WO2012131728A2

WO2012131728A2 - A herbal medication to cure bloat in animals

Info

Publication number: WO2012131728A2
Application number: PCT/IN2012/000225
Authority: WO
Inventors: Somabhai Dhulabhai PARMAR
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-03-31
Filing date: 2012-03-30
Publication date: 2012-10-04
Anticipated expiration: 2013-09-30
Also published as: WO2012131728A3

Abstract

The present invention provides a herbal composition to treat bloating in animals. Said composition is a synergistic combination of extracts of plants Cassia occidentalis, Matricaria chamomilla, Ocimum basilicum and Origanum vulgare. The present invention also provides a process for the preparation of said herbal formulation for the treatment of bloat in animals.

Description

A HERBAL MEDICATION TO CURE BLOAT IN ANIMALS

FIELD OF INVENTION

The present invention relates to a herbal medication to cure bloat in animals. More particularly, the present invention relates to a herbal composition comprising extracts of plants Cassia occidentalis, Matricaria chamomilla, Ocimum basilicum and Origanum vulgare for the treatment of bloating and a method for preparation thereof.

BACKGROUND OF THE INVENTION

Bloating is any abnormal general swelling, or increase in diameter of the abdominal area. As a symptom, the patient feels a full and tight abdomen, which may cause abdominal pain sometimes accompanied by increased borborygmus or more seriously the total lack of borborygmus.

Bloat occurs when pressure builds up in the stomach due to accumulation of gas, fluid or foam creating pressure on the surrounding organs. The animal experiences intense abdominal pain and breathing difficulty and can die if left untreated. Bloat is characterized by a distended, swollen- looking belly and sometimes become apparent when the animal tries to empty its stomach. Particularly seen in dogs and cats when they try to vomit or belch but aren't able to; they retch and seem restless and nauseated. They may also become short of breath as their abdomens become compressed. Some animals may act depressed or show signs of pain. In severe cases, the pressure the stomach places on blood vessels can cause irregular blood flow, abnormal heart rhythms, and shock, which can cause animals to collapse and can lead to rapid death.

Ruminant animals produce large volumes of gas during the process of digestion. This gas either is belched up or passes through the gastrointestinal tract. Bloat occurs when something interferes with gas escape from the rumen resulting in distention of the rumen. The ruminant suffering from bloat has symptoms of abnormal hypertrophy of rumen capacity, decline in feeding activity, decline in rumination behaviour, dyspnea, and the like. In acute cases, the animal dies as the swollen rumen compresses the lungs, interfering with breathing and tissue oxygenation obstructing the blood flow. Bloat has been recognized as one of the major diseases that cause large economic loss in production field of domestic animals.

The medications that have been used to treat bloating includes anti-foaming agents, antibiotics and some herbs like Brassica nigra, Ocimum basilicium, Grewia ferruginea, turmeric and Anthocephalus sp. However, it is desirable to develop a more effective biological treatment for bloat.

The present invention provides a herbal formulation prepared from Cassia occidentalis, Matricaria chamomilla, Ocimum basilicum, Origanum vulgare.

Cassia occidentalis belongs to family fabeaceae and called as kasundi in Hindi. It is found in tropical and temperate area and is very commonly seen all over. It is found every where in India. Seeds of this plant contain tannic acid, mucilage which is about 36%, stable oils that are about 2.56%. It also contains amodiene, toxalbumin and crisarobin.

This plant is kapha dosha suppressant. It has good effects on skin related ailments. It also decreases the effect of. poison. It acts as analgesic and thus helps in minimizing the pain in the body. It is also effective in convulsions. It normalizes the digestion and rectifies the secretions in the body. It tones up the respiratory tract. It is also effective in pyrexia. It is used for skin disease, convulsions and fits, respiratory tract disorder, urine disorder, fever.

Reference is made to "Tropical plant database- Fedegoso (Cassia occidentalis)" , wherein it has been disclosed that the leaves and roots of Cassia occidentalis are used as a remedy for bacterial and fungal infections are also shown to boost "immune function". The leaves/roots are an ingredients of many popular herbal liver tonics and medicines for liver disorders. It is also used for the treatment of abscesses, insect bites, scorpion sting, constipation, diabeties, oedema, fever, inflammation, itch, rheumatism, ringworm, scabies, skin diseases, snakebite and wounds.

Matricaria chamomilla or German chamomile also commonly called as chamomile. It grows as a weed all over dry parts of India. Chamomile is used for peptic ulcer, nervous dyspepsia, travel sickness, nasal catarrh, restlessness, and mild sleep disorders. It is used for hemorrhoids, mastitis, boils, burns, leg ulcers, eczema and irritations of the skin, skin care (most skin-types), acne, and mucosa anywhere in the body. It is good for allergies, colds, fever, sore gums, sore throats, bronchitis, inflamed skin conditions, earache, wounds, menstrual pain, premenstrual syndrome, headache, insomnia, nervous tension and other stress related disorders. It has a very low toxicity; therefore it is useful for children. Chamomile flowers are recommended as a tonic in dropsical complaints for their diuretic and tonic properties, and are also combined with diaphoretics and other stimulants with advantage. It is used in the treatment of anxiety and nervous tension, for the relief of spasmodic pain such as dysmenorrhoea or migraine, and is a safe remedy for children's problems with a nervous component. The bitter glycosides in chamomile stimulate the appetite and digestive activity, and the herb also helps relieve inflammatory conditions of the upper digestive tract, menopausal symptoms, mastitis, amenorrhea with a psychological component (e.g. anorexia nervosa), and hysteria.

Ocimum basilicum also called as albahaca in Hindi. It is very useful in the case of the hiatal hernia. The aroma of the plant stimulates the appetite, reduces nausea, and can also stimulate the production of milk in nursing mothers. It strengthens the nervous system, treats mouth ulcers and bad breath, and can even be used in abdominal massages. A seed of albahaca placed in the eye will remove unwanted material from the eye, like mucus.

Oreganum vulgare commonly called as oregano. It belongs to mint family-labiateae. Its active components are rosemarinic acid, stearic acid, palmitic acid, oleic acid, ursolic acid. Essential oil rich in thymol, cineol, carvacrol, borneol, beta-bisolobene, limonene, alpha-pynene, beta-pynene, myrcene, camphene, minerals, tannins and vitamins niacin, (beta-carotene).

It is used medicinally as bactericide, anti inflammatory, expectorant, antiseptic and febrifuge. SUMMARY OF THE INVENTION

The present invention provides an herbal composition useful in the treatment of bloat. The herbal composition comprises a therapeutically effective combination of extracts prepared from the plants Cassia occidentalis, Matricaria chamomilla, Ocimum basilicum and Origanum vulgare.

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to a synergistic herbal composition useful for the treatment of bloating, said composition comprising a therapeutically effective amount of extracts obtained from the plants Cassia occidentalis, Matricaria chamomilla, Ocimum basilicum and Origanum vulgare, optionally along with pharmaceutically acceptable additives.

The herbal composition of the present invention containing the combination of extracts of plants Cassia occidentalis, Matricaria chamomilla, Ocimum basilicum and Origanum vulgare, is prepared by a process comprising the steps of :

(i) Washing and mixing plant material obtained from the plants Cassia occidentalis, Matricaria chamomilla, Ocimum basilicum and Origanum vulgare;

(ii) Drying the plant material of step (i) under shade condition to remove the excess moisture followed by grinding and sieving to obtain fine powder of the plant materials;

(iii) weighing amount of plant powder obtained in step (ii) and adding double volume of water into it;

(iv) allowing the mixture of step (iii) to stand for some time followed by stirring continuously, repeating this step for several times;

(v) filtering the resulting mixture of step (iv) to obtain water extract of the plant;

(vi) evaporating excess water from the resulting extract with the help of a rotary vacuum evaporator followed by lyophilizing the extract to obtain fine powder;

(vii) mixing the powder obtain in step (vi) with water to obtain the final formulation.

In an embodiment, the plants are mixed in a proportion of Cassia occidentalis 50 to 60 wt. %, Matricaria chamomilla 15 to 20 wt. %, Ocimum basilicum 5 to 10 wt. %, Origanum vulgare 5-10 wt. %, along with conventional additives to form an oral dosage form. In an embodiment, the plant material is selected from the group consisting of a whole plant, a rhizome, a leaf, a seed, a root, a bark, a flower or a fruit. In another preferred embodiment, plant material is leaves of Cassia occidentalis, leaves of Matricaria chamomilla, stem of Ocimum basilicum and leaves of Origanum vulgare.

In an embodiment, the mixture of step (iv) is allowed to stand for 2-3 hours followed by stirring continuously for 30 minutes, repeating this step for 3-4 times.

The composition of the present invention may be administered as such or in admixture with a pharmaceutically acceptable vehicle, adjuvants, inactive excipients, diluents or lubricants.

Non-limiting examples of pharmaceutically acceptable vehicle, adjuvants, inactive excipients, diluents or lubricants which can be used in the composition of the present invention include: cellulose, substituted cellulose, calcium carbonate, dicalcium phosphate, starches, lactose, modified food starches, dextrose, calcium sulfate, magnesium carbonate, magnesium stearate, stearic acid, glycerin, vegetable oils, polysorbates or lecithin. The herbal composition can be formulated in the form of decoction, dried decoction, infusion, tincture, dried extract, capsule, tablet, syrup or the like.

A dose of 50-150 gm of formulation, 2 times daily for 2 days is effective for treatment of bloating. There exist a synergism in the ingredients of the formulation of the present invention. The following example is given by way of illustration and therefore should not be construed to limit the scope of the present invention.

Example 1: The formulation of present invention was prepared by mixing leaves of Cassia occidentalis (60g), leaves of Matricaria chamomill (20g), stem of Ocimum basilicum (lOg) and leaves of Origanum vulgare (lOg). The Plant samples were collected brought to laboratory and dried under shade condition to remove the excess moisture. The dried plant sample is powdered with the help of laboratory grinder and sieved through mesh to obtain fine powder of the plant. Weighed amount of plant powder is taken into a vessel and double volume of water is added to it. The solution is allowed to stand for 2 to 3 hours and then stirred continuously for 30 minutes with the help of a laboratory stirrer. The above process is repeated 3 - 4 times. After stirring the solution is filtered with a filter paper to obtain water extract of the plant. Excess water of the solution is evaporated with the help of a rotary vacuum evaporator and extract is then lyophilized to obtain fine powder. The lOOg mixed powder is used for medication.

Twelve experimental animals were identified based on the clinical symtoms involving position, distention of flank, type of respiration, appetite. Animals were found with partially anorectic to total anorexia. A dose of 50 gm of formulation twice a day was fed to these affected animals and observed for a day. It was found that test animals were the formulations was fed recovered from clinical signs in less than 8 hours duration.

Example 2

The formulation of present invention was prepared from Ocimum basilicum (lOOg). The Plant samples were collected brought to laboratory and dried under shade condition to remove the excess moisture. The dried plant sample is powdered with the help of laboratory grinder and sieved through mesh to obtain fine powder of the plant. Weighed amount of plant powder is taken into a vessel and double volume of water is added to it. The solution is allowed to stand for 2 to 3 hours and then stirred continuously for 30 minutes with the help of a laboratory stirrer. The above process is repeated 3 - 4 times. After stirring the solution is filtered with a filter paper to obtain water extract of the plant. Excess water of the solution is evaporated with the help of a rotary vacuum evaporator and extract is then lyophilized to obtain fine powder. The lOOg mixed powder is used for medication.

Six experimental animals were identified based on the clinical symtoms involving position, distention of flank, type of respiration, appetite. Animals were found with partially anorectic to total anorexia. A dose of 50 gm of formulation twice a day was fed to these affected animals and observed for a day. It was found that test animals were the formulations was fed recovered from clinical signs after 3 days.

Example 3

The formulation of present invention was prepared from Origanum vulgare (100g). The Plant samples were collected brought to laboratory and dried under shade condition to remove the excess moisture. The dried plant sample is powdered with the help of laboratory grinder and sieved through mesh to obtain fine powder of the plant. Weighed amount of plant powder is taken into a vessel and double volume of water is added to it. The solution is allowed to stand for 2 to 3 hours and then stirred continuously for 30 minutes with the help of a laboratory stirrer. The above process is repeated 3 - 4 times. After stirring the solution is filtered with a filter paper to obtain water extract of the plant. Excess water of the solution is evaporated with the help of a rotary vacuum evaporator and extract is then lyophilized to obtain fine powder. The lOOg mixed powder is used for medication.

Eight experimental animals were identified based on the clinical symtoms involving position, distention of flank, type of respiration, appetite. Animals were found with partially anorectic to total anorexia. A dose of 50 gm of formulation twice a day was fed to these affected animals and observed for a day. It was found that test animals were the formulations was fed recovered from clinical signs after 4 days.

ADVANTAGES OF THE INVENTION

1. The present invention provides a synergistic composition for the treatment of bloating in animals.

2. Cost effective

Claims

We claim:

1. A herbal composition to treat bloating, the said composition comprising combination of extracts of plants Cassia occidentalis, Matricaria chamomilla, Ocimum basilicum and Origanum vulgare, prepared by a process comprising the steps of :

(i) washing and mixing plant material obtained from the plants Cassia occidentalis,

Matricaria chamomilla, Ocimum basilicum and Origanum vulgare;

2. The herbal composition as claimed in claim 1, wherein the plant material in step (a) is selected from the group consisting of a whole plant, a rhizome, a leaf, a seed, a root, a bark, a flower or a fruit.

3. The herbal composition as claimed in claim 1, wherein the plant material in step (a) is in a proportion of: Cassia occidentalis 50 to 60 wt. %, Matricaria chamomilla 15 to 20 wt. %, Ocimum basilicum 5 to 10 wt. %, Origanum vulgare 5-10 wt. %,

4. The herbal composition as claimed in any of the preceding claims, wherein the plant material is leaves of Cassia occidentalis, leaves of Matricaria chamomilla, stem of Ocimum basilicum and leaves of Origanum vulgare.

5. The herbal composition as claimed in any of the preceding claims, wherein the herbal

y composition is formulated in a form selected from the group consisting of decoction, dried decoction, infusion, tincture, dried extract, capsule, tablet, syrup or the like thereof.

6. The herbal composition as claimed in any of the preceding claims, wherein the herbal composition is formulated in a form selected from the group consisting of decoction, dried decoction, infusion, tincture, dried extract, capsule, tablet, syrup or the like thereof.

7. The herbal composition as claimed in any of the preceding claims, wherein the herbal composition is in admixture with a pharmaceutically accepted vehicle or an adjuvant.