RU2016568C1 - Method for treating disseminated sclerosis - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: essence of this method resides in perorally administering comminuted fibrous carbon sorbent impregnated by immunity stimulating sodium nucleinate or methyluracil of vitamin B₁₂ into patients suffering from acute multiple sclerosis accompanied by pronounced immunity deficiency, both primary and that provoked by intake of enormous doses of immunodepressants. Disclosed method prescribes administering sorbent per os in amount of 50 to 100 mg per 1 kg of patient's body mass 3 or 4 times a day at food intake intervals during 2 to 3 weeks. EFFECT: this method allows scaling up effectiveness of treatment by accelerating regression of neurologic disorders, reducing daily dose of medicine, curtailing entire course of treatment of patients suffering from exacerbation of disseminated sclerosis aggravated by pronounced immunity deficiency, eliminating complications caused by intake of large doses of immunity depressants, and rapid correction of cellular and humoral immunity for shorter period of patient's stay in hospital. 1 tbl

Description

 The invention relates to medicine, neuropathology and can be used in the treatment of patients with multiple sclerosis with severe immunodeficiency.

 Known pathogenetic method of treating multiple sclerosis by taking immunosuppressive drugs (corticosteroid hormones, cytostatics) and immunostimulating drugs. The choice of certain drugs depends on the initial state of the immunocompetent system. However, the prolonged use of steroid hormones causes a number of serious complications: the occurrence of hormonal dependence, steroid diabetes, arterial hypertension, decreased adrenal function, the formation of erosion and ulcers on the gastrointestinal mucosa, steroid psychoses, etc. Cytostatics are contraindicated in case of anemia, cachexia, liver and kidney pathology, they cause inhibition of hematopoiesis and leukopenia, toxic hepatitis. The most serious side effect of immunosuppressive drugs is the elimination of T and B lymphocyte precursors, which leads to an increase in immunodeficiency already present in patients with multiple sclerosis. Correction of this condition is extremely difficult. The use of immunostimulants for the treatment of immunodeficiency does not give a good and lasting effect. In addition, with the use of immunosuppressants, the regression of neurological symptoms occurs very slowly, in particular from several weeks to several months. Immunostimulating drugs after the end of the course of treatment with corticosteroid hormones and cytostatics are prescribed for at least another six months. Such long courses of treatment are highly undesirable in people of young working age. In some cases, such a treatment regimen is completely ineffective. Therefore, the development of new effective pathogenetic methods of treating multiple sclerosis is required.

 A new pathogenetic method for treating patients with multiple sclerosis by taking a carbon sorbent at a dose of 50-100 mg per 1 kg of patient’s body weight 3 times a day in between meals for 3-4 weeks is proposed. This method is selected for the prototype. The method does not give any complications, is extremely simple to use, has an immunocorrective property. The use of this method allowed to reduce the patient’s hospital stay by 20-25%, to quickly worsen the exacerbation of the disease (improvement begins 3-4 days after the start of sorbent administration and continues throughout the course of treatment), to extend the period of remission (5 years Observation relapse occurred in only 10% of patients).

 However, in some patients at the stage of exacerbation of multiple sclerosis, immunodeficiency from both cellular and humoral immunity is significantly pronounced (often persistent immunodeficiency develops after a course of treatment with immunosuppressants). Reception of a fibrous carbon sorbent corrects the content of T- and B-lymphocytes in the blood, increasing them, but only by the end of the course of treatment (after 3 weeks).

 The aim of the invention is the correction of T and B lymphocytes in the blood of patients with multiple sclerosis with severe immunodeficiency.

This goal is achieved by the fact that in the method of treating multiple sclerosis by oral administration of drugs as a medicine, the patient is injected with a carbon sorbent impregnated with drugs that stimulate hematopoiesis, for example, sodium nucleinate in an amount of 1-2 wt. % or methyluracil in an amount of 2.5-5 wt.%, or vitamin B ₁₂ in an amount of 0.001-0.002 wt.%, moreover, the therapeutic agent is prescribed in a dose of 50-100 mg per 1 kg of patient body weight in between meals.

The inventive method uses a fibrous carbon sorbent obtained by carbonation and subsequent activation of fibrous cellulose hydrate raw materials (tow fiber, fabric, non-woven material, etc.). The porosity of such materials is 0.30-1.20 cm ³ / g, the specific surface is 700-2000 m ² / g. The fibrous carbon sorbent "vaulen" was adopted by the pharmacological committee and permission was obtained for its use as an enterosorbent.

The method of impregnating an immunostimulant, in particular sodium nucleinate, on a fibrous carbon sorbent (vaulen) consists of the following: 14 powders of sodium nucleinate 0.1-0.2 g each are dissolved in 500 ml of distilled water, 140-150 g of fibrous carbon sorbent are added, carefully moisten the sorbent with a solution and incubate for 15-30 minutes. Then the sorbent is removed, dried in air for 2-3 days. The fibrous carbon sorbent, processed as indicated, is ground to 50-100 microns, sterilized at a temperature of 100-130 ^o C and packaged in plastic bags.

 Impregnation of methyluracil is carried out as follows: 28 tablets of 0.5 g of methyluracil are dissolved in 1 liter of distilled water, 200-250 g of vaulen are added, the sorbent is thoroughly moistened and incubated for 15-30 minutes. Then the sorbent is removed, dried in air for 2-3 days, crushed to 50-100 microns, sterilized and packaged in plastic bags.

The method of impregnation of vitamin B ₁₂ on a coal sorbent is as follows: 0.15 g of vitamin B _{12 is} dissolved in 500 ml of distilled water, 140 g of sorbent (vaulen) is added, the sorbent is thoroughly moistened and incubated for 10-20 minutes. Then the sorbent is removed, dried in air for 2-3 days, crushed to 50-100 microns, sterilized and packaged in plastic bags.

A significant distinguishing feature of the proposed method is that the patient is administered a chemotherapy drug (sodium nucleinate, methyluracil or vitamin B ₁₂ ) in combination with a fibrous carbon sorbent in small doses: sodium nucleinate 0.04-0.08 g instead of 0.6-1, 0 g; methyluracil 0.1-0.3 g instead of 0.5-1.0 g; vitamin B ₁₂ 40-80 mcg instead of 200-500 mcg 3 times a day in between meals for 15-20 days, which provides the following effect:
- quickly (by 3-4 days), immunocorrection of cellular and tissue immunity is achieved in patients with multiple sclerosis with severe immunodeficiency compared with the prototype;
- the regression of neurological symptoms is significantly accelerated, in particular, the improvement of neurological status also occurs 3-4 days after the start of medication;
- The begun regression of neurological symptoms continues throughout the course of treatment;
- the method allows to avoid complications associated with the administration of large doses of immunosuppressants;
- recurrence of the disease is reduced;
- the period of patients' working capacity is extended.

The method is as follows: the patient takes inside 50-100 mg per 1 kg of body weight of a coal sorbent containing in this dose 1-2 wt.% Sodium nucleinate or 2.5-5 wt.% Methyluracil, or 0.001-0.002 wt.% vitamin B ₁₂ 3 times a day in between meals for 15-20 days.

 Observation of patients showed that the use of the proposed method allows, along with accelerating the regression of neurological disorders, reducing the bed day, to quickly increase the content of T and B lymphocytes in the peripheral blood, thereby eliminating the immunodeficiency present in patients both initially and after the course immunosuppressant treatment. The begun regression of neurological disorders and an increase in the content of T- and B-lymphocytes in the blood continues throughout the course of treatment.

 PRI me R 1. Patient D.G.A., 40 years old, disabled person of group II, was treated in the clinic of nervous diseases I LMI named after acad. I.P. Pavlov from 10/06/08 to 11/01/08, with a diagnosis of multiple sclerosis in the acute stage (medical history N 21911).

 Complaints of weakness in the legs, more in the left, weakness in the left hand, double vision when looking directly, shakiness when walking, impaired function of the pelvic organs in the form of urinary retention.

 Considers herself ill since 1976, when visual disturbances appeared in the form of loss of visual fields from all sides. Soon double vision appeared when looking into the distance. Treated stationary with improvement. In March, April 1977, the disease again exacerbated. Re-treatment in the hospital again gave an improvement. In 1983, weakness appeared in the left leg; after 5 months, the precariousness of walking joined. Inpatient treatment did not give much effect. Since then, with frequent exacerbations of the disease, he was repeatedly treated in hospitals, each time he received courses of corticosteroid therapy. The effect of the treatment was minimal. Got a disability of group II. The last exacerbation of the disease occurred in February 1988 after the flu. There was weakness in the arms and legs, urinary retention. The next course of corticosteroid therapy was carried out, after which the weakness in the limbs decreased slightly, he began to move around the ward with great difficulty, but the shakiness during walking and the dysfunction of the pelvic organs remained. The patient was transferred to the clinic of nervous diseases I LMI named after Acad. I.P. Pavlova for further treatment.

 Neurological status at admission to the clinic: Euphoria. There are no local changes in cortical functions. Pupils of medium diameter without a difference of sides with a lively reaction to light and accommodation. The movement of the right eyeball inside is limited, convergence is weakened. Diplopia when looking in both directions. Horizontal rotator nystagmus when viewed from both sides, more to the right. The face is symmetrical, the tongue is in the midline. Reduced muscle strength in all muscle groups of the left arm to 2-3 points. Deep reflexes on the arms S> D. Muscle strength in the left leg is reduced to 3 points. Muscle tone in both legs is increased, more in the left. Deep reflexes on legs S> D. Pathological foot reflexes on both sides. Ataxia in coordinated tests from two sides, adiadokhokinesis from two sides. In the Romberg position, he is unstable, walks with great difficulty, holding on to objects, the spastic-atactic gait. On a scale (Sipe etal.), The neurological status was assessed by 32 points (with a norm of 100 points).

At the fundus, atrophy of the optic disc on both sides. With ECHO-encephaloscopy, the width of the third ventricle is 8 mm (with a norm of 5 mm), echo satellites are expressed, the index of the “brain cloak” is 2.4 mm (with a norm of up to 2.2 mm), that is, there are signs of expansion of the ventricular system . Indicators of cellular and humoral immunity in the blood: T-lymphocytes 32% (normal 60-70%) B-lymphocytes 9% (normal 20-30%) Neutrophilic phagocytosis 59% (normal 20-30%) Complement 25.5 units CH ₅₀ (norm 29.5-31.0) The circulating immune complex 0.048 units (norm 0.06-0.08)
IgA 2.48 g / l (normal 0.8-5.2)
IgG 13.6 g / l (normal 6.0-18.0)
IgM 2.32 g / l (normal 0.6-3.8)
During his stay in the clinic, the patient received a course of treatment with a carbon sorbent impregnated with sodium nucleinate. The content of sodium nucleinate is 1 wt.%, The dose of the drug is 100 mg per 1 kg of body weight of the patient.

 On the third day of taking the drug, the patient noted an improvement in function and pelvic organs, weakness in the left hand decreased slightly.

 At the same time, an increase in T- and B-lymphocytes in the blood appeared: T-lymphocytes 43% B-lymphocytes 16% Neutrophilic phagocytosis decreased to 48% After 15 days - the end of the course of treatment. Euphoria decreased significantly, diplopia decreased when looking in both directions, nystagmus disappeared. Muscle strength in the left hand increased to 4-5 points, reflexes remain S> D. Muscle strength in the left leg increased to 5 points, the tone in the legs became lower, the reflexes remain S> D. Significantly decreased ataxia during coordination tests and when walking. Well stands in the Romberg position. He walks much better, not holding on to objects; he can walk for quite a while. The function of the pelvic organs was normalized. On a scale (Sipe et al.) - 78 points. With ECHO-encephaloscopy, there are no signs of expansion of the ventricular system.

Indicators of cellular and humoral immunity are even more normalized: T-lymphocytes 58% B-lymphocytes 23% Neutral phagocytosis 42% Complement 27.2 u CH ₅₀ Circulating immune complex 0.075 u

IgA 4.6 g / l
IgG 18.4 g / l
IgM 2.32 g / l
So, in a 40-year-old patient with a 12-year experience of the disease with multiple sclerosis with relapsing remitting and frequent exacerbations after the next course of treatment with steroid hormones, there was no significant change in the neurological status. At the same time, severe immunodeficiency of cellular and humoral immunity, complement of blood serum and even indicators of the circulating immune complex occurred with significantly increased neutrophilic phagocytosis, which indicates continued activity of the process despite the course of treatment with corticosteroid hormones. With such immunodeficiency, it was impossible to continue treatment with corticosteroid hormones. After a 15-day course of treatment with a fibrous carbon sorbent impregnated with sodium nucleinate (content of sodium nucleinate 1 wt.%) At a dose of 100 mg per 1 kg of the patient’s body weight, the neurological status improved significantly: from 32 points to 78 points on a scale (Sipe et al .). The patient was able to move well on his own, began to take care of himself, the function of the pelvic organs completely normalized, the expansion of the ventricular system disappeared. At the same time, immunodeficiency in the blood disappeared (indicators of cellular and humoral immunity normalized, as well as the content of complement and circulating immune complex, neutrophilic phagocytosis decreased).

 When examining the patient 7 months after the end of the course of treatment, his condition is good, the neurological status has not worsened, the patient continues to serve himself well, walks well, and there is no immunodeficiency.

 PRI me R 2. Treatment with a carbon fiber sorbent impregnated with sodium nucleinate. The content of sodium nucleinate in the preparation of 1.5 wt.%. The dose of the drug is 75 mg per 1 kg of patient body weight, the course of treatment is 20 days.

 Patient I.N.M., 44 years old, was treated at the clinic of nervous diseases 1 LMI named after acad. I.P. Pavlov from 01/27/90 to 02/22/90 with a diagnosis of multiple sclerosis in the acute stage (medical history N 1641).

 Complaints of weakness and heaviness in the legs when walking, unsteadiness when walking.

 For the first time, weakness in the legs appeared in August 1988, a month later the gait changed, shakiness appeared when walking, and could not walk for long. Received a restorative treatment without effect. In March 1989, leg weakness and shakiness in walking intensified. Again I received a course of general strengthening therapy, which also did not give an effect.

 Neurological status: Euphoria. There are no local changes in cortical functions. Pupils of medium diameter, without a difference of sides with a lively reaction to light and accommodation. The movements of the eyeballs in full. Horizontal nystagmus when looking in both directions, vertical nystagmus when looking up. The face is symmetrical, the tongue is in the midline. The muscular strength in the hands is full, the tone in the hands is normal. Reflexes are live, no difference. Symptom of Rossolimo-Venderovich from two sides. Abdominal reflexes are absent. Muscle strength in the legs is reduced in the hip flexors and lower leg flexors to 3 points. The tone in the legs is increased. The knee and Achilles reflexes are high, no difference in sides. Symptoms of Babinsky from two sides. Intensive tremor with a finger-nasal test on both sides, adiadokhokinesis on the left, ataxia with a calcaneo-knee test on both sides. Unstable in the Romberg position. The gait is spastic-atactic. Neurological status on a scale of Sipe et al.-60 points. Fundus of the eye: optic nerve disc of satisfactory nutrition, clear boundaries, no focal changes.

 On ECHO scopy, a slight expansion of the III and lateral ventricles (width of the third ventricle is 6 mm with a norm of up to 5 mm, the index of the “brain cloak” is 2.34 mm with a norm of up to 2.2 mm).

Cellular and humoral immunity: T-lymphocytes 28% (normal 60-70%) B-lymphocytes 19% (normal 20-30%) Neutrophilic phagocytosis 60% (normal 20-30%) Complement 14.5 units CH ₅₀ (normal 20 -30 units) A circulating immune complex 0.05 units Immunoglobulin content: IgA 1.94 g / l (normal 0.8-5.9) IgG 15.2 g / l (normal 6.0-18.0) IgM 3 , 38 g / l (norm 0.6-3.8) Spontaneous migration: Granulocytes 0.08 units (norm 1.8-4.0) Mononuclear cells 1.0 unit (norm 2.3-5.0) Inhibition index : Granulocytes - 150% (norm 31-79) Mononuclear cells 0% (norm 29-56).

After a 4-day course of treatment with a fibrous carbon sorbent impregnated with sodium nucleinate, a dose of 75 mg per 1 kg of body weight, a regression of neurological symptoms appeared: the patient began to walk better, began to stagger less when walking. Data on cellular and humoral immunity: N-lymphocytes 32% B-lymphocytes 20% Neutrophilic phagocytosis 54% Complement 19.8 u CH ₅₀ Circulating immune complex 0.04 u The content of immunoglobulins: IgA 3.4 g / l IgG 18.0 g / l IgM 4.8 g / l Spontaneous migration: Granulocytes 2.9 units Mononuclear cells 8.6 units Inhibition index: Granulocytes 72.5% Mononuclelers 9.0%
So, in a 44-year-old patient with a progressive form of multiple sclerosis, primary immunodeficiency of cellular immunity, complement and immunoglobulin was observed. There was also a significant change in the spontaneous migration of granulocytes and mononuclear cells and their inhibition index also downward.

 After a 20-day course of treatment with a fibrous carbon sorbent impregnated with sodium nucleinate (the content of sodium nucleinate in the preparation is 1.5 wt.%). The dose of the drug is 75 mg per 1 kg of body weight of the patient. Along with a significant improvement in neurological status, normalization of cellular and humoral immunity is noted. The beginning of the normalization of immunity occurred on the 4th day of taking the drug and coincided with the beginning of the regression of pathological neurological symptoms. Neurological status at the end of treatment increased according to the Sipe etal scale. from 60 points to 80 points.

 On examination after 4 months: the patient feels well, copes with work, notes only a slight heaviness in the legs with long walking, there is no shakiness when walking, and there is no immunodeficiency in the blood.

 PRI me R 3. Patient G.S.Z., 34 years old, designer, was treated in the clinic of nervous diseases I LMI named after acad. I.P. Pavlov from 05.24.90 to 06.21.90 with a diagnosis of multiple sclerosis in the acute stage (medical history N 13325).

 Complaints of double vision when looking to the right, a feeling of stuffiness in the right ear, dizziness, and shakiness when walking.

 Considers herself ill since May 1982, when for the first time after a vacation in the south, diplopia appeared when looking to the right. Treated stationary with improvement. Until 1989, I felt good. At the beginning of April 1989, double vision appeared again when looking to the right, unsteadiness when walking. In the summer of 1989, a feeling of congestion in the right ear appeared. Outpatient treatment did not work.

 Neurological status at admission to the clinic: Cortical functions are not impaired. D-S pupils with a lively reaction to light and accommodation. Does not bring both eyeballs out. Horizontal nystagmus when looking in both directions. The face is symmetrical. Tongue in the midline. The muscular strength of the arms is complete. Higher tone in the pronators of the left hand. Deep reflexes S> D. There are no pathological reflexes. Abdominal reflexes are absent. The muscular strength in the legs is complete. The tone is normal. Knee reflexes are animated by D-S. Achilles D> S. Symptom of Babinsky on the left and inconstant on the right. Sensitivity is not changed. In the Romberg staggering position. On a scale of Sipe et al. neurological status rated 75 points. The fundus is normal. With ECHO-encephaloscopy, the width of the third ventricle is 7 mm (at a rate of 5 mm); In the study of evoked auditory potentials, there are symptoms of a disorder of cortical auditory synthesis and an acoustic reflex disorder.

Indicators of cellular and humoral immunity in the blood: T-lymphocytes 30% (normal 60-70%) B-lymphocytes 17% (normal 20-30%) Neutrophilic phagocytosis 32% (normal 20-30%) Circulating immune complex 0.02 units (norm 0.06-0.08) IgA 2.3 g / l (norm 0.8-5.2) IgG 19.0 g / l (norm 6.0-18.0) IgM 2.4 g / l (norm 0.6-3.8)
The patient started treatment with a fibrous carbon sorbent impregnated with sodium nucleinate at a dose of 50 mg per 1 kg of patient body weight, the content of sodium nucleinate is 2 wt.%. The treatment was carried out for ≈ 17 days.

 On the 4th day from the start of treatment, the patient underwent diplopia and congestion of the right ear. hearing improved, in the following days, the shakiness of walking disappeared. When examining the neurological status after the end of the course of treatment (after 17 days), pathology was not detected. On a scale of Sipe et al. - 100 points.

 Auditory evoked potentials: the disorder of cortical synthesis was eliminated, the disorders of the acoustic reflex are less pronounced. With ECHO-encephaloscopy, the width of the third ventricle decreased - 6 mm.

 The study of cellular and humoral immunity on the 4th day from the start of treatment: T-lymphocytes 60% B-lymphocytes 36% Neutrophilic phagocytosis 66% Circulating immune complex 0.02 units IgA 1.3 g / l IgG 12.7 g / l IgM 0.7 g / l On examination of the patient after a year: feels good, works. Neurological status on a scale of Sipe et al. continues to hold 100 points. Cellular and humoral immunity are normal.

 So, a 34-year-old patient with exacerbation of multiple sclerosis, lasting for a year with severe immunodeficiency of cellular and humoral immunity, on the 4th day from the start of treatment with a fibrous carbon sorbent impregnated with sodium nucleinate in a dose: content of sodium nucleate 2 wt.%, Dose 50 mg per 1 kg of the patient’s body weight, immunodeficiency of cellular and humoral immunity completely disappeared, neutrophilic phagocytosis intensified, the content of immunoglobulin G was normalized. This coincided with the normalization of neurological status, according to the Sipe et al. 100 points. When viewed after a year, the neurological status and picture of cellular and humoral immunity has not changed.

 PRI me R 4. The absence of a positive effect when taking the drug at a dose of 35 mg per 1 kg of body weight and the content of sodium nucleinate 2 wt.%.

 Patient S. N. N., 18 years old, nurse, was treated at the clinic of nervous diseases 1 LMI named after acad. I.P. Pavlov from 03/02/90 to 03/22/90 (medical history N 5765) with a diagnosis of multiple sclerosis in the stage of decaying exacerbation.

 Complaints about a slight weakness of the right limbs.

 Considers herself a patient since December 1989, when, after suffering an ARI, her right leg weakened. A week later, the function of the right leg was restored, but soon the weakness of the right leg reappeared, while the weakness of the right arm appeared. It was treated stationary with improvement.

 Neurological status: cortical functions are not impaired. Light anisocoria D> S. The reaction of the pupils to light and accommodation is normal. The movements of the eyeballs in full. Slight smoothing of the right nasolabial fold. Tongue in the midline. The range of motion and muscle strength in the limbs are complete. Tone on the right above. Deep reflexes on the arms D> S, on the legs D-S. An intermittent symptom of Babinsky on the right, a symptom of Strumpel on both sides. Abdominal reflexes D <S. Light intentional tremor on both sides with a finger-nasal test. Heel-knee test performs well. In the Romberg position and when walking is stable. On a scale of Sipe et al. neurological status rated 64 points. The fundus is normal. In cerebrospinal fluid 0.25% protein, cytosis 85/3 lymphocytes.

Indicators of cellular and humoral immunity: T-lymphocytes 21% (normal 60-70%) B-lymphocytes 17% (normal 20-30%) Neutrophilic phagocytosis 76% (normal 20-30%) Complement 20.6 units CH ₅₀ Circulating immune complex 0.048 units IgA 3.6 g / l (normal 0.8-5.2) IgG 20.3 g / l (normal 6.0-18.0) IgM 3.4 g / l (normal 0.6- 3.8)
The patient received treatment with a fibrous carbon sorbent impregnated with sodium nucleinate in a dose: the content of sodium nucleinate is 2 wt.%, The dose of the drug is 35 mg per 1 kg of body weight of the patient. Neurological status almost completely normalized on the 4th-5th day after the start of treatment. On a scale of Sipe et al. 96 points. However, immunodeficiency of cellular and humoral immunity remained until the end of treatment and by the time the patient was discharged from the hospital: T-lymphocytes 23% B-lymphocytes 15% Neutrophilic phagocytosis 67% Complement 19.4 units CH ₅₀ Circulating immune complex 0.01 units IgA 2.5 g / l IgG 12.6 g / l IgM 4.0 g / l By the end of treatment: T-lymphocytes 29% B-lymphocytes 19% Neutrophilic phagocytosis 25%.

 So, a patient of 18 years old, with exacerbation of multiple sclerosis, as evidenced by increased pleocytosis in the cerebrospinal fluid and increased IgG in the blood, with severe immunodeficiency of cellular and humoral immunity, was treated with a fibrous carbon sorbent impregnated with sodium nucleate at a dose of 35 mg per 1 kg of body weight and the content of sodium nucleinate 2 wt.%. The treatment was carried out for 20 days. Despite the almost complete normalization of neurological status, immunodeficiency remained, only the content of IgG and neutrophilic phagocytosis decreased. Thus, this dose of the drug does not stop immunodeficiency.

 PRI me R 5. Taking the drug in a larger dose: 115 mg per 1 kg of body weight with a content of sodium nucleinate of 1.5 wt.% For 15 days gives the same result as in examples 1,2 and 3.

 Patient B.I.N., 24 years old, 1st year student, was treated at the clinic of nervous diseases of the I LMI named after Acad. I.P. Pavlov from 10/11/08 to 11/15/08 (and / b N 22374).

 Complaints of headaches, paroxysmally aggravated, with intensification of headaches, lacrimation and photophobia, weakness of the fingers, trembling of the hands with tension, periodic incontinence of urine and feces appear.

 Sick since 1978, when there was trembling hands, drowsiness, general weakness. In 1984, urinary retention appeared. He was diagnosed with multiple sclerosis. Repeatedly treated in hospitals: in 1984, 1985, 1986 and 1987. Received hormone therapy with short-term improvement. Last exacerbation since September 1988

 Neurological status: normal cortical function, D-S pupils with a lively response to light and accommodation. The movements of the eyeballs in full. Horizontal pronounced nystagmus when viewed from both sides. The face is symmetrical. Tongue along the midline, pronounced tremor of the tongue. Muscle strength is reduced in the distal arms to 4 points. The tone in the hands is normal. Deep reflexes S> D. There are no pathological carpal symptoms. The abdominal reflexes are extremely low. The muscular strength of the legs is full, the tone in the legs is increased. Reflexes are high S> D. There are no pathological foot symptoms. Sensitivity is normal. Pronounced intentional tremor in the hands. In the Romberg position is steady. On a scale of Sipe et al. 55 points. The fundus of the eye: the optic nerve disc is plain, the boundaries are clear.

The state of cellular and humoral immunity: T-lymphocytes 44% (normal 60-70%) B-lymphocytes 28% (normal 20-30%) Neutrophilic phagocytosis 41% (normal 20-30%) Complement 30.8 units. CH ₅₀ (norm 29.5-31.0) The circulating immune complex 0.05 u IgA 1.72 g / l (norm 0.8-5.2) IgG 6.8 g / l (norm 6.0-18 , 0) IgM 1.0 g / l (normal 0.6-3.8)
The patient underwent a course of treatment with a fibrous carbon sorbent at a dose of 115 mg per 1 kg of body weight with a content of sodium nucleinate of 1.5 wt.% For 15 days. Four days after the start of treatment, pelvic disorders disappeared, by the end of the course of treatment, the abdominal reflexes revived, and the strength in the distal arms increased to 5 points. Nystagmus persists when looking in both directions. Neurological status according to the scale et al. 73 points. The content of cellular and humoral immunity: T-lymphocytes 67% B-lymphocytes 33% Neutrophilic phagocytosis 53% complement 28.9 units. CH ₅₀ Circulating immune complex 0.07 U IgA 1.6 g / L IgG 7.6 g / L IgM 1.24 g / L Thus, in a 24-year-old patient with immunodeficiency in cellular immunity, the drug was taken at a dose of 115 mg per 1 kg body weight with a content of sodium nucleinate in an amount of 1.5 wt.% for 15 days led to an improvement in the neurological status on the 4th day of drug administration and the simultaneous disappearance of cellular immunodeficiency in the blood.

 The following five examples show the effectiveness of taking a carbon sorbent impregnated with methyluracil in a dose of 50-100 mg per 1 kg of patient body weight with methyluracil content of 2.5-5.0 wt.%.

 PRI me R 6. The content of methyluracil 2.5 wt.%. The dose of the drug is 100 mg per 1 kg of patient body weight.

 Patient Z.I.V., 29, engineer, was in the clinic of nervous diseases of the I LMI named after Acad. I.P. Pavlov from 09.09.88 to 12.10.88 with a diagnosis of multiple sclerosis in the stage of exacerbation (and / b N 19344).

 Complaints of weakness of the right leg, shakiness when walking, peremptory urination.

 Sick since 1978, when decreased vision in the right eye. This condition lasted for two weeks. In 1980, there was a paresis of facial muscles on the left, in 1985 a violation of sensitivity on the right half of the body, weakness of the right leg. Repeatedly treated stationary. Last exacerbation since October 1988

Neurological status upon admission: cortical function is normal. Installation nystagmus with extreme leads of the eyeballs. Smoothness of the right nasolabial fold. The strength of the muscles of the hands is complete, the tone is normal, deep reflexes without a difference of sides. Symptom of Rossolimo-Venderovich on the left. Abdominal reflexes are absent. Reduced strength in the hip flexors on the left to 4 points, on the right to 3 points. Reflexes on the legs are high without a difference of sides. Bilateral symptom of Babinsky. Adiadochokinesis, instability in the Romberg position. On a scale (Sipe et al.), Neurological status was rated 62 points. When examining the fundus revealed the monotony of the optic nerve discs with blanching of the temporal halves. Indicators of cellular and humoral blood immunity: T-lymphocytes 30% (normal 60-70%) B-lymphocytes 17% (normal 20-30%) Neutrophilic phagocytosis 38% (normal 20-30%) Circulating immune complex 0.09 units. (norm 0.06-0.08) IgA 1.96 g / l (norm 0.8-5.2) IgG 10.8 g / l (norm 6.0-18.0) IgM 2.4 g / l (norm 0.6-3.8)
The patient was treated for 15 days with a carbon fiber sorbent impregnated with methyluracil at a dose of 100 mg per 1 kg of body weight. The content of methyluracil is 2.5 wt.%. On the fourth day of treatment, nystagmus and a symptom of Rossolimo-Venderovich disappeared. In the following days, adiadochokinesis, ataxia decreased, strength in the legs increased. On a scale of Sipe et al. 81 points The study of cellular and humoral immunity: T-lymphocytes 60% B-lymphocytes 29% Circulating immune complex 0,049 units
So, in a 29-year-old patient with exacerbation of multiple sclerosis, accompanied by cellular and humoral immunodeficiency on the 4th day of treatment with a carbon fiber sorbent impregnated with methyluracil at a dose of 100 mg per 1 kg of body weight (methyluracil content of 2.5 wt.%), Immunodeficiency disappeared, neutrophil was activated phagocytosis. This coincided with an improvement in neurological status.

 PRI me R 7. The content of methyluracil 3.5 wt.%. The dose of the drug is 75 mg per 1 mg of body weight of the patient.

 Patient G. E.V., 38 years old. honey. sister, was in the clinic of nervous diseases I LMI them. Acad. I.P. Pavlov from 12/07/90 to 01/11/91 with a diagnosis of multiple sclerosis in the acute stage (and / b N 25202).

 Complaints of decreased vision, weakness in the legs, and shakiness when walking.

 Sick since 1988, when at the same time with visual impairment, shakiness appeared when walking. Two months later, these phenomena have passed. In the subsequent periodically disturbed dizziness during head turns.

 In 1989, at the Clinic of Nervous Diseases, I LMI was treated with hemosorption with a positive effect. Last exacerbation since November 1990

 Neurological status: cortical function is normal. Light anisocoria S> D, the remaining cranial nerves are normal. Muscle strength in the hands is complete. Deep reflexes are reduced. Abdominal reflexes are absent. The muscular strength in the legs is complete. The tone and deep reflexes are normal. Intentional tremor of fingers, dysmetria, instability in the Romberg position. On a scale of Sipe et al. neurological status rated 80 points.

 Fundus: fading of the temporal half of the right disc of the optic nerve.

Indicators of cellular and humoral immunity: T-lymphocytes 27% (normal 60-70%) B-lymphocytes 20% (normal 20-30%) Neutrophilic phagocytosis 35% (normal 20-30%) Circulating immune complex 0.05 u IgA 1 , 38 g / l (norm 0.8-5.2) IgG 18.4 g / l (norm 6.0-18.0) IgM 1.3 g / l (norm 0.6-3.8)
The patient was treated with a carbon fiber sorbent impregnated with methyluracil at a dose of 75 mg per 1 kg of body weight (methyluracil content of 3.5 wt.%) For 20 days. At the end of the course of treatment, ataxia, intentional tremor and dysmetria were moderate, the patient's well-being improved significantly. Assessment of neurological status on a scale of Sipe et al. 92 points. Indicators of cellular and humoral immunity: T-lymphocytes 37% B-deficiency 29% Neutrophilic phagocytosis 66% Circulating immune complex 0.04 units IgA 1.38 g / l IgG 18.4 g / l IgM 1.5 g / l
Thus, the intake of a fibrous carbon sorbent impregnated with methyluracil at a dose of 75 mg per 1 kg of body weight with a content of methyluracil of 3.5 wt.% Led to the correction of T- and B-lymphocytes in peripheral blood, a decrease in immunodeficiency and activation of neutrophilic phagocytosis. This coincided with an improvement in neurological status.

 PRI me R 8. The positive effect when the content of methyluracil is 5.0 wt.% The Dose of the drug is 50 mg per 1 kg of body weight of the patient.

 Patient M.V.I., 41 years old, engineer, was in the clinic of nervous diseases of the I LMI named after Acad. I.P. Pavlov from 01/26/89 to 02/17/89 (and / b N 2606).

 Complaints of difficulty speaking, a feeling of heaviness and numbness in the legs.

 Sick since 1975, when there was a feeling of numbness of the feet, which soon passed. In February 1980, it became unclear to see, first small objects, and then large ones. Left-sided hemianopsia was detected. After the course of treatment, vision was restored, but atrophy of the temporal half of the optic nerve was detected by the optometrist. In December 1982, a feeling of numbness of the legs reappeared, which soon spread to the knee joints, and a feeling of heaviness and tightening of the legs appeared. In 1988, he was treated stationary, received a course of hormone therapy with slight improvement.

 Neurological status: somewhat inhibited, ponders the meaning of words. Cranial nerves are normal. The strength of the muscles of the hands is sufficient, the tone is normal. Deep reflexes no difference. There are no pathological carpal symptoms. Abdominal reflexes are absent. The muscle strength of the hip flexors on both sides is reduced to three points. The tone in the legs is increased. Deep reflexes are high without a difference of sides, clones of the feet. The finger-nasal test is normal. Muscular-articular sensation in the toe is impaired. In the Romberg position is unstable. Neurological status according to the Sipe et al. 69 points.

 Fundus: optic disc is monophonic, pale gray, clear borders.

The study of cellular and humoral immunity: T-lymphocytes 23% (normal 60-70%) B-lymphocytes 14% (normal 20-30%) Neutrophilic phagocytosis 22% (normal 20-30%) Complement 36.6 units CH ₅₀ (normal 29.5-31.0) A circulating immune complex of 0.1 units. (norm 0.06-0.08) IgA 4.0 g / l (norm 0.8-5.2) IgG 10.4 g / l (norm 6.0-18.0) IgM 1.16 g / l (norm 0.6-3.8)
Within 15 days, the patient received a fibrous carbon sorbent impregnated with methyluracil at a dose of 50 mg per 1 kg of body weight, a dose of methyluracil of 5 wt.%. The condition improved: muscle strength in the legs increased, the reflex background decreased, and sensitive ataxia decreased. On a scale of Sipe et al, 80 points. Indicators of cellular and humoral immunity: T-lymphocytes 58% B-lymphocytes 35% Neutrophilic phagocytosis 45% Complement 32.7 u CH ₅₀ Circulating immune complex 0.06 u IgA 3.12 g / l IgG 8.8 g / l IgM 1 72 g / l
So, this example shows the immunocorrection of T- and B-lymphocytes in the patient’s peripheral blood during treatment with a carbon sorbent impregnated with methyluracil with its content of 5 wt.%. The dose of the drug is 50 mg per 1 kg of body weight. The drug was given for 15 days. Low levels of T- and B-lymphocytes in this patient were after treatment with corticosteroids in 1988.

 PRI me R 9. Shows the ineffectiveness of the therapeutic agent at a dose of 35 mg per 1 kg of patient body weight. The content of methyluracil is 5 wt.%. The course of treatment is 20 days.

 Patient G.B.P., 31 years old, senior engineer, was treated at the clinic of nervous diseases of 1 LMI named after Acad. I.P. Pavlov from 06/07/88 to 06/28/08 with a diagnosis of multiple sclerosis in the acute stage (and / b N 15140).

 Complaints of decreased vision in the left eye, weakness and fatigue of the legs when walking.

 Considers herself ill since November 1986, when, after suffering an acute respiratory infections, a scotoma appeared on the right eye. A few days later the field of vision fell from the bow. He was treated in the clinic of eye diseases with a diagnosis of retrobulbar neuritis of the right eye. Checked out with full restoration of vision. In April 1987, the lower left visual field of vision appeared. Outpatient treatment without effect. There was weakness of the legs when walking.

 Neurological status: cortical functions are not impaired. D-S pupils with a lively response to light and accommodation. There is no hemianopsia, with convergence, the right eyeball goes outside. From the upper extremities without pathology. Increased muscle tone in the right leg. Deep reflexes high with clonuses of the patella and feet. Pathological foot reflexes on both sides. Abdominal reflexes are not triggered. Sensitivity is not impaired. Intentional tremor and adiadochokinesis on both sides. In the Romberg position and while walking, staggering to the sides. Neurological status on a scale of Sipe et al. 68 points.

 Fundus: optic nerve disc is paler than normal with clear contours. A sharp narrowing of the visual field to blue and white color from the bow of the right eye.

Liquor: 0.5% protein, cytosis 3/3 lymphocytes
The study of cellular and humoral immunity: T-lymphocytes 37% (normal 60-70%) B-lymphocytes 39% (normal 20-30%) Neutrophilic phagocytosis 57% (normal 20-30%) Complement 27.2 u CH ₅₀ (normal 29.5-31.0) IgA 3.4 g / l (normal 0.8-5.2) IgG 18.0 g / l (normal 6.0-18.0) IgM 1.6 g / l ( norm 0.6-3.8)
For 20 days the patient received treatment with a carbon sorbent impregnated with methyluracil (methyluracil content 5 wt.%), The dose of the drug is 35 mg per 1 kg of body weight.

 6 days after the start of treatment, convergence improved, deep reflexes decreased. By the time of discharge from the clinic, cranial nerves were normal, there were no paresis, deep reflexes were revitalized. There are no pathological symptoms. Mild ataxia in the hands remains. In the Romberg position is steady. On a scale of Sipe et al. 82 points.

Use of cellular and humoral immunity: T-lymphocytes 34% B-lymphocytes 39% Neutrophilic phagocytosis 21% Complement 30.1 units SN ₅₀ IgA 2.0 g / l IgG 14.0 g / l IgM 1.48 g / l
So, taking a carbon sorbent impregnated with methyluracil at a dose of 35 mg per 1 kg of body weight and a methyluracil content of 5 wt. % within 20 days did not lead to immunocorrection of T- and B-lymphocytes in the patient’s peripheral blood, despite the improvement of the neurological status.

 PRI me R 10. This example shows that when treated with a drug at a dose of 115 mg per 1 kg of body weight of the patient with a content of methyluracil of 3.5 wt. % within 15 days, the positive effect is the same as in examples 6, 7 and 8.

 Patient V.A.G., 37 years old, engineer, was treated at the clinic of nervous diseases of 1 LMI named after Acad. I.P. Pavlov from 04/17/90 to 05/20/90 (and / b N 12639).

 Complaints of headaches, decreased visual acuity, double vision when looking up and to the side, numbness of the left half of the face, shakiness when walking.

 Sick since May 1987, when he suddenly had double vision when looking up to the right and shakiness when walking. In July, shakiness decreased, but visual acuity decreased. He was treated stationary with some improvement. In December 1987, vision deteriorated again. 02/28/90 there was a feeling of numbness in the left hand, then in the right hand, the precariousness intensified, double vision appeared when looking in all directions. In March-April 1990, vision deteriorated even more, difficulty appeared in pronouncing certain words, and a feeling of numbness of the left and right half of the body appeared. After inpatient treatment, there was some improvement: shakiness and numbness decreased, but double vision did not change.

 Neurological status: cortical functions are not impaired. Light anisocoria D> S, the movement of the eyeballs in full, diplopia when viewed from the side. The face is symmetrical. Tongue in the midline. Muscle strength and tone in the hands are normal. Deep reflexes are low without a difference of sides. There are no pathological carpal symptoms. Abdominal reflexes are absent. The muscular strength in the legs is complete. The tone in the left leg is increased. Knee and Achilles reflexes S> D. There are no pathological foot symptoms. Hypesthesia in the hands. Vibration sensitivity in the legs 3-4 s. A ride in the Romberg pose with closed eyes. Neurological status according to the Sipe et al. 77 points.

 Fundus: partial atrophy of the optic nerve in both eyes.

Indicators of cellular and humoral immunity: T-lymphocytes 26% (normal 60-70%) B-lymphocytes 14% (normal 20-30%) Neutrophilic phagocytosis 61% (normal 20-30%) Circulating immune complex 0.02 units of IgA 1 6 g / l (norm 0.8-5.2) IgG 19.2 g / l (norm 6.0-18.0) IgM 2.6 g / l (norm 0.6-3.8)
Within 15 days, the patient received coal sobet, impregnated with methyluracil at a dose of 115 mg per 1 kg of body weight with methyluracil content of 3.5 wt. % After 4 days, the headaches disappeared. After 6 days, the shakiness of walking decreased significantly. By the end of the course of treatment, the feeling of numbness of the face disappeared, diplopia significantly decreased. On a scale of Sipe et al. neurological status 92 points.

Indicators of cellular and humoral immunity: T-lymphocytes 28% B-lymphocytes 24% Neutrophilic phagocytosis 72%
The remaining immunological parameters without dynamics.

 Thus, in this example, the positive effect of treatment with a carbon sorbent impregnated with methyluracil with a content of 3.5 wt. % at a dose of 115 mg per 1 kg of patient body weight. This effect is the same as in examples 6, 7 and 8. There is also a coincidence of correction of T and B lymphocytes in the blood with an improvement in neurological status.

The following 5 examples show a positive effect: immunocorrection of T and B lymphocytes in the peripheral blood of patients with severe immunodeficiency under the influence of treatment with a carbon sorbent impregnated with vitamin B ₁₂ at a dose of 50-100 mg per 1 kg of patient’s body weight with vitamin B ₁₂ 0.001- 0.002 wt. %

PRI me R 11. The positive effect. The content of vitamin B ₁₂ 0,001 wt. %

 The dose of the drug is 100 mg per 1 kg of body weight.

 Patient B.K.V., 20 years old, locksmith, was in the clinic of nervous diseases I LMI named. Acad. I.P. Pavlov from 04/26/90 to 05/21/90 with a diagnosis of multiple sclerosis in the acute stage (and / b N 10978).

 Complaints of a feeling of numbness of the left half of the face, left limbs, double vision when looking into the distance, shakiness when walking.

 Sick since 1985, when there was double vision. It held for several days. In the next three months, numbness of the right half of the face was noted. After dexamethasone treatment, these symptoms disappeared. In 1988, numbness of the right extremities and shakiness when walking appeared. In 1989, weakness of the right limbs, difficulty speaking. In March 1990, double vision appeared when looking into the distance, speech difficulty increased, shakiness increased, numbness of the left half of the face and limbs appeared.

 Neurological status: euphoria. D-S pupils with a lively response to light and accommodation. The right eyeball does not bring the inside, the left eye does not. Diplopia when looking to the left. Nystagmus when looking in both directions. The face is symmetrical. Tongue in the midline. The muscular strength in the limbs is complete. The tone is reduced. Deep reflexes on the hands without a difference of sides, knee D> S, Achilles without a difference of sides. Symptoms of Babansky, Strumpel, Rossolimo on both sides. Abdominal reflexes are absent. Hyperpathy on the left half of the face and hands on both sides. Intentional tremor in the hands, adiadhokinesis. Unstable in the Romberg position with closed eyes and in the complicated position of the Romberg.

 Neurological status on a scale of Sipe et al. rated 70 points.

 The fundus is normal.

 Liquor: 0.16% protein, 16/3 cytosis of lymphocytes.

ECHO-EG within normal limits
Evoked auditory potentials: with almost normal tonal hearing, changes in the function of the auditory system are observed at the level of the brain stem, subcortical region and, possibly, the cerebral cortex.

Indicators of cellular and humoral immunity: T-lymphocytes 21% (normal 60-70%) B-lymphocytes 9% (normal 20-30%) Neutrophilic phagocytosis 74% (normal 20-30%) Complement 21.1 units of CH ₅₀ (normal 20-23) The circulating immune complex 0.07 units of IgA 1.3 g / l (normal 0.8-5.2) IgG 16.8 g / l (normal 6.0-18.0) IgM 1.2 g / l (norm 0.6-3.8)
The patient was treated for 20 days with a carbon sorbent impregnated with vitamin B ₁₂ at a dose of 100 mg per 1 kg of body weight (vitamin B ₁₂ content of 0.001 wt.%). During treatment, the patient decreased shakiness while walking, diplopia, euphoria disappeared, pathological foot reflexes disappeared, abdominal reflexes appeared, intentional tremor disappeared, adiadochokinesis significantly decreased, and he became more stable in the Romberg position. On a scale of Sipe et al. - 91 points.

Indicators of cellular and humoral immunity: on the fifth day from the start of treatment: T-lymphocytes 28% B-lymphocytes 14% Phagocytosis 60% complement 22.1 units of CH ₅₀ circulating immune complex 0.03 units of IgA 1.1 g / l IgG 16, 2 g / l IgM 0.8 g / l
Indicators of T- and B-lymphocytes at the end of the course of treatment: T-lymphocytes 41%; B-lymphocytes 24%
So, the patient’s treatment for 20 years with a carbon sorbent impregnated with vitamin B ₁₂ at a dose of 100 mg per 1 kg of body weight with vitamin B ₁₂ content of 0.001 wt. % led to a positive effect: immunocorrection of T- and B-lymphocytes in peripheral blood, i.e. reduction of immunodeficiency on the fifth day of treatment with an even greater effect by the end of the course of treatment. This coincided with a significant improvement in neurological status.

PRI me R 12. The positive effect. The content of vitamin B ₁₂ 0,0015 wt. % The dose of the drug is 75 mg per 1 kg of body weight.

 Patient Kh.T.M., 34 years old, engineer, was in the clinic of nervous diseases of the I LMI named after Acad. I.P. Pavlov from 15.04.90 to 12.05.90 with a diagnosis of multiple sclerosis in the acute stage (and / b N 10353).

 Complaints of decreased vision in both eyes, pain in the right eyeball.

 Considers herself a patient since November 1987, when there was a decrease in vision in the left eye. It was treated on an outpatient basis with improvement. In January 1988, vision in the left eye decreased again and left limb weakness appeared. After inpatient treatment, the visual acuity of the left eye increased to 0.9. In April 1988, there was pain in the right eye and decreased vision in the right eye.

 Neurological status: cortical function is normal. Pupils D-S. The response to light and accommodation is lively. Soreness when moving the right eyeball. The convergence of the right eye is weakened. The face is symmetrical. Tongue in the midline. The muscle strength of the left hand is reduced to 3 points, m. interossei up to 2 points on both sides. Deep reflexes S> D. Rossolimo-Venderovich symptom on both sides, brighter on the left. Abdominal reflexes are absent. Reduced muscle strength in the hip flexors on both sides to 3 points, in the muscles of the left foot to 3 points. Muscle tone in the left leg is reduced. Reflexes S> D. Left-sided hemigesthesia. Plantar reflexes are sluggish. Light adiadhokinesis on the right. Staggering in the Romberg pose with closed eyes. On a scale of Sipe et al. 63 points.

The fundus of the eye: the optic disc is solid, the boundaries are clear. Visual acuity: 0.7 n / k on the right
left 0.9 n / a Liquor: protein 0.33%, cytosis 10/3 lymphocytes Indicators of cellular and humoral immunity: T-lymphocytes 35% (normal 60-70%) B-lymphocytes 23% (normal 20-30%) Neutrophilic phagocytosis 54% (normal 20-30%); Complement 26 units of CH ₅₀ (normal 29.5-31.0); Circulating immune complex 0.055 units. IgA 2.8 g / l (norm 0.8-5.2) IgG 12.8 g / l (norm 6.0-18.0) IgM 2.32 g / l (norm 0.6-3.8 )
In the course of treatment with a fibrous carbon sorbent impregnated with vitamin B ₁₂ at a dose of 75 mg per 1 kg of body weight containing vitamin B _12, 0.0015 wt. % the patient's condition has improved significantly. So, on the fifth day from the start of treatment, visual acuity increased, strength in the left limbs increased to 4 points, the reflex background decreased. By the end of the treatment, visual acuity in both eyes:
right: -0.8 Cyl + 0.75-1.0
left: -0.8 Cyl + 0.75-0.9 Fully restored muscle strength in the limbs to 5 points, coordination was normalized. There remains a hint of a Babinsky symptom on the left and mild left-sided hemigipesthesia. On a scale of Sipe et al. 94 points.

The study of cellular and humoral immunity on the 4th day of treatment: T-lymphocytes 54% B-lymphocytes 28% Neutrophilic phagocytes 54%
The remaining immunological parameters have not changed. When examining a patient after a year: good condition, copes well with his work. There are no complaints. Neurological status on a scale of Sipe et al. 100 points.

Thus, the oral administration of the drug at a dose of 75 mg per 1 kg of body weight of the patient containing vitamin B ₁₂ 0.0015 wt. %, gave a positive effect: rapid immunocorrection of T- and B-lymphocytes in the peripheral blood of the patient and a significant improvement in neurological status.

PRI me R 13. The positive effect. The dose of the drug is 50 mg per 1 kg of patient body weight. The content of vitamin B _{12 of} 0.002 wt.%.

 Patient A.S.L., 25 years old, student, was admitted to the clinic of eye diseases I LMI them. Acad. I.P. Pavlova 03/13/89 and transferred to the clinic of nervous diseases 03/21/89. Discharged 04/11/89 (and / b N 6778).

 Complaints of a sharp decrease in vision in the right eye.

 Sick since 1982, when the numbness of the left arm was twice observed, which lasted several hours. I did not go to the doctor. In March 1989, visual acuity in the right eye suddenly decreased.

 Neurological status: There are no local disorders of cortical functions. The right pupil is dilated with medication. The reaction to the light and accommodation of the left pupil is lively. The movements of the eyeballs in full. The face is symmetrical. Tongue in the midline. The muscular strength in the limbs is complete. The tone is normal. Deep reflexes S> D. Abdominal reflexes are not triggered. There are no pathological symptoms. Sensitivity is normal. Coordination is not broken. In the Romberg position is stable.

 On a scale of Sipe et al. neurological status is 88 points.

 The fundus of the eye: the optic nerve on the right side of the nose is fused, hyperemic, the arteries are convoluted, and the veins are dilated.

 The optic disc on the left is normal.

Visual acuity: on the right, finger counting at a distance of 20 cm on the left 0.8 sph -0.75-1.0
Indicators of cellular and humoral immunity: T-lymphocytes 54% (normal 60-70%) B-lymphocytes 18% (normal 20-30%) Neutrophilic phagocytosis 48% (normal 20-30%) Complement 24.1 units of CH ₅₀ (normal 29.5-31.0) The circulating immune complex 0.12 u (normal 0.06-0.08) IgA 2.4 g / l (normal 0.8-5.2) IgG 19.1 g / l ( normal 6.0-18.0) IgM 1.2 g / l (normal 0.6-3.8)
The patient received fibrous carbon sorbent impregnated with vitamin B ₁₂ at a dose of 50 mg per 1 kg of body weight for 15 days.

The content of vitamin B _{12 of} 0.002 wt.%.

 On the third day from the start of treatment, anisoreflexia of the upper extremities disappeared, it became better to see. By the end of the course of treatment, visual acuity was fully restored. On a scale of Sipe et al. 100 points.

Indicators of cellular and humoral immunity: T-lymphocytes 53% B-lymphocytes 26% Neutrophilic leukocytosis 64%
The remaining immunological parameters are the same.

So, a 25-year-old patient with the debut of multiple sclerosis, manifested in retrobulbar neuritis of the right eye with B-lymphocyte immunodeficiency, underwent a 25-day course of treatment with the oral administration of a carbon sorbent impregnated with vitamin B ₁₂ at a dose of 50 mg per 1 kg of body weight containing vitamin B ₁₂ 0.002 wt.%. A good positive effect was revealed, consisting in the normalization of the content of B-lymphocytes in the peripheral blood of the patient with the simultaneous restoration of neurological status to 100 points.

PRI me R 14. This example shows the negative effect of oral administration of a therapeutic agent at a dose of 35 mg per 1 kg of patient body weight. The content of vitamin B _{12 of} 0.002 wt.%. The drug was given for 20 days.

 Patient B.L.I., 55 years old, disabled person of group II, was treated in the clinic of nervous diseases of the I LMI named after Acad. I.P. Pavlov from 03/15/90 to 04/19/90 (and / b N 24240).

 Complaints of weakness of the arms and legs, more left, periodic choking when eating.

 Sick since 1971, when a transient weakness in the left limbs began to appear. In 1973, left-sided hemiparesis was revealed. In 1988, he significantly increased, joined by the weakness of the right limbs. Repeatedly treated in hospitals with slight improvement.

 Neurological status: cortical functions are not impaired. D-S pupils with a lively response to light and accommodation. The movements of the eyeballs in full. Slight smoothing of the left nasolabial fold, slight deviation of the tongue to the left. The strength in the muscles of the arms and right leg was reduced to 4 points. In the left leg 0-1 point. The tone is increased, more on the left. Deep reflexes are animated without a difference of parties. Symptom of Rossolimo-Venderovich and Babinsky on both sides. Abdominal reflexes are not triggered. Light intentional tremor with a finger-nasal test, mild adiadochokinesis.

 Neurological status on a scale of Sipe et al. 65 points.

 Fundus: retinal vascular angiosclerosis.

Indicators of cellular and humoral immunity: T-lymphocytes 32% (normal 60-70%) B-lymphocytes 18% (normal 20-30%) Neutrophilic phagocytosis 86% (normal 20-30%) Complement 22.3 u CH ₅₀ (normal 29.5-31.0) The circulating immune complex 0.05 u IgA 2.37 g / l (normal 0.8-5.2) IgG 15.5 g / l (normal 6.0-18.0) IgM (1.68 g / l) norm 0.6-3.8)
The patient within 20 days of treatment performed carbon sorbent impregnated with vitamin B ₁₂ at a dose of 35 mg per 1 kg of body weight with a content of vitamin B ₁₂ 0.002 wt.%.

After 4 days, weakness in the legs decreased. After 7 days, muscle strength increased to 5 points in the arms and right leg and up to 3 points in the left leg. He began to walk confidently without a wand in the compartment. Muscle tone in the legs decreased. On a scale of Sipe et al. 81 points Indicators of cellular and humoral immunity: T-lymphocytes 34% B-lymphocytes 18% Neutrophilic phagocytosis 72% Complement 23.1 u CH ₅₀ Circulating immune complex 0.07 u IgA 1.1 g / l IgG 13.8 g / l IgM 0 7 g / l
Thus, the patient with the oral administration of a coal sorbent containing 0.002 wt. % of vitamin B ₁₂ at a dose of 35 mg per 1 kg of body weight for 20 days despite a significant improvement in the neurological status of correction of T and B lymphocytes in peripheral blood did not occur, i.e. such a dose of a drug gives a negative effect.

PRI me R 15. Taking a medicine containing vitamin B ₁₂ 0.0015 wt. %, at a dose of 115 mg per 1 kg of body weight of the patient for 20 days gives the same positive effect as in examples 11, 12 and 13.

 Patient C.E.E .., 31 years old, a radio technician, was treated in the clinic of nervous diseases of the I LMI named after Acad. I.P. Pavlov from 5.10.89 to 3.11.89 with a diagnosis of multiple sclerosis in the acute stage (and / b N 21125).

 Complaints of weakness in the feet, shakiness when walking.

 Considers herself a patient since February 1984, when after the flu appeared double vision when looking into the distance and paresis of the left facial muscles. It was treated stationary with improvement. In 1986, weakness appeared in the right foot. Received a course of corticosteroid therapy also with improvement. The last exacerbation of the disease from 09.29.89 - there was a weakness in the left foot.

Neurological status: there are no local violations of cortical functions. DS pupils with a lively response to light and accommodation. The movements of the eyeballs in full. The face is symmetrical. Tongue in the midline. Upper extremities without pathology. Abdominal reflexes are absent. Limited range of motion in the right ankle joint. The muscle strength of the right leg is reduced to 2-3 points, the left to 3-4 points. The tone in the legs is increased, deep reflexes are high D> S. Babinsky's symptom on the right and a hint of Babinsky's symptom on the left. Left-side hemigipesthesia and hypesthesia with L ₂ level _{on the} right. Ataxia with a heel-knee test on both sides. In the Romberg position and when walking unstable.

 On a scale of Sipe et al. neurological status rated 64 points.

 The fundus without pathology.

Liquor: protein 0.33%, cytosis 5/3 lymphocytes
There are no changes on ECHO-EG.

Indicators of cellular and humoral immunity: T-lymphocytes 13% (normal 60-70%) B-lymphocytes 10% (normal 20-30%) Neutrophilic phagocytosis 69% (normal 20-30%) Complement 21.0 units CH ₅₀ Circulating immune complex of 0.075 units. IgA 1.4 g / l (norm 0.8-5.2) IgG 26.9 g / l (norm 6.0-18.0) IgM 2.2 g / l (norm 0.6-3.8 )
The patient received a course of treatment with a fibrous carbon sorbent impregnated with vitamin B ₁₂ at a dose of 115 mg per 1 kg of body weight with a vitamin B content of ₁₂ 0.0015 wt.% For 20 days. 6 days after the start of treatment, foot weakness decreased, pathological reflexes on the legs disappeared. After 8 days, abdominal reflexes appeared. By the end of the course of treatment, the muscle strength in the legs is complete - 5 points. In the Romberg position is stable. On a scale of Sipe at al. 100 points.

Indicators of cellular and humoral immunity after 6 days from the start of treatment: T-lymphocytes 33% B-lymphocytes 21% Neutrophilic phagocytosis 66% Complement 20.4 u CH ₅₀ Circulating immune complex 0.055 u IgA 1.3 g / l IgG 12.2 g / l IgM 0.5 g / l
So, the drug at a dose of 115 mg per 1 kg of body weight of the patient with a vitamin B content of ₁₂ 0.0015 wt.% Has the same positive effect as in examples 11, 12 and 13, i.e. increases the number of T and B lymphocytes in the peripheral blood of patients with severe immunodeficiency and at the same time significantly improves neurological status.

 The effectiveness of the treatment of the proposed drug in various doses is shown in the table.

 From the above examples it is seen that the proposed method for the treatment of patients with multiple sclerosis with severe immunodeficiency, both primary and coming after treatment with immunosuppressants, has a positive therapeutic effect.

Using the method allows to achieve the following positive effect:
- quickly achieve immunocorrection with severe immunodeficiency;
- 5-15 times reduce the dose of an immunostimulating drug;
- to achieve a reduction in relapse of the disease with its remitting course;
- extend the period of work of patients;
- differentially approach the treatment of patients in the stage of exacerbation of multiple sclerosis;
- quickly achieve a dehydrating effect in patients with hypertension syndrome, accompanying in some cases, exacerbation of the disease;
- eliminate the complications associated with the use of large doses of immunosuppressants, especially immunodeficiency, formed during prolonged treatment with these drugs.

Claims (1)

METHOD FOR TREATING MULTIPLE SCLEROSIS by oral administration of a charcoal sorbent at a dose of 50-100 mg per 1 kg of body weight between meals, characterized in that, in order to increase the timing of remission due to correction of the immunological status, preliminarily, the charcoal sorbent is impregnated with sodium nucleinate in an amount 1.0 to 2.0 wt.%, Or methyluracil in an amount of 2.5 to 5.0 wt.%, Or vitamin B ₁₂ in an amount of 0.001 to 0.002 wt.%.

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