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RU2018121610A3 - - Google Patents

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Publication number
RU2018121610A3
RU2018121610A3 RU2018121610A RU2018121610A RU2018121610A3 RU 2018121610 A3 RU2018121610 A3 RU 2018121610A3 RU 2018121610 A RU2018121610 A RU 2018121610A RU 2018121610 A RU2018121610 A RU 2018121610A RU 2018121610 A3 RU2018121610 A3 RU 2018121610A3
Authority
RU
Russia
Application number
RU2018121610A
Other versions
RU2018121610A (ru
RU2743349C2 (ru
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of RU2018121610A publication Critical patent/RU2018121610A/ru
Publication of RU2018121610A3 publication Critical patent/RU2018121610A3/ru
Application granted granted Critical
Publication of RU2743349C2 publication Critical patent/RU2743349C2/ru

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2018121610A 2015-11-18 2016-11-17 Твердые формы пладиенолидпиридиновых соединений и способы их применения RU2743349C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562257088P 2015-11-18 2015-11-18
US62/257,088 2015-11-18
PCT/US2016/062525 WO2017087667A1 (en) 2015-11-18 2016-11-17 A solid state form of pladienolide pyridine compounds and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2021102393A Division RU2021102393A (ru) 2015-11-18 2016-11-17 Твердые формы пладиенолидпиридиновых соединений и способы их применения

Publications (3)

Publication Number Publication Date
RU2018121610A RU2018121610A (ru) 2019-12-18
RU2018121610A3 true RU2018121610A3 (ru) 2020-03-02
RU2743349C2 RU2743349C2 (ru) 2021-02-17

Family

ID=57472076

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2018121610A RU2743349C2 (ru) 2015-11-18 2016-11-17 Твердые формы пладиенолидпиридиновых соединений и способы их применения
RU2021102393A RU2021102393A (ru) 2015-11-18 2016-11-17 Твердые формы пладиенолидпиридиновых соединений и способы их применения

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2021102393A RU2021102393A (ru) 2015-11-18 2016-11-17 Твердые формы пладиенолидпиридиновых соединений и способы их применения

Country Status (15)

Country Link
US (2) US10745387B2 (ru)
EP (1) EP3377485B1 (ru)
JP (2) JP6312282B2 (ru)
KR (1) KR20180083376A (ru)
CN (1) CN108473479B (ru)
AU (2) AU2016357433B2 (ru)
BR (1) BR112018009995B1 (ru)
CA (1) CA3004623C (ru)
ES (1) ES2757174T3 (ru)
IL (1) IL259198B2 (ru)
MD (1) MD3377485T2 (ru)
MX (2) MX379655B (ru)
RU (2) RU2743349C2 (ru)
SG (2) SG10201913045PA (ru)
WO (1) WO2017087667A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20212327A1 (es) * 2018-04-09 2021-12-14 Eisai Randd Man Co Ltd Ciertos compuestos de pladienolida y metodos de uso
IL313949A (en) 2018-04-12 2024-08-01 Eisai R&D Man Co Ltd Palladianolide history as spliceosome targeting agents for cancer therapy
IL305047A (en) * 2018-06-01 2023-10-01 Eisai R&D Man Co Ltd Methods for using splicing modulators
WO2021113773A2 (en) * 2019-12-04 2021-06-10 Pai Athma A Identifying non-productive splice sites
MX2022015374A (es) * 2020-06-05 2023-01-16 Eisai R&D Man Co Ltd Conjugados de anticuerpo anti antigeno de maduracion de linfocitos b (bcma)-farmaco y metodos de uso.
TW202233187A (zh) 2020-11-04 2022-09-01 日商衛材R&D企管股份有限公司 骨髓發育不良症候群(mds)之生物標記物及其使用方法
WO2023131866A1 (en) 2022-01-05 2023-07-13 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI311558B (en) * 2001-02-01 2009-07-01 Mercian Corporatio Novel physiologically active substance
TWI334866B (en) 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
EP1548121B1 (en) 2002-07-31 2015-04-29 Eisai R&D Management Co., Ltd. Physiologically active substances
AU2003252299A1 (en) 2002-07-31 2004-02-16 Eisai Co., Ltd. Novel physiologically active substance
AU2003285012A1 (en) 2002-10-24 2004-05-13 Sepracor, Inc. Compositions comprising zopiclone derivatives and methods of making and using the same
MXPA05005672A (es) 2002-11-29 2005-08-16 Eisai Co Ltd Metodo para producir un compuesto a macrolido.
WO2005052152A1 (ja) 2003-11-27 2005-06-09 Mercian Corporation マクロライド系化合物の水酸化に関与するdna
JP4695982B2 (ja) 2003-11-28 2011-06-08 財団法人神奈川科学技術アカデミー 肝癌の検出方法及び肝癌診断薬並びに癌治療薬
WO2006003706A1 (ja) 2004-07-02 2006-01-12 Plus One Techno & Co., Ltd. 組み合わせ計量技術
WO2006009276A1 (ja) 2004-07-20 2006-01-26 Eisai R & D Management Co., Ltd. プラジエノライドの生合成に関与するポリペプチドをコードするdna
TW200716744A (en) 2005-05-26 2007-05-01 Eisai R&D Man Co Ltd Genetically modified microorganism and process for production of macrolide compound using the microorganism
EP1935893A4 (en) 2005-10-13 2009-07-22 Eisai R&D Man Co Ltd TOTAL SYNTHESIS OF PLADIENOLIDE B AND PLADIENOLIDE D
WO2008111464A1 (ja) * 2007-03-05 2008-09-18 Eisai R & D Management Co., Ltd. スプライシング異常を指標とする抗ガン剤の作用検定方法
US20080312317A1 (en) 2007-04-12 2008-12-18 Eisai R&D Management Co., Ltd. 12 membered-ring macrolactam derivatives
PE20170384A1 (es) 2014-05-15 2017-05-11 Eisai Randd Man Co Ltd Compuesto piridinicos de planieolida y metodos de uso

Also Published As

Publication number Publication date
BR112018009995B1 (pt) 2024-04-30
EP3377485B1 (en) 2019-09-25
MX2021001441A (es) 2022-05-19
CA3004623C (en) 2024-05-14
RU2021102393A (ru) 2021-03-17
CA3004623A1 (en) 2017-05-26
JP6312282B2 (ja) 2018-04-18
IL259198B2 (en) 2023-04-01
CN108473479B (zh) 2024-05-07
US20200361915A1 (en) 2020-11-19
AU2016357433B2 (en) 2020-11-19
US20190100513A1 (en) 2019-04-04
AU2021200974B2 (en) 2022-03-17
KR20180083376A (ko) 2018-07-20
US10745387B2 (en) 2020-08-18
WO2017087667A8 (en) 2017-08-03
CN108473479A (zh) 2018-08-31
IL259198B (en) 2022-12-01
ES2757174T3 (es) 2020-04-28
RU2018121610A (ru) 2019-12-18
SG10201913045PA (en) 2020-02-27
JP2018111715A (ja) 2018-07-19
MX392475B (es) 2025-03-24
IL259198A (en) 2018-07-31
AU2021200974A1 (en) 2021-03-11
RU2743349C2 (ru) 2021-02-17
MX379655B (es) 2025-03-11
JP2018502831A (ja) 2018-02-01
AU2016357433A1 (en) 2018-05-17
EP3377485A1 (en) 2018-09-26
SG11201803519YA (en) 2018-06-28
WO2017087667A9 (en) 2017-10-12
MX2018006155A (es) 2018-08-01
JP6353620B1 (ja) 2018-07-04
BR112018009995A2 (pt) 2018-11-21
WO2017087667A1 (en) 2017-05-26
MD3377485T2 (ro) 2020-02-29

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