RU2113853C1 - Preparation "kurdlipid" - Google Patents

Abstract

FIELD: medicine, pharmacy. SUBSTANCE: preparation has components of animal origin and sugar being endemic sheep tincture of melted fat tail of sheep is used as a latter at the following ratio of components, g: melted fat tail of sheer tincture 1•10^-12-1•10^-16 and sugar 0.9-1.1. Preparation can be used for treatment of patients with disorders of lipid metabolism, hypercholesterolemia, hyperlipoproteinemia, for prophylaxis and treatment of atherosclerosis, as a hepatoprotective agent eliminating effect of drugs and toxins on liver. EFFECT: enhanced effectiveness of preparation. 5 ex

Description

 The invention relates to medicines and can be used to treat disorders of lipid metabolism, hypercholesterolemia, hyperlipoproteinemia, the prevention and treatment of atherosclerosis, as a hepatoprotector, eliminating the effects of drugs and toxic substances on the liver. The drug "Kurdlipid" can be used both in clinical and at home.

 Known drug obtained from excrement of animal origin - mountain goat (patent N 20331711, Russia, CL A 61 K 35/32, 18. 05. 92).

 This drug has a limited scope, as solves only one side of the regulation of metabolic processes when changing the functional activity of the digestive system.

 The known drug allahol is used for chronic hepatitis, cholangitis, cholecystitis, as well as related dysfunctions of the gastrointestinal tract (intestinal atony). The drug in one tablet contains, g: bovine bile 0.08; dry garlic extract - 0.04; nettle extract dry 0.005; activated carbon 0.025 (Mashkovsky M. D. Medicines. M.: Medicine, 1972, part 1, p. 406). The therapeutic effect of this drug is associated with increased secretory function of the liver, motor activity of the gastrointestinal tract.

 However, the use of this drug is limited by its high ability to cause allergic reactions, the inability to use in acute periods of liver disease, with calculous cholecystitis.

 Known drug cholezin, used for hepatitis and cholecystitis, for diseases of the gastrointestinal tract. The drug in one tablet contains, wt.%: Dry bile of livestock 1; dry intestinal powder 1; pancreatic powder 1 (Mashkovsky M.D. Medicines. M: Medicine, 1972, part 1, p. 406). The therapeutic effect of this drug is unidirectional and is mainly associated with its choleretic activity.

 However, the need for long-term use of the drug, a wide range of contraindications (mainly associated with increased secretory function) and a relatively unstable therapeutic effect make us resort to the help of other complex drugs.

 Closest to the invention is a preparation containing a component of animal origin - bear bile and sugar, with the following mass ratios of components, g: bear bile 0.00003 - 0.0045; sugar 0.015 - 1.5 [1].

 The therapeutic effect of this drug is also low, due to its narrow focus on accelerating bile formation.

 The aim of the invention is to provide a drug having a lipid-mobilizing effect and not simultaneously possessing a choleretic effect.

This goal is achieved by the fact that as a component of animal origin take melted fat tail fat of endemic sheep with the following mass ratios of components, g: melted fat tail fat 1 • 10 ^-12 - 1 • 10 ^-16 ; sugar 0.9 - 1.1.

 From reference medical literature, the following drugs are known: Oleum animale, obtained by dissolving bone fat in alcohol and Oleum Lecovis aselli. The latter preparation is made from the liver fat of various fish species, mainly of the genus Gadus, especially the species Gadus Morrhua, L (Allen T. F. The Encyclopedia of Pure Materia Medica, Vol. 7, p. 149 - 169). These drugs do not have a lipid-stabilizing effect and are not used in our country.

 The essence of this invention lies in the fact that all currently known substances of hypercholesterolemic, hyperlipoproteinemic action are mainly derivatives of organic acids and their salts or a mixture of esters of unsaturated fatty acids (for example, Cetamiphene, Lipoic acid, Linetol, Lipamide, Prodectin and other). Being unsaturated fatty acids, these drugs have more or less pronounced choleretic effect, which makes them contraindicated for use in people with cholecystitis, especially calculous, as well as other diseases of the liver, pancreas, and kidneys.

 A study of the Kurdlipid preparation showed that, with high lipid mobilization activity, it does not have a choleretic effect, which allows it to be used more widely. In addition to the described properties of Kurdlipid used to treat lipid metabolism and as a hepatoprotector, additional positive effects were obtained.

 When using the drug Kurdlipid, an improvement in memory and attention was observed in patients with cerebral arteriosclerosis, leading to transient disorders of cerebral circulation. The pronounced nootropic effect of the Kurdlipid preparation is primarily associated with its lipid-stabilizing effect, as well as an increase in redox processes, in particular nerve cells, in ischemic areas of the brain. Improving energy processes under the influence of Kurdlipid leads to an increase in the stability of brain tissue during hypoxia and toxic effects.

 As an additional effect, anorexigenic effect can also be noted. After taking Kurdlipid in certain doses, a feeling of fullness quickly ensues, which makes it possible to significantly reduce the amount of food taken and to achieve a decrease in body weight in overweight individuals. Unlike the known anorexigenic substances, which have a strong stimulating effect on the central nervous system and excite peripheral adrenoreactive structures, Kurdlipid does not cause insomnia, general excitement, increased blood pressure, tachycardia, arrhythmia, etc. On the contrary, there is a slight sedative effect.

 Of particular note is the fact that Kurdlipid, being essentially a homeopathic remedy, is absolutely harmless and can be taken for a long time without any side effects, as well as addiction and allergic reactions.

 The drug is prepared as follows.

In a porcelain mortar, the molten fat tail fat of the Central Asian ram is crushed with a porcelain pestle. 1 wt. including crushed fat mixed with 10 wt. including 96.5% ethyl alcohol (GOST 18300-87) in a glass vessel. The vessel is shaken for 20 minutes and after shaking is placed in the refrigerator. It is kept in the refrigerator for 14 days at 0-5 ^o C. Every day, twice a day, intensive manual shaking of the vessel is carried out for 20 minutes. Then the tincture is filtered. The residue is squeezed and filtered twice through filter paper, after which it is mixed with the first portion of tincture. Next, the tincture is placed in the refrigerator for 8 days. After this period, the tincture is again filtered, resulting in a matrix tincture. From the matrix tincture, the Kurdlipid preparation is prepared in the following dilutions: 3, 6, 12, 30, 50, 100, 200, 1000. The dilution is carried out according to the Hahnemann method. Granules are prepared by saturating the standard sugar grains with 70% alcohol (GOST 5962-67), and then spraying the appropriate dilution of the tincture on the sugar grains, followed by air drying.

According to the described method, the preparation Kurdlipid 6 was obtained with the following ratios of components, g: melted fat tail fat (0.5 - 1.5) • 10 ^-12 ; sugar 0.9 - 1.1.

 Example 1. Patient S., 27 years old, complained of overweight and the absence of pregnancy for 5 years with regular sexual activity.

 Anamnesis: considers herself a patient for 5 years, when after the onset of sexual activity there were pains in the lower abdomen, she began to gain weight significantly, despite regular sex life and the absence of contraception, pregnancy did not occur.

 Of the chronic diseases - chronic tonsillitis, tonsillectomy at 7 years. Past diseases - childhood infections, flu, pneumonia. Menses from 13 years, established immediately, a cycle of 27 days, moderate, painless.

 During the examination: hysterosalpingography - tubes are passable, ultrasound examination of the uterus and appendages - cystic changes in the ovaries, according to the tests of functional diagnostics - anovulatory cycle.

 Objectively: normal physique, increased nutrition, height 170 cm, weight 98 kg.

 Diagnosis: neutro-endocrine syndrome. Primary infertility.

 During treatment with Kurdlipid 6, 3 grains 1 time per day for three months there was a decrease in body weight by 10 kg, the two-phase cycle was restored, the woman became pregnant.

 Example 2. Patient D., 56 years old. He was diagnosed with calculous cholecystitis, cerebral arteriosclerosis, hypertension of the II degree, alimentary obesity.

 The main complaints: pain in the right hypochondrium, nausea, headaches, memory loss, poor performance, increased fatigue, increased irritability, shortness of breath.

 Objectively: increased nutrition, barrel-shaped chest. HELL 170/100 mm Hg In the neurological status - uncertainty when performing coordinoid tests, more on the right, instability in the Romberg position (lateropulse to the left). A neuropsychological study noted a narrowing of the volume of auditory-speech memory and attention.

 Against the background of the therapy carried out by Kurlipid 6, five grains 2 times a day for four months, the patient lost 7 kg in weight, indicators of the blood lipid spectrum returned to normal, memory improved, clinical symptoms of cholecystitis disappeared and blood pressure numbers returned to normal.

 During the control study, only insignificant pronounced disturbances of statics were noted, which was due to severe osteochondrosis of the cervical spine, leading to circulatory disorders in the pool of the helicobasilar vessels.

 Example 3. Patient K., 28 years old. She complained of aching pain in the right hypochondrium, nausea, loss of appetite.

 Based on the examination data - ultrasound of the hepatopancreatic system, laparoscopy with biopsy - the diagnosis was made: cirrhosis of the liver.

 Kurdlipid therapy 6 5 grains 2 times a day was carried out for 8 months.

 Repeated examination 10 months after treatment for cirrhosis of the liver did not reveal.

 Example 4. Patient F., 34 years old. She complained of discharge from the mammary glands.

 Of the diseases - childhood infections, acute respiratory infections, influenza, Botkin's disease, appendectomy at 13 years old.

 Menses from 14 years, established immediately, a cycle of 23 - 25 days, moderate, painless. Pregnancy - 1, ending in timely physiological birth.

 He considers himself to be sick during the year, when the engorgement of the mammary glands before menstruation intensified, the allocation of drops of milk from the nipples appeared.

 During the examination, high prolactin numbers in combination with CT scan of the brain made it possible to diagnose: prolactinoma; lactorrhea. For therapeutic purposes, parlodel was prescribed, against the background of which two weeks later there were complaints of severe nausea and pain in the right hypochondrium.

 Given the inappropriateness of canceling parlodel, it was decided to continue the course of treatment while taking Kurdlipid 6. The last patient received 6 grains 2 times a day. 10 days after the start of taking Kurdlipid, the above complaints completely disappeared, in a maintenance dose, the patient received the drug until the end of the course of treatment with parlodel, complaints did not resume.

 Example 5. Patient R., 65 years old. He complained of frequent headaches, memory and sleep disorders, a feeling of bitterness in the mouth in the morning, poor tolerance of fatty foods and many other foods, frequent diarrhea.

 Examination (ultrasound) of the hepatopancreatic system revealed signs of calculous cholecystitis, chronic pancreatitis; biochemical blood tests showed the presence of hypercholisterinemia, increased amounts of β - lipoproteins, atherogenicity coefficient, triglycerides, emission computed tomography recorded asymmetry of blood flow in the middle cerebral artery pool due to a sharp decrease on the left to 63%, which was caused by the presence of atherosclerotic changes in the walls of the main arterial trunks.

 Diagnosis: cerebral arteriosclerosis, chronic calculous cholecystitis; chronic pancreatitis.

 Kurdlipid therapy 6 5 grains 3 times a day was carried out for 6 months (3 months - a course, 1 month - a break, 2 months - a course). As a result of treatment, changes in the blood lipid spectrum were significantly reduced, in particular, cholesterol levels returned to normal. Complaints from the gastrointestinal tract disappeared completely, the range of products transferred to the patient expanded. The memory improved, increased efficiency, ceased to bother headaches.

 It follows from the foregoing that the Kurdlipid preparation can be successfully used in the treatment of lipid metabolism disorders, neuro-exchange endocrine syndrome, atherosclerosis, for the prevention and elimination of side effects of drugs on the liver.

Claims (1)

A preparation for regulating fat metabolism, including a component of animal origin and sugar, characterized in that as a component of animal origin use tincture of melted fat tail fat of an endemic ram in the following ratio of components, g:
Tincture of melted fat tail fat - 1 • 10 ^-12 - 1 • 10 ^-16
Sugar - 0.9 - 1.1%