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RU2378009C2 - Иммунизация против менингококков серогруппы y с помощью белков - Google Patents

Иммунизация против менингококков серогруппы y с помощью белков Download PDF

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RU2378009C2
RU2378009C2 RU2006140958/13A RU2006140958A RU2378009C2 RU 2378009 C2 RU2378009 C2 RU 2378009C2 RU 2006140958/13 A RU2006140958/13 A RU 2006140958/13A RU 2006140958 A RU2006140958 A RU 2006140958A RU 2378009 C2 RU2378009 C2 RU 2378009C2
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serogroup
neisseria
meningococci
polypeptides
infection
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Марио КОНТОРНИ (IT)
Марио Конторни
Марция ДЖУЛИАНИ (IT)
Марция ДЖУЛИАНИ
Марияграция ПИЦЦА (IT)
Марияграция ПИЦЦА
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Новартис Вэксинс Энд Диагностикс С.Р.Л.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение предусматривает использование полипептидных антигенов и/или аутомембранных везикул (OMV) Neisseria meningitidis для иммунизации против менингококков серогрупп А, С, W135 и Y (и, в частности, против менингококков серогруппы Y. В соответствии с изобретением полипептиды менингококков серогруппы В способны обеспечить защиту от менингококков всех серогрупп А, В, С, W135 и Y, предпочтительно Y. На основе этих полипептидов и/или аутомбранных везикул созданы иммуногенные композиции для иммунизации субъектов от инфекции, обусловленной Neisseria meningitidis серогруппы Y и другими серогруппами. Иммуногенные композиции по изобретению обеспечивают защиту субъекта от инфекции Neisseria meningitidis серогрупп А, В, С, W135 и/или Y. Использование изобретения позволит осуществлять защиту субъектов от заболеваний, вызванных Neisseria meningitidis, используя в качестве активного компонента только полипептиды нейссерий серогруппы В вместо нескольких капсульных полисахаридных антигенов, которые не обеспечивают защиту от нейссерий серогруппы В. 4 н. и 1 з.п. ф-лы.

Description

Текст описания приведен в факсимильном виде.
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Claims (5)

1. Способ иммунизации субъекта против инфекции Neisseria meningitidis серогруппы Y, предусматривающий введение субъекту композиции, содержащей один или несколько иммуногенных полипептидов Neisseria meningitidis серогруппы В.
2. Способ иммунизации субъекта против инфекции Neisseria meningitidis серогруппы Y, предусматривающий введение субъекту композиции, содержащей менингококковые аутомембранные везикулы (OMV) и фармацевтически приемлемый носитель.
3. Применение одного или нескольких иммуногенных полипептидов Neisseria meningitidis серогруппы В для производства композиции для иммунизации субъекта против инфекции Neisseria meningitidis серогруппы Y.
4. Применение менингококковых аутомембранных везикул (OMV) и фармацевтически приемлемого носителя для производства композиции для иммунизации субъекта против инфекции Neisseria meningitidis серогруппы Y.
5. Способ по любому из пп.1 и 2 для иммунизации субъекта также против инфекции N. meningitidis серогрупп А, В, С и/или W135.
RU2006140958/13A 2004-04-22 2005-04-22 Иммунизация против менингококков серогруппы y с помощью белков RU2378009C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0408977.7A GB0408977D0 (en) 2004-04-22 2004-04-22 Immunising against meningococcal serogroup Y using proteins
GB0408977.7 2004-04-22

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RU2006140958A RU2006140958A (ru) 2008-05-27
RU2378009C2 true RU2378009C2 (ru) 2010-01-10

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US (1) US10195264B2 (ru)
EP (1) EP1737486B2 (ru)
JP (2) JP4918479B2 (ru)
CN (1) CN1946420B (ru)
AU (1) AU2005235265A1 (ru)
BR (1) BRPI0510104A8 (ru)
CA (1) CA2566509C (ru)
CY (1) CY1114179T1 (ru)
ES (1) ES2401481T5 (ru)
GB (1) GB0408977D0 (ru)
MX (1) MXPA06012041A (ru)
PT (1) PT1737486E (ru)
RU (1) RU2378009C2 (ru)
WO (1) WO2005102384A2 (ru)

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