PE20170384A1 - Compuesto piridinicos de planieolida y metodos de uso - Google Patents
Compuesto piridinicos de planieolida y metodos de usoInfo
- Publication number
- PE20170384A1 PE20170384A1 PE2016002233A PE2016002233A PE20170384A1 PE 20170384 A1 PE20170384 A1 PE 20170384A1 PE 2016002233 A PE2016002233 A PE 2016002233A PE 2016002233 A PE2016002233 A PE 2016002233A PE 20170384 A1 PE20170384 A1 PE 20170384A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- oxacyclododec
- dien
- hepta
- pyridin
- Prior art date
Links
- -1 PYRIDINE COMPOUND Chemical class 0.000 title 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- KNWWGBNAUNTSRV-UHFFFAOYSA-N 4-methylpiperazine-1-carboxylic acid Chemical compound CN1CCN(C(O)=O)CC1 KNWWGBNAUNTSRV-UHFFFAOYSA-N 0.000 abstract 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940125904 compound 1 Drugs 0.000 abstract 1
- 229940125782 compound 2 Drugs 0.000 abstract 1
- 229940126214 compound 3 Drugs 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se refiere a derivados piridinicos de pladienolida seleccionados de la formula 1, 2, 3 o 4. Tambien comprenden composiciones que contienen dichos compuestos. Estos compuestos pueden ser utiles en el tratamiento del cancer como sindrome mielodisplasico, leucemia o tumores solidos. Estos compuestos son: 4-cicloheptilpiperazina-1-carboxilato de (2S,3S,6S,7R,10R,E)-7,10-dihidroxi-3,7-dimetil-12-oxo-2-((R,2E,4E)-6-(piridin-2-il)hepta-2,4-dien-2-il)oxaciclododec-4-en-6-il (Compuesto 1); 4-metilpiperazina-1-carboxilato de (2S,3S,6S,7R,10R,E)-7,10-dihidroxi-3,7-dimetil-12-oxo-2-((R,2E,4E)-6-(piridin-2-il)hepta-2,4-dien-2-il)oxaciclododec-4-en-6-ilo (Compuesto 2); 4-(azepan-1-il)piperidina-1-carboxilato de (2S,3S,6S,7R,10R,E)-7,10-dihidroxi-3,7-dimetil-12-oxo-2-((R,2E,4E)-6-(piridin-2-il)hepta-2,4-dien-2-il)oxaciclododec-4-en-6-ilo (Compuesto 3); y [1,4-bipiperidina]-1-carboxilato de (2S,3S,6S,7R,10R,E)-7,10-dihidroxi-3,7-dimetil-12-oxo-2-((R,2E,4E)-6-(piridin-2-il)hepta-2,4-dien-2-il)oxaciclododec-4-en-6-iol (Compuesto 4)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461993423P | 2014-05-15 | 2014-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20170384A1 true PE20170384A1 (es) | 2017-05-11 |
Family
ID=53284528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016002233A PE20170384A1 (es) | 2014-05-15 | 2015-05-13 | Compuesto piridinicos de planieolida y metodos de uso |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US9481669B2 (es) |
| EP (2) | EP3514154B1 (es) |
| JP (1) | JP6067943B1 (es) |
| KR (2) | KR102146726B1 (es) |
| CN (1) | CN107074827B (es) |
| AR (1) | AR100431A1 (es) |
| AU (1) | AU2015259237B2 (es) |
| BR (1) | BR112016026638B1 (es) |
| CA (1) | CA2947754C (es) |
| CL (1) | CL2016002835A1 (es) |
| CY (1) | CY1121550T1 (es) |
| DK (1) | DK3143016T3 (es) |
| ES (1) | ES2712401T3 (es) |
| HR (1) | HRP20190432T1 (es) |
| HU (1) | HUE041838T2 (es) |
| IL (1) | IL248529B (es) |
| JO (1) | JO3668B1 (es) |
| LT (1) | LT3143016T (es) |
| MA (1) | MA39915B1 (es) |
| ME (1) | ME03417B (es) |
| MX (2) | MX388580B (es) |
| MY (1) | MY195081A (es) |
| PE (1) | PE20170384A1 (es) |
| PH (1) | PH12016502249B1 (es) |
| PL (1) | PL3143016T3 (es) |
| PT (1) | PT3143016T (es) |
| RS (1) | RS58400B1 (es) |
| RU (1) | RU2707730C2 (es) |
| SG (1) | SG11201609693XA (es) |
| SI (1) | SI3143016T1 (es) |
| SM (1) | SMT201900158T1 (es) |
| TR (1) | TR201902328T4 (es) |
| TW (1) | TWI634115B (es) |
| UA (1) | UA119458C2 (es) |
| WO (1) | WO2015175594A1 (es) |
| ZA (1) | ZA201607354B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10889866B2 (en) | 2015-09-01 | 2021-01-12 | Eisai R&D Management Co., Ltd. | Splice variants associated with neomorphic SF3B1 mutants |
| MD3377485T2 (ro) * | 2015-11-18 | 2020-02-29 | Eisai R&D Man Co Ltd | Formă în stare solidă a unor compuși de piridină pladienolidă și metode de utilizare |
| CN110914457A (zh) * | 2017-03-15 | 2020-03-24 | 卫材研究发展管理有限公司 | 剪接体突变及其用途 |
| WO2019089641A1 (en) * | 2017-10-31 | 2019-05-09 | Eisai R&D Management Co., Ltd. | Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from bcl2 inhibitors, bcl2/bclxl inhibitors, and bclxl inhibitors and methods of use |
| PE20212327A1 (es) * | 2018-04-09 | 2021-12-14 | Eisai Randd Man Co Ltd | Ciertos compuestos de pladienolida y metodos de uso |
| IL313949A (en) * | 2018-04-12 | 2024-08-01 | Eisai R&D Man Co Ltd | Palladianolide history as spliceosome targeting agents for cancer therapy |
| IL305047A (en) * | 2018-06-01 | 2023-10-01 | Eisai R&D Man Co Ltd | Methods for using splicing modulators |
| IL262658A (en) * | 2018-10-28 | 2020-04-30 | Memorial Sloan Kettering Cancer Center | Prevention of age related clonal hematopoiesis and diseases associated therewith |
| MX2022015374A (es) * | 2020-06-05 | 2023-01-16 | Eisai R&D Man Co Ltd | Conjugados de anticuerpo anti antigeno de maduracion de linfocitos b (bcma)-farmaco y metodos de uso. |
| TW202233187A (zh) | 2020-11-04 | 2022-09-01 | 日商衛材R&D企管股份有限公司 | 骨髓發育不良症候群（ｍｄｓ）之生物標記物及其使用方法 |
| EP4361136A4 (en) * | 2021-06-18 | 2025-08-13 | Univ Cordoba | Compound for the treatment of glioblastoma |
| CN113876771B (zh) * | 2021-11-12 | 2022-09-23 | 中国医学科学院基础医学研究所 | 一种靶向pabpc1的小分子药物及其在慢性髓系白血病中的应用 |
| WO2023131866A1 (en) | 2022-01-05 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
| EP4570796A1 (en) | 2022-11-07 | 2025-06-18 | Eisai R&D Management Co., Ltd. | Method for producing macrolide compound |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI311558B (en) * | 2001-02-01 | 2009-07-01 | Mercian Corporatio | Novel physiologically active substance |
| TWI334866B (en) | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| EP1548121B1 (en) | 2002-07-31 | 2015-04-29 | Eisai R&D Management Co., Ltd. | Physiologically active substances |
| AU2003252299A1 (en) | 2002-07-31 | 2004-02-16 | Eisai Co., Ltd. | Novel physiologically active substance |
| AU2003285012A1 (en) | 2002-10-24 | 2004-05-13 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
| MXPA05005672A (es) | 2002-11-29 | 2005-08-16 | Eisai Co Ltd | Metodo para producir un compuesto a macrolido. |
| WO2005052152A1 (ja) | 2003-11-27 | 2005-06-09 | Mercian Corporation | マクロライド系化合物の水酸化に関与するｄｎａ |
| JP4695982B2 (ja) | 2003-11-28 | 2011-06-08 | 財団法人神奈川科学技術アカデミー | 肝癌の検出方法及び肝癌診断薬並びに癌治療薬 |
| WO2006003706A1 (ja) | 2004-07-02 | 2006-01-12 | Plus One Techno & Co., Ltd. | 組み合わせ計量技術 |
| WO2006009276A1 (ja) | 2004-07-20 | 2006-01-26 | Eisai R & D Management Co., Ltd. | プラジエノライドの生合成に関与するポリペプチドをコードするｄｎａ |
| TW200716744A (en) * | 2005-05-26 | 2007-05-01 | Eisai R&D Man Co Ltd | Genetically modified microorganism and process for production of macrolide compound using the microorganism |
| EP1935893A4 (en) | 2005-10-13 | 2009-07-22 | Eisai R&D Man Co Ltd | TOTAL SYNTHESIS OF PLADIENOLIDE B AND PLADIENOLIDE D |
| WO2008111464A1 (ja) * | 2007-03-05 | 2008-09-18 | Eisai R & D Management Co., Ltd. | スプライシング異常を指標とする抗ガン剤の作用検定方法 |
| US20080312317A1 (en) | 2007-04-12 | 2008-12-18 | Eisai R&D Management Co., Ltd. | 12 membered-ring macrolactam derivatives |
-
2015
- 2015-05-13 PE PE2016002233A patent/PE20170384A1/es unknown
- 2015-05-13 AR ARP150101485A patent/AR100431A1/es active IP Right Grant
- 2015-05-13 MX MX2020004476A patent/MX388580B/es unknown
- 2015-05-13 CA CA2947754A patent/CA2947754C/en active Active
- 2015-05-13 HU HUE15727125A patent/HUE041838T2/hu unknown
- 2015-05-13 JO JOP/2015/0113A patent/JO3668B1/ar active
- 2015-05-13 KR KR1020177004442A patent/KR102146726B1/ko active Active
- 2015-05-13 DK DK15727125.5T patent/DK3143016T3/en active
- 2015-05-13 PL PL15727125T patent/PL3143016T3/pl unknown
- 2015-05-13 US US14/710,687 patent/US9481669B2/en active Active
- 2015-05-13 EP EP18210019.8A patent/EP3514154B1/en active Active
- 2015-05-13 CN CN201580025344.0A patent/CN107074827B/zh active Active
- 2015-05-13 LT LTEP15727125.5T patent/LT3143016T/lt unknown
- 2015-05-13 MA MA39915A patent/MA39915B1/fr unknown
- 2015-05-13 JP JP2016526218A patent/JP6067943B1/ja active Active
- 2015-05-13 PT PT15727125T patent/PT3143016T/pt unknown
- 2015-05-13 RS RS20190233A patent/RS58400B1/sr unknown
- 2015-05-13 SI SI201530641T patent/SI3143016T1/sl unknown
- 2015-05-13 RU RU2016148887A patent/RU2707730C2/ru active
- 2015-05-13 EP EP15727125.5A patent/EP3143016B1/en active Active
- 2015-05-13 ME MEP-2019-81A patent/ME03417B/me unknown
- 2015-05-13 SM SM20190158T patent/SMT201900158T1/it unknown
- 2015-05-13 TW TW104115293A patent/TWI634115B/zh active
- 2015-05-13 KR KR1020167016648A patent/KR101710318B1/ko active Active
- 2015-05-13 MY MYPI2016001944A patent/MY195081A/en unknown
- 2015-05-13 PH PH1/2016/502249A patent/PH12016502249B1/en unknown
- 2015-05-13 ES ES15727125T patent/ES2712401T3/es active Active
- 2015-05-13 TR TR2019/02328T patent/TR201902328T4/tr unknown
- 2015-05-13 AU AU2015259237A patent/AU2015259237B2/en active Active
- 2015-05-13 MX MX2016014997A patent/MX373324B/es active IP Right Grant
- 2015-05-13 WO PCT/US2015/030464 patent/WO2015175594A1/en not_active Ceased
- 2015-05-13 SG SG11201609693XA patent/SG11201609693XA/en unknown
- 2015-05-13 BR BR112016026638-2A patent/BR112016026638B1/pt active IP Right Grant
- 2015-05-13 HR HRP20190432TT patent/HRP20190432T1/hr unknown
- 2015-05-13 UA UAA201612731A patent/UA119458C2/uk unknown
-
2016
- 2016-10-25 ZA ZA2016/07354A patent/ZA201607354B/en unknown
- 2016-10-26 IL IL24852916A patent/IL248529B/en active IP Right Grant
- 2016-11-08 CL CL2016002835A patent/CL2016002835A1/es unknown
-
2019
- 2019-02-22 CY CY20191100228T patent/CY1121550T1/el unknown
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