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RU2018127510A - METHOD FOR TREATING Squamous cell carcinoma of the oral cavity and pharynx - Google Patents

METHOD FOR TREATING Squamous cell carcinoma of the oral cavity and pharynx Download PDF

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Publication number
RU2018127510A
RU2018127510A RU2018127510A RU2018127510A RU2018127510A RU 2018127510 A RU2018127510 A RU 2018127510A RU 2018127510 A RU2018127510 A RU 2018127510A RU 2018127510 A RU2018127510 A RU 2018127510A RU 2018127510 A RU2018127510 A RU 2018127510A
Authority
RU
Russia
Prior art keywords
pharynx
oral cavity
cell carcinoma
squamous cell
sod
Prior art date
Application number
RU2018127510A
Other languages
Russian (ru)
Other versions
RU2689875C2 (en
RU2018127510A3 (en
Inventor
Анна Владимировна Бойко
Артем Рубенович Геворков
Руслан Наильевич Плавник
Лариса Владимировна Болотина
Андрей Дмитриевич Каприн
Original Assignee
Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) filed Critical Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России)
Priority to RU2018127510A priority Critical patent/RU2689875C2/en
Publication of RU2018127510A publication Critical patent/RU2018127510A/en
Publication of RU2018127510A3 publication Critical patent/RU2018127510A3/ru
Application granted granted Critical
Publication of RU2689875C2 publication Critical patent/RU2689875C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Claims (1)

Способ лечения плоскоклеточного рака полости рта и глотки, включающий введение цетуксимаба в стартовой дозе 400 мг/м2 с последующей дозой 250 мг/м2 1 раз в неделю в сочетании с лучевой терапией, отличающийся тем, что с 8 дня лечения проводится лучевая терапия в РОД 1,8 Гр ежедневно по 5-дневной «рабочей неделе» до СОД 54 Гр на локорегионарную область, включая регионарные лимфоколлекторы (CTV2/PTV2), при этом в течение последних 12 дней, после подведения СОД 32,4 Гр, дополнительно с ≥6-часовым интервалом ежедневно проводится дополнительное облучение опухоли (GTV/CTV1/PTV1) в РОД 1,5 Гр до СОД 72 Гр.A method of treating squamous cell carcinoma of the oral cavity and pharynx, including the introduction of cetuximab at a starting dose of 400 mg / m 2 followed by a dose of 250 mg / m 2 once a week in combination with radiation therapy, characterized in that radiation therapy is carried out from day 8 of treatment ROD of 1.8 Gy daily for a 5-day “working week” up to SOD 54 Gy per locoregional region, including regional lymph collectors (CTV2 / PTV2), while over the past 12 days, after adding SOD 32.4 Gy, additionally with ≥ A 6-hour interval daily additional irradiation of the tumor and (GTV / CTV1 / PTV1) in a genus of 1.5 Gy to a SOD of 72 Gy.
RU2018127510A 2018-07-26 2018-07-26 Method for treating oropharyngeal squamous cell carcinoma RU2689875C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2018127510A RU2689875C2 (en) 2018-07-26 2018-07-26 Method for treating oropharyngeal squamous cell carcinoma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2018127510A RU2689875C2 (en) 2018-07-26 2018-07-26 Method for treating oropharyngeal squamous cell carcinoma

Publications (3)

Publication Number Publication Date
RU2018127510A true RU2018127510A (en) 2018-09-06
RU2018127510A3 RU2018127510A3 (en) 2019-03-07
RU2689875C2 RU2689875C2 (en) 2019-05-29

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Family Applications (1)

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RU2018127510A RU2689875C2 (en) 2018-07-26 2018-07-26 Method for treating oropharyngeal squamous cell carcinoma

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RU (1) RU2689875C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2751818C2 (en) * 2020-12-14 2021-07-19 Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ радиологии» Минздрава России) Method for treatment of squamous cell p-16 positive oropharyngeal cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2429032C1 (en) * 2010-04-02 2011-09-20 Федеральное государственное учреждение "Московский научно-исследовательский онкологический институт им. П.А. Герцена Федерального агентства по высокотехнологичной медицинской помощи" РФ Method of treating oropharyngeal squamous cell carcinoma

Also Published As

Publication number Publication date
RU2689875C2 (en) 2019-05-29
RU2018127510A3 (en) 2019-03-07

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Effective date: 20200727