RU2008130367A - Применение питательных композиций с фосфолипидами, сфинголипидами и холестерином - Google Patents
Применение питательных композиций с фосфолипидами, сфинголипидами и холестерином Download PDFInfo
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- RU2008130367A RU2008130367A RU2008130367/15A RU2008130367A RU2008130367A RU 2008130367 A RU2008130367 A RU 2008130367A RU 2008130367/15 A RU2008130367/15 A RU 2008130367/15A RU 2008130367 A RU2008130367 A RU 2008130367A RU 2008130367 A RU2008130367 A RU 2008130367A
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- oligosaccharides
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- 239000000203 mixture Substances 0.000 title claims abstract 18
- 235000016709 nutrition Nutrition 0.000 title claims abstract 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title claims abstract 6
- 235000012000 cholesterol Nutrition 0.000 title claims abstract 3
- 229920001542 oligosaccharide Polymers 0.000 claims abstract 13
- 150000002632 lipids Chemical class 0.000 claims abstract 12
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims abstract 8
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims abstract 8
- 235000020778 linoleic acid Nutrition 0.000 claims abstract 8
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims abstract 8
- 230000002265 prevention Effects 0.000 claims abstract 8
- 208000008589 Obesity Diseases 0.000 claims abstract 6
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims abstract 6
- 235000020824 obesity Nutrition 0.000 claims abstract 6
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract 5
- 150000001720 carbohydrates Chemical class 0.000 claims abstract 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract 4
- 229930195729 fatty acid Natural products 0.000 claims abstract 4
- 239000000194 fatty acid Substances 0.000 claims abstract 4
- 150000004665 fatty acids Chemical class 0.000 claims abstract 4
- 229960004488 linolenic acid Drugs 0.000 claims abstract 4
- 238000004519 manufacturing process Methods 0.000 claims abstract 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract 4
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims abstract 3
- 150000003271 galactooligosaccharides Chemical class 0.000 claims abstract 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract 2
- 229920001202 Inulin Polymers 0.000 claims abstract 2
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract 2
- 229940029339 inulin Drugs 0.000 claims abstract 2
- -1 inulin) Chemical class 0.000 claims abstract 2
- 150000003904 phospholipids Chemical class 0.000 claims abstract 2
- 235000004252 protein component Nutrition 0.000 claims abstract 2
- 235000018102 proteins Nutrition 0.000 claims abstract 2
- 102000004169 proteins and genes Human genes 0.000 claims abstract 2
- 108090000623 proteins and genes Proteins 0.000 claims abstract 2
- 150000003408 sphingolipids Chemical class 0.000 claims abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000004611 Abdominal Obesity Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 201000001431 Hyperuricemia Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 206010023230 Joint stiffness Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 235000001434 dietary modification Nutrition 0.000 claims 1
- 235000003642 hunger Nutrition 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 1
- 201000008980 hyperinsulinism Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 150000003272 mannan oligosaccharides Chemical class 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 201000002859 sleep apnea Diseases 0.000 claims 1
- 230000037351 starvation Effects 0.000 claims 1
- 230000001228 trophic effect Effects 0.000 claims 1
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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Abstract
1. Применение композиции, содержащей липидный, белковый и перевариваемый углеводный компонент, а также: ! (a) 0,5-20 мас.% фосфолипидов от общего содержания липидов; ! (b) 0,1-20 мас.% сфинголипидов от общего содержания липидов; и ! (c) 0,005-10 мас.% холестерина от общего содержания липидов, ! для производства питательной композиции для введения не страдающему ожирением ребенку возрастом до 36 месяцев для профилактики ожирения и/или диабета второго типа. ! 2. Применение по п.1, в котором композиция дополнительно содержит не менее 0,5 мас.% от сухой массы композиции как минимум одного растворимого неперевариваемого олигосахарида. ! 3. Применение по п.1, в котором липидный компонент включает a) линолевую кислоту (LA) и альфа-линоленовую кислоту (ALA) в массовом соотношении LA/ALA от 2 до 7; b) менее 15 мас.% LA от общего содержания жирных кислот; и c) не менее 1 мас.% ALA от общего содержания жирных кислот. ! 4. Применение по п.1, в котором липидный компонент обеспечивает 35-55% общей калорийности, белковый компонент обеспечивает 5-15% общей калорийности, и перевариваемый углеводный компонент обеспечивает 30-60% общей калорийности. ! 5. Применение по любому из пп.1-4, для профилактики развития ожирения в более зрелом возрасте и/или для профилактики развития ожирения, когда возраст указанного ребенка превысит 36 месяцев. ! 6. Применение по любому из пп.1-4, в котором питательную композицию дают ребенку в возрасте до 12 месяцев. ! 7. Применение по любому из пп.1-4, в котором композиция включает как минимум один растворимый неперевариваемый олигосахарид, выбранный из группы, состоящей из фрукто-олигосахаридов (включая инулин), галакто-олигосахаридов (включая трансгалакто-олигос
Claims (10)
1. Применение композиции, содержащей липидный, белковый и перевариваемый углеводный компонент, а также:
(a) 0,5-20 мас.% фосфолипидов от общего содержания липидов;
(b) 0,1-20 мас.% сфинголипидов от общего содержания липидов; и
(c) 0,005-10 мас.% холестерина от общего содержания липидов,
для производства питательной композиции для введения не страдающему ожирением ребенку возрастом до 36 месяцев для профилактики ожирения и/или диабета второго типа.
2. Применение по п.1, в котором композиция дополнительно содержит не менее 0,5 мас.% от сухой массы композиции как минимум одного растворимого неперевариваемого олигосахарида.
3. Применение по п.1, в котором липидный компонент включает a) линолевую кислоту (LA) и альфа-линоленовую кислоту (ALA) в массовом соотношении LA/ALA от 2 до 7; b) менее 15 мас.% LA от общего содержания жирных кислот; и c) не менее 1 мас.% ALA от общего содержания жирных кислот.
4. Применение по п.1, в котором липидный компонент обеспечивает 35-55% общей калорийности, белковый компонент обеспечивает 5-15% общей калорийности, и перевариваемый углеводный компонент обеспечивает 30-60% общей калорийности.
5. Применение по любому из пп.1-4, для профилактики развития ожирения в более зрелом возрасте и/или для профилактики развития ожирения, когда возраст указанного ребенка превысит 36 месяцев.
6. Применение по любому из пп.1-4, в котором питательную композицию дают ребенку в возрасте до 12 месяцев.
7. Применение по любому из пп.1-4, в котором композиция включает как минимум один растворимый неперевариваемый олигосахарид, выбранный из группы, состоящей из фрукто-олигосахаридов (включая инулин), галакто-олигосахаридов (включая трансгалакто-олигосахариды), глюко-олигосахаридов (включая гентио-, нигеро- и циклодекстрин-олигосахариды), арабино-олигосахаридов, маннан-олигосахаридов, ксило-олигосахаридов, фуко-олигосахаридов, арабиногалакто-олигосахаридов, глюкоманно-олигосахаридов, галактоманно-олигосахаридов, олигосахаридов, включающие сиаловую кислоту и олигосахаридов на основе уроновой кислоты.
8. Применение по любому из пп.1-4, в котором композиция включает галакто-олигосахариды.
9. Применение композиции, описанной в любом из пп.1-4, 7, 8, для производства питательной композиции для введения ребенку в возрасте до 36 месяцев для профилактики развития расстройства, когда возраст указанного ребенка превысит 36 месяцев, причем это расстройство выбрано из группы, состоящей из диабета второго типа, гипергликемии при голодании, невосприимчивости к инсулину, висцерального ожирения, гиперинсулинемии, гипертонии, сердечно-сосудистых заболеваний, заболеваний сосудов мозга, артросклероза, дислипидемии, гиперурикемии, жировой дистрофии печени, остеоартрита и апноэ во сне.
10. Применение композиции, описанной в любом из пп.1-4, 7, 8, для производства питательной композиции для профилактики и/или лечения диабета второго типа и/или питательного регулирования диабета второго типа.
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| EP20050077972 EP1800675B1 (en) | 2005-12-23 | 2005-12-23 | Composition comprising polyunsaturated fatty acids, proteins, manganese and/or molybden and nucleosides/nucleotides for treating dementia |
| EP05077972.7 | 2005-12-23 | ||
| NLPCT/NL2006/050274 | 2006-11-02 | ||
| PCT/NL2006/050274 WO2008054192A1 (en) | 2006-11-02 | 2006-11-02 | Use of nutritional compositions for preventing disorders |
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| RU2008130370/13A RU2417712C2 (ru) | 2005-12-23 | 2006-12-22 | Питательная композиция для младенцев, предназначенная для предупреждения ожирения |
| RU2008130367/15A RU2414905C2 (ru) | 2005-12-23 | 2006-12-22 | Применение питательных композиций с фосфолипидами, сфинголипидами и холестерином |
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| RU2008130370/13A RU2417712C2 (ru) | 2005-12-23 | 2006-12-22 | Питательная композиция для младенцев, предназначенная для предупреждения ожирения |
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