RU2273484C2 - Agent for treatment of infectious diseases - Google Patents

Abstract

FIELD: medicine, pharmaceutical industry, phytotherapy.

SUBSTANCE: invention proposes an agent used in treatment of infectious diseases. Agent used in treatment of infectious diseases comprises chitosan of polyfraction composition with amine groups of molecular mass from monomeric link - glucosamine to ~350 kDa and deacetylation degree from ~68 to ≤ 95% and vegetable raw aqueous extract chosen from the following group: Cetraria thallus, sage official herb, cocklebur leaves, black poplar buds, common wormwood herb, red roots, burdock roots, French honey-suckle herb, bur-marigold tripartite herb, sandy common immortelle flowers, dropwort elm-leaved flowers, river avens (Geum) roots, licorice glabrous roots, swampy sweet flag roots, burnet official roots,, nettle dioecious herb, swampy cudweed herb, common milfoil herb, sweet clover official herb, gum-free leaves, dropwort, willow bark, birch leaves, bilberry leaves, willow-herb narrow-leaves herb, peppermint herb, fenestrate Saint-John's-wort herb, knot-grass herb, shepherd's purse herb, violet pensy tricolor herb, speedwell herb, pot-marigold flowers, common tansy flowers, matricary official flowers, chicory roots, dandelion official roots, tormentil roots, cinnamon wild rose fruits, viburnum leaves, pinnate kalanchoe and maize stigmas. Aqueous extract is prepared by extraction of vegetable raw with demineralized water under definite conditions. Agent promotes to effective treatment of infectious diseases, such as chlamydiosis, herpes, erysipelas, viral hepatitis A and B, gastroenteric tract diseases, acute enteric infectious, and to declining period of clinical symptoms of diseases said.

EFFECT: valuable medicinal properties of agent.

10 cl, 2 dwg, 12 ex

Description

The invention relates to the field of clinical phytology and herbal medicine and relates to the production of biologically active substances of natural origin based on complexes of a water-soluble form of chitosan - chitodez with a dry extract of plant materials, which can be used in medicine, as a means for the treatment of infectious diseases, in veterinary medicine and cosmetics.

Recently, therapeutic and prophylactic agents based on phytochitodes - a molecular complex of chitodez - a water-soluble form of chitosan with a dry extract of plant materials have become widespread.

Known tool for the treatment of bronchial asthma and concomitant diseases of the respiratory system, containing a mixture of a water-soluble form of food chitosan and a dry extract of herbal medicines of a special composition used in various dosage forms (Patent RU No. 2172634, A 61 K 35/78, publ. 27.08.2001).

The disadvantage of the analogue is the limited spectrum of biological activity.

Known tool "Hitokor" for the treatment of viral hepatitis B and C, including the phytocomposite powder of lectin-containing medicinal plants, the powder of water-soluble low molecular weight chitosan and the filler is starch or carboxymethyl cellulose (Patent RU No. 2185185, A 61 K 35/78, publ. 20.07.2002).

However, the known tool "Hitokor" is limited by a narrow anti-infectivity.

A biologically active preparation based on phytochitodes is known in the form of a molecular complex of a dry extract of a medicinal plant or phyto collection and a water-soluble form of chitosan of a polyfraction composition with a molecular weight from monomer unit - glucosamine to ~ 150 kDa and a degree of deacetylation from ~ 68 to ≤95% (Patent RU No. 2204402 A 61 K 35/78, publ. 05.20.2003).

The disadvantage of this analogue is the use of chitosan with a polyfraction composition with a molecular weight of not more than 150 kDa, which limits the bacteriostatic activity of the salt forms of chitosan (Chervynets V.M. Abstract of thesis. Diss. M. April 2002). In addition, the conditions for the production of phytosboron extracts do not contribute to the extraction of plant lectins without changing their structure (Study and use of lectins. "Lectins in Biology and Medicine". Scientific works of the University of Tartu. V.2. 1989; Krapivina LI Lectins of hexaploid wheat Abstract of dissertation of Candidate of Biol. Sciences. 1988. Saratov).

The closest analogue is a complex phytopreparation for the treatment of infectious diseases, which is a mixture of water-soluble chitosan and a dry aqueous extract of the collection of medicinal plants at doses of components at a time of 25 mg and 22-25 mg, respectively (Patent RU No. 2174000, A 61 K 31/722, publ. 02.22.2000).

However, the known phytopreparation is not effective due to incomplete extraction of a complex of biologically active substances.

The objective of the invention is to develop a new effective and affordable means for the treatment of infectious diseases, which can be used both independently and in combination with other drugs.

The technical result of the invention is to create a new tool for the treatment of infectious diseases, which reduces the duration of the clinical manifestations of infectious diseases of various etiologies.

The essence of the invention is as follows: an agent for the treatment of infectious diseases, characterized in that it contains a chitosan of polyfraction composition with amine groups of molecular weight from a monomer unit - glucosamine to ~ 350 kDa and a degree of deacetylation from ~ 68 to ≤95%, an aqueous extract of plant materials selected from the group: cetraria thallus, medicinal sage grass, gorse leaf, black poplar buds, bitter wormwood grass, red root, burdock roots, penny grass and a three-part succession, colorless sandworm and birch grass, roots of river gravel, licorice, calamus swamp and hemorrhagic medicinal herb, dioecious nettle grass, dried marshmallow, yarrow and honey clover, eucalyptus leaf, willow bark, birch and bilberry leaf, brown boiled grass Hypericum perforatum, mountaineer bird, shepherd’s bag, tricolor violet and Veronica Dubrava, calendula officinalis, common tansy and chamomile, chicory roots, medicinal dandelion, cinquefoil erect (galangal), cinnamon rose hips, viburnum leaf, Kalanch cirrus and corn stigmas, while it was obtained by extraction of plant materials with demineralized water at a temperature of not more than 65 ° C for 1-48 hours and the extractant: raw material ratio (3-5) :one.

At the same time, for the treatment of chlamydia, the remedy (phytochitodes-33) contains an extract of plant materials of the following composition: cetrari thallus, medicinal sage herb, gingerbread leaf, poplar buds and bitter wormwood grass, red root in equal amounts; with herpes (phytochitodes-18): burdock root, penny grass and a series of three-parted, the color of sandy immortelle and meadowsweet, black poplar buds, river gravel and licorice roots in equal amounts; with erysipelas (phytochitodes-15): roots of calamus swamp, hemorrhagic medicinal, licorice naked, herb dioica nettle, dried marshmallow, yarrow and honey clover, eucalyptus leaf, meadowsweet, willow bark in equal amounts; in chronic hepatitis and pancreatitis (phytochitodes-07): leaf of birch and blueberry, grass of narrow-leaved fireweed, peppermint, St. John's wort, yarrow and honey clover, color of calendula officinalis, chicory roots and calamus marsh in equal parts; in chronic hepatitis with cytolytic syndrome (hepherm - phytochitodes-14): cinnamon rose hips, licorice roots, peppermint and St. John's wort, perforated in two parts, dicotyledonous nettle and medicinal sweet clover, viburnum leaf in one piece; in case of chronic hepatitis and hypotonic dyskinesia (phytochitodes-12B): dioecious nettle grass and bird highlander in three parts, the color of immortelle sandy and licorice roots in two parts, medicinal sweet clover - one and a half parts; in chronic hepatitis and hypertensive dyskinesia (phytochitodes-12K): dioecious nettle grass and bird highlander in three parts, corn stigmas and licorice roots in two parts, clover medicinal - one and a half parts; with viral hepatitis A and B with biliary dyskinesia (phytochitodes-11): dandelion roots, common tansy, chamomile and calendula officinalis, corn stigmas, medicinal sweet clover grass, Kalanch cirrus, bird highlander and nettle in an equal amount; for infectious diseases of the gastrointestinal tract and acute intestinal infections (phytochitodes-06): roots of calamus swamp, cinquefoil erect (galangal), licorice, grass nettle dioecious, shepherd's purse, dried marshmallow, yarrow, bitter wormwood, tricolor violet and oak, leaf of eucalyptus, the color of tansy, willow bark in two parts, the herb of the clover medicinal - one part.

The proposed tool for the treatment of infectious diseases is obtained as follows: to preserve the structure and properties of plant lectins, extracts of plant materials in demineralized water are first obtained by combining dry phytobrain with demineralized water, followed by holding it with periodic stirring for 1-48 hours at a temperature of no more than 65 ° C and the ratio of extractant: raw material (3-5): 1. Then, after filtration in an aqueous extract, a complex of extracted substances is obtained from plant materials, including plant lectins, with amine (and other functional) molecular chitosan groups from a monomer unit - glucosamine to ~ 350 kDa and a degree of deacetylation from ~ 68 to ≤95%.

The increased effectiveness of the proposed tool for the treatment of infectious diseases is due to the integrated use of chitosan-containing various phytochemicals, the use of water-soluble forms of chitosan of a polyfraction composition, the high molecular weight fraction of which has an enhanced bacteriostatic property and provides a prolonged effect of phytocomponents, and the oligomeric fraction is rapidly absorbed into the blood when sublingually applied to various organs and performs immunocorrective action. The dynamics of penetration and excretion of ³ H-chitosan oligomers in the blood and various organs is clearly demonstrated by a study on mice of the C-57 / BC line (Figs. 1 and 2).

These data obtained on a laboratory model allow, we believe, to confirm a similar trend in the content of oligomeric chitosan (with the number of links in the chain from monomer glucosamine to octamer) in the blood and various organs of a person. Especially important is the information on the dynamics of penetration and excretion of high molecular weight ³ H-chitosan with a molecular mass of 87 kDa when it is introduced as a solution in water and the infusion of the collection of medicinal plants used in the preparation of phytochitodes-14 (hepaferm) (Fig. 2).

It was found that by 4 hours after administration, there is a tendency to increase the blood chitosan content by ~ 40% compared with the control experiment (the introduction of aqueous acidified chitosan solutions). The content of chitosan in the liver during the observation time, on the contrary, decreases, while the dynamics of the content in other organs is almost the same. Once in the liver, chitosan forms complexes with heparin, which have an anticoagulating effect and the ability to activate enzymes that eliminate foci of inflammation, intoxication and restore the liver’s working capacity [Y. Kikuchi, Macromol. Chem., 175, 2209, 3593. (1974)]. The fact of an increase in the content of chitosan in the blood may be due to the fact that some plant lectins can play the role of chitinase and chitosanase, which will increase the oligomeric fraction of chitosan that penetrates the blood and various organs.

It is important to emphasize that in order to increase the effectiveness of the prevention of infectious diseases, the presence of plant pectins in the unchanged state of their structure and in the optimal ratio with the water-soluble form of chitosan of a polyfraction composition, which is governed by the extraction conditions and the extractant / raw material ratio, is essential.

A significant contribution to the effectiveness of treatment of infectious diseases is the expansion of the molecular mass range of chitosan of polyfraction composition to 350 kDa, which increases the sensitivity of pathogenic microflora to salt forms of chitosan, especially in the foci of inflammation of the gastrointestinal mucosa with the sublingual method of phytochitosis without any fluid.

Chitosan and chitin, especially their water-soluble oligomeric digestible fractions, can be considered as a building material for the synthesis of mucopolysaccharides in connective tissue cells. When applied externally, chitosan not only quickly penetrates the skin through the mouth of the hair follicles and through the mouth of the glands, but also activates the enzymes hyauluronidase and β-glucuronidase, which are responsible for diffuse processes in the extracellular matrix. If, with the oral administration of phytochitodes, as we see, chitosan can also penetrate into the blood and various organs, then in this case the transport in the extracellular matrix of all human organs will also improve, which means that the products of vital activity of cells will be more efficiently taken away and nutrition will be delivered to cells, salt exchange will occur. If we take into account the antioxidant properties of not only phytosorbate extract, but also chitosan, for which these properties are enhanced by the presence of an amino group in the coordination sphere of a transition metal atom (Zn, Cu, Ni, Fe) [B. Komarov. Why is chitosan good for humans? "New advances in the study of chitin and chitosan." Materials of the 6th Int. conf. October 22-24, 2001. M: VNIRO. 2001. P.187-195], then phytochitodes, to a certain extent, can play the role of adaptogens, especially those phytochitodes, which are obtained on the basis of multicomponent collections of medicinal plants, when the preparation becomes rich not only in various extractable organic substances, similar in composition to adaptogens , but also vital micro and macro elements in an easily digestible form.

The invention is illustrated by the following examples.

Example 1. Patient D., 49 years old, was observed on an outpatient basis. From the anamnesis it is known that in the past 10 years, itching of the vulva, frequent cystitis, accompanied by frequent urination, pain in the eyes, pain in the joints - knee, hip, have been disturbing. The examination was diagnosed with urogenital chlamydia, Reiter's syndrome. The diagnosis is confirmed by isolation of Ch. Trachomatis from the cervix, by detecting chlamydia DNA in the polymerase chain reaction (PCR), in an enzyme-linked immunosorbent assay (ELISA), positive antibodies to chlamydia type JgG - 0.692 (+++), RIF of smears-scrapings of the cervix, conjunctive - positive. The phytochitodes-33 treatment was carried out for six weeks with simultaneous douching with a decoction of bitter wormwood (one month), using ointment on the joints (one and a half months). Improvement of health was observed from the third week: vulvar itching disappeared, pain in the eyes and urination, joint pain decreased, and completely stopped by the fifth week of treatment. After treatment, the results of control studies in PCR and immunofluorescence reactions (RIF) are negative. In ELISA, JgG antibody titers decreased to normal (0.225).

Example 2. Patient S., 38 years old, was observed on an outpatient basis. Diagnosis: urogenital chlamydia, detected 3 years ago and confirmed in cell culture in ELISA and RIF. Conducted treatment with traditional antibiotic therapy (doxycycline, sumamed). Discharged with negative control studies in cell culture, ELISA, RIF. However, two years later, chlamydia was detected again against the background of a pronounced clinic (joint pain, inguinal region, painful and enlarged inguinal lymph nodes, loose stool up to two times with mucus, discharge from the urethra and anus, itching). In addition to chlamydia Ch. Trachomatis detected ureaplasma. The patient again underwent a course of antibiotic therapy - without effect. The disease is regarded as reinfection - a mix: chlamydia + ureaplasmosis, complicated by antibiotic therapy, decompensated staphylococcal intestinal dysbiosis of the 3rd degree. Recommended treatment with antichlamydial phytochitodesis (6 weeks) in combination with tincture of birch buds (1 month), instillation of decoction of bitter wormwood (3 weeks), bifidiumbacterin (4 weeks). The patient’s health improved markedly. Control studies showed a negative result in cell culture, ELISA, RIF. After 3 months, PCR was done: DNA Ch. Trachomatis not detected.

Example 3. Patient P., 60 years old, was observed on an outpatient basis for a chronic, often recurring herpetic infection with lesions of the skin and mucous membranes (type 1 and 2 in PCR). Suffers for 10 years with recurrent herpes with localization on the mucous membranes of the lips and genitals, the skin of the wings of the nose and buttocks. The previous antiviral therapy with acyclovir (zovirax), alpizarin inside and topically, interferon inducers and interferon (amiksin, reaferon, velferon), half-dan gave a temporary effect with a short remission (from 2 weeks to 1 month). In case of exacerbation of herpes infection (confirmed by PCR - types 1 and 2 of herpes virus), phytochitodes-18 and locally chitosan-containing ointment, prepared on antiherpetic phytosorption, were prescribed. Course of treatment: 3 weeks of oral administration of 1 tablet of phytochitodes-18 4 times a day with a weekly break and simultaneous 2-week use of chitosan-containing ointment on the foci of inflammation. Courses were repeated with exacerbation. After 1 course of treatment, relapse occurred at the end of the first month, but was mild. The next relapse developed after 3 months, after 6 and after 1 year. A total of 5 courses of treatment were carried out. Attention is drawn to significant changes in the immune status. Before treatment: decrease in the total pool of T-lymphocytes, violation of the immunoregulatory index in the direction of suppression, blockade of cells by serum factors, decrease in natural killers. After the treatment, all immunity indicators returned to normal. The patient is on maintenance therapy (1.2 courses per year, if necessary).

Example 4. Patient K., 65 years old. Diagnosis: chronic recurrent erysipelas of the lower extremities. Lymphostasis For 5 years, he suffers from recurrent erysipelas of the lower extremities with a relapse rate of 3 to 5 times a year. The patient is on bicillin prophylaxis. In relapses, antibiotic therapy (lincomycin, ampicillin, etc.) was used, while lymphostasis increased, relapses repeated. It is recommended that during the year, one month before the onset of relapse, start taking anti-foto phytochitodes - 15 to 1 tab. 3-4 times a day, dissolving in the mouth. The duration of taking phytochitodes is 2-3 months with a repeat of the course twice a year - in early spring and autumn (before relapses). Observations of the patient during the year indicate a decrease in the number of relapses - up to 1 time per year with mild clinical manifestations.

Example 5. Patient K., 52 years old. Diagnosis: chronic cholecystopancreatitis, biliary dyskinesia. Sick for 5 years since the diagnosis. Ultrasound of the abdominal organs - an increase in the liver, diffuse changes in the parenchyma of the liver and pancreas, thickening of the walls of the gallbladder, atony, the presence of thick bile. Markers of viral hepatitis (C, B, G) - not identified. Biochemical blood test: bilirubin 17.4 / 16.0 g / l. ALT - 62, AST - 48 mmol / l, amylase - 405, alkaline phosphatase - 168, CPK - 96 units / liter, LDF - 412 units / liter. Phytochitodes-07 was prescribed for 1 tablet. 3 times a day (dissolve) 30 minutes before eating, milk thistle - Mariol - MK for 1 tsp. 3 times 20 minutes before meals for three months with a break of 6 days. Control ultrasound after 3 months: the size of the liver is normal, the parenchyma is quite uniform, the contours are wavy, the pancreas is not enlarged. Blood biochemical parameters: ALT-32, AST - 36 units / L, glucose - 5.7 mmol / L, amylase - 114 units / L, bilirubin-18.2 mmol / L, CPK - 96, γHT - 29. Recommended in repeat the course throughout the year.

Example 6. Patient S., 29 years old, was hospitalized and then outpatient. Diagnosis: acute viral hepatitis B, moderate to severe. The diagnosis is confirmed by specific markers of HBV infection. Biochemical parameters at admission: total protein -76.0, bilirubin - 90/64 g / l, ALT - 1450 mmol / l, AST - 930 mmol / l, alkaline phosphatase -430, prothrombin index - 76%. Markers: HBsAg +, anti-HBCor JgM +. Basic detoxification therapy was carried out (iv administration of glucose, vitamins, riboxin), against which the general condition improved, intoxication syndrome decreased. An improvement in biochemical parameters was noted: a decrease in bilirubin to 45/30 g / l, trans-kinases ALT - 1000 mmol / l, AST - 620 mmol / l. During the convalescence period, the cytolytic syndrome persisted for a long time: ALT - 800, AST - 500 mmol / L. Assigned phytochitodes-14 to 1 table. under the tongue 3 times a day for two weeks. A control study of biochemical parameters of bilirubin - 19 g / l, ALT - 56, AST - 40 mmol / l, alkaline phosphatase - 120, HBsAg in the blood was not determined. Treatment continued for another two weeks. All benchmarks returned to normal.

Example 7. Patient K., 42 years old, was observed on an outpatient basis, with a diagnosis of acute viral hepatitis A in the stage of convalescence, a month before that she was undergoing inpatient treatment in the hospital named after S.P. Botkin, where acute viral hepatitis A was diagnosed on the basis of epidemiological history, the pre-icteric and icteric period of the disease occurring with the phenomena of cholestasis and cytolysis. The diagnosis is confirmed by the presence of anti-HAV JgM markers. Basic therapy was carried out (hemodesis, glucose, iv saline, vitamin C). Intoxication, cholestasis disappeared, however, at discharge hyperfermentemia persisted: ALT - 420, AST - 360 mmol / l. Phytochitodes-14 was prescribed according to one table. 3 times a day. After 2 weeks, control studies of blood biochemical parameters were performed, which had a normal value: bilirubin 14.5 / 9.5 g / l, ALT - 42 mmol / l, AST - 32 mmol / l, alkaline phosphatase - 128. Total protein 75 g / l

Example 8. Patient K., 25 years old. Diagnosis: acute viral hepatitis A, moderate severity, based on epidemiological history (contact with a patient with hepatitis A), the presence of the prodromal period according to the flu-like variant, the presence of jaundice, hepatosplenomegaly, cholestatic and cytolytic syndromes. Confirmed by the presence of JgM antibodies to hepatitis A. Upon admission to the hospital (during jaundice), a biochemical blood test: bilirubin 110/80 g / l, ALT - 650, AST - 350 mmol / l, alkaline phosphatase - 640. Basic therapy (glucose , vitamin C, hemodez). After 10 days, the condition improved, but jaundice, moderate itching of the skin, persisted. During the control blood test: LAT - 80, AST - 50 mmol / l, bilirubin - 100/80 g / l, alkaline phosphatase - 520. With ultrasound: hepatosplenomegaly phenomena, diffuse changes in the liver, gall bladder is atonic, contains thick bile, moderate changes in the pancreas glands. Phytochitodes-12B was assigned according to 1 table. 3 times a day, milk thistle powder for 1 tsp. 3 times a day 30 minutes before meals. Control studies of a biochemical blood test after two weeks: bilirubin - 25 g / l, transaminases returned to normal, ALT - 30, AST - 20 mmol / l, alkaline phosphatase - 120. Treatment with phytochitdes-12B was continued. Ultrasound after a month: moderate changes in the liver parenchyma, gall bladder reduced, biliary dyskinesia. All biochemical parameters are normal.

Example 9. Patient P., 24 years old, was observed on an outpatient basis. A month ago I was hospitalized for viral hepatitis A. During the period of convalescence, hyperbilirubinemia persisted, periodically there were pains in the right hypochondrium, bitterness in the mouth. Biochemical blood test: bilirubin - 60/48 g / l, ALT - 32, AST - 38 mmol / l, alkaline phosphatase -390 u / l, with ultrasound: moderate hepatomegaly, moderate diffuse changes in the liver, gallbladder walls are thickened, gall bladder tone tense, pancreatic parenchyma homogeneous. Assigned phytochitodes-12K for 1 table. 3 times a day 30 minutes before meals under the tongue for two weeks. The results of the control biochemical study: bilirubin - 18.5 g / l, ALT - 28, AST - 36 mmol / l, alkaline phosphatase - 140 u / l. With ultrasound in a month, thickening of the walls of the gallbladder, tension of the tone, which was regarded as the formation of chronic cholecystitis, dyskinesia of the biliary tract according to the hypertonic hyperkinetic type, remain. It is recommended to continue taking phytochitodes-12K for up to a month.

Example 10. Patient B., 54 years old, was observed on an outpatient basis. Diagnosis: chronic viral hepatitis B in outcome in cirrhosis, moderate activity in the stage of subcompensation. For 5 years he has been suffering from chronic hepatitis B. He was treated with lamivudine, against which the activity of the process decreased. Last year, he does not take antiviral therapy. Revealed cirrhosis in the stage of subcompensation. With ultrasound - cirrhosis is confirmed. Biochemical blood parameters: bilirubin increased to 180 g / l, LAT - 550, AST -400 mmol / l, alkaline phosphatase - up to 300 units / l. Conducted basic therapy, including enzymes, antispasmodics, heptral, diuretics, led to a decrease in transaminases by half, bilirubin remained high (110 g / l). Phytochitodes-11 was prescribed for 1 tablet. 3 times a day 20 minutes before meals under the tongue. After two weeks of administration, the condition improved, bilirubin levels decreased significantly (up to 30 g / l), but transaminases remained elevated, ALT - 98, AST - 72 mmol / l. In addition, hepaferm (phytochitodes-14) was prescribed. After two weeks, control studies of biochemical blood parameters indicated a compensation process.

Example 11. Patient S., 38 years old, was admitted to the hospital with complaints of fever, cramping abdominal pain, frequent stool in small portions mixed with mucus and blood. Diagnosed with acute Flexner dysentery, confirmed by the isolation of Shigella Flexner 2a. When RRS-examination picture of catarrhal-erosive proctosigmoiditis, sphincteritis. Phytochitodes-06 was prescribed according to 1 table. 4 times a day (dissolve), enterosorbent "pecto", no-spa. The patient's condition improved by the end of the day: abdominal pain decreased, stool frequency decreased, blood impurities disappeared. Subsequently, a regression of symptoms was observed. An RRS study after 5 days revealed no pathology of the intestinal mucosa. The control bacteriological culture of feces for dysentery and intestinal groups is negative.

Example 12. Patient E., 38 years old. Diagnosis: viral hepatitis B, moderate to severe, complicated by cholecystic pancreatitis. Sick for a month, the diagnosis of hepatitis B is confirmed by markers: Hbs Ag +, anti HBCor IgM +, DNA-HBV +. On the 4th week of the disease, against the background of decreasing transaminases (ACT up to 60, AST up to 45 mmol / L) and improving the general condition after an error in the diet, girdle pains appeared and in the right hypochondrium, the temperature increased, blood leukocytosis increased from 6000 to 12000 and amylase up to 600 units. Diagnosed with cholecystic pancreatitis. On ultrasound, liver enlargement, diffuse parenchyma of the liver and pancreas, thickening of the gallbladder walls. The ongoing therapy (antibiotics, detoxification) has developed a drug disease. In this regard, on the 6th day phytochitodes-07 is prescribed three times a day, 1 tablet is absorbed 30 minutes before meals and fluids. Against the background of the therapy, all biochemical parameters returned to normal after 10 days. For three months, the patient took phytochitodes-07 with weekly intervals after a month of admission according to this scheme. Control ultrasound after 6 months: signs of pancreatitis were not detected, diffuse changes in the liver and thickening of the walls of the gallbladder persist. It is recommended to repeat the course of phytochitodes therapy after three months.

Claims (10)

1. An agent for the treatment of infectious diseases, characterized in that it contains chitosan of a polyfraction composition with amine groups of molecular weight from a monomer unit - glucosamine up to ~ 350 kDa and a degree of deacetylation from ~ 68 to ≤95%, an aqueous extract of plant material selected from the group : thallus of cetraria, medicinal sage grass, cobweed leaf, black poplar buds, bitter wormwood grass, red root, burdock roots, penny grass and a series of three-parted ones, the color of sandy immortelle and meadowsweet, Orni of river gravel, licorice, calamus swamp and hemorrhagic officinalis, dioica nettle grass, marsh cinnamon, common yarrow and sweet clover, eucalyptus leaf, meadowsweet, willow bark, birch and blueberry leaf, grass of common-leaved, peppermint, St. John's wort, St. John's wort bird, shepherd’s bag, tricolor violet and Veronica oak, calendula officinalis, common tansy and chamomile, chicory roots, medicinal dandelion, erect cinquefoil (galangal), rosehip fruits and cinnamyl, leaf viburnum, Kalanchoe pinnate and corn silk, while it is obtained by extraction of plant materials with demineralized water at a temperature of not more than 65 ° C for 1-48 hours and a ratio of extractant: raw material = (3-5): 1. 2. The tool according to claim 1, characterized in that for the treatment of chlamydia contains an extract of plant materials of the following composition: cetraria thallus, medicinal sage herb, gingerbread leaf, poplar buds and bitter wormwood grass, red root in equal amounts. 3. The tool according to claim 1, characterized in that for the treatment of herpes it contains an extract of plant materials of the following composition: burdock root, grass of penny and a series of tripartite, color of immortelle sandy and meadowsweet, black poplar buds, roots of river gravel and licorice equal amount. 4. The tool according to claim 1, characterized in that for the treatment of erysipelas contains an extract of plant material of the following composition: roots of calamus swamp, hemorrhagic medicinal, licorice naked, herb nettle, dried marshmallow, yarrow and honey clover, eucalyptus leaf, meadowsweet, Willow bark in equal amounts. 5. The tool according to claim 1, characterized in that for the treatment of viral hepatitis B contains an extract of plant materials of the following composition: leaf of birch and blueberry, fireweed grass, peppermint, St. John's wort, common yarrow and sweet clover, color of calendula officinalis, roots chicory and calamus swamp in equal parts. 6. The tool according to claim 1, characterized in that for the treatment of viral hepatitis A and B contains an extract of plant materials of the following composition: cinnamon rose hips, licorice roots, peppermint and hypericum perforated in two parts, dicotyledonous nettle and medicinal sweet clover , viburnum leaf in one piece. 7. The tool according to claim 1, characterized in that for the treatment of viral hepatitis A, accompanied by hypotonic dyskinesia, contains an extract of plant materials of the following composition: dioecious nettle grass and bird highlander in three parts, sand immortelle color and licorice roots in two parts, Melilotus officinalis - one and a half parts. 8. The tool according to claim 1, characterized in that for the treatment of viral hepatitis A, accompanied by hypertensive dyskinesia, contains an extract of plant materials of the following composition: dioecious nettle grass and bird highlander in three parts, corn stigmas and licorice roots in two parts, melilot medicinal - one and a half parts. 9. The tool according to claim 1, characterized in that for the treatment of viral hepatitis A and B, accompanied by biliary dyskinesia, contains an extract of plant materials of the following composition: dandelion roots, tansy ordinary, chamomile and calendula officinalis, corn stigmas, grass Melilotus officinalis, Kalanch pinnate, mountaineer bird and nettle dioecious in equal amounts. 10. The tool according to claim 1, characterized in that for the treatment of infectious diseases of the gastrointestinal tract and acute intestinal infections, it contains an extract of plant material of the following composition: calamus roots, cinquefoil erect (galangal), licorice, grass nettle, dioecious, shepherd’s bag , dried marshmallow, common yarrow, bitter wormwood, tricolor violet and veronica oak, eucalyptus leaf, tansy ordinary, willow bark in two parts, medicinal sweet clover grass - one part.

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