RU2383352C1 - Agent for prevention of development and treatment of inflammatory processes in animals - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: agent for prevention of development and treatment of inflammatory processes in animals is represented by a medication, for preparation of which the mixture of the following components ground to fine and ultrafine particles, which are treated with beams of ultraviolet lamps is placed into dry sterile reservoir made of dark glass, such as medicinal plants at their ratio in powder of 25.0 g (by 1.25 wt %): dry leaves, stems, flowers of peppermint, dry flowers of wild chamomile, dry leaves of costmary anthodes, dry leaves, stems, flowers, fruit of plaster clover, dry herb of touch-and-heal, dry flowers of pot marigold (calendula), dry herb of yarrow, dry herb of thyme, dry leaves, stems, flowers, fruit of killwort, dry leaves of eucalyptus, dry leaves and anthodes of foalfoot, dry leaves of garden sage, dry leaves of stinging nettle, dry herb of lady's thumb, dry flowers of densely flowered mullein corolla (dense mullein), ground fruit of anis and fruit of cinnamon rose, ground kernels of walnut fruit, seedless pulp of sea-buckthorn (if not available, sea-buckthorn oil), vegetable raw materials with weight of 500.0 g (25 wt %) is mixed with 1500.0 g (75 wt %) of vegetable oil (corn, sunflower-seed, olive). After maintenance at room temperature and permanent mixing during 10 days, dark glass reservoir with mixture is placed into water bath for 5 days at the temperature of up to 40°C. Oil infusion is separated from vegetable raw materials, preserved at the temperature of 2-4°C in dark glass reservoirs or in dark room.

EFFECT: improved efficiency of treatment and prophylactics.

3 cl

Description

The present invention relates to veterinary medicine, specifically to means and preparations from medicinal plants to prevent the development and treatment of inflammatory processes on the surface of the body and inside the body of the animal.

According to the patent of the Russian Federation No. 2336868 (5), a method of treating wounds is known in which a medicine is applied to the surface of the damaged part of the animal’s body to prepare which medicinal substances are placed in a dark glass container in the following ratio of components in g (wt.%): Sea buckthorn 150.0 (39.68), 0.9% sterile sodium chloride solution - 150.0 (39.68), a mixture of dry leaves, stalks, peppermint flowers, crushed to an amorphous powder - 20.0 (5.29 ), dried flowers of chamomile pharmacy - 20.0 (5.29), dry leaves of large plantain - 20.0 (5.29), dry flower baskets tansy - 15.0 (3.97) formalin - 3.0 (0.8) and left under stirring at room temperature for 10-15 days, then the liquid portion was separated and used for other purposes. It was experimentally determined that after a single treatment of a fresh wound and its plentiful lubrication with the liquid part of the preparation or with vegetable-lanolin ointment, flies do not sit on it and do not lay eggs and larvae for up to 2 hours, the wound defect is filled with granulation tissue in 1-2 days, infected wounds - in 3-4 days, by the end of 4-5 days, inflamed wounds heal after removal of the larvae of bestial flies.

The purpose of the invention is the rational use of herbal medicines of Russia with the maximum extraction of therapeutic substances from them.

This goal is achieved by the fact that in a dry sterile container of dark glass is placed a mixture of crushed to small and tiny particles treated with ultraviolet light, medicinal plants with a powder ratio of 25.0 g (1.25 wt.% Each): dry leaves , stalks, peppermint flowers, dried chamomile flowers, dry flower tansy baskets ordinary, dry leaves, stems, flowers, fruits of sweet clover, dry grass St. John's wort, dried flower marigold (calendula), dry grass thousand ovary, dry thyme grass, dry leaves, stems, flowers, large celandine fruits, dry eucalyptus leaves, dry leaves and coltsfoot flower baskets, dry leaves of sage officinalis, dry leaves of dioecious nettle, dry grass of highlander, dried flowers of corolla mullein of dense (scepter-like), crushed anise fruits and brown rose hips, crushed walnut kernels, pulp without seeds of sea buckthorn fruit (if there are no sea buckthorn oil), mix the plant raw materials oh 500.0 g (25 wt.%) with 1500.0 g (75 wt.%) vegetable oil (corn, sunflower, olive) and leave at room temperature with constant stirring for 10 days, then a container of dark glass with the mixture is placed in a water bath for 5 days at temperatures up to 40 ° C, then the oil infusion is separated from the plant material, stored at a temperature of 2-4 ° C in closed containers of dark glass or in a dark room.

The rationale for the preparation technology:

- when processing dry plants with ultraviolet rays, provitamins (karanoids, stearins, etc.) are converted into vitamins, the digestibility of phosphoric-calcium salts increases, microorganisms die (1, t.2, p.335);

- when grinding the dry source of plant materials to a fine and finest powder, the total contact surface of its particles with vegetable oil significantly increases, and at room temperature, oily, essential, oil-soluble and other substances that have a therapeutic effect are extracted when the mixture is heated in a water bath to 40 ° C their amount in the solvent increases to a maximum;

- when the temperature in a water bath and mixture rises above 40 ° C, substances working at temperatures above the animal’s body temperature are extracted into vegetable oil, therefore they do not have a therapeutic effect, and sometimes they can even be harmful.

Drug preparation technology

1. Select, exempt from unnecessary inclusions, dry medicinal plants necessary for preparation, weigh them, place them in a thin layer on a table and treat them with hypererythemic biodoses (1, t.2, p.335) of ultraviolet rays of PRK-2M mercury-quartz lamps, PRK-4, PRK-5, PRK-7, PRK-8 for those. conditions No. 16-3-10, LRK-2 or others (8), but at the same time the maintenance personnel should be in special safety glasses, and the room in which the plants are irradiated should be well ventilated. At the same time, provitamins A, D, E, K are converted into vitamins and extracted with oil, because they are oil soluble.

2. Dry medicinal plants, fruits of common anise and wild rose hips of full maturity are crushed to a fine and finest powder, the fruits of walnut are crushed in a mixture with dry plants.

3. The crushed vegetable raw materials are placed in a dark glass container, mixed thoroughly with the vegetable oil poured here, the pulp of seedless sea buckthorn fruits or sea buckthorn oil are added.

4. The resulting mixture was left at room temperature and with constant stirring for 10 days, then the container with the mixture was placed for 5 days in a water bath with a temperature of up to 40 ° C and constantly stirred.

5. The oil infusion is separated from the plant material, packaged in a container of dark glass, stored at 2-4 ° C in closed vessels.

Note: when indicated, any of these operations is repeated.

6. Waste plant materials are included in the diet of pigs and chickens as a feed and therapeutic agent, chickens - when pecking as a medicine.

Pharmacodynamics of the ingredients of the drug:

- stems, leaves, flowers of peppermint contain substances that have local anesthetizing, antispasmodic, wound healing, anti-inflammatory effects (1, t.2, p.138; 2, p.177; 3, p.1 p.346; 6, p .191);

- substances of chamomile pharmacy flowers have anti-inflammatory, hemostatic, antiseptic, astringent, analgesic, sedative, anticonvulsant, antispasmodic disinfecting effects, reduce tension of cells and tissues, accelerate the growth and development of granulation tissue cells (1, v.2, p. 318; 2, p.212; 3, p.1, p.341; 4, p.212; 6, p.247-250);

- substances of large plantain leaves have anti-inflammatory, bacteriostatic, wound healing, anti-sclerotic, antispasmodic effects (2, p.192; 3, part 1 p.368; 6, p.234);

- flower tansy common baskets contain substances that have anti-inflammatory, antimicrobial, antihelminthic effects on roundworm and pinworms (2, p. 189-191; 6, p. 234-237);

- in the thin stems, leaves, flowers, fruits of the medicinal sweet clover there are substances with anticonvulsant, anti-inflammatory, narcotic, distracting, emollient action (1, t.1, p.297, 2, p.99; 4, p.212; 6 , p. 95);

- Hypericum perforatum grass contains substances that have anti-inflammatory, astringent, hemostatic, antimicrobial effects, stimulating effect on the growth and development of normal cells in wounds and burns of the 2nd and 3rd degree (2, p. 116; 3, part 1, p.339; 6, p.108);

- substances of flower marigold flower baskets (calendula) have anti-inflammatory, bactericidal, wound healing, antispasmodic effects (2, p.126; 3, part 2, p.423; 6, p.139);

- yarrow herb has anti-inflammatory, hemostatic, wound healing, analgesic effects (1, t. 1, p. 467; 2, p. 240; 3, part 2, p. 86; 4, p. 223; 6, p. 293);

- thyme herb contains substances that have a disinfectant, analgesic, sedative, anti-inflammatory effect (2, p. 252; 3, part 1, p. 364);

- leaves, stems, flowers, fruits of large celandine contain substances that have a fungistatic, bacteriostatic, analgesic, antispasmodic effect, and substances that delay the proliferation of cells of malignant neoplasms (1, v.2, s.542; 2, s.261-262; 6, p. 328-329);

- substances of leaves of ball, ash, twig eucalyptus have analgesic, antispasmodic, anti-inflammatory, antiseptic, antiparasitic, expectorant effects, accelerate the growth and maturation of granulation tissue (2, p.272; 3, p.1, p.350; 4, p .216; 6, p. 345);

- leaves and flower baskets of coltsfoot contain substances that have anti-inflammatory, emollient, antispasmodic, expectorant, enveloping, antimicrobial effects (2, p. 169; 3, part 1, p. 344; 6, p. 180) ;

- stems, leaves, flowers of medicinal sage contain substances that have anti-inflammatory, astringent, disinfectant, antimicrobial effects (1, t.2, p.255; 2, p.264; 3, part 1, p.340; 4, s .187; 6, p. 329-331);

- dioecious nettle leaves contain vitamins K, A, C, have a hemostatic effect, accelerate blood coagulation, increase hemoglobin in it, increase smooth muscle tone, stimulate the growth of granulation tissue (2, p. 142; 3, part 2, p. 86; 6, p. 133-135);

- the grass of the highlander contains the substances with hemostatic and antibacterial action (2, p. 95; 3, part 2, p. 86; 6, p. 80);

- flowers of the corolla of the mullein of the dense (scepter-like) contain substances that have an emollient, anti-inflammatory, analgesic, astringent, enveloping, anti-inflammatory effect (1, v. 1, p. 517; 2, p. 140; 4, p. 190; 6, p .140);

- the substances of the fruits of anise ordinary have an antipyretic, anti-inflammatory, expectorant, slightly disinfecting effect (1, v. 1, p. 34; 2, p. 73; 3, part 1, p. 344; 4, p. 210; 6, p.29);

- fruits of full maturity of brown rose (brown roses, needle roses, Daurian roses, Fedchenko roses and other types of rosaceae and dog rose) contain vitamins and provitamins, anti-inflammatory, antipyretic, choleretic substances, contain substances that reduce the permeability and fragility of blood capillaries substances that delay the development of arteriosclerosis, stimulating the reproduction, growth and development of granulation tissue cells (2, p. 266; 3, part 2, p. 30 and 46; 4, p. 316-188; 6, p. 344);

- walnut kernels contain substances and oils that have a bactericidal, anti-inflammatory, anti-sclerotic, hemostatic, astringent, epithelizing, wound healing effect (7, p. 37-42);

- substances from the pulp of sea buckthorn fruit or pear-shaped buckthorn oil or oil from the pulp of sea buckthorn fruit have analgesic, epithelizing, granulating, anti-inflammatory effects, are used in the treatment of radiation injuries of the skin, in radiation therapy for cancer of the esophagus, to reduce degenerative changes in the inflamed area, are used in the treatment of eczema, gastric ulcer (3, part 2, p. 47; 6, p. 203);

- vegetable oil;

- corn oil is obtained from grains, has an emollient effect, reduces the level of cholesterol in the blood, is recommended for the prevention and treatment of atherosclerosis (2, p.148; 6, p.156);

- sunflower oil is obtained from seeds peeled from the husk, - it is a thick, clear, light yellow liquid after sedimentation with a peculiar smell or without it, it dries slowly in the air (1, t.1, p.198, 4, p.191) ;

- olive oil: a) simple - a clear brown-yellow or greenish liquid with a peculiar smell and taste, does not dry out in air; b) Provence - the highest grade of olive oil, obtained by cold pressing the pulp of selected fresh olives (1, t. 1, p. 57; 4, p. 191).

Due to the fact that the resulting oil-herbal preparation (agent) contains many low-melting medicinal substances of medicinal plants that have been tested by the centuries-old practice of traditional medicine, it simultaneously has a versatile effect in preventing the development and treatment of inflammatory processes on the body surface and inside the body.

During experimental tests of the effectiveness of the drug (agent), quite encouraging results were obtained, for example, fresh damage to the body surface after the toilet and the application of tampons lubricated with the preparation were covered with granulation tissue by the end of the first day, the inflamed lesions healed by the end of 4 days, signs of acute vaginitis in cows disappeared by the 3rd day, acute postpartum endometritis by the end of the 5th day, signs of diarrhea in piglets of the group 2-4 months with disorders of the gastrointestinal tract is ezali by the end of the day, after feeding barley Durty dampened oil-herbal preparation.

We believe that the proposed drug will find wide application in veterinary medicine.

Literature

1. Veterinary Encyclopedic Dictionary. M.: Selkhozizdat, volumes 1 and 2, 1950 and 1951.

2. Kovaleva N.G. Treatment with plants. M .: Medicine, 1971

3. Mashkovsky M.D. Medicines M .: Medicine, parts 1 and 2, 1987.

4. Brains I.E. Pharmacology. M .: Selkhozizdat, 1954

5. Moiseev O.N. A method of treating wounds. RF patent No. 2336868, 2008

6. Schreter A.I., Muravyova D.A., Pakaln D.A., Efimova F.V. Medicinal flora of the Caucasus. M .: Medicine, 1979

7. Nesterova A.V. editor - compiler. Black and walnuts against cancer. LLC "ID RIPOL classic". 107140, Moscow, Krasnoprudnaya St., d. No. 22 "a", p. 1. Ed. persons No. 04620 dated April 24, 2001

8. Mercury-quartz irradiator. Operation manual and passport. Odessa edition of the Reklama publishing house, 07/22/1968.

8 "a" Instruction manual for mercury-quartz lamps of types PRK-2M, PRK-4, PRK-5, PRK-7M, PRK-8. Those. conditions No. 16-3-10

8 "b" Mercury-quartz irradiator. Manual. Odessa Laboratory Equipment Plant, 1978

8 "g" Edited by V.M. Bogolyubov. Technique and methods of physiotherapeutic procedures. Directory. M .: Medicine, 1983, p. 252-276.

Claims (3)

1. Means for preventing the development and treatment of inflammatory processes in animals, containing a medicinal product, for the preparation of which vegetable oil is placed in a dark glass container, a mixture of crushed dry leaves, stems, peppermint flowers, dried pharmacy chamomile flowers, dried large plantain leaves, dried tansy flower baskets ordinary and left with stirring at room temperature for 10 days, characterized in that in a dry sterile container of dark glass is placed a mixture of crushed about small and smallest particles treated with ultraviolet light, medicinal plants with a powder ratio of 25.0 g (1.25 wt.% each): dry leaves, stalks, peppermint flowers, dried flowers of pharmacy chamomile, dried flower leaves baskets of tansy, dry leaves, stems, flowers, fruits of sweet clover, dry herb St. John's wort, dried flowers of marigolds (calendula), dry grass of yarrow, dry grass of thyme, dry leaves, stems, flowers, fruits of large celandine, dry leaf eucalyptus eucalyptus, dry leaves and flower baskets of coltsfoot, dry leaves of medicinal sage, dry leaves of nettle nettle, dry grass of highlander, dried flowers of corolla of mullein (scepter), chopped anise fruits and brown rosehip kernels, chopped walnuts, seedless fruit of sea buckthorn fruits (if they are not, sea buckthorn oil), vegetable raw materials weighing 500.0 g (25 wt.%) are mixed with 1500.0 g (75 wt.%) vegetable oil (corn, sunflower, olive). 2. The tool for preventing the development and treatment of inflammatory processes in animals according to claim 1, characterized in that after leaving at room temperature and constant stirring for 10 days, a container of dark glass with the mixture is placed in a water bath for 5 days at temperatures up to 40 ° C. . 3. The tool for preventing the development and treatment of inflammatory processes in animals according to claim 1, characterized in that the oil infusion is separated from the plant material, stored at a temperature of 2-4 ° C in dark glass containers or in a dark room.