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RU2018102606A - Молекулы, связывающиеся с psl pseudomonas, и пути их применения - Google Patents

Молекулы, связывающиеся с psl pseudomonas, и пути их применения Download PDF

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RU2018102606A
RU2018102606A RU2018102606A RU2018102606A RU2018102606A RU 2018102606 A RU2018102606 A RU 2018102606A RU 2018102606 A RU2018102606 A RU 2018102606A RU 2018102606 A RU2018102606 A RU 2018102606A RU 2018102606 A RU2018102606 A RU 2018102606A
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seq
wapr
antibody
fragment
cam
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RU2018102606A3 (ru
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Антонио ДИДЖАНДОМЕНИКО
Пол Дж. УОРРЕНЕР
Чарльз К. СТОУВЕР
Брет СЕЛЛМАН
Сандрин ГИЛЛАРД
Ральф МИНТЕР
Стивен РАСТ
Младен ТОМИЧ
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МЕДИММЬЮН, ЭлЭлСи
Медиммьюн Лимитед
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Claims (39)

1. Выделенное антитело или его антиген-связывающий фрагмент, который специфически связывается с Psl Pseudomonas, содержащий вариабельную область тяжелой цепи (VH) и вариабельную область легкой цепи (VL), которые содержат аминокислотные последовательности VHCDR1, VHCDR2, VHCDR3, VLCDR1, VLCDR2 и VLCDR3, выбранные из группы, состоящей из:
SEQ ID NO: 17, 18, 19, 20, 21 и 22 (Cam-003),
SEQ ID NO: 23, 24, 25, 20, 21 и 22 (Cam-004),
SEQ ID NO: 26, 27, 28, 20, 21 и 22 (Cam-005),
SEQ ID NO: 29, 30, 31, 32, 33 и 34 (WapR-001),
SEQ ID NO: 35, 36, 37, 38, 39 и 40 (WapR-002),
SEQ ID NO: 41, 42, 43, 44, 45 и 46 (WapR-003),
SEQ ID NO: 47, 48, 49, 50, 51 и 52 (WapR-004),
SEQ ID NO: 53, 54, 55, 56, 57 и 58 (WapR-004RAD) и
SEQ ID NO: 59, 60, 61, 62, 63 и 64 (WapR-016).
2. Выделенное антитело или его антиген-связывающий фрагмент, который специфически связывается с тем же эпитопом Psl Pseudomonas, что и антитело или его антиген-связывающий фрагмент, содержащий вариабельную область тяжелой цепи (VH) и вариабельную область легкой цепи (VL), которые содержат аминокислотные последовательности VHCDR1, VHCDR2, VHCDR3, VLCDR1, VLCDR2 и VLCDR3, выбранные из группы, состоящей из:
SEQ ID NO: 17, 18, 19, 20, 21 и 22 (Cam-003),
SEQ ID NO: 23, 24, 25, 20, 21 и 22 (Cam-004),
SEQ ID NO: 26, 27, 28, 20, 21 и 22 (Cam-005),
SEQ ID NO: 29, 30, 31, 32, 33 и 34 (WapR-001),
SEQ ID NO: 35, 36, 37, 38, 39 и 40 (WapR-002),
SEQ ID NO: 41, 42, 43, 44, 45 и 46 (WapR-003),
SEQ ID NO: 47, 48, 49, 50, 51 и 52 (WapR-004),
SEQ ID NO: 53, 54, 55, 56, 57 и 58 (WapR-004RAD) и
SEQ ID NO: 59, 60, 61, 62, 63 и 64 (WapR-016).
3. Выделенное антитело или его антиген-связывающий фрагмент, который специфически связывается с Psl Pseudomonas и осуществляет конкурентное ингибирование связывания Psl Pseudomonas с антителом или его антиген-связывающим фрагментом, содержащим вариабельную область тяжелой цепи (VH) и вариабельную область легкой цепи (VL), которые содержат аминокислотные последовательности VHCDR1, VHCDR2, VHCDR3, VLCDR1, VLCDR2 и VLCDR3, выбранные из группы, состоящей из:
SEQ ID NO: 17, 18, 19, 20, 21 и 22 (Cam-003),
SEQ ID NO: 23, 24, 25, 20, 21 и 22 (Cam-004),
SEQ ID NO: 26, 27, 28, 20, 21 и 22 (Cam-005),
SEQ ID NO: 29, 30, 31, 32, 33 и 34 (WapR-001),
SEQ ID NO: 35, 36, 37, 38, 39 и 40 (WapR-002),
SEQ ID NO: 41, 42, 43, 44, 45 и 46 (WapR-003),
SEQ ID NO: 47, 48, 49, 50, 51 и 52 (WapR-004),
SEQ ID NO: 53, 54, 55, 56, 57 и 58 (WapR-004RAD) и
SEQ ID NO: 59, 60, 61, 62, 63 и 64 (WapR-016).
4. Антитело или его фрагмент по любому из пп.1-3, который является гуманизированным.
5. Антитело или его фрагмент по любому из пп.1-3, который является химерным.
6. Антитело или его фрагмент по любому из пп.1-3, который является полностью человеческим.
7. Антитело или его фрагмент по любому из пп.1-3, который представляет собой Fab-фрагмент.
8. Антитело или его фрагмент по любому из пп.1-3, которые представляют собой Fab'-фрагменты.
9. Антитело или его фрагмент по любому из пп.1-3, которые представляют собой F(ab)2-фрагменты.
10. Антитело или его фрагмент по любому из пп.1-3, который представляет собой одноцепочечный Fv- (scFv-) фрагмент.
11. Антитело или его фрагмент по любому из пп.1-3, который является моноклональным.
12. Фармацевтическая композиция, содержащая антитело или его фрагмент по любому из пп.1-3 и носитель.
RU2018102606A 2011-06-10 2012-06-08 Молекулы, связывающиеся с psl pseudomonas, и пути их применения RU2708977C2 (ru)

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US201161495460P 2011-06-10 2011-06-10
US61/495,460 2011-06-10
US201161530461P 2011-09-02 2011-09-02
US61/530,461 2011-09-02
US201261613317P 2012-03-20 2012-03-20
US61/613,317 2012-03-20

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RU2014100111/10A Division RU2014100111A (ru) 2011-06-10 2012-06-08 МОЛЕКУЛЫ, СВЯЗЫВАЮЩИЕСЯ С Psl Pseudomonas, И ПУТИ ИХ ПРИМЕНЕНИЯ

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RU2018102606A3 RU2018102606A3 (ru) 2019-02-22
RU2708977C2 RU2708977C2 (ru) 2019-12-12

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RU2018102606A RU2708977C2 (ru) 2011-06-10 2012-06-08 Молекулы, связывающиеся с psl pseudomonas, и пути их применения

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