RU2007113156A - SOLID NANOCOMPOSITION FOR DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES - Google Patents
SOLID NANOCOMPOSITION FOR DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES Download PDFInfo
- Publication number
- RU2007113156A RU2007113156A RU2007113156/15A RU2007113156A RU2007113156A RU 2007113156 A RU2007113156 A RU 2007113156A RU 2007113156/15 A RU2007113156/15 A RU 2007113156/15A RU 2007113156 A RU2007113156 A RU 2007113156A RU 2007113156 A RU2007113156 A RU 2007113156A
- Authority
- RU
- Russia
- Prior art keywords
- polymer
- kollidon
- hydrophobic
- polyvinylpyrrolidone
- inert
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Botany (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
- Nutrition Science (AREA)
- Medical Informatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Твердая нанокомпозиция для доставки биологически активных веществ, содержащая 0,1-15% активного компонента, 40-95% полимера, 0-6% гидрофобного или инертного полимера и 0-56% водорастворимого компонента, отличающаяся тем, что содержит до 15% активного компонента, в качестве которого выступает таксифолин, 40-95% полимера, в качестве которого используют арабиногалактан, полиэтиленгликоли, поливинилпирролидоны и поливинолы различных молекулярных масс, 0-56% водорастворимого полимера, выбираемого из ряда возможных наполнителей: kollidon VA64 (сополимер винилпирролидона и винилацетата), kollidon 90F (высокомолекулярный поливинилпирролидон с М.м. 1000000-1500000), ludipress (модифицированная лактоза), сахарная пудра, изомальтоза, 0-6% гидрофобного или инертного полимера с целью достижения контролируемого высвобождения лекарственного вещества, где в качестве гидрофобного компонента используют compritol 888 АТО, Gatefosse (композиция моно-, ди- и триглицеридов бегеновой кислоты), в качестве инертного - kollidon SR, Basf (смесь полимеров поливинилпирролидона и поливинилацетата).2. Нанокомпозиция по п.1, в которой в качестве полимера использован полиэтиленгликоль (ПЭГ) (М.м. от 4000 до 8000), вносимый в систему при различных соотношениях с активным веществом.3. Нанокомпозиция по п.1, в которой в качестве полимера использован поливинилпирролидон (ПВП) (М.м. от 7000 до 20000), вносимый в систему при различных соотношениях с активным веществом.4. Нанокомпозиция по п.1, в которой в качестве полимера использован полисахарид арабиногалактан, вносимый в систему при различных соотношениях с активным веществом1. Solid nanocomposite for the delivery of biologically active substances, containing 0.1-15% of the active component, 40-95% of the polymer, 0-6% of a hydrophobic or inert polymer and 0-56% of a water-soluble component, characterized in that it contains up to 15% the active component, which is taxifolin, 40-95% of the polymer, which is used arabinogalactan, polyethylene glycols, polyvinylpyrrolidones and polyvinyls of various molecular weights, 0-56% water-soluble polymer, selected from a number of possible fillers: kollidon VA64 (vinyl copolymer irrolidone and vinyl acetate), kollidon 90F (high molecular weight polyvinylpyrrolidone with M.M. 1,000,000 to 1,500,000), ludipress (modified lactose), powdered sugar, isomaltose, 0-6% hydrophobic or inert polymer in order to achieve controlled release of the drug substance, where as the hydrophobic component uses compritol 888 ATO, Gatefosse (a composition of mono-, di- and triglycerides of behenic acid), as inert - kollidon SR, Basf (a mixture of polymers of polyvinylpyrrolidone and polyvinyl acetate) .2. The nanocomposite according to claim 1, in which polyethylene glycol (PEG) is used as the polymer (M.m. from 4000 to 8000), introduced into the system at various ratios with the active substance. The nanocomposition according to claim 1, in which polyvinylpyrrolidone (PVP) (M.M. from 7000 to 20,000) is used as a polymer, introduced into the system at various ratios with the active substance. The nanocomposite according to claim 1, in which the arabinogalactan polysaccharide used as a polymer is introduced into the system at various ratios with the active substance
Claims (4)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2007113156/15A RU2351352C2 (en) | 2007-04-09 | 2007-04-09 | Solid nanocomposition for delivery of biologically active substances |
| PCT/RU2008/000201 WO2008123798A1 (en) | 2007-04-09 | 2008-04-02 | Solid nanocomposition for delivering biologically active substances |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2007113156/15A RU2351352C2 (en) | 2007-04-09 | 2007-04-09 | Solid nanocomposition for delivery of biologically active substances |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007113156A true RU2007113156A (en) | 2008-10-27 |
| RU2351352C2 RU2351352C2 (en) | 2009-04-10 |
Family
ID=39831180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007113156/15A RU2351352C2 (en) | 2007-04-09 | 2007-04-09 | Solid nanocomposition for delivery of biologically active substances |
Country Status (2)
| Country | Link |
|---|---|
| RU (1) | RU2351352C2 (en) |
| WO (1) | WO2008123798A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2401118C1 (en) * | 2009-04-14 | 2010-10-10 | Государственное образовательное учреждение высшего профессионального образования Новосибирский государственный университет (НГУ) | Composition of betulin and biocompatible carriers and method for making thereof |
| RU2410109C1 (en) * | 2009-05-22 | 2011-01-27 | Закрытое акционерное общество "Санкт-Петербургский институт фармации" | Method for production of sugars-based nanocomposition |
| TWI540132B (en) | 2009-06-08 | 2016-07-01 | 亞培公司 | Pharmaceutical dosage form for oral administration of a bcl-2 family inhibitor |
| RU2411027C1 (en) * | 2009-06-24 | 2011-02-10 | Пация Мераби Георгиевич | Nanodisperse coenzyme q10 composition and method for making thereof |
| UA113500C2 (en) | 2010-10-29 | 2017-02-10 | MEL EXTRUSION SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT | |
| US8710027B2 (en) * | 2012-04-10 | 2014-04-29 | Flavitpure, Inc. | Method of using nutritional compounds dihydroquercetin (taxifolin) and arabinogalactan in combination with dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors associated with metabolic syndrome and hypercholesterolemia |
| RU2533231C1 (en) * | 2013-05-14 | 2014-11-20 | Владимир Сергеевич Остронков | Supramolecular complex, possessing anti-inflammatory and angioprotective activity and method of obtaining thereof |
| WO2021177930A1 (en) | 2020-03-06 | 2021-09-10 | Vyshnevskyy Ihor Anatoliyovych | Pharmaceutical composition with increased solubility of gesperidine and method of its preparation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2014841C1 (en) * | 1992-06-23 | 1994-06-30 | Международная ассоциация фитотерапии и традиционной медицины "Фитосан-интер" | Antioxidant, capillary-protective, antiinflammatory and antihistamine agent |
| DK0675710T3 (en) * | 1992-12-23 | 2000-03-27 | Saitec Srl | Process for the preparation of controlled release pharmaceutical forms and the resulting forms |
| RU2180848C1 (en) * | 2001-01-30 | 2002-03-27 | Плотников Марк Борисович | Agent eliciting antiaggregative and hemorheological activity |
| RU2187325C1 (en) * | 2001-09-14 | 2002-08-20 | Ткач Тамара Александровна | Agent "khitolen" showing radioprotective effect |
| RU2276990C2 (en) * | 2003-07-09 | 2006-05-27 | Общество с ограниченной ответственностью "Компания "Чистая линия" | Radioprotection composition and method for producing the composition |
-
2007
- 2007-04-09 RU RU2007113156/15A patent/RU2351352C2/en active
-
2008
- 2008-04-02 WO PCT/RU2008/000201 patent/WO2008123798A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008123798A1 (en) | 2008-10-16 |
| RU2351352C2 (en) | 2009-04-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2007113156A (en) | SOLID NANOCOMPOSITION FOR DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES | |
| RU2013114406A (en) | DRUG-RESISTANT DRUG FORM THAT CONTAINS AN Anionic POLYMER | |
| WO2006017852A3 (en) | Pharmaceutical compositions for controlled release delivery of biologically active compounds | |
| IL195407A0 (en) | Pharmaceutical composition with controlled active ingredient delivery for active ingredients with good solubility in water | |
| RU2011103085A (en) | PHARMACEUTICAL DOSED FORM CONTAINING A POLYMERIC CARRIER COMPOSITION | |
| WO2005084639A3 (en) | Polymeric drug delivery system for hydrophobic drugs | |
| RU2002135623A (en) | RECIPE BASED ON HEPARIN, GLUCOSAMINOGLICAN OR HEPARINOID AND APPLICATION OF THE RECIPE AND ITS BASIS | |
| EP1974726A3 (en) | Matrix compositions for controlled delivery of drug substances | |
| WO2003084513A1 (en) | Controlled release solid dosage carbamazepine formulations | |
| WO2010130728A3 (en) | Solid pharmaceutical preparations containing copolymers based on polyethers combined with poorly water-soluble polymers | |
| RU2014101228A (en) | COVERING COMPOSITION SUITABLE FOR PHARMACEUTICAL OR NUTRICEUTIC MEDICINAL FORMS | |
| EP2621479A1 (en) | Protective coatings for acidic active ingredients | |
| TR201820076T4 (en) | Release of drug combinations. | |
| WO2011045775A4 (en) | A delayed release pharmaceutical composition of mesalamine | |
| CN110709068B (en) | Improved sustained release high load pharmaceutical compositions | |
| CN102292110A (en) | hard capsule | |
| UA93530C2 (en) | Composition with sustained release of an active ingredient, process for the preparation and use thereof | |
| KR20190111149A (en) | Base for patch and patch using it | |
| NZ705802A (en) | Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it. | |
| EP1416918A1 (en) | Synergistic filler composition | |
| WO2021033182A1 (en) | Adhesive drug delivery film and a microparticle comprising thereof | |
| Gwon et al. | New route for synthesizing poly (ethylene glycol)-acrylic acid hydrogels using γ-irradiation for drug delivery carriers | |
| US20210347978A1 (en) | Peroxide stable polymer composition and process for its preparation and applications thereof | |
| WO2005023181A3 (en) | Polymeric systems for controlled drug therapy | |
| Williams et al. | Polyethylene glycol-polyvinyl alcohol graft copolymer: a peroxide-free binder |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Invention patent assignment |
Effective date: 20100216 |
|
| PD4A | Correction of name of patent owner | ||
| PC41 | Official registration of the transfer of exclusive right |
Effective date: 20211027 |