RU2406505C2 - Method of treating inflammatory disease of metacarpus and metatarsus in dogs - Google Patents

Abstract

FIELD: medicine, veterinary science.

SUBSTANCE: invention refers to veterinary science, and can be used in treating an inflammatory disease of metacarpus and metatarsus in dogs. The method provides application of tourniquet on the affected extremity above a drug introduction point. The drug is introduced daily or every second day; the drug is presented with antibiotics or antihistamines, or proteinase inhibitors, or cytostatics for 5-15 days towards a distal part of the extremity in the amount 5-10 ml; thereafter physiologic saline 1-2 ml is introduced in the drug introduction point. The tourniquet is applied below the drug introduction point. The tourniquet is kept on an animal's body for 10 minutes; the introduction point is covered with a sterile bandage.

EFFECT: invention allows to reduce treatment length and to improve clinical effectiveness.

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Description

The invention relates to veterinary medicine and can also be used to treat dog finger tumors, prevent complications and accelerate healing after surgical interventions on the distal extremities.

Known methods of treating inflammatory diseases in animals, including dogs, consisting in intramuscular, or intravenous, or in the area of damage administration of drugs. (See: 1. RF patent No. 2139695, A61D 7/00. "A method for the treatment of inflammatory processes in joints, tendons and their vaginas in cattle and dogs." 2. RF patent No. 22533456, A61K 31/635. "Method treatment of inflammation or inflammation-related illness in dogs. "3. Book" General Veterinary Surgery ", authors: Bashkirov B.A., Belov A.D. et al., Moscow, VO" Agropromizdat ", 1990, chapter XVI" Diseases bones ", p. 440. 4. The book" Complex therapy and therapeutic technique in veterinary medicine ", M., Doe, edited by A. Stekolnikov, signed on 11/20/2006, pp. 119-121 - prot otip.)

The disadvantages of the known methods of treating inflammatory diseases are: a long treatment period, low treatment effectiveness. These shortcomings are especially evident in the treatment of various etiologies of inflammatory diseases of the metacarpus and metatarsus in dogs of all breeds. The treatment is complicated by the fact that it is almost impossible to reduce the load on the metacarpus and metatarsus, even during the treatment of the animal, and also due to the fact that tendons and articular cartilages have weak vascularization. Intramuscular and simple intravenous administration of antibiotics and other anti-inflammatory drugs does not allow them to create a sufficiently high concentration at the site of inflammation.

The objective of the invention is to increase the effectiveness of the treatment of inflammatory diseases of the metacarpus and metatarsus in dogs of all breeds by quickly creating a high concentration of antibiotics and / or anti-inflammatory drugs locally, directly at the site of inflammation, which is achieved by the introduction of drugs intravenously against blood flow (retrograde).

The technical result of the task is achieved by the fact that in the method of treating inflammatory diseases of the metacarpus and metatarsus in dogs, comprising applying a tourniquet to the affected limb above the injection site of the drug, daily or every other day intravenous administration of the drug - antibiotics, or antihistamines, or proteinase inhibitors, or cytostatics, for 5-15 days in the direction of the distal limb in a volume of 5-10 ml, the introduction of 1-2 ml of sterile saline in m hundred drug administration, overlay harness below the site of administration, the retention of an animal body harness for 10 minutes and overlay in place of drug administration with sterile bandages.

A method of treating inflammatory diseases of the metacarpus and metatarsus in dogs is as follows.

Excitable or vicious animals should be immobilized before conducting therapeutic manipulations. Otherwise, there is a high probability of injury to the vessel wall with a needle when the animal is disturbed. To simplify the implementation of medical manipulation in the vein of an animal’s limbs, a special plastic catheter can be left for the entire treatment period. Depending on the etiology and pathogenesis of the disease, antibiotics, antihistamines, proteinase inhibitors, and cytostatics can be used as therapeutic agents.

A tourniquet is placed on the shoulder (or thigh) of the affected limb above the needle injection site. In the superficial vein of the forearm (or) lower leg in a volume of 5-10 ml (depending on the size of the dog) in the direction of the distal part of the limb (from head to fingers - against blood flow), a drug of the following composition is injected: for example, in one syringe are collected: an antibiotic - cefazolin 0.5 grams, a proteinase inhibitor - gordox 2 ml (which corresponds to 200,000 units / d) and an anti-inflammatory cytostatic - dexamethasone 1 ml. The volume of drugs is brought to 5-10 ml with sterile physiological sodium chloride solution. The drug is administered slowly. In order for the entire drug to completely get into the inflammation zone, and not to remain on the superficial vein, after the end of administration, we add 1-2 ml of sterile physiological saline through the same needle. Then, distally from the injection site of the needle (to prevent blood and drug leakage under the skin), we apply a second tourniquet. Hold the harnesses on the animal's body for 10 minutes. After 10 minutes, remove the harnesses. At the injection site, we apply a sterile dressing. To achieve a therapeutic effect (depending on the cause and extent of the lesion), 5-10-15 injections are performed. One injection of 5-10 ml per day or every other day. The duration of treatment is 5-15 injections. Intravenous retrograde administration of drugs can be combined with other methods of drug administration.

Studies were conducted on 25 dogs for the three most common diseases.

Diagnosis The number of animals studied ALT before treatment (mmol / L) ALT after treatment (mmol / L) Duration of treatment (days) Exodus Phlegmon 7 180-320 80-150 5-10 Recovery Eczema fifteen 170-230 80-145 7-10 Recovery Dermatitis 3 170-195 80-120 3-7 Recovery

Comparative data of the claimed method and the prototype method Total treated (number of animals) The average time of onset of cytological healing criteria (day from the start of treatment) The average term of clinical recovery (day from the start of treatment) Remission, duration over 6 months (number of animals) Standard treatment fifteen 7 14 (8-20) 3 Treatment using the claimed method 19 four 9 (5-13) fifteen

The table of comparative data shows that:

- when implementing the claimed method, cytological signs of healing occur earlier;

- when implementing the inventive method, clinical recovery occurs earlier;

- when implementing the claimed method, remission lasts longer (the period from recovery to relapse of the disease);

- when implementing the claimed method, remission (the period from recovery to relapse of the disease) occurs in a larger number of treated animals.

The positive effect of the use of the present invention lies in the high treatment efficiency due to the creation and retention of a high concentration of retrogradely administered drugs directly to the site of inflammation, which also significantly reduces the treatment time for the disease.

Claims (1)

A method of treating an inflammatory metacarpal and metatarsal disease in dogs, comprising applying a tourniquet to the affected limb above the drug injection site, daily or every other day intravenous drug administration - antibiotics, or antihistamines, or proteinase inhibitors, or cytostatics for 5-15 days direction to the distal part of the limb in a volume of 5-10 ml, the introduction of 1-2 ml of sterile physiological saline at the injection site of the drug, applying a tourniquet below the injection site the preparation, holding the tourniquets on the animal’s body for 10 minutes and applying a sterile dressing to the injection site.