C (en) Process for producing 3-fluoro-4-aminophenol
US4683086A (en) Azido derivatives of pentaerythritol
US4233250A (en) Process for synthesizing the alkali metal salts of dinetromethane
SU578885A3 (en) Method of preparing 2,5,8,-tris-(o-or p-nitrophenyl-tris-triazolebenzol)
JPS62198678A (en) Manufacture of fluorinated o-diaminobenzo-1,4-dioxenes
SE8305453L (en) PROCEDURE FOR PREPARING LIGNOSULPHONATE BASED MIXTURES SPECIFICALLY USED AS CONCRETE ADDITIVES
JPS56100748A (en) Preparation of n,n'-unsubstituted-5-nitrosophthalic acid diamide
US3474092A (en) Nitro-derivatives of uron and urea
KR100281825B1 (en) Process for preparing dinitroamide salt
JPH02233649A (en) Preparation of 2-nitro-4-trifluoromethylaniline