RU2010125605A - Антитело против глипикана-3 с улучшенными кинетическими показателями в плазме - Google Patents
Антитело против глипикана-3 с улучшенными кинетическими показателями в плазме Download PDFInfo
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- RU2010125605A RU2010125605A RU2010125605/10A RU2010125605A RU2010125605A RU 2010125605 A RU2010125605 A RU 2010125605A RU 2010125605/10 A RU2010125605/10 A RU 2010125605/10A RU 2010125605 A RU2010125605 A RU 2010125605A RU 2010125605 A RU2010125605 A RU 2010125605A
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- 210000004027 cell Anatomy 0.000 claims abstract 8
- 210000004102 animal cell Anatomy 0.000 claims abstract 6
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims abstract 4
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims abstract 4
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims abstract 4
- 239000002246 antineoplastic agent Substances 0.000 claims abstract 4
- 238000004519 manufacturing process Methods 0.000 claims abstract 4
- 102000039446 nucleic acids Human genes 0.000 claims abstract 4
- 108020004707 nucleic acids Proteins 0.000 claims abstract 4
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 4
- 229920001184 polypeptide Polymers 0.000 claims abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 4
- 102000006471 Fucosyltransferases Human genes 0.000 claims abstract 2
- 108010019236 Fucosyltransferases Proteins 0.000 claims abstract 2
- 102000010956 Glypican Human genes 0.000 claims abstract 2
- 108050001154 Glypican Proteins 0.000 claims abstract 2
- 108050007237 Glypican-3 Proteins 0.000 claims abstract 2
- 206010028980 Neoplasm Diseases 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims abstract 2
- 230000001093 anti-cancer Effects 0.000 claims abstract 2
- 201000011510 cancer Diseases 0.000 claims abstract 2
- 238000004113 cell culture Methods 0.000 claims abstract 2
- 238000012258 culturing Methods 0.000 claims abstract 2
- 239000003937 drug carrier Substances 0.000 claims abstract 2
- 201000007270 liver cancer Diseases 0.000 claims abstract 2
- 208000014018 liver neoplasm Diseases 0.000 claims abstract 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1. Антитело против глипикана-3, которое содержит вариабельную область тяжелой цепи SEQ ID NO:27 и вариабельную область легкой цепи SEQ ID NO:29. ! 2. Антитело по п.1, содержащее константную область антитела человека. ! 3. Антитело по п.2, где константная область содержит последовательность SEQ ID NO:32 и 33. ! 4. Антитело по п.1, где антитело имеет уменьшенное количество фукозы, присоединенной к Fc-области антитела. ! 5. Противораковая композиция, содержащая эффективное количество антитела по любому из пп.1-4 и фармацевтически приемлемый носитель. ! 6. Противораковое средство, содержащее антитело по пп.1-4 в качестве активного ингредиента. ! 7. Противораковое средство по п.6, где раком является рак печени. ! 8. Нуклеиновая кислота, которая кодирует полипептид антитела по любому из пп.1-4. ! 9. Клетка-хозяин, содержащая нуклеиновую кислоту по п.8, для продукции антитела по любому из пп.1-4. ! 10. Клетка-хозяин по п.9, где клетка-хозяин является клеткой животного, лишенной транспортера фукозы, клеткой животного с удаленной фукозилтрансферазой или клеткой животного с модифицированной сложной разветвленной цепью сахара. ! 11. Способ получения антитела, включающий культивирование клетки-хозяина по п.9 или 10 и выделение полипептида из клеточной культуры.
Claims (11)
1. Антитело против глипикана-3, которое содержит вариабельную область тяжелой цепи SEQ ID NO:27 и вариабельную область легкой цепи SEQ ID NO:29.
2. Антитело по п.1, содержащее константную область антитела человека.
3. Антитело по п.2, где константная область содержит последовательность SEQ ID NO:32 и 33.
4. Антитело по п.1, где антитело имеет уменьшенное количество фукозы, присоединенной к Fc-области антитела.
5. Противораковая композиция, содержащая эффективное количество антитела по любому из пп.1-4 и фармацевтически приемлемый носитель.
6. Противораковое средство, содержащее антитело по пп.1-4 в качестве активного ингредиента.
7. Противораковое средство по п.6, где раком является рак печени.
8. Нуклеиновая кислота, которая кодирует полипептид антитела по любому из пп.1-4.
9. Клетка-хозяин, содержащая нуклеиновую кислоту по п.8, для продукции антитела по любому из пп.1-4.
10. Клетка-хозяин по п.9, где клетка-хозяин является клеткой животного, лишенной транспортера фукозы, клеткой животного с удаленной фукозилтрансферазой или клеткой животного с модифицированной сложной разветвленной цепью сахара.
11. Способ получения антитела, включающий культивирование клетки-хозяина по п.9 или 10 и выделение полипептида из клеточной культуры.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007-256063 | 2007-09-28 | ||
| JP2007256063 | 2007-09-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010116756/10A Division RU2010116756A (ru) | 2007-09-28 | 2008-09-26 | Антитело против глипикана-3 с улучшенными кинетическими показателями в плазме |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010125605A true RU2010125605A (ru) | 2011-12-20 |
| RU2445366C2 RU2445366C2 (ru) | 2012-03-20 |
Family
ID=40510966
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010125605/10A RU2445366C2 (ru) | 2007-09-28 | 2008-09-26 | Антитело против глипикана-3 с улучшенными кинетическими показателями в плазме |
| RU2010116756/10A RU2010116756A (ru) | 2007-09-28 | 2008-09-26 | Антитело против глипикана-3 с улучшенными кинетическими показателями в плазме |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010116756/10A RU2010116756A (ru) | 2007-09-28 | 2008-09-26 | Антитело против глипикана-3 с улучшенными кинетическими показателями в плазме |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US8497355B2 (ru) |
| EP (3) | EP2196541B1 (ru) |
| JP (3) | JP4535406B2 (ru) |
| KR (2) | KR20150126724A (ru) |
| CN (1) | CN101809162B (ru) |
| AR (1) | AR066172A1 (ru) |
| AU (1) | AU2008305851B2 (ru) |
| BR (1) | BRPI0817637A2 (ru) |
| CA (1) | CA2700986A1 (ru) |
| CL (1) | CL2008002873A1 (ru) |
| CO (1) | CO6270266A2 (ru) |
| CR (1) | CR11369A (ru) |
| DK (1) | DK2196541T3 (ru) |
| EC (1) | ECSP10010135A (ru) |
| ES (1) | ES2394471T3 (ru) |
| IL (1) | IL204754A0 (ru) |
| MA (1) | MA31780B1 (ru) |
| MX (1) | MX2010003158A (ru) |
| MY (1) | MY148637A (ru) |
| NZ (1) | NZ584769A (ru) |
| PE (1) | PE20091218A1 (ru) |
| RU (2) | RU2445366C2 (ru) |
| TW (1) | TWI418363B (ru) |
| WO (1) | WO2009041062A1 (ru) |
| ZA (1) | ZA201002741B (ru) |
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| CN101198698B (zh) | 2005-03-31 | 2014-03-19 | 中外制药株式会社 | 通过调节多肽缔合制备多肽的方法 |
| US20070087005A1 (en) | 2005-10-14 | 2007-04-19 | Lazar Gregory A | Anti-glypican-3 antibody |
| JP5144499B2 (ja) | 2006-03-31 | 2013-02-13 | 中外製薬株式会社 | 二重特異性抗体を精製するための抗体改変方法 |
| EP3056568B1 (en) | 2006-03-31 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| RU2526512C2 (ru) | 2007-09-26 | 2014-08-20 | Чугаи Сейяку Кабусики Кайся | Модифицированная константная область антитела |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| WO2009072604A1 (ja) * | 2007-12-05 | 2009-06-11 | Chugai Seiyaku Kabushiki Kaisha | 抗nr10抗体、およびその利用 |
| US8124725B2 (en) | 2007-12-19 | 2012-02-28 | General Electric Company | PDGF-Rβ binders |
| US8937047B2 (en) | 2007-12-19 | 2015-01-20 | General Electric Company | Biokinetics of fast-clearing polypeptides |
| CL2009000647A1 (es) * | 2008-04-04 | 2010-06-04 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto. |
| CA2721052C (en) | 2008-04-11 | 2023-02-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| TWI440469B (zh) * | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
| EP2409990A4 (en) | 2009-03-19 | 2013-01-23 | Chugai Pharmaceutical Co Ltd | VARIANT OF A CONSTANT ANTIBODY REGION |
| KR20120024763A (ko) | 2009-05-15 | 2012-03-14 | 추가이 세이야쿠 가부시키가이샤 | 항ａｘｌ 항체 |
| GB0914691D0 (en) | 2009-08-21 | 2009-09-30 | Lonza Biologics Plc | Immunoglobulin variants |
| WO2011037158A1 (ja) | 2009-09-24 | 2011-03-31 | 中外製薬株式会社 | 抗体定常領域改変体 |
| WO2011108714A1 (ja) * | 2010-03-04 | 2011-09-09 | 中外製薬株式会社 | 抗体定常領域改変体 |
| AU2011225716A1 (en) * | 2010-03-11 | 2012-09-27 | Pfizer Inc. | Antibodies with pH dependent antigen binding |
| CN103052649B (zh) * | 2010-07-29 | 2015-12-16 | Xencor公司 | 具有修改的等电点的抗体 |
| KR101962483B1 (ko) | 2010-11-17 | 2019-03-29 | 추가이 세이야쿠 가부시키가이샤 | 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자 |
| CN103328632A (zh) * | 2010-11-30 | 2013-09-25 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| EP4279513A3 (en) | 2010-11-30 | 2024-02-28 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
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| KR20230143201A (ko) | 2011-11-30 | 2023-10-11 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약 |
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