RU2174000C1 - Method of treatment of patients with infectious diseases - Google Patents

Abstract

FIELD: medicine, infectology. SUBSTANCE: invention relates to treatment of patients with different diseases with pathogenesis induced by infective agent. Method involves the use of a mixture of water-soluble chitosan (chitodes) and medicinal plants species dry aqueous extract taken in doses of components 25 mg and 22-25 mg, respectively, per a single dose. Phyto-chitodes is dosed by sublingual route in tablets or used in the form of chitodes-containing phyto-ointments. EFFECT: enhanced effectiveness of treatment, decreased complications of diseases and adverse effects of conventional therapy. 9 cl, 19 ex

Description

 The invention relates to medicine, namely to clinical phytology and herbal medicine, and also includes in the complex treatment (along with traditional means and herbal medicine) the use of water-soluble forms of food chitosan polyfraction composition for the treatment of infectious diseases.

 Herbal collections and scientifically based herbal medicine in infectious practice are known [Pogorelskaya L.V., Korsun V.F., Zhuravlev Yu.S., Turyanov M.Kh. Herbal medicine in infectious diseases. M .: RON, 1998; Pogorelskaya L.V., Korsun V.F., Tryakina I.P., Turyanov M.Kh. Features of herbal medicine for viral hepatitis B in old age. Practical herbal medicine. N 3. 1999. Page 39; Treskunov K.A., Komarov B.A. A method of treating cancer. Application for patent N 98101398 from 01.20.98; A method of treating bronchial asthma. Application for patent N 98116163 from 08/18/98; Treskunov K.A. Patents N 2008012 dated 05.30.88 and N 2007177 dated 13.04.87; Patent applications N 4234970/1467433 dated 04/23/87 and N 166198/14155627 dated 11/10/86: Treskunov V.K., Treskunov K.A., Treskunova O.K. Herbal medicine M .: RIPI, 1992. Pp. 121-125; Makhlayuk V.P. Medicinal plants in traditional medicine. Saratov: Volga Book Publishing House. 1991. p. 519; Treskunov K.A. Notes phytotherapist. Book one. M .: CONNEX, 1996; The second book. M .: CONNEX, 1996; The third book. M .: CONNEX, 1997; Book Four. M .: CONNEX, 1998].

 A known method of treating cancer [Treskunov K.A., Komarov B.A. Patent application N 98101398 of 01.20.98] and a method for the treatment of bronchial asthma [Treskunov K.A., Komarov B.A. Patent application N 98116163 from 08/18/98], characterized in using, along with conventional phytotherapy agents, water-soluble forms of food chitosan in combination with phyto-collections used strictly in accordance with the prognosis of cancer or for the treatment of bronchial asthma and associated respiratory diseases.

 A known method of using chitosan to increase the immunity of the human body [S. Podolski, K. Hsu, G. Stingh US Patent N 5912000. 06/15/99], which consists in the use of complexes of antigens in the form of proteins, carbohydrates, lipids, glycoproteins or their combinations with soluble or insoluble chitosan or its chelates based on iron, zinc, copper or nickel and characterized by complex multi-stage preparation of the target product in the form of a suspension, gel or colloidal solution with the obligatory inclusion of the stages of dissolution, ultrasonic mixing and dispersion, crosslinking mainly using glutaraldehyde, ultracentrifugation anija and repeated washing with sterile buffered medium.

 It is known that the water-soluble form of chitosan - chitosan glutamate has increased activity compared, for example, with microcrystalline cellulose in binding lipopolysaccharides - components of the cell wall of gram-negative microflora microbes [I.N. Bolshakov, S.M. Nasibov. Binding of bacterial lipopolysaccharide with chitosan during enterosorption in the experiment. Materials of the 5th Conf. "New perspectives in the study of chitin and chitosan." M.: ed. VNIRO, May 25-27, 1999. 120]. It is significant that in this case, the effect of detoxification is expressed not only in reducing the total damage to blood cells, but also in significantly less antigenic sensitization of the cell membranes of lymphocytes, maintaining a high function of their receptor apparatus and, therefore, a significant decrease in the level of intoxication (4 times).

 It has been established that many properties of chitosan derivatives are determined by their charge, for example, adhesion on the mucin layer of the intestine, interaction with cells and bacterial spores, interaction with collagen, chondroitin sulfate, bile acids [A.P. Kaplun, O.O. Burdelev, Yu.E. Andia the True. Modulation of complement activity by charged substances. Materials of the 5th Conf. "New Perspectives in the Study of Chitin and Chitosan" M .: ed. VNIRO, May 25-27, 1999. 146]. It is significant that the interaction of proteins at the stage determined by electrostatic forces can be blocked by both anion-exchange polymers and cation-exchange (for example, chitosan sulfate or succinate). The most effective inhibitors of polyelectrostatic interactions should be flexible polymers with a high charge density or liposomes, the charged lipids of which are in a liquid crystal bilayer. Authors [A.P. Kaplun and others. Materials of the 5th Conf. "New perspectives in the study of chitin and chitosan." M .: VNIRO, May 25-27, 1999. P. 146] believe that these effects are general in nature, since the interaction of polyelectrolytes in living nature is a common phenomenon.

 Important results were obtained in the study of the effect of chitosan on phage infections [Z. M. Kochkina, S.N. Chirkov. The effect of chitosan on phage infections. Materials of the 5th Conf. "New perspectives in the study of chitin and chitosan." M.: ed. VNIRO, May 25-27, 1999. 151]. It was found that coliphage reproduction was more effectively suppressed by higher molecular weight chitosan, and short chitosan oligomers were significantly more active in suppressing phage reproduction in a bacillus culture. Chitosan, introduced into the phage suspension, reduces its titer, neutralizing its infectivity. Moreover, the level of inactivation depends on the chemical form of chitosan, its concentration and the type of bacteriophage. It was established that the higher the concentration of amino groups in chitosan, the greater its inactivating ability. It can be concluded that to expand the positive spectrum of action, it is necessary to use chitosan of a polyfraction composition.

 These findings are supported by data from a study of the sensitivity of microorganisms isolated from biopsy samples of the gastric mucosa and duodenum of patients with peptic ulcer [V.M. Chervynets, B.A. Komarov, S.V. Moskvin, A.A. Kurochkin. The sensitivity of the microflora of the stomach and duodenum to chitosan and low-intensity laser radiation. Materials scientific conf. "Herbal medicine and laser therapy in the 21st century." Chernogolovka: RIO IPCP RAS, December 7–9, 1999. Pp. 105]. It was established that with the exception of Candida tropicalis, all microorganisms, including Helicobacter pylori, were sensitive to a 1% solution of chitosan in 0.25% aqueous hydrochloric acid, and their sensitivity was directly dependent on molecular weight (MM) and degree deacetylation (DM) or on the concentration of amino groups in the chitosan macromolecule. We note that the charge density of the chitosan macromolecule in solution is approximately in direct proportion to the magnitude of the SD. From the point of view of preserving the chelating and complexing properties of chitosan, we believe that the magnitude of diabetes should not be extremely possible.

Note that chitosan is able to normalize the content of heavy metals in the blood [M.I. Rabinovich, A.R. Tairov. The use of chitosan as a pharmacocorrector of heavy metals in animals in the southern Urals. Materials of the 5th Conf. "New perspectives in the study of chitin and chitosan." M .: ed. VNIRO, May 25-27, 1999. 186] and exhibit pronounced radioprotective and antitoxic properties with respect to ²⁰³ Hg [G.A. Tarasenko. Radioprotective and antitoxic properties of chitosan from the shell of the king crab in relation to ¹³⁷ Cs and ²⁰³ Hg. Materials of the 5th Conf. "New perspectives in the study of chitin and chitosan." M .: ed. VNIRO, May 25-27, 1999. 197]. It was established that upon transition to a colloidal state, the adsorption capacity of chitosan, as expected, significantly increases [V.I. Filatov, A.N. Bogdanova, V.A. Slepnev, I.V. Sushkov, S.V. Germans. Adsorption capacity of chitosan-protein complex preparations in relation to fish metabolites. Materials of the 5th Conf. "New Perspectives in the Study of Chitin and Chitosan" M .: ed. VNIRO, May 25-27, 1999. Pp. 201].

 When studying the effect of chitosan on lipid metabolism in experimental models of atherosclerosis obtained after three months of keeping animals on an atherogenic diet, a significant decrease in the content of total lipids, triglycerides, serum cholesterol was detected against a background of a significant increase in the phospholipid-cholesterol index, an increase in glucose and a decrease in pyruvic acid acids indicating a positive effect on carbohydrate metabolism, as well as a significant decrease in the activity of serum aminotransferases to ditch, which in turn indicates the positive effect of chitosan on liver function [G.A. Tarasenko. Experimental substantiation of the hypocholesterolemic effect of chitosan from the carapace of the king crab. Materials of the 5th Conf. "New perspectives in the study of chitin and chitosan." M.: ed. VNIRO, May 25-27, 1999. 198; V.A. Petrov, G.A. Tarasenko. Toxicological and hygienic assessment of chitosan from the carapace of the king crab in a chronic experiment. In the same place. Page 179).

Closest to the claimed object is "Mikoton", which is a complex of natural biopolymers obtained from the cell walls of higher basidiomycetes [L.F. Gorovoy, V.N. Shoals. A method of obtaining a chitin-containing material. Patent of the Russian Federation N 2073015, MKI C 08 B 37/08. 1997; Conclusion of the Pharmaceutical Committee of the Ministry of Health of Ukraine N 10 dated 12/28/95; Permission of the State Sanitary and Hygienic Expertise of the Ministry of Health of Ukraine N 7.09.2806 of 11/13/97 for use as a food additive]. Mikoton consists of 70% chitin in microfibrillar form, 20% β-1,3- and β-1,6-glucans in amorphous form and 10% melanin pigments. Structurally, Mikoton is a fibrous material with a fiber thickness of 3-5 μm and a length of several millimeters, the fibers have a hollow structure with a wall thickness of 0.2 to 1 μm. The fiber walls are composed of chitin microfibrils, for which glucans are an amorphous matrix. Due to this structure, Mikoton is characterized by a large specific surface area of chitin microfibrils - more than 1000 m ² per 1 g of material. The developed chitin surface of Mikoton determines its high sorption, antimicrobial and immunomodulating properties [O.F. Senyuk, L.F. Gorovoy, I.A. Trutnev. The use of the chitin drug Mikoton as a radioprotector. Materials of the 5th Conf. "New perspectives in the study of chitin and chitosan." M .: ed. VNIRO, May 25-27, 1999. 193: A.I. Prilutsky, V.S. Zemskov, L.F. Gorovoy, L.I. Burdyukova. Antimicrobial properties of the new chitin drug Mikoton. In the same place. Page 181; A.A. Nakonechnaya, G.N. Drannik, L.F. Gorovoy, L.Ya. Kushko, I.L. Mount. Clinical and immunological effectiveness of the chitin drug Mikoton in the complex treatment of chronic hepatitis. In the same place. Page 172]. The authors found that the inclusion of enterosorption by Mikoton in the complex treatment of patients with chronic viral hepatitis contributes to the rapid improvement of clinical and biochemical parameters and leads to a significant reduction in the duration of treatment.

 The disadvantage of Mikoton is its insolubility in the environment of the gastrointestinal tract, therefore, after decay, the effectiveness of its therapeutic effect can be determined, apparently, only by the enterosorption properties of the resulting highly dispersed suspension of chitin microfibrils and their complexes.

These disadvantages are eliminated by using water-soluble forms of chitosan. In order to expand the spectrum of anti-infectious action and the effectiveness of treatment, food grade chitosan of a polyfraction composition is used to obtain water-soluble forms (chitosan glutamate = chitodez and chitosan succinate H-form = chitodez ^* ) [Komarov B.A., Albulov A.I., Belov M.Yu. ., Samuilenko A. Ya., Fomenko A.S., Shinkarev S.M., Trunov A.M. A method of obtaining a sodium salt of chitosan succinate. Application for patent N 98106316/04 (006924) from 04/07/98] and combining them with a dry extract of herbs (phytochitodez), carried out in a single technological cycle without the use of organic solvents with the final stage of lyophilization under mild conditions. Given the presence in the medicinal plant raw materials of micro- and macroelements, various complex organic compounds, including complex proteins, metal-containing glycoproteins - lectins [Pogorelskaya L.V. et al. Phytotherapy in infectious diseases. M.: RON, 1998. P. 44], the technology used allows to obtain complex chitosan-chelate-protein complexes, as well as various metal-containing chitosanorganic complexes with enhanced antioxidant, antimicrobial, detoxifying and immunostimulating properties. At the same time, the following pattern is observed: the more tannin herbs (organic compounds with aldehyde groups) in the herbal extract extract, for example, as in the N 8 extract, the more likely the formation of colloidal particles when the working aqueous mixture is exposed to cavitation or mechanical fields with shear deformation, and vice versa - the less tannins, the more likely the formation of a working true solution of phytochitodes.

 It is known that at any stages of the inflammatory process, it is important to reduce the intensity of oxidative reactions, carry out the correction of lipid metabolism and lipid peroxidation processes. This is especially important in the treatment and prevention of gerontological patients, when it is necessary to simultaneously carry out the correction of the body's immune system. It is important to note that the established antioxidant activity of chitosan is sharply enhanced in its chelates. This happens due to the activation of the amino group located in the coordination sphere of the metal (as, for example, in the preparation of phytochitodes) in the reactions of the destruction of hydroperoxides without the formation of active radicals, which is equivalent to breaking the oxidation chain or enhancing the antioxidant properties of chitosan [Treskunov K. A., Komarov B. A Application for patent N 98116163 from 08/18/98].

 An increase in the therapeutic effect may be due to the very method of taking chitodesis or phytochitodesis: on a free stomach before or after eating under the tongue, without washing down with liquid for 40-60 minutes. With this method of administration, a certain part of the oligomeric chitosan can be absorbed already in the mouth, the remaining part of chitosan can undergo biodegradation under the influence of lysozyme [C. Podolsky et al. US Patent No. 5,912,000 dated 06/15/99], effective at pH ≥ 7, which will also contribute to the partial absorption of chitosan. As noted earlier [Treskunov K.A., Komarov B.A. Patent applications N 98101398 of 01.20.98 and N 98116163 of 08/18/98], partial assimilation of oligomeric fractions of chitosan, originally present in chitodez (phytochitodes) or formed as a result of acid hydrolysis of the glycosidic bond of the aminopolysaccharide in the folds of the stomach, can occur in the gastrointestinal tract intestinal tract. In turn, the presence of optimal amounts of chitosan in the blood and lymph can lead to an increase in its immunostimulating effect. The presence of high molecular weight fractions of 50,000-120,000 carbon units in the preparations contributes to the preservation of anti-inflammatory, antimicrobial and antifungal effects, the binding and elimination of heavy metals and toxins from the body, the cleansing of the intestinal epithelium, and ensures the prolonged action of dry extracts of medicinal plants.

A positive factor is the transition of chitosan from soluble to colloidal state with a gradual change in the environment in the duodenum from acidic to neutral and slightly alkaline (7 <pH ≅ 7.3). The specific surface of colloidal chitosan particles can reach 10 ⁶ - 10 ⁸ m ² per 1 g. Obviously, the adsorption, chelating and complexing properties of chitosan in this state are significantly increased and this allows the use of moderate doses at a single dose - 25 mg of chitodez and 22 -25 mg of dry extract of the fees of medicinal plants.

 For the treatment, freshly prepared infusions were used: 1-2 tablespoons of phytobrain brew 0.5 l of boiling water, bring to a boil, insist 1 h, strain. Drink 1/4 cup every hour for two days 8 times a day, then 1/2 cup 4 times a day 15 minutes before meals and at bedtime. The internal intake should be combined with topical application in the form of lotions, poultices, microclysters (50 ml) from the second fraction (re-infusion of thick grass collection 0.25-0.5 l of boiling water, strain after soaking for 1 hour).

 Phyto-ointments are prepared on the basis of pork interior fat according to the technology described in [Treskunov K.A. Notes phytotherapist. Book one. M .: CONNEX, 1996] and the patent [Treskunov K.A. Patent N 2008012 dated 05/30/88], contain phytosborne extract and low molecular weight chitosan or its water-soluble form at a concentration of 0.25-0.5%.

 The presence of chitosan (or chitodez) in ointments facilitates transdermal transport, increases shelf life, eliminates toxic and allergic effects with prolonged use, and prevents hydrolytic breakdown and deactivation of biologically active substances [Zelenkov V.N. The use of chitosan in medical biotechnology and medical cosmetics. Materials of the 5th Conf. "New perspectives in the study of chitin and chitosan." M.: VNIRO, May 25-27, 1999. S. 140].

Chitodez is obtained at an equimolecular ratio of L-glutamic acid and amino groups of chitosan with a polyfraction composition. Chitodez ^* contains 80-85% chitosan succinate [Komarov B.A. et al. Patent Application N 981063116/04 (006924) dated 04/07/98] and 15-20% free succinic acid.

Chitodez and chitodez ^* take 0.025 g (1 tablet) under the tongue 30 minutes after eating, rinse your mouth and swallow after 40-60 minutes. The intake of phytochitodes tablets is similar. At the discretion of the doctor in the acute period, the use of shock doses is possible. Phytomus with chitosan is applied to the skin of the neck, chest, as well as per rectum and to the nose. The end-to-end numbering of phytochitodesis and phyto-collection is preserved, taking into account patent applications N 98101398 of 01/20/98 and N 98116163 of 08/18/98.

 Starch, lactose or powdered sugar is used as fillers in tabletting. One tablet contains 25 mg of chitodez. One tablet of phytochitodez contains 25 mg of chitodez and 22-25 mg of dry extract of the collection of medicinal plants.

 Since plants have an adequate effect on the human body only if they live in the same climatic zone [Muradova N. AiF "Health" N 1-2. 2000. S. 11], this principle was taken as a basis in compiling all collections of medicinal plants.

 The following are the compositions of phyto-collections used in the treatment of infectious diseases and the preparation of phytochitodesis.

 Collection No. 1 - anti-oncological [Patent Application No. 98101398 of 01/20/98] (phytochitodez 01 series): medicinal sweet clover grass, large celandine, narrow-leaved fireweed, common tansy, white birch leaf, 9 parts by weight; the roots and grass of the meadowsweet, cinquefoil marsh, 7 parts by weight; grass of dried marshmallow, buddy ivy, common wormwood, silver cinquefoil, leaves and branches of common raspberry, the color of medicinal marigolds, upright roots of 5 parts by weight: ordinary yarrow grass, Hypericum perforatum, mountaineer bird, large plantain, common chickpea, marjoram the color of meadow clover, lingonberry leaf, burdock roots, 3 parts by weight each; grass of oak biloba, shepherd’s bag, five-lobed motherwort, potato mountaineer, medicinal smoky, real bedstraw, meadow geranium, common cinnamon, field horsetail, barbed quinoa, prickly tartar, medicinal dandelion roots, elecampane tall, buckthorn bark buckthorn, crustacean buckthorn bark, bark buckthorn bark, -red, dogrose of May, the color of chamomile officinalis in 2 parts by weight; grass of Veronica officinalis and Dubrava, sowing oats, tricolor series, tricolor and field violets, garden sow thistle, bitter wormwood, Canadian goldenrod (golden rod), wild chicory, goose cinquefoil, lily of the valley May, thyme creeping, meadow cornflower, common grasshopper tarragon, peppermint leaf, dioica nettle, black currant, dill seeds, common pine buds, gray alder cones, wheatgrass creeping roots, angelica officinalis 1 weight part.

 Collection No. 1M - oncological prophylaxis: add to 300 g of collection No. 1: medicinal sage leaf, ordinary hop cones, meadow clover color, licorice roots, sulphurous licorice, medicinal dandelion, angelica officinalis, medicinal comfrey, burdock, erect cinquefoil, 10 g each everyone.

 Collection No. 2 - for the treatment of acute gastrointestinal diseases [Patent application N 98101398 of 01/20/98] (phytochitodez of the 02 series): peppermint leaf, large plantain, color of chamomile officinalis, 2 parts by weight; St. John's wort grass perforated and yarrow in 1 part by weight.

 Collection No. 6 - for hemorrhoids (phytochitodes of series 17): grass of the sweet clover medicinal and white - 5 parts by weight, grass of the goose cinquefoil, St. John's wort, perforated geranium, common yarrow, white birch leaf, large plantain, tansy common color, 3 parts by weight , the color of calendula officinalis, chamomile officinalis, grass of the mountaineer, field horsetail, dandelion leaf, the roots of the cinquefoil are erect in 2 parts by weight, grass is dried cinnamon, oregano, dioica nettle, golden ro gi sheet mother coltsfoot to 1 parts by weight.

 Collection No. 8 - antifungal [Patent Application No. 98101398 of 01.20.98] (phytochitodez of 08 series) in parts by weight: common yarrow - 9, white birch leaf - 7, common wormwood grass - 5, medicinal veronica - 4, tricolor violets - 4, chamomile - 2, oregano - 2, the color of calendula officinalis - 2, the color of tansy ordinary - 1, the color of clover meadow - 1.

 Collection No. 9 - antistaphylococcal [Patent application N 98101398 dated 01/20/98] (phytochitodes series 09) in weight parts: yarrow grass - 6, burdock leaf - 5, St. John's wort perforated, medicinal sweet clover, oregano leaf, dioica nettle large plantain in 3 parts by weight; grass of coltsfoot, mountaineer, bird rosehips of cinnamon, roots of cinquefoil erect, dandelion officinalis, the color of calendula officinalis, tansy ordinary in 2 parts by weight; the color of chamomile officinalis and grass of horsetail in 1 part by weight.

 Collection N 9M - for mastitis of staphylococcal etiology: leaf of burdock - 7 parts by weight, grass of yarrow, plantain leaf of large 5 parts by weight, grass of clover medicinal - 3 parts by weight, sheet of dandelion officinalis, grass of silver footweed, nettle 2 by weight parts, a sheet of white birch and goose cinquefoil in 1 weight part.

 Collection No. 10 - anti-inflammatory (phytochitodes of series 10): a leaf of burdock, a large plantain, grass of a common yarrow, St. John's wort, perforated and sweet clover in 9 parts by weight; white birch leaf, dioecious nettle grass, calendula officinalis color, 7 parts by weight; large celandine grass and horsetail, common tansy color in 5 parts by weight: peppermint leaf, leaves and roots of dandelion officinalis, bird mountain grass and meadow geranium in 3 parts by weight; the color of meadow clover, leaf of narrow-leaved fireweed, coltsfoot common and lingonberry ordinary, grass of goose cinquefoil, ivy buds and a series of three parts in 1 part by weight.

 Collection N 11 - during hypolactation [Treskunov V.K., Treskunov K.A., Treskunova O.K. Herbal medicine. M .: RIPI, 1992. P. 121]: dandelion officinalis leaf - 9 parts by weight, dandelion root, common yarrow, common oregano in 7 parts by weight, dioecious nettle leaf, large burdock in 5 parts by weight, white clover grass, prickly hawthorn fruit in 3 parts by weight, dill fruit, garden fennel and caraway seeds, herb galega officinalis and common cuff in 1 part by weight.

 Collection N P-1, for cholestasis, (phytochitodes series 12B): dicotyledonous nettle grass and bird highlander in 3 parts by weight; immortelle sand and licorice root bare, 2 parts by weight; Melilotus officinalis - 1.5 parts by weight.

 Collection N P-2, with cholestasis, (phytochitodes 12K series): dicotyledonous nettle grass and bird highlander in 3 parts by weight; corn stigmas and naked licorice root in 2 parts by weight; Melilotus officinalis - 1.5 parts by weight.

 Collection N P-3, anti-infectious, (phytochitodez of 06 series): calamus root, cinquefoil erect (galangal), licorice, grass, nettle, shepherd’s bag, dried marshmallow, yarrow, bitter wormwood, tricolor violet, veronica oak eucalyptus, the color of tansy and willow bark, 2 parts by weight, sweet clover - 1 weight part.

 Collection N P-4, hepatoprotective and choleretic, (phytochitodes series 11): dandelion root, medicinal chamomile, calendula officinalis, tansy, corn stigmas, dioecious nettle grass, Kalanch pinnate and mountaineer, medicinal clover in equal parts.

 Collection N P-5, in case of hyperfermentemia, (phytochitodes of series 14): cinnamon rose hips, licorice root, peppermint and St. John's wort perforated in 2 parts by weight, dicotyledonous nettle grass and 1 gallon officinalis.

 Collection N P-6, for chronic hepatitis and pancreatitis, (phytochitodesis series 07): leaf of white birch and common blueberry, grass of narrow-leaved fireweed, peppermint, St. John's wort, yarrow and sweet clover, color of calendula officinalis, common chicory roots and calamus bog in equal parts.

 The proposed method for the treatment of infectious diseases is justified by the following examples.

 Example 1. Patient V., 24 years old, student, medical history N 100096. From the anamnesis: sick about two years; Concerned about weakness, decreased performance, weight, bloating in the abdomen, loose stools.

Upon admission to the department, the condition is defined as satisfactory. In the clinical aspect, asthenic, dyspeptic syndromes prevailed. In general blood tests, urine tests and biochemical tests, pathological abnormalities were not found. Gastroscopy showed: against the background of hyperemic, edematous, with erosion of the mucosa, there is a peptic ulcer of the duodenal bulb. Conclusion: duodenal ulcer, erosive gastroduodenitis. In the analysis of feces for dysbiosis: a decrease in aerobic coliform flora (120 million / g), a deficiency of bifidumbacteria (10 ² ), bacteroids (10 ³ ), a significant increase in Klebsiella (10 ⁶ ).

 Treatment was carried out by phytochitodez of a series 06 according to the scheme: 1 tab. under the tongue three times a day for two weeks. In addition, the patient took enzymatic, antispasmodic drugs.

 During the control gastroscopy, eight days later, a complete scarring of the peptic ulcer of the duodenal bulb and repair of the gastric mucosa were found. In repeated studies of fecal flora, Klebsiella was not found, an increase in the number of coli and bifidumbacteria was noted. The observation period for the patient was six months. The condition remained satisfactory, there were no complaints, pathological syndromes were stopped.

Example 2. Patient S., 18 years old, soldier, medical history N 100237. Diagnosis: salmonellosis, gastrointestinal form, moderate severity. The disease was characterized by acute onset, intoxication, dyspeptic, pain syndromes, the release of salmonella enteriditis in the stool culture. Complete blood count: white blood cells 8 • 10 ⁹ / l, hemoglobin HB 140 g / l, ESR 10 mm / hour. The result of sigmoidoscopy: the mucosa of the rectum and sigmoid colon is hyperemic, swollen, multiple erosions on the mucosa.

 The treatment was carried out by phytochitosis series 10, one tablet under the tongue three times a day for 10 days.

 A control sigmoidoscopy was performed after six days, complete healing of intestinal mucosal erosion, and a decrease in hyperemia were noted. The rapid regression of clinical symptoms, the lack of growth of salmonella in the control cultures of feces were the basis for the discharge of the patient on the 14th day of inpatient treatment.

 Example 3. Patient C., 44 years old, doctor; outpatient card N 1247/98. From the anamnesis it is known that the patient for four years suffers from chronic enterocolitis, intestinal dysbiosis.

Standard therapy with eubiotics, enzymatic, antispasmodic and sorbent drugs did not lead to a clinical effect. The patient was disturbed by bloating, rumbling in the abdomen, constant aching pain in the mesogastric region, loose stools alternated with constipation. Biochemical tests, blood and urine tests did not reveal abnormalities. Gastroscopy showed the presence of chronic gastritis, sigmoidoscopy - the intestinal mucosa with focal hyperemia, in the lumen of the intestine there is mucus. Gynecological diseases were not detected. Analysis of feces on the flora showed a decrease in the concentration of bifidobacteria (10 ³ ), a change in the properties of Escherichia coli (lactose-negative 25%, hemolytic 50%), an increased number of coccal forms.

 The phytochitosis series 09 and 10 were simultaneously treated, one tablet of each under the tongue three times a day for two weeks.

At the end of treatment, the condition improved, the pain disappeared, bloating in the abdomen, stool returned to normal. An analysis of feces for dysbiosis revealed an increase in bifidobacteria to 10 ⁸ , the disappearance of coccal flora, and restoration of b. coli, 350 million, in the absence of altered microflora.

 Example 4. Patient T., 10 months old, outpatient card N 548/98. Diagnosis: intestinal dysbiosis, atonic dermatitis.

 On examination, the condition was found to be satisfactory, increased nutrition, a slight increase in the cervical, submandibular lymph nodes. On the skin of the face, limbs, buttocks there was an abundant, bright, small-point rash with traces of scratching. In the analysis of blood and urine pathological abnormalities were not found. In stool crops, a predominance of Staphylococcus aureus, Escherichia coli with hemolytic properties was revealed. According to endogastroduodenoscopy (endoscopy) before treatment, the patient had a picture of superficial gastritis, duodenitis. The combination of dermatitis and gastroduodenitis indicated a widespread lesion of the mucous membranes of the gastrointestinal tract and skin, that is, the presence of dermatogastrointestinal syndrome. Treatment with enzymatic preparations, colibacterin, staphylococcal bacteriophage was not effective, and loose stools, an itchy rash on the skin continued to disturb.

 The phytochitodes series 09 treatment was carried out half a tablet twice a day for two weeks. After the end of the prescribed course of treatment, relief of dyspeptic syndrome, a decrease in the manifestation of dermatitis were noted. When analyzing feces for dysbiosis, Staphylococcus aureus was not determined, the number of E. coli with hemolytic properties decreased. A control study (endoscopy, clinic) a month later indicated the disappearance of the dermatogastrointestinal syndrome.

 Example 5. Patient S., 18 years old, soldier, medical history N 100331. Diagnosis: acute Flexner dysentery, enterocolitic form, moderate severity.

. В посеве кала обнаружена шигелла Флекснера. При ректороманоскопии обнаружен эрозивный проктосигмоидит - множественные эрозии на фоне гиперемированной, отечной слизистой кишечника. Исследование ЭКГ свидетельствует о наличии синусовой тахикардии.The disease was characterized by acute onset, fever, pain, dyspeptic syndromes, an admixture of blood in the feces. A blood test showed a white blood cell count of 10 ⁹ / L, hemoglobin HB 150 g / L, ESR 20 mm / hour. Urinalysis revealed the presence of white blood cells up to 10 in the field of view, protein - 0,033

. Shigella Flexner was found in the feces. When sigmoidoscopy revealed erosive proctosigmoiditis - multiple erosion on the background of hyperemic, edematous intestinal mucosa. An ECG test indicates the presence of sinus tachycardia.

The treatment was carried out using only chitodez ^* - 1 tablet under the tongue three times a day for ten days. Against the background of the therapy, the patient's condition improved: the temperature normalized, stool, intoxication decreased, abdominal pain disappeared. In the control cultures of feces, the causative agent of dysentery was not found. With a control sigmoidoscopy, after 10 days, complete epithelization of erosion, the disappearance of hyperemia, and swelling of the intestinal mucosa were noted.

 Example 6. Patient M., 19 years old, soldier, medical history N 100338. Diagnosis: food toxicoinfection, gastrointestinal form, moderate severity.

 The disease was characterized by acute onset, abdominal pain, nausea, decreased appetite, loose stools with urges up to 4 times a day. Blood and urine tests revealed no pathological abnormalities. No pathogenic pathogens were found in feces. Gastroscopy revealed changes due to hyperemia of the gastric mucosa with multiple erosions and hemorrhages, thickening of folds.

Chitodesis treatment ^* 1 tablet three times a day for 10 days. After the course of treatment, the condition improved, abdominal pain disappeared, diarrheal syndrome was stopped. Control gastroscopy after 8 days showed a decrease in hyperemia and swelling of the gastric mucosa, epithelialization of erosion was noted, which completely disappeared after a week.

 Example 7. Patient F., 58 years old, lawyer, medical history N 100441. Diagnosis: cirrhosis of the liver of moderate activity in the stage of subcompensation.

 The patient's condition is rated as moderate. Complaints of weakness, loss of appetite, skin itching. Yellowness of the skin and mucous membranes, the presence of vascular "stars", and an increase in the liver were noted. Biochemical tests found an increased content of bilirubin up to 200 g / l, alkaline phosphatase up to 240 IU, ALT / AST up to 700/600 μmol / l. An ultrasound scan showed signs of cirrhosis. Conducted standard therapy using basic therapy, enzymatic, antispasmodic, diuretics. A very slow decrease in bilirubin, alkaline phosphatase, and transaminases was noted.

 On the 20th day of hospitalization, 12B series phytochitodez was added to the treatment, 1 tablet under the tongue three times a day for 10 days, then series 11 phytochitodes in the same dosage. After a course of treatment, the condition improved, complaints of itching and weakness disappeared. Bilirubin decreased to 60 g / l, alkaline phosphatase to 150 IU, ALT / AST to 180/100 μmol / l.

 Example 8. Patient F., 21 years old, joiner, medical history N 100630. Diagnosis: chronic viral hepatitis "C" - established on the basis of clinical and biochemical data, ultrasound studies, identification of anti HCV markers, HCV RNA.

The data of biochemical analyzes: bilirubin 100 g / l, ALT / AST 300/190 μmol / l, alkaline phosphatase 190, GGTP - 210. General blood test showed: HB 120 g / l, L 4.5 • 10 ⁹ / l, ESR 18 mm / hour. Conclusion Ultrasound of the abdominal cavity: diffuse changes in the structure of the liver, thickening of the walls of the gallbladder. Gastroscopy revealed signs of chronic gastroduodenitis.

 A course of treatment with phytochitodesis series 11 was carried out, one tablet under the tongue three times a day for two weeks. At the same time, the patient was taking enzymatic and antispasmodic drugs. After treatment, an improvement in bilirubin, alkaline phosphatase, ALT / AST was noted. After the second course, normalization of bilirubin to 22 g / l, alkaline phosphatase to 120, and a decrease in ALT and AST to 140 and 90 μmol / l, respectively, were noted. Anti HCV was not detected after three and six months. The condition is rated satisfactory, biochemical tests are within normal limits. Slight pain in the right hypochondrium, appearing after a meal, was probably due to the presence of chronic cholecystitis.

 Example 9. Patient K., 59 years old, doctor, medical history N 4039. Diagnosis: viral hepatitis B, severe course.

 The disease was characterized by severe intoxication syndrome, significant changes in biochemical tests (bilirubin up to 400 g / l, alkaline phosphatase up to 420, ALT / AST up to 2540/1700 mmol / l), a decrease in prothrombin index up to 58%, signs of cholestasis were noted. Conducted intravenous detoxification therapy, two sessions of plasmapheresis.

 On the eighth day of stay in the department, phytochitodes-12B was prescribed, 1 tablet three times a day. The condition began to improve. After two weeks of taking phytochitodes-12B, bilirubin decreased to 80 g / l, alkaline phosphatase to 140, there was a rapid decrease in ALT enzymes to 400, AST to 200 μmol / l, skin itching disappeared. Observation of the patient continued.

 Example 10. Patient E., 15 years old, and / b N 276. He was hospitalized from 01/09/98 to 02/10/98. Diagnosis: viral hepatitis B, severe course.

 The diagnosis was made on the basis of an epidemiological history (he treated his teeth three months ago), the presence of a pre-icteric period with asthenovegetative and dyspeptic symptoms, fever, development of jaundice, severe cytolytic and cholestatic syndromes, hepatosplenias, and the presence of specific markers of HBV infection: HBs - Ad (+) , anti HBcor JgM (+). Biochemical parameters: ALT 2400 μmol / l, AST 2350 μmol / l, bilirubin 158/113 g / l, alkaline phosphatase - 410, prothrombin index 77%, thymol sample 33.

 Basic therapy was carried out: intravenous administration of hemodesis, glucose, no-spa, riboxin, folic and ascorbic acid. By the end of the second week of treatment, the temperature returned to normal, intoxication decreased, but the enzymes remained high: ALT 1985 μmol / L, AST 1335 μmol / L, bilirubin 111/78 g / L, ALP 375, thymol sample 28, prothrombin 86%, remained antigenemia - (HBs - Ag +). Despite the observance of diet, regimen, continued basic therapy, cytolysis persisted until the 4th week of illness (ALT 1495, AST 1200 μmol / L), a tendency toward a decrease in cholestasis: bilirubin 28/28 g / L, alkaline phosphatase - 370, thymol sample 12 HBS Ag, HBC Ag, as well as anti ABcor JgM were still determined. An enlarged liver (+ 3 cm) • E was clinically preserved.

 The phytochitodezis of series 14 were treated with 1 tablet under the tongue three times a day 30 minutes before meals for 12 days. On the 7th day, the enzymes decreased by more than 7 times (ALT - 205 μmol / L, AST - 130 μmol / L), bilirubin, alkaline phosphatase and thymol sample reached normal values (bilirubin 14/14 g / l, alkaline phosphatase - 180 , thymol test 8), antigenemia disappeared (HBS Ag - neg., HBC - neg.), antibodies (HBcor JgM -) were not detected. Treatment with phytochitodez series 14 continued. After the course, all indicators of enzymes, bilirubin became within normal limits, markers of HBV infection were not determined.

 Example 11. Patient G., 26 years old, and / b N 746, was in the hospital from 01/23/98 to 12/12/98. Diagnosis: acute viral hepatitis B, moderate to severe.

 The diagnosis was made on the basis of epidemiological history (in the group of friends who shared parenteral heroin, there were cases of viral hepatitis), the presence of a pre-icteric period with a severe dyspeptic syndrome, moderate fever, exanthema, the appearance of jaundice with severe cytolytic and cholestatic syndromes, hepatosplenomegaly. Confirmed by the presence of specific markers of HBV infection: HBs Ag, anti HBcor JgM. Biochemical parameters at admission: total protein 72.0, bilirubin 148/76 g / l, ALT - 1850 mmol / l, AST - 970 mmol / l, alkaline phosphatase - 480, prothrombin index 78%, thymol sample 33. Markers: HBS - Ag +, anti HBcor JgM +.

 Two weeks later, against the background of basic detoxification therapy (glucose, hemodesis, vitamin C, riboxin), the patient's condition improved: intoxication decreased, nausea disappeared, appetite appeared, there was a decrease in ALT aminotransferase activity to 960, AST to 885 μmol / L, and also decreased activity of cholestasis enzymes: bilirubin up to 66/43 g / l, alkaline phosphatase - 370, thymol sample 28, HBS antigenemia was preserved, which provided the basis for the appointment of phytochitodes therapy.

 Phytochitodes of series 14 was prescribed, one tablet under the tongue three times a day for two weeks. On the eighth day of taking phytochitodes (tolerance is good), there was a decrease in bilirubin levels to 28/4 g / l, aminotransferase activity: ALT to 173, AST to 130 μmol / l. By the end of the course of treatment, all indicators returned to normal: protein 80.2 g / l, bilirubin 7.2 g / l, ALT - 46, AST - 52 mmol / l, ALP - 170. HBS Ag was not detected in the blood. The liver contracted to normal size.

 Example 12. Patient H., a student, and / b N 3071, was hospitalized from 04/04/98 to 04/15/98 with a diagnosis of acute viral hepatitis B, moderate severity.

 The diagnosis was made on the basis of an epidemiological history (he took heroin for 8 months parenterally), the presence of a pre-icteric, icteric period, with cholestasis and cytolysis, hepatosplenomegaly. Confirmed by the presence of hepatitis B markers (HBS Ag, anti HBcor JgM). Blood biochemical parameters at admission: bilirubin 110/56 g / l, alkaline phosphatase 370, prothrombin index 65%, ALT - 1350, AST 1440 μmol / l, total protein 60.0%. Markers: HBS Ag - +, anti HBcor JgM - +, anti HC - neg.

 Against the background of basic therapy (glucose, vitamin C, riboxin), a series 14 phytochitodes was treated one tablet under the tongue three times a day for two weeks. On the eighth day of treatment, the patient's condition improved: jaundice, intoxication decreased, the activity of aminotransferases decreased by more than six (ALT) and ten (AST) times, the size of the liver decreased, the HBS antigen in the blood was not detected; blood biochemical parameters: total protein - 68 g / l, bilirubin 28/28 g / l, ALT - 280 μmol / l, AST - 130 μmol / l, alkaline phosphatase 170, prothrombin index 78%. HBS Ag - Neg., Anti HBcor JgM - +.

 The patient was discharged in satisfactory condition for outpatient follow-up with phytochitode 14 series. After eight days, a second blood test was performed, indicating normalization of biochemical parameters: ALT - 20 μmol / l, AST - 38 μmol / l, total protein 70.8 g / l, alkaline phosphatase 130. HBS Ag - negative, DNA-HBV - negative.

 Example 13. Patient J., 56 years old, and / b N 103939, was hospitalized from 12/23/98 to 01/15/99 with a diagnosis of viral hepatitis B (HBS - Ag +), moderate severity; type 2 diabetes mellitus, moderate to severe, subcompensated. Related: atherosclerotic cardiosclerosis, grade 3 hypertension, NK1, hypertrophic gastritis, gastric polyposis.

 The diagnosis was made on the basis of epidemiological history, clinical symptoms of the preicteric period, jaundice, which occurs with the syndrome of cytolysis and cholestasis, hepatosplenomegaly and is confirmed by markers of hepatitis B (HBS Ag +). The disease was accompanied by severe cholestasis (increased bilirubin to 92 g / l, alkaline phosphatase - 415) and cytolysis (ALT - 92 μmol / l, AST - 118 μmol / l, GGTP - 2838).

 Basic therapy (glucose, vitamin C, riboxin) was carried out in combination with 12K phytochitodez followed by the appointment of phytochitodez series 14 according to the scheme: 1 tablet under the tongue three times a day for three weeks. On the background of treatment with cholelitic phytochitodesis (12K series), there was a gradual decrease in cholestasis enzymes, bilirubin from 104 to 35 after two weeks and to 19 after three weeks of administration. Long-term preservation of hyperfermentemia (from 12/30/98 and 01/06/99 ALT of 92 and 104 µmol / respectively, AST - 178 and 161 µmol / l) served as an indication for the appointment of phytochitodes series 14.

 Ultrasound examination of the abdominal cavity 12/24/98 revealed pronounced diffuse changes in the liver, hepatomegaly (<180 mm), xp. cholecystitis, pancreatitis, splenomegaly (137 mm). On endoscopic endoscopy on 12/25/98 - hyperplastic gastritis, intestinal polyposis. Blood sugar: from 12.24.98 - 14.5, from 06.01.99 - 7.6. After the therapy, bilirubin decreased to normal by 02.16.99, aminotransferases maintained moderately increased activity, ALT - 35, AST - 47 μmol / L, after a week the latter returned to normal. The liver contracted to normal size, the sugar content stabilized (up to 5 mg% in the blood, absent in the urine). On the control endoscopy from 02.29.99 - the phenomenon of gastritis decreased. Erosion, ulcers were not found. HBV DNA - not detected.

 Example 14. Patient L., 56 years old, outpatient card N 1448/97. Diagnosis: chronic gastritis, pancreatitis, intestinal dysbiosis 4, fungal.

 For 10 years, suffers from chronic gastritis, pancreatitis. Constantly observed by a gastroenterologist. Three weeks ago, she had a sore throat, about which she took antibiotics. The last 5 days there was bloating, unstable stool, pain in the epigastric region, belching, bitterness in the mouth. In the analysis of feces for dysbiosis, a decrease in b. coli up to 120 million, an increase in lactose-negative strains up to 20%, the absence of bifidumbacteria, the presence of a large percentage of candida fungi. Endoscopic endoscopy on 12/27/97 - erosion of the antrum, chronic gastritis with atrophy of the mucosa, indirect signs of bile reflux.

Treatment: phytochitodes series 02, "plastofarm", digistex and vitabalance 3000. Phytochitodes was prescribed one tablet under the tongue before meals three times a day for three weeks. On the background of taking the drugs, positive dynamics were noted: bloating decreased, stool normalized, bitterness and pain disappeared. Three weeks later (01/17/98) in the control analyzes of feces, the number b. coli increased to 350 million, bifidumbacteria - up to 10 ⁷ , lactobacilli - up to 10 ⁶ . However, fungi of the genus Candida were determined in a titer of 1 • 10 ⁵ . The phytochitodez of series 08 was prescribed in a similar dosage for 7 days. A control study of feces from 01/24/98 indicated the disappearance of fungi and the complete restoration of microbiocinosis of the large intestine. Control endoscopy from 01/22/98 - chronic gastritis with focal atrophy, no erosion was found.

 Example 15. Patient P., 30 years old, and / b N 1356. Diagnosis: chronic gastroduodenitis, cholecystic pancreatitis, biliary dyskinesia.

 From the anamnesis: sick for 10 years, worried about weakness, periodically pain in the hypochondrium and epigastric region, periodically pains of herpes zoster, bitterness in the mouth, alternating diarrhea and constipation. When examining for endoscopy - hyperemia and swelling of the mucosa, foci of atrophy, in the lumen of the stomach in the antrum, signs of bile reflux; edema, hyperemia of the bulbar and duodenum, erosion, no ulcers are noted. Conclusion: chronic gastritis, duodenitis. Ultrasound of the abdominal organs - an increase in the liver, diffuse changes in the pancreas, signs of chronic pancreatitis, anatomical constriction of the gallbladder. RRS - mild cataract proctosigmocyte events.

 Detoxification treatment (glucose, saline, enzymes, choleretic) led to a decrease in pain and severity in the right hypochondrium, but bitterness in the mouth, sometimes pain in the left hypochondrium, remained. This was the rationale for the additional appointment of phytochitodez series 07, two tablets under the tongue before meals three times a day for the first three days, then the first tablet three times a day for three weeks. After the course of treatment, the patient's condition improved, the pain stopped, stool returned to normal. Control endoscopy showed that the gastric mucosa is pale pink, erosion, no ulcers, in some places the folds of the mucosa are thickened, there is no swelling. The result of the control ultrasound is signs of chronic cholecystitis and pancreatitis. After a two-week break, a repeated month-long intake of phytochitodesis series 07 is recommended.

Example 16. Patient I., 27 years old, came 10.02.95 with complaints of pain, redness and tightening of the right breast. Concerned about high fever up to 40 ^o C, chills, fever, heavy sweating at night, temperature drop to 36 ^o C, severe weakness. Lactation decreased sharply. Constant tachycardia of up to 120 beats per minute was noted. During the examination, sharp hyperemia, swelling and tightening of the right mammary gland (inflammation at the stage of infiltration and beginning necrosis) were determined. Acute mastitis of staphylus-streptococcal etiology, decreased lactation. Clinical blood test: GB 103 g / l, erythro. 3.2 • 10 ¹² / l, ESR 45 mm / h, leukocytes 17 • 10 ⁹ / l, s - 3%, p - 9%, s - 70%, LMF - 14%, e - 1%, m - 2% In urine: protein 0.33 g / l, alkaline reaction, beats. weight 1022, white blood cells - 30 in n. sp., erythritol. 1-3. Diagnosed with acute right-sided mastitis, staphylococcal infection, acute pyelonephritis. Decreased lactation.

 The surgeon prescribed antibiotic treatment (lincomycin), UHF, half-alcohol compresses. The condition worsened, the phenomenon of mastitis and pyelonephritis increased. 02.17.95 and 02.19.95 twice opened the abscess, but again there was an infiltration. From 02.25.95 phytotherapy was prescribed (milk collection and N 9 - N M9 collection option). Two tablespoons of collection N M9 brew 1 liter of boiling water, bring to a boil, insist 1 hour, drain. Drink half a glass every hour for two days, then 1 glass 4 times a day. The second fraction: thicken the grass again to brew 0.5 l of boiling water, insist 1 h, strain. Make microclysters 2 times a day, 50 ml each and lotions on a diseased mammary gland, changing them as they dry. At the same time, it is prescribed to take phytochitodes series 09 one tablet under the tongue 4 times a day 30 minutes after eating and at bedtime and lubricate the mammary gland, nose and rectum with phytomase with chitosan based on anti-hemorrhoid collection. Eight hours later, a significant improvement in general condition occurred, body temperature returned to normal, pain and hyperemia of the mammary gland disappeared. Then the infiltrate gradually resolved, blood and urine returned to normal. After 10 days, recovery came.

 Example 17. Patient S., 21 years old, 02/28/95 gave birth to a healthy girl. During pregnancy - thrush. After birth, the scraping of the remainder of the placenta was performed. From 03/05/95 to 03/22/95, she was treated with an antibiotic - cefazolin, resulting in candidomycosis: septic fever, chills, night sweats, severe weakness, frequent urination, pain during urination, itching in the perineum, uterine bleeding, pain in the lumbar region, decreased appetite , weight loss, decreased lactation. In blood, GB 97 g / l, ESR - 20 mm / h, toxic granularity of neutrophils, stab leukocytes 56%. In urine: protein 0.099 g / l, red blood cells cover the entire field of view, yeast.

 03/22/95 phytotherapy appointed: alternate fees N 8 and milk. Prepare as in example 16. Take alternating half a cup every hour for two days, then one glass in small sips 1 hour before meals and 1 hour before bedtime. For microclysters and douching of 50 ml once a day, as well as wiping the skin of the mammary glands, the second collection fraction N 8 is used. At the same time, phytochitodes 08 series is prescribed one tablet under the tongue 30 minutes after eating 4 times a day and lubricate the nose, in the mouth for cheeks on turundas, in the rectum and vagina twice a day, phyto-ointment with chitosan based on the collection of N 8. A significant improvement came in five days, recovery - after two weeks.

Example 18. Patient S., 24 years old, became ill 23.06.98 acutely. It began with pain in the left mammary gland, with chills, fever up to 38.5 ^o C. 06/24/98 hyperemia, infiltration was determined, lactation decreased sharply. Diagnosed with acute mastitis of the left mammary gland of staphylococcal etiology; decreased lactation.

 Appointed herbal medicine collection N M9. Brew, drink and apply the second fraction similarly to example 16. At the same time, it is prescribed to use phytochitodez of the 09 series, one tablet under the tongue 4 times a day 30 minutes after eating and at bedtime and lubricate the nose, mammary gland and rectum with phyto-ointment with chitosan based on anti-hemorrhoids collection. After a day, the condition improved dramatically. Recovery came on 07/01/98.

 Example 19. Patient B., 38 years old, for 10 years was unsuccessfully treated with hormones for endometriosis. Fungal dysbiosis developed, which was manifested by abdominal pain, severe flatulence, loose stools 5-6 times a day, decreased appetite, weight loss, weakness, and depression.

 Appointed 01.24.98 herbal medicine collection N M20. Brew one tablespoon of this collection with half a liter of boiling water, bring to a boil, insist for one hour, strain. Drink half a cup 4 times a day 15 minutes before meals and at bedtime. Use the second fraction for microclysters, douching and lotions once a day for each procedure. Pour the third fraction (dried spinning herbs collected during the week, brew with 3 liters of boiling water, leave for one hour, strain) pour into a bathtub filled with warm water. At the same time, a sequential intake of 10 days of phytochitodes series 02, 01 and 08 was prescribed, one tablet under the tongue 4 times a day 30 minutes after eating and at bedtime, and the use of phytomaz with chitosan based on the collection of N 8 in the nose, rectum, and vagina and stomach. The condition improved after 15 days. Recovery was noted 03/21/98 - two months later.

What determines the therapeutic effect of the proposed drugs? Note that dysentery bacillus, as we discovered earlier [Treskunov K.A., Komarov B.A. Patent application N 98116163 from 08/18/98], is not sensitive to various salt forms of chitosan, in which chitosan is in a state of polycationic electrolyte. The opposite effect is observed when chitosan is converted to the polyanionic state — the H-form of chitosan succinate (chitodez ^* ), which is demonstrated in the 5th example. Considering that high molecular weight electrolytes of cationic and anionic types possess immunostimulating properties [Andronova TM, Dozmorov IM, Mustafaev MI and others. Synthetic immunomodulators. M.: Science. 1991. S. 191], we can conclude about the wide possibilities of therapeutic anti-infectious action of drugs based on chitosan and its derivatives. Firstly, chitosan is able to cause a prolonged effect of phyto-harvests. The uniquely wide spectrum of bactericidal action, antioxidant properties enhanced by the chelate structure, excellent detoxifying and complexing properties, especially intensifying during the transition from the true solution to the colloidal state, the adhesive and coating properties of chitosan provide its anti-inflammatory effect (starch - filler during tabletting also has an enveloping property).

 Secondly, chitosan, as a non-toxic aminopolysaccharide capable of biological degradation under the influence of lysozyme, can enter the blood and lymph in an oligomeric form and participate in the universal defense mechanism for viral infections - inducing the formation of endogenous interferon. It is significant that biologically active substances of many medicinal plants and adaptogens can also stimulate the production of interferon [Pogorelskaya L.V. et al. Phytotherapy in infectious diseases. M .: RON. 1998]. In addition, the inclusion of chitosan and medicinal plants and another mechanism is possible: direct stimulation of the function of natural killers and increased phagocytic activity of neutrophils and macrophages. Complex metal-containing chitosanorganic and chelate-chitosan-lectin complexes can play an essential role in the immunostimulating effect [S. Polish. US patent N 5912000 from 06.15.99]. All this can cause the observed increased therapeutic effect.

Claims (9)

 1. A method for the treatment of infectious diseases, including phytotherapy, characterized in that phytotherapy uses the introduction of phytochitodes - a mixture of water-soluble chitosan - chitodez and a dry aqueous extract of the collection of medicinal plants at doses of components at a time of 25 mg and 22-25 mg, respectively.  2. The method according to claim 1, characterized in that the phytochitodes are administered under the tongue in tablets or used in the form of chitodetic phytomases in the nose, on the skin, in the rectum, in the vagina.  3. The method according to claim 1, characterized in that in case of peptic ulcer disease against a deficiency of bifidumbacteria and an increase in Klebsiella, phytochitodes is used based on the collection: calamus root, cinquefoil erect (galangal), licorice naked, dicotyledonous nettle grass, shepherd’s nettle, dried cotton grass , yarrow, bitter wormwood, tricolor violet, Veronica oak, eucalyptus leaf, tansy and willow bark, 2 parts by weight, medicinal sweet clover - 1 weight.  4. The method according to claim 1, characterized in that in salmonellosis, accompanied by a lot of erosion on the mucosa of the rectum and sigmoid colon, phytochitodes is used based on the collection of: burdock leaf, large plantain, common yarrow, perforated St. John's wort and medicinal melilot 9 weight .h., white birch leaf, dioecious nettle grass, medicinal calendula color 7 parts by weight, large celandine grass and field horsetail, common tansy color 5 parts by weight, peppermint leaf, medicinal dandelion leaf and roots, grassortsa bird meadow geranium and 3 parts by weight , the color of meadow clover, leaf of narrow-leaved fireweed, coltsfoot common and lingonberry ordinary, grass of goose cinquefoil, ivy buds and a three-part succession of 1 weight. h  5. The method according to claim 1, characterized in that for intestinal dysbiosis and staphylococcal infection, phytochitodes as in claim 4 and anti-staphylococcal phytochitodes are used based on the collection: yarrow grass 6 weight. o'clock, leaf of burdock large - 5 parts by weight, grass of St. John's wort perforated, sweet clover, marjoram ordinary, nettle leaf of dioecious, plantain large 3 parts by weight, grass of coltsfoot, mountaineer, bird rosehips, rosehips of cinnamon, the roots of the erect cinquefoil, dandelion officinalis, the color of calendula officinalis, tansy ordinary for 2 parts by weight, the color of chamomile and the grass horsetail field for 1 part by weight  6. The method according to claim 1, characterized in that in case of fungal dysbiosis in patients with pancreatitis and chronic gastritis, phytochitodes is used alternately on the basis of collection: peppermint leaf, large plantain, color of chamomile officinalis 2 parts by weight, St. John's wort perforated and yarrow for 1 weight.h. and antifungal phytochitodes based on the collection, parts by weight: yarrow grass - 9, white birch leaf - 7, common wormwood grass - 5, medicinal veronica - 4, tricolor violet - 4, chamomile - 2, oregano - 2, the color of calendula officinalis is 2, the color of tansy is 1, the color of meadow clover is 1.  7. The method according to claims 1 and 2, characterized in that in case of candidomycosis, the presence of yeast fungi, simultaneously use an antifungal phytochitodes as in claim 6 and a chitodez-containing phyto-ointment based on antifungal collection.  8. The method according to claims 1 and 2, characterized in that in case of acute mastitis, acute pyelonephritis, strepto-staphylococcal infection, phytochitodes is used simultaneously based on the collection: ordinary yarrow grass - 6 parts by weight, burdock leaf - 5 weight. including grass perforated St. John’s wort, sweet clover, common oregano, dioica nettle leaf, large plantain, 3 parts by weight, coltsfoot grass, mountaineer bird, cinnamon rose hips, upright cinquefoil roots, medicinal dandelion. the color of calendula officinalis, tansy ordinary for 2 parts by weight, the color of chamomile and horsetail grass for 1 part by weight, and the chitodez-containing phyto-ointment based on the collection: medicinal and white melilot grass - 5 parts by weight, goose grass, St. John's wort perforated, meadow geranium, yarrow, white birch leaf, large plantain, tansy color 3 parts by weight, color of calendula officinalis, medicinal chamomile, bird mountain grass, field horsetail, officinalis dandelion leaf, upright roots 2 parts by weight, grass of dried marshmallow, common oregano, dioica nettle, gold rod, coltsfoot leaf, 1 part by weight  9. The method according to claim 1, characterized in that in case of viral hepatitis, in accordance with the activity of the process and the presence of concomitant diseases, phytochitodes is used for cholestasis based on the collection: dioecious nettle grass and bird highlander, 3 parts by weight, immortelle sand and licorice root naked for 2 weight. hours, sweet clover - 1.5 parts by weight; or based on the collection: dioecious nettle and mountaineer grass by 3 parts by weight, corn stigmas and licorice root naked, 2 parts by weight, medicinal sweet clover - 1.5 parts by weight, phytochitodes in case of hyperfermentemia based on the collection: fruits cinnamon rosehips, licorice root, peppermint and St. John's wort grass perforated in 2 parts by weight, dioecious nettle and honey clover herb in 1 part by weight, hepatoprotective and choleretic phytochitodes based on the collection: dandelion root, medicinal chamomile, calendula medicinal, tansy, cook stigma stigmas, dioica nettle grass, Kalanch pinnate and mountaineer, bird clover in equal parts.