RU2275214C2 - Method for treating patients for chronic urethroprostatitis - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves removing pathological content from urogenital tract. To do it, 4-5 ml of aqueous mixture of iron nanopowder is introduced into urethra for 40-60 min. Then permanent magnetic field is endourethrally applied.

EFFECT: enhanced effectiveness of treatment.

Description

The invention relates to medicine and is intended for the treatment of patients with chronic urethroprostatitis.

In recent years, there has been a significant increase in inflammatory diseases of the genitourinary tract, the treatment of which presents significant difficulties. The protracted nature of the pathological process in the urethra and prostate gland is largely due to the difficulties of discharge of mucus, pus, decayed cells from crypts and gaps. The method proposed for the treatment of chronic urethroprostatitis is based on creating negative pressure in the urethra using a special device (Guskov A.R., Vasiliev A.I., Bogacheva I.D., Kulinich A.Yu., Abrazheev V.G. Transurethral drainage prostate gland in chronic prostatitis by means of an electric stimulator of the Intraton-4 aspirator. - Urology and Nephrology, - 1997. - No. 1. - P.34-37). However, in this case, an attraction of both pathologically altered tissue and clinically unchanged occurs equally. Naturally, the arising rush of blood to the prostate and urethra, due to the vacuum formed in the urethral lumen, only aggravates microcirculation disorders in the pelvic organs and thereby contributes to the chronicity of the inflammatory process.

We first proposed a method for the treatment of chronic urethroprostatitis, which consists in introducing an aqueous suspension of iron nanopowder into the urethra of the patient, and then acting endourethrally with a magnetic field. On a course of 6-8 procedures.

The method is as follows.

After urination, 5-6 ml of an aqueous suspension of iron nanopowder is installed in the patient urethra for 40-60 minutes. In this case, the finely dispersed iron advances into the crypts and gaps of the genitourinary tract, filled with pathological contents. Then, a catheter with a built-in magnet is inserted into the urethra, the cavity of which is connected with the urethra with numerous holes. Under the influence of a magnetic field, the resulting mixture of pathological contents of the genitourinary tract and iron powder moves from crypts and gaps through numerous holes into the catheter cavity, for which you can use a device-tool for magnetotherapy (Kobzev Yu.A., Suvorov A.P. et al. Physical methods of treatment of urethroprostatitis. Saratov. 1994. 44 p.).

Clinical observations of 8 patients with chronic urethroprostatitis, who received traditional treatment (including the prototype) for 2 to 5 years without clear results, allowed us to state a distinct therapeutic effect of using the recommended method.

In addition, we evaluated the changes in microcirculation by the value of blood viscosity. Microcirculation changes were judged by blood viscosity (in cps) at a shear rate of 200 s ^-1 . As you know, microcirculation is largely determined by the state of the rheological properties of blood, the main characteristic of which is viscosity (Kirichuk V.F. Physiology of blood. // Saratov. - SSMU - 2002. - 116 s). For a viscometric study, a rheological rotational blood analyzer (AKP-2) was used.

Under observation were 2 groups of patients (the main group and the comparison group) with a parenchymal form of chronic prostatitis (8 patients each). In the main group, patients received treatment according to the claimed method, and in the comparison group - according to the prototype.

In both groups, patients aged 23 to 34 years and the duration of the pathological process from 6 months to 1 year predominated.

As a result of the study, it was found that in healthy male donors, blood viscosity is 3.30 ± 0.06 cP. After treatment in the main group of patients with CP, blood viscosity decreased from 3.57 ± 0.04 (results before treatment) to 3.31 ± 0.07 cP (results after treatment according to the claimed method) (p <0.001). The obtained positive results are reliable and stated in all patients who used the applicant's method.

In the comparison group, the blood viscosity remained practically unchanged (before treatment, the indicator was 3.58 ± 0.04 and after a course of therapy according to the method of the prototype 3.60 ± 0.13 cP, respectively; p> 0.05).

Example 1. Patient S., 34 years old. He complained of pain in the perineum and pubis, dysuric disorders (pollakiuria, nocturia, stranguria). Sick for 2 years. In smears from the urethra: the content of leukocytes 10-12 in the field of view. Ultrasound revealed signs of chronic prostatitis: the size of the prostate was 45 × 31 × 46 mm, the contours were fuzzy, the structure was heterogeneous, and there were areas of increased echo density. Blood viscosity was 3.53 cP, which indicates significant microcirculation disorders. The effect of the traditional treatment, including the prototype method (rectal suppositories, laser, electrostimulator, Intraton 4 aspirator), was absent. During therapy according to the recommended method, after the 1st and 2nd procedures in the discharge of the urethra and prostate gland, the presence of a large amount of iron nanopowder in a mixture with leukocytes, epithelial cells, pus and follicular secretion was detected. After 3 procedures, the patient's pain decreased, after the 5th, urination returned to normal. In the separated urethra and prostate after the 6th procedure, only the presence of nanopowder was detected. After the 7th procedure, positive dynamics was noted during ultrasound examination of the prostate: dimensions 40 × 29 × 34 mm, the contours were clear, even, the structure was homogeneous, and the density was homogeneous. Blood viscosity normalized - 3.30 cP.

Example 2. Patient C., 42 years old. He complained of dysuric disorders and pain radiating to the perineum, noted a decrease in libido. Sick 5 years. In smears from the urethra and prostate secretion: the content of leukocytes up to 6-8 in the field of view. Ultrasound revealed signs of chronic prostatitis (dimensions of the prostate 48 × 33 × 44 mm, contours are fuzzy, the structure is heterogeneous, the fate of increased echo density is determined). Blood viscosity is 3.55 cP, which indicates microcirculation disorders. The effect of the traditional treatment, including the prototype method (phytopreparations, rectal subpositories, electrical stimulator, Intraton 4 aspirator), was ineffective. During therapy according to the recommended method, after 1, 2, and 3 procedures, smears from the urethra revealed the presence of a large amount of nanopowder mixed with leukocytes, epithelial cells, pus, and secretion of the glands of the mucous membrane. After 4 treatments, pain decreased, after 6 treatments, dysuric disorders and pains radiating to the perineum disappeared. After the 8th procedure, sexual function was restored, in the discharge from the urethra and prostate only the presence of nanopowder was detected. Ultrasound revealed: a decrease in the size of the prostate gland to 42 × 28 × 36 mm, the contours are clear, the structure is homogeneous). At the same time, blood viscosity returned to normal - 3.36 cP.

As can be seen from the above clinical observations, the developed method has a high therapeutic efficacy in the treatment of patients with chronic urethroprostatitis.

Claims (1)

A method for the treatment of chronic urethroprostatitis, including the removal of pathological contents from the genitourinary tract, characterized in that 4-5 ml of an aqueous suspension of iron nanopowder is introduced into the urethra for 40-60 minutes, followed by exposure to a constant magnetic field endourethrally.